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Entry version 200 (18 Sep 2019)
Sequence version 2 (16 Nov 2001)
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Protein

Reticulon-4

Gene

RTN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).Curated5 Publications
Isoform A: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity).By similarity2 Publications
Isoform B: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).By similarityCurated2 Publications
Isoform C: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-193634 Axonal growth inhibition (RHOA activation)

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9NQC3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulon-4Curated
Alternative name(s):
Foocen
Neurite outgrowth inhibitor
Short name:
Nogo protein1 Publication
Neuroendocrine-specific protein
Short name:
NSP
Neuroendocrine-specific protein C homolog
RTN-x
Reticulon-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTN4Imported
Synonyms:KIAA0886, NOGO1 Publication
ORF Names:My043, SP1507
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14085 RTN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604475 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 1018CytoplasmicSequence analysisAdd BLAST1018
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1019 – 1039HelicalSequence analysisAdd BLAST21
Topological domaini1040 – 1133LumenalSequence analysisAdd BLAST94
Transmembranei1134 – 1154HelicalSequence analysisAdd BLAST21
Topological domaini1155 – 1192CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57142

Open Targets

More...
OpenTargetsi
ENSG00000115310

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34883

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712895

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2838

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RTN4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17369290

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001681651 – 1192Reticulon-4Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei7PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1 Publication1
Modified residuei107PhosphoserineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei184PhosphoserineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei450PhosphothreonineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei858PhosphothreonineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei991PhosphoserineCombined sources1
Modified residuei1104N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQC3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQC3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NQC3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NQC3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NQC3

PeptideAtlas

More...
PeptideAtlasi
Q9NQC3

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQC3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82133 [Q9NQC3-1]
82134 [Q9NQC3-2]
82135 [Q9NQC3-3]
82136 [Q9NQC3-4]
82137 [Q9NQC3-5]
82138 [Q9NQC3-6]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NQC3-2 [Q9NQC3-2]
Q9NQC3-3 [Q9NQC3-3]
Q9NQC3-4 [Q9NQC3-4]
Q9NQC3-5 [Q9NQC3-5]
Q9NQC3-6 [Q9NQC3-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NQC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NQC3

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9NQC3

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9NQC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A: is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform B: widely expressed except for the liver. Highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:15034570, PubMed:21183689). Isoform C: is expressed in brain, skeletal muscle and adipocytes. Isoform D is testis-specific.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115310 Expressed in 250 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NQC3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NQC3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005388
HPA023977

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to RTN4R (PubMed:19052207).

Interacts with ATL1 (PubMed:19665976).

Interacts with TMEM170A (PubMed:26906412, PubMed:19665976).

Interacts with RTN4IP1 (By similarity). Isoform A: interacts in trans with CNTNAP1 (By similarity). Isoform B: homodimerizes (PubMed:27786289). Isoform B: interacts with BAD/Bcl-xl and BCL2. Isoform B: binds to NGBR and RTN3 (PubMed:16835300, PubMed:16979658, PubMed:12811824). Isoform B: interacts with SPTLC1 (By similarity). Isoform B: interacts with GRAMD4 (By similarity). Isoform B: interacts with CDH5 (PubMed:21183689). Isoform B: interacts with BACE1 and BACE2 (PubMed:15286784, PubMed:16965550). Isoform C: interacts with BACE1 and BACE2 (PubMed:15286784, PubMed:16965550). Isoform C: interacts with TMEM33 (PubMed:25612671).

By similarity11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121400, 134 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9NQC3

Database of interacting proteins

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DIPi
DIP-42003N

Protein interaction database and analysis system

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IntActi
Q9NQC3, 88 interactors

Molecular INTeraction database

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MINTi
Q9NQC3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337838

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NQC3

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9NQC3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1005 – 1192ReticulonPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 47Poly-GluAdd BLAST18
Compositional biasi143 – 148Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).By similarity
Isoform B: N-terminal part, called Am-Nogo-B(1-200), is the functional domain for RTN4B-mediated signaling in endothelial and vascular smooth muscle cells.1 Publication

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1792 Eukaryota
ENOG410XPKH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000148576

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NQC3

KEGG Orthology (KO)

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KOi
K20720

Database of Orthologous Groups

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OrthoDBi
1201347at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NQC3

TreeFam database of animal gene trees

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TreeFami
TF105431

Family and domain databases

Database of protein disorder

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DisProti
DP00524

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003388 Reticulon

Pfam protein domain database

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Pfami
View protein in Pfam
PF02453 Reticulon, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50845 RETICULON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9NQC3-1) [UniParc]FASTAAdd to basket
Also known as: RTN4A2 Publications, Nogo-A2 Publications, RTN-xL1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE
60 70 80 90 100
ELEVLERKPA AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV
110 120 130 140 150
APERQPSWDP SPVSSTVPAP SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS
160 170 180 190 200
VSPQAEPVWT PPAPAPAAPP STPAAPKRRG SSGSVDETLF ALPAASEPVI
210 220 230 240 250
RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP LSAASFKEHE
260 270 280 290 300
YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
310 320 330 340 350
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL
360 370 380 390 400
TKLVKEDEVV SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK
410 420 430 440 450
EDSDMLAAGG KIESNLESKV DKKCFADSLE QTNHEKDSES SNDDTSFPST
460 470 480 490 500
PEGIKDRSGA YITCAPFNPA ATESIATNIF PLLGDPTSEN KTDEKKIEEK
510 520 530 540 550
KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE EVVANMPEGL
560 570 580 590 600
TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
610 620 630 640 650
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK
660 670 680 690 700
HEPENPPPYE EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD
710 720 730 740 750
LIKETKLSAE PAPDFSDYSE MAKVEQPVPD HSELVEDSSP DSEPVDLFSD
760 770 780 790 800
DSIPDVPQKQ DETVMLVKES LTETSFESMI EYENKEKLSA LPPEGGKPYL
810 820 830 840 850
ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY SNDDLFISKE
860 870 880 890 900
AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
910 920 930 940 950
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL
960 970 980 990 1000
LPPDVSALAT QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL
1010 1020 1030 1040 1050
SKTSVVDLLY WRDIKKTGVV FGASLFLLLS LTVFSIVSVT AYIALALLSV
1060 1070 1080 1090 1100
TISFRIYKGV IQAIQKSDEG HPFRAYLESE VAISEELVQK YSNSALGHVN
1110 1120 1130 1140 1150
CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL LILALISLFS
1160 1170 1180 1190
VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE
Length:1,192
Mass (Da):129,931
Last modified:November 16, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDE239BBF31589CA
GO
Isoform B (identifier: Q9NQC3-2) [UniParc]FASTAAdd to basket
Also known as: RTN4B1 Publication, ASY1 Publication, Nogo-B1 Publication, RTN-xS1 Publication, Foocen-M, RTN4B11 Publication, Nogo-B11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     186-1004: Missing.

Show »
Length:373
Mass (Da):40,318
Checksum:i8A19379EF91A59B4
GO
Isoform C (identifier: Q9NQC3-3) [UniParc]FASTAAdd to basket
Also known as: RTN4C2 Publications, Nogo-C2 Publications, Foocen-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-993: Missing.
     994-1004: AIFSAELSKTS → MDGQKKNWKDK

Show »
Length:199
Mass (Da):22,395
Checksum:iC60161DF3FB34D80
GO
Isoform 6 (identifier: Q9NQC3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-289: Missing.

Show »
Length:960
Mass (Da):106,360
Checksum:i51B5E94CF103BA74
GO
Isoform B2 (identifier: Q9NQC3-5) [UniParc]FASTAAdd to basket
Also known as: RTN4B21 Publication, Nogo-B21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     205-1004: Missing.

Show »
Length:392
Mass (Da):42,274
Checksum:iD7B2AA5E839E58AD
GO
Isoform D (identifier: Q9NQC3-6) [UniParc]FASTAAdd to basket
Also known as: Rtn-T, RTN4Aa1 Publication, RTN4Ab1 Publication, RTN4D1 Publication, RTN4E1 Publication, RTN4F1 Publication, RTN4G1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.

Show »
Length:986
Mass (Da):108,450
Checksum:i0CDE8F647036415A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W914F8W914_HUMAN
Reticulon
RTN4
345Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C106H7C106_HUMAN
Reticulon
RTN4
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQR6A0A0U1RQR6_HUMAN
Reticulon
RTN4
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J685C9J685_HUMAN
Reticulon-4
RTN4
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD39920 differs from that shown. Reason: Frameshift at positions 1149 and 1156.Curated
The sequence AAG43160 differs from that shown. Reason: Frameshift at positions 684 and 700.Curated
The sequence AAG43160 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA74909 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107S → C in BAA83712 (Ref. 6) Curated1
Sequence conflicti135E → Q in BAA83712 (Ref. 6) Curated1
Sequence conflicti458S → P in CAB99248 (PubMed:10667780).Curated1
Sequence conflicti564N → S in AAK20831 (PubMed:11866689).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053633357D → V. Corresponds to variant dbSNP:rs11677099Ensembl.1
Natural variantiVAR_035904429L → V in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053634899E → Q. Corresponds to variant dbSNP:rs6757519Ensembl.1
Natural variantiVAR_053635920S → C. Corresponds to variant dbSNP:rs6757705Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0056521 – 993Missing in isoform C. 8 PublicationsAdd BLAST993
Alternative sequenceiVSP_0371121 – 206Missing in isoform D. 2 PublicationsAdd BLAST206
Alternative sequenceiVSP_00565458 – 289Missing in isoform 6. 2 PublicationsAdd BLAST232
Alternative sequenceiVSP_005655186 – 1004Missing in isoform B. 7 PublicationsAdd BLAST819
Alternative sequenceiVSP_037113205 – 1004Missing in isoform B2. 2 PublicationsAdd BLAST800
Alternative sequenceiVSP_005653994 – 1004AIFSAELSKTS → MDGQKKNWKDK in isoform C. 8 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF087901 mRNA Translation: AAG12205.1
AF148537 mRNA Translation: AAG12176.1
AF148538 mRNA Translation: AAG12177.1
AJ251383 mRNA Translation: CAB99248.1
AJ251384 mRNA Translation: CAB99249.1
AJ251385 mRNA Translation: CAB99250.1
AB040462 mRNA Translation: BAB18927.1
AB040463 mRNA Translation: BAB18928.1
AF333336 mRNA Translation: AAK20831.1
AY102285 Genomic DNA Translation: AAM64240.1
AY102285 Genomic DNA Translation: AAM64241.1
AY102285 Genomic DNA Translation: AAM64242.1
AY102285 Genomic DNA Translation: AAM64243.1
AY102285 Genomic DNA Translation: AAM64244.1
AY102276 mRNA Translation: AAM64245.1
AY102277 mRNA Translation: AAM64246.1
AY102278 mRNA Translation: AAM64247.1
AY102279 mRNA Translation: AAM64248.1
AY123245 mRNA Translation: AAM64249.1
AY123246 mRNA Translation: AAM64250.1
AY123247 mRNA Translation: AAM64251.1
AY123248 mRNA Translation: AAM64252.1
AY123249 mRNA Translation: AAM64253.1
AY123250 mRNA Translation: AAM64254.1
AB015639 mRNA Translation: BAA83712.1
AF077050 mRNA Translation: AAD27783.1
AF132047 mRNA Translation: AAD31021.1
AF132048 mRNA Translation: AAD31022.1
AF320999 mRNA Translation: AAG40878.1
AB020693 mRNA Translation: BAA74909.2 Different initiation.
AF125103 mRNA Translation: AAD39920.1 Frameshift.
AF177332 mRNA Translation: AAG17976.1
AC013414 Genomic DNA No translation available.
AC092461 Genomic DNA No translation available.
AC093165 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00115.1
CH471053 Genomic DNA Translation: EAX00116.1
CH471053 Genomic DNA Translation: EAX00117.1
CH471053 Genomic DNA Translation: EAX00118.1
CH471053 Genomic DNA Translation: EAX00119.1
CH471053 Genomic DNA Translation: EAX00121.1
CH471053 Genomic DNA Translation: EAX00122.1
CH471053 Genomic DNA Translation: EAX00123.1
CH471053 Genomic DNA Translation: EAX00124.1
CH471053 Genomic DNA Translation: EAX00125.1
CH471053 Genomic DNA Translation: EAX00127.1
CH471053 Genomic DNA Translation: EAX00130.1
CH471053 Genomic DNA Translation: EAX00132.1
BC001035 mRNA Translation: AAH01035.1
BC007109 mRNA Translation: AAH07109.1
BC010737 mRNA Translation: AAH10737.1
BC012619 mRNA Translation: AAH12619.1
BC014366 mRNA Translation: AAH14366.1
BC016165 mRNA Translation: AAH16165.1
BC026788 mRNA Translation: AAH26788.1
BC068991 mRNA Translation: AAH68991.1
BC150182 mRNA Translation: AAI50183.1
BC152425 mRNA Translation: AAI52426.1
BC152555 mRNA Translation: AAI52556.1
AF063601 mRNA Translation: AAG43160.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1851.1 [Q9NQC3-2]
CCDS1852.1 [Q9NQC3-6]
CCDS42683.1 [Q9NQC3-5]
CCDS42684.1 [Q9NQC3-1]
CCDS42685.1 [Q9NQC3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001308788.1, NM_001321859.1 [Q9NQC3-6]
NP_001308789.1, NM_001321860.1 [Q9NQC3-6]
NP_001308790.1, NM_001321861.1 [Q9NQC3-6]
NP_001308791.1, NM_001321862.1 [Q9NQC3-6]
NP_001308792.1, NM_001321863.1 [Q9NQC3-6]
NP_001308833.1, NM_001321904.1 [Q9NQC3-6]
NP_008939.1, NM_007008.2 [Q9NQC3-3]
NP_065393.1, NM_020532.4 [Q9NQC3-1]
NP_722550.1, NM_153828.2 [Q9NQC3-2]
NP_997403.1, NM_207520.1 [Q9NQC3-5]
NP_997404.1, NM_207521.1 [Q9NQC3-6]
XP_005264491.1, XM_005264434.3
XP_016860007.1, XM_017004518.1
XP_016860008.1, XM_017004519.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317610; ENSP00000322147; ENSG00000115310 [Q9NQC3-2]
ENST00000337526; ENSP00000337838; ENSG00000115310 [Q9NQC3-1]
ENST00000357376; ENSP00000349944; ENSG00000115310 [Q9NQC3-6]
ENST00000357732; ENSP00000350365; ENSG00000115310 [Q9NQC3-5]
ENST00000394609; ENSP00000378107; ENSG00000115310 [Q9NQC3-3]
ENST00000394611; ENSP00000378109; ENSG00000115310 [Q9NQC3-6]
ENST00000404909; ENSP00000385650; ENSG00000115310 [Q9NQC3-6]
ENST00000405240; ENSP00000384471; ENSG00000115310 [Q9NQC3-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57142

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57142

UCSC genome browser

More...
UCSCi
uc002ryc.4 human [Q9NQC3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087901 mRNA Translation: AAG12205.1
AF148537 mRNA Translation: AAG12176.1
AF148538 mRNA Translation: AAG12177.1
AJ251383 mRNA Translation: CAB99248.1
AJ251384 mRNA Translation: CAB99249.1
AJ251385 mRNA Translation: CAB99250.1
AB040462 mRNA Translation: BAB18927.1
AB040463 mRNA Translation: BAB18928.1
AF333336 mRNA Translation: AAK20831.1
AY102285 Genomic DNA Translation: AAM64240.1
AY102285 Genomic DNA Translation: AAM64241.1
AY102285 Genomic DNA Translation: AAM64242.1
AY102285 Genomic DNA Translation: AAM64243.1
AY102285 Genomic DNA Translation: AAM64244.1
AY102276 mRNA Translation: AAM64245.1
AY102277 mRNA Translation: AAM64246.1
AY102278 mRNA Translation: AAM64247.1
AY102279 mRNA Translation: AAM64248.1
AY123245 mRNA Translation: AAM64249.1
AY123246 mRNA Translation: AAM64250.1
AY123247 mRNA Translation: AAM64251.1
AY123248 mRNA Translation: AAM64252.1
AY123249 mRNA Translation: AAM64253.1
AY123250 mRNA Translation: AAM64254.1
AB015639 mRNA Translation: BAA83712.1
AF077050 mRNA Translation: AAD27783.1
AF132047 mRNA Translation: AAD31021.1
AF132048 mRNA Translation: AAD31022.1
AF320999 mRNA Translation: AAG40878.1
AB020693 mRNA Translation: BAA74909.2 Different initiation.
AF125103 mRNA Translation: AAD39920.1 Frameshift.
AF177332 mRNA Translation: AAG17976.1
AC013414 Genomic DNA No translation available.
AC092461 Genomic DNA No translation available.
AC093165 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00115.1
CH471053 Genomic DNA Translation: EAX00116.1
CH471053 Genomic DNA Translation: EAX00117.1
CH471053 Genomic DNA Translation: EAX00118.1
CH471053 Genomic DNA Translation: EAX00119.1
CH471053 Genomic DNA Translation: EAX00121.1
CH471053 Genomic DNA Translation: EAX00122.1
CH471053 Genomic DNA Translation: EAX00123.1
CH471053 Genomic DNA Translation: EAX00124.1
CH471053 Genomic DNA Translation: EAX00125.1
CH471053 Genomic DNA Translation: EAX00127.1
CH471053 Genomic DNA Translation: EAX00130.1
CH471053 Genomic DNA Translation: EAX00132.1
BC001035 mRNA Translation: AAH01035.1
BC007109 mRNA Translation: AAH07109.1
BC010737 mRNA Translation: AAH10737.1
BC012619 mRNA Translation: AAH12619.1
BC014366 mRNA Translation: AAH14366.1
BC016165 mRNA Translation: AAH16165.1
BC026788 mRNA Translation: AAH26788.1
BC068991 mRNA Translation: AAH68991.1
BC150182 mRNA Translation: AAI50183.1
BC152425 mRNA Translation: AAI52426.1
BC152555 mRNA Translation: AAI52556.1
AF063601 mRNA Translation: AAG43160.1 Sequence problems.
CCDSiCCDS1851.1 [Q9NQC3-2]
CCDS1852.1 [Q9NQC3-6]
CCDS42683.1 [Q9NQC3-5]
CCDS42684.1 [Q9NQC3-1]
CCDS42685.1 [Q9NQC3-3]
RefSeqiNP_001308788.1, NM_001321859.1 [Q9NQC3-6]
NP_001308789.1, NM_001321860.1 [Q9NQC3-6]
NP_001308790.1, NM_001321861.1 [Q9NQC3-6]
NP_001308791.1, NM_001321862.1 [Q9NQC3-6]
NP_001308792.1, NM_001321863.1 [Q9NQC3-6]
NP_001308833.1, NM_001321904.1 [Q9NQC3-6]
NP_008939.1, NM_007008.2 [Q9NQC3-3]
NP_065393.1, NM_020532.4 [Q9NQC3-1]
NP_722550.1, NM_153828.2 [Q9NQC3-2]
NP_997403.1, NM_207520.1 [Q9NQC3-5]
NP_997404.1, NM_207521.1 [Q9NQC3-6]
XP_005264491.1, XM_005264434.3
XP_016860007.1, XM_017004518.1
XP_016860008.1, XM_017004519.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G31NMR-A1055-1114[»]
2JV5NMR-A1055-1108[»]
SMRiQ9NQC3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121400, 134 interactors
CORUMiQ9NQC3
DIPiDIP-42003N
IntActiQ9NQC3, 88 interactors
MINTiQ9NQC3
STRINGi9606.ENSP00000337838

Chemistry databases

ChEMBLiCHEMBL3712895
GuidetoPHARMACOLOGYi2838

PTM databases

iPTMnetiQ9NQC3
PhosphoSitePlusiQ9NQC3
SwissPalmiQ9NQC3

Polymorphism and mutation databases

BioMutaiRTN4
DMDMi17369290

Proteomic databases

EPDiQ9NQC3
jPOSTiQ9NQC3
MassIVEiQ9NQC3
MaxQBiQ9NQC3
PaxDbiQ9NQC3
PeptideAtlasiQ9NQC3
PRIDEiQ9NQC3
ProteomicsDBi82133 [Q9NQC3-1]
82134 [Q9NQC3-2]
82135 [Q9NQC3-3]
82136 [Q9NQC3-4]
82137 [Q9NQC3-5]
82138 [Q9NQC3-6]
TopDownProteomicsiQ9NQC3-2 [Q9NQC3-2]
Q9NQC3-3 [Q9NQC3-3]
Q9NQC3-4 [Q9NQC3-4]
Q9NQC3-5 [Q9NQC3-5]
Q9NQC3-6 [Q9NQC3-6]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9NQC3

The DNASU plasmid repository

More...
DNASUi
57142
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317610; ENSP00000322147; ENSG00000115310 [Q9NQC3-2]
ENST00000337526; ENSP00000337838; ENSG00000115310 [Q9NQC3-1]
ENST00000357376; ENSP00000349944; ENSG00000115310 [Q9NQC3-6]
ENST00000357732; ENSP00000350365; ENSG00000115310 [Q9NQC3-5]
ENST00000394609; ENSP00000378107; ENSG00000115310 [Q9NQC3-3]
ENST00000394611; ENSP00000378109; ENSG00000115310 [Q9NQC3-6]
ENST00000404909; ENSP00000385650; ENSG00000115310 [Q9NQC3-6]
ENST00000405240; ENSP00000384471; ENSG00000115310 [Q9NQC3-6]
GeneIDi57142
KEGGihsa:57142
UCSCiuc002ryc.4 human [Q9NQC3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57142
DisGeNETi57142

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RTN4
HGNCiHGNC:14085 RTN4
HPAiCAB005388
HPA023977
MIMi604475 gene
neXtProtiNX_Q9NQC3
OpenTargetsiENSG00000115310
PharmGKBiPA34883

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00940000156568
HOGENOMiHOG000148576
InParanoidiQ9NQC3
KOiK20720
OrthoDBi1201347at2759
PhylomeDBiQ9NQC3
TreeFamiTF105431

Enzyme and pathway databases

ReactomeiR-HSA-193634 Axonal growth inhibition (RHOA activation)
SIGNORiQ9NQC3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RTN4 human
EvolutionaryTraceiQ9NQC3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Reticulon_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57142

Pharos

More...
Pharosi
Q9NQC3
PMAP-CutDBiQ9NQC3

Protein Ontology

More...
PROi
PR:Q9NQC3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115310 Expressed in 250 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ9NQC3 baseline and differential
GenevisibleiQ9NQC3 HS

Family and domain databases

DisProtiDP00524
InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTN4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQC3
Secondary accession number(s): O94962
, Q7L7Q5, Q7L7Q6, Q7L7Q8, Q8IUA4, Q96B16, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: September 18, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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