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UniProtKB - Q9NQB0 (TF7L2_HUMAN)

Protein

Transcription factor 7-like 2

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi350 – 418HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-4086398 Ca2+ pathway
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-4641265 Repression of WNT target genes
R-HSA-5339700 TCF7L2 mutants don't bind CTBP
R-HSA-8951430 RUNX3 regulates WNT signaling
SignaLinkiQ9NQB0
SIGNORiQ9NQB0

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 7-like 2
Alternative name(s):
HMG box transcription factor 4
T-cell-specific transcription factor 4
Short name:
T-cell factor 4
Short name:
TCF-4
Short name:
hTCF-4
Gene namesi
Name:TCF7L2
Synonyms:TCF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148737.15
HGNCiHGNC:11641 TCF7L2
MIMi602228 gene
neXtProtiNX_Q9NQB0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Constitutive activation and subsequent transactivation of target genes may lead to the maintenance of stem-cell characteristics (cycling and longevity) in cells that should normally undergo terminal differentiation and constitute the primary transforming event in colorectal cancer (CRC).
Diabetes mellitus, non-insulin-dependent (NIDDM)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10 – 11DD → AA: Reduces CTNNB1 binding. 1 Publication2
Mutagenesisi16D → A: Abolishes CTNNB1 binding. 1 Publication1
Mutagenesisi17E → A: Reduces CTNNB1 binding. 1 Publication1
Mutagenesisi19I → A: Reduces transcription activation. 1 Publication1
Mutagenesisi21F → A: Reduces transcription activation. 1 Publication1
Mutagenesisi23 – 24DE → AA: Reduces CTNNB1 binding. 1 Publication2
Mutagenesisi24E → A: Reduces CTNNB1 binding, and abolishes CTNNB1 binding; when associated with A-26; A-28 and A-29. 1 Publication1
Mutagenesisi26E → A: Abolishes CTNNB1 binding; when associated with A-24; A-28 and A-29. 1 Publication1
Mutagenesisi28E → A: Abolishes CTNNB1 binding; when associated with A-24; A-26 and A-29. 1 Publication1
Mutagenesisi29E → A: Reduces CTNNB1 binding, and abolishes CTNNB1 binding; when associated with A-24; A-26 and A-28. 1 Publication1
Mutagenesisi48L → A: Abolishes CTNNB1 binding. 1 Publication1
Mutagenesisi201T → V: Reduced phosphorylation by NLK and enhanced DNA-binding; when associated with V-212. 1 Publication1
Mutagenesisi212T → V: Reduced phosphorylation by NLK and enhanced DNA-binding; when associated with V-201. 1 Publication1
Mutagenesisi320K → R: Loss of sumoylation. No effect on localization to nuclear bodies. 1 Publication1
Mutagenesisi322E → A: Loss of sumoylation. 1 Publication1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNETi6934
MalaCardsiTCF7L2
MIMi125853 phenotype
OpenTargetsiENSG00000148737
PharmGKBiPA36394

Chemistry databases

ChEMBLiCHEMBL3038511

Polymorphism and mutation databases

BioMutaiTCF7L2
DMDMi29337146

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000486231 – 619Transcription factor 7-like 2Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei201Phosphothreonine; by NLK1 Publication1
Modified residuei212Phosphothreonine; by NLK1 Publication1
Cross-linki320Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki539Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

In vitro, phosphorylated by TNIK.1 Publication
Phosphorylated at Thr-201 and/or Thr-212 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway.1 Publication
Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NQB0
PaxDbiQ9NQB0
PeptideAtlasiQ9NQB0
PRIDEiQ9NQB0
ProteomicsDBi82120
82121 [Q9NQB0-10]
82122 [Q9NQB0-2]
82123 [Q9NQB0-3]
82124 [Q9NQB0-4]
82125 [Q9NQB0-5]
82126 [Q9NQB0-6]
82127 [Q9NQB0-7]
82128 [Q9NQB0-8]
82129 [Q9NQB0-9]

PTM databases

iPTMnetiQ9NQB0
PhosphoSitePlusiQ9NQB0

Expressioni

Tissue specificityi

Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.1 Publication

Developmental stagei

Highly expressed in crypt regions and barely detectable in villi in epithelium from fetal small intestine at week 16. At week 22 expression in villi had increased strongly.

Gene expression databases

BgeeiENSG00000148737 Expressed in 228 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_TCF4
ExpressionAtlasiQ9NQB0 baseline and differential
GenevisibleiQ9NQB0 HS

Organism-specific databases

HPAiCAB013535
HPA038800

Interactioni

Subunit structurei

Interacts with TGFB1I1 (By similarity). Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promZIPK/DAPK3oters, negatively modulating its transcriptional activity. Interacts with ZIPK/DAPK3. Interacts with XIAP/BIRC4 and TLE3. Interacts with DDIT3/CHOP. The CTNNB1 and TCF7L2/TCF4 complex interacts with PML (isoform PML-4). Identified in a complex with CTNNB1 and FERMT2. Interacts with SPIN1 (PubMed:22258766, PubMed:24589551, PubMed:29061846). Interacts with C11orf84/SPINDOC in a SPIN1-dependent manner (PubMed:29061846).By similarity21 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112795, 38 interactors
CORUMiQ9NQB0
DIPiDIP-36236N
IntActiQ9NQB0, 54 interactors
MINTiQ9NQB0
STRINGi9606.ENSP00000444972

Chemistry databases

BindingDBiQ9NQB0

Structurei

Secondary structure

1619
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00175
ProteinModelPortaliQ9NQB0
SMRiQ9NQB0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NQB0

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 53CTNNB1-bindingBy similarityAdd BLAST53
Regioni201 – 395Mediates interaction with MAD2L21 PublicationAdd BLAST195
Regioni459 – 505Promoter-specific activation domainAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi425 – 430Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 317Pro-richAdd BLAST140

Domaini

The promoter-specific activation domain interacts with the transcriptional coactivator EP300.

Sequence similaritiesi

Belongs to the TCF/LEF family.Curated

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00390000009964
HOVERGENiHBG000419
InParanoidiQ9NQB0
KOiK04491
OMAiHSAKHQD
OrthoDBiEOG091G0705
PhylomeDBiQ9NQB0
TreeFamiTF318448

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028773 TCF7L
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF25 PTHR10373:SF25, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (17+)i

Sequence statusi: Complete.

This entry describes 17 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 17 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQB0-1) [UniParc]FASTAAdd to basket
Also known as: TCF-4M

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN 
        60         70         80         90        100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY 
       110        120        130        140        150
PGYPFIMIPD LTSPYLPNGS LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ 
       160        170        180        190        200
YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP AHIVSNKVPV VQHPHHVHPL 
       210        220        230        240        250
TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS PYYPLSPGTV 
       260        270        280        290        300
GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SRFPPHMVPP 
       310        320        330        340        350
HHTLHTTGIP HPAIVTPTVK QESSQSDVGS LHSSKHQDSK KEEEKKKPHI 
       360        370        380        390        400
KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY 
       410        420        430        440        450
ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETNE HSECFLNPCL 
       460        470        480        490        500
SLPPITDLSA PKKCRARFGL DQQNNWCGPC RRKKKCVRYI QGEGSCLSPP 
       510        520        530        540        550
SSDGSLLDSP PPSPNLLGSP PRDAKSQTEQ TQPLSLSLKP DPLAHLSMMP 
       560        570        580        590        600
PPPALLLAEA THKASALCPN GALDLPPAAL QPAAPSSSIA QPSTSSLHSH 
       610 
SSLAGTQPQP LSLVTKSLE
Length:619
Mass (Da):67,919
Last modified:March 25, 2003 - v2
Checksum:i4DD2D3CC814AE16E
GO
Isoform 2 (identifier: Q9NQB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-494: RKKKCVRYIQGEG → CKYSKEVSGTVRA
     495-619: Missing.

Show »
Length:494
Mass (Da):55,152
Checksum:iAC0B8049DF6F4498
GO
Isoform 3 (identifier: Q9NQB0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-478: DLSAPKKCRARFGLDQQNNWCG → DANTPKKCRALFGLDRQTLWCK

Show »
Length:619
Mass (Da):67,976
Checksum:i6F0250E096854CC0
GO
Isoform 4 (identifier: Q9NQB0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-456: Missing.
     482-494: RKKKCVRYIQGEG → CKYSKEVSGTVRA
     495-619: Missing.

Show »
Length:477
Mass (Da):53,270
Checksum:i380199CA672A41A8
GO
Isoform 5 (identifier: Q9NQB0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-456: Missing.

Show »
Length:602
Mass (Da):66,037
Checksum:iA52CA392A33AB61C
GO
Isoform 6 (identifier: Q9NQB0-6) [UniParc]FASTAAdd to basket
Also known as: TCF-4I

The sequence of this isoform differs from the canonical sequence as follows:
     457-619: DLSAPKKCRA...PLSLVTKSLE → GEKKSAFATYKVKAAASAHPLQMEAY

Show »
Length:482
Mass (Da):53,676
Checksum:iB68AD303BF9F3E25
GO
Isoform 7 (identifier: Q9NQB0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-456: Missing.
     457-478: DLSAPKKCRARFGLDQQNNWCG → DANTPKKCRALFGLDRQTLWCK

Show »
Length:602
Mass (Da):66,094
Checksum:i87FC20BEB4F51BB2
GO
Isoform 8 (identifier: Q9NQB0-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.

Show »
Length:596
Mass (Da):65,291
Checksum:iA022284FEC164B09
GO
Isoform 9 (identifier: Q9NQB0-9) [UniParc]FASTAAdd to basket
Also known as: TCF-4G

The sequence of this isoform differs from the canonical sequence as follows:
     440-465: EHSECFLNPCLSLPPITDLSAPKKCR → GEKKSAFATYKVKAAASAHPLQMEAY
     466-619: Missing.

Show »
Length:465
Mass (Da):51,794
Checksum:i5E1E47B5DCB132BE
GO
Isoform 10 (identifier: Q9NQB0-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.
     260-263: Missing.
     457-482: DLSAPKKCRARFGLDQQNNWCGPCRR → GEKKSAFATYKVKAAASAHPLQMEAY
     483-619: Missing.

Show »
Length:455
Mass (Da):50,611
Checksum:i2775B43A2E392581
GO
Isoform 11 (identifier: Q9NQB0-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.
     184-184: V → VSPLPCCTQGHDCQHFYPPSDFTVSTQVFRDMKRSHSLQKVGEPWCIE
     440-465: EHSECFLNPCLSLPPITDLSAPKKCR → GEKKSAFATYKVKAAASAHPLQMEAY
     466-619: Missing.

Show »
Length:489
Mass (Da):54,572
Checksum:i9817D6DB995CBCD2
GO
Isoform 12 (identifier: Q9NQB0-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.
     481-619: RRKKKCVRYI...PLSLVTKSLE → SL

Note: Low expression in pancreas and colon.
Show »
Length:459
Mass (Da):51,159
Checksum:i59C37C6D178BD813
GO
Isoform 13 (identifier: Q9NQB0-13) [UniParc]FASTAAdd to basket
Also known as: TCF-4J

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.
     440-456: Missing.
     457-478: DLSAPKKCRARFGLDQQNNWCG → DANTPKKCRALFGLDRQTLWCK

Note: Common splicing form, lowest expression in skeletal muscle.
Show »
Length:579
Mass (Da):63,466
Checksum:iB2DEA916F03B0F63
GO
Isoform 14 (identifier: Q9NQB0-14) [UniParc]FASTAAdd to basket
Also known as: TCF-4B, short

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.
     440-465: EHSECFLNPCLSLPPITDLSAPKKCR → GEKKSAFATYKVKAAASAHPLQMEAY
     466-619: Missing.

Note: High transcriptional activity. Major isoform in liver.
Show »
Length:442
Mass (Da):49,166
Checksum:i57D7E679A87FF4C3
GO
Isoform 15 (identifier: Q9NQB0-15) [UniParc]FASTAAdd to basket
Also known as: TCF-4A

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.
     290-290: M → MSSFLS
     440-465: EHSECFLNPCLSLPPITDLSAPKKCR → GEKKSAFATYKVKAAASAHPLQMEAY
     466-619: Missing.

Show »
Length:447
Mass (Da):49,688
Checksum:i1363601E57F2AA39
GO
Isoform 16 (identifier: Q9NQB0-16) [UniParc]FASTAAdd to basket
Also known as: TCF-4K

The sequence of this isoform differs from the canonical sequence as follows:
     128-150: Missing.
     290-290: M → MSSFLS
     440-456: Missing.

Show »
Length:584
Mass (Da):63,930
Checksum:i7AA2B6E62420108B
GO
Isoform 17 (identifier: Q9NQB0-17) [UniParc]FASTAAdd to basket
Also known as: TCF-4X2

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MPQLNG → MSSFLS
     7-290: Missing.

Show »
Length:335
Mass (Da):36,884
Checksum:i6085EDAAE3D893A5
GO

Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VVR7Q5VVR7_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-...
TCF7L2
455Annotation score:
E2GH26E2GH26_HUMAN
T-cell factor-4 variant L
TCF7L2
607Annotation score:
C6ZRK5C6ZRK5_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_ex1-11-...
TCF7L2 hCG_40998
579Annotation score:
A0A0A0MTL7A0A0A0MTL7_HUMAN
Transcription factor 7-like 2
TCF7L2
408Annotation score:
C6ZRJ7C6ZRJ7_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-...
TCF7L2
476Annotation score:
A0A0D9SGH8A0A0D9SGH8_HUMAN
Transcription factor 7-like 2
TCF7L2
584Annotation score:
Q5JRY5Q5JRY5_HUMAN
Transcription factor 7-like 2
TCF7L2
206Annotation score:
Q5JRY3Q5JRY3_HUMAN
Transcription factor 7-like 2
TCF7L2
157Annotation score:
H0YEE5H0YEE5_HUMAN
Transcription factor 7-like 2
TCF7L2
108Annotation score:
C6ZRJ6C6ZRJ6_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,...
TCF7L2
534Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118 – 121NGSL → KRSV in CAB97212 (PubMed:10919662).Curated4
Sequence conflicti118 – 121NGSL → KRSV in CAB97213 (PubMed:10919662).Curated4
Sequence conflicti167Q → R in ADK35180 (PubMed:21256126).Curated1
Sequence conflicti226P → L in ADK35180 (PubMed:21256126).Curated1
Sequence conflicti290M → V in CAA72166 (PubMed:9065401).Curated1
Sequence conflicti331L → H in ACI28527 (PubMed:19602480).Curated1
Sequence conflicti596S → W in CAA72166 (PubMed:9065401).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047126346K → N1 PublicationCorresponds to variant dbSNP:rs2757884Ensembl.1
Natural variantiVAR_035939465R → C in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0537481 – 6MPQLNG → MSSFLS in isoform 17. 1 Publication6
Alternative sequenceiVSP_0537497 – 290Missing in isoform 17. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_006962128 – 150Missing in isoform 8, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15 and isoform 16. 5 PublicationsAdd BLAST23
Alternative sequenceiVSP_045821184V → VSPLPCCTQGHDCQHFYPPS DFTVSTQVFRDMKRSHSLQK VGEPWCIE in isoform 11. Curated1
Alternative sequenceiVSP_006963260 – 263Missing in isoform 10. 1 Publication4
Alternative sequenceiVSP_053750290M → MSSFLS in isoform 15 and isoform 16. 1 Publication1
Alternative sequenceiVSP_006965440 – 465EHSEC…PKKCR → GEKKSAFATYKVKAAASAHP LQMEAY in isoform 9, isoform 11, isoform 14 and isoform 15. 5 PublicationsAdd BLAST26
Alternative sequenceiVSP_006964440 – 456Missing in isoform 4, isoform 5, isoform 7, isoform 13 and isoform 16. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_006967457 – 619DLSAP…TKSLE → GEKKSAFATYKVKAAASAHP LQMEAY in isoform 6. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_006968457 – 482DLSAP…GPCRR → GEKKSAFATYKVKAAASAHP LQMEAY in isoform 10. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_006966457 – 478DLSAP…NNWCG → DANTPKKCRALFGLDRQTLW CK in isoform 3, isoform 7 and isoform 13. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_006969466 – 619Missing in isoform 9, isoform 11, isoform 14 and isoform 15. 5 PublicationsAdd BLAST154
Alternative sequenceiVSP_045822481 – 619RRKKK…TKSLE → SL in isoform 12. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_006970482 – 494RKKKC…IQGEG → CKYSKEVSGTVRA in isoform 2 and isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_006971483 – 619Missing in isoform 10. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_006972495 – 619Missing in isoform 2 and isoform 4. CuratedAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11306 mRNA Translation: CAA72166.2
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270778 Genomic DNA Translation: CAB97212.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270778 Genomic DNA Translation: CAB97213.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270777, AJ270778 Genomic DNA Translation: CAB97214.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270777, AJ270778 Genomic DNA Translation: CAB97215.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270778 Genomic DNA Translation: CAB97216.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270778 Genomic DNA Translation: CAB97217.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270777 Genomic DNA Translation: CAB97218.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270777 Genomic DNA Translation: CAB97219.1
FJ010167 mRNA Translation: ACI28525.1
FJ010169 mRNA Translation: ACI28527.1
FJ010172 mRNA Translation: ACI28530.1
HM352839 mRNA Translation: ADK35175.1
HM352842 mRNA Translation: ADK35178.1
HM352844 mRNA Translation: ADK35180.1
HM352845 mRNA Translation: ADK35187.1
HM352846 mRNA Translation: ADK35181.1
HM352847 mRNA Translation: ADK35182.1
HM352849 mRNA Translation: ADK35184.1
HM352850 mRNA Translation: ADK35185.1
AB440195 mRNA Translation: BAH24004.1
AK299295 mRNA Translation: BAG61310.1
AL135792 Genomic DNA No translation available.
AL158212 Genomic DNA No translation available.
AL445486 Genomic DNA No translation available.
AL451084 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49513.1
CH471066 Genomic DNA Translation: EAW49515.1
CH471066 Genomic DNA Translation: EAW49516.1
BC032656 mRNA Translation: AAH32656.1
AB034691 mRNA Translation: BAA86225.1
CCDSiCCDS53577.1 [Q9NQB0-7]
CCDS53578.1 [Q9NQB0-11]
CCDS55729.1 [Q9NQB0-12]
CCDS7576.1 [Q9NQB0-8]
CCDS86148.1 [Q9NQB0-6]
PIRiS22807
RefSeqiNP_001139746.1, NM_001146274.1 [Q9NQB0-7]
NP_001139755.1, NM_001146283.1 [Q9NQB0-11]
NP_001139756.1, NM_001146284.1 [Q9NQB0-10]
NP_001139758.1, NM_001146286.1 [Q9NQB0-14]
NP_001185455.1, NM_001198526.1 [Q9NQB0-13]
NP_001185457.1, NM_001198528.1 [Q9NQB0-12]
NP_001185460.1, NM_001198531.1 [Q9NQB0-9]
XP_005270141.1, XM_005270084.1 [Q9NQB0-1]
XP_005270146.1, XM_005270089.1
XP_005270153.1, XM_005270096.2
XP_005270160.1, XM_005270103.1 [Q9NQB0-15]
XP_016872081.1, XM_017016592.1 [Q9NQB0-3]
XP_016872082.1, XM_017016593.1 [Q9NQB0-5]
UniGeneiHs.593995

Genome annotation databases

EnsembliENST00000352065; ENSP00000344823; ENSG00000148737 [Q9NQB0-12]
ENST00000355717; ENSP00000347949; ENSG00000148737 [Q9NQB0-11]
ENST00000355995; ENSP00000348274; ENSG00000148737 [Q9NQB0-1]
ENST00000369397; ENSP00000358404; ENSG00000148737 [Q9NQB0-8]
ENST00000538897; ENSP00000446172; ENSG00000148737 [Q9NQB0-6]
ENST00000627217; ENSP00000486891; ENSG00000148737 [Q9NQB0-7]
GeneIDi6934
KEGGihsa:6934
UCSCiuc001lac.5 human [Q9NQB0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11306 mRNA Translation: CAA72166.2
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270778 Genomic DNA Translation: CAB97212.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270778 Genomic DNA Translation: CAB97213.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270777, AJ270778 Genomic DNA Translation: CAB97214.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270777, AJ270778 Genomic DNA Translation: CAB97215.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270778 Genomic DNA Translation: CAB97216.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270778 Genomic DNA Translation: CAB97217.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270777 Genomic DNA Translation: CAB97218.1
AJ270770
, AJ270771, AJ270772, AJ270773, AJ270774, AJ270775, AJ270776, AJ270777 Genomic DNA Translation: CAB97219.1
FJ010167 mRNA Translation: ACI28525.1
FJ010169 mRNA Translation: ACI28527.1
FJ010172 mRNA Translation: ACI28530.1
HM352839 mRNA Translation: ADK35175.1
HM352842 mRNA Translation: ADK35178.1
HM352844 mRNA Translation: ADK35180.1
HM352845 mRNA Translation: ADK35187.1
HM352846 mRNA Translation: ADK35181.1
HM352847 mRNA Translation: ADK35182.1
HM352849 mRNA Translation: ADK35184.1
HM352850 mRNA Translation: ADK35185.1
AB440195 mRNA Translation: BAH24004.1
AK299295 mRNA Translation: BAG61310.1
AL135792 Genomic DNA No translation available.
AL158212 Genomic DNA No translation available.
AL445486 Genomic DNA No translation available.
AL451084 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49513.1
CH471066 Genomic DNA Translation: EAW49515.1
CH471066 Genomic DNA Translation: EAW49516.1
BC032656 mRNA Translation: AAH32656.1
AB034691 mRNA Translation: BAA86225.1
CCDSiCCDS53577.1 [Q9NQB0-7]
CCDS53578.1 [Q9NQB0-11]
CCDS55729.1 [Q9NQB0-12]
CCDS7576.1 [Q9NQB0-8]
CCDS86148.1 [Q9NQB0-6]
PIRiS22807
RefSeqiNP_001139746.1, NM_001146274.1 [Q9NQB0-7]
NP_001139755.1, NM_001146283.1 [Q9NQB0-11]
NP_001139756.1, NM_001146284.1 [Q9NQB0-10]
NP_001139758.1, NM_001146286.1 [Q9NQB0-14]
NP_001185455.1, NM_001198526.1 [Q9NQB0-13]
NP_001185457.1, NM_001198528.1 [Q9NQB0-12]
NP_001185460.1, NM_001198531.1 [Q9NQB0-9]
XP_005270141.1, XM_005270084.1 [Q9NQB0-1]
XP_005270146.1, XM_005270089.1
XP_005270153.1, XM_005270096.2
XP_005270160.1, XM_005270103.1 [Q9NQB0-15]
XP_016872081.1, XM_017016592.1 [Q9NQB0-3]
XP_016872082.1, XM_017016593.1 [Q9NQB0-5]
UniGeneiHs.593995

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JDHX-ray1.90B12-49[»]
1JPWX-ray2.50D/E/F6-54[»]
2GL7X-ray2.60B/E1-53[»]
DisProtiDP00175
ProteinModelPortaliQ9NQB0
SMRiQ9NQB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112795, 38 interactors
CORUMiQ9NQB0
DIPiDIP-36236N
IntActiQ9NQB0, 54 interactors
MINTiQ9NQB0
STRINGi9606.ENSP00000444972

Chemistry databases

BindingDBiQ9NQB0
ChEMBLiCHEMBL3038511

PTM databases

iPTMnetiQ9NQB0
PhosphoSitePlusiQ9NQB0

Polymorphism and mutation databases

BioMutaiTCF7L2
DMDMi29337146

Proteomic databases

MaxQBiQ9NQB0
PaxDbiQ9NQB0
PeptideAtlasiQ9NQB0
PRIDEiQ9NQB0
ProteomicsDBi82120
82121 [Q9NQB0-10]
82122 [Q9NQB0-2]
82123 [Q9NQB0-3]
82124 [Q9NQB0-4]
82125 [Q9NQB0-5]
82126 [Q9NQB0-6]
82127 [Q9NQB0-7]
82128 [Q9NQB0-8]
82129 [Q9NQB0-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352065; ENSP00000344823; ENSG00000148737 [Q9NQB0-12]
ENST00000355717; ENSP00000347949; ENSG00000148737 [Q9NQB0-11]
ENST00000355995; ENSP00000348274; ENSG00000148737 [Q9NQB0-1]
ENST00000369397; ENSP00000358404; ENSG00000148737 [Q9NQB0-8]
ENST00000538897; ENSP00000446172; ENSG00000148737 [Q9NQB0-6]
ENST00000627217; ENSP00000486891; ENSG00000148737 [Q9NQB0-7]
GeneIDi6934
KEGGihsa:6934
UCSCiuc001lac.5 human [Q9NQB0-1]

Organism-specific databases

CTDi6934
DisGeNETi6934
EuPathDBiHostDB:ENSG00000148737.15
GeneCardsiTCF7L2
HGNCiHGNC:11641 TCF7L2
HPAiCAB013535
HPA038800
MalaCardsiTCF7L2
MIMi125853 phenotype
602228 gene
neXtProtiNX_Q9NQB0
OpenTargetsiENSG00000148737
PharmGKBiPA36394
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00390000009964
HOVERGENiHBG000419
InParanoidiQ9NQB0
KOiK04491
OMAiHSAKHQD
OrthoDBiEOG091G0705
PhylomeDBiQ9NQB0
TreeFamiTF318448

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-4086398 Ca2+ pathway
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-4641265 Repression of WNT target genes
R-HSA-5339700 TCF7L2 mutants don't bind CTBP
R-HSA-8951430 RUNX3 regulates WNT signaling
SignaLinkiQ9NQB0
SIGNORiQ9NQB0

Miscellaneous databases

ChiTaRSiTCF7L2 human
EvolutionaryTraceiQ9NQB0
GeneWikiiTCF7L2
GenomeRNAii6934
PROiPR:Q9NQB0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148737 Expressed in 228 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_TCF4
ExpressionAtlasiQ9NQB0 baseline and differential
GenevisibleiQ9NQB0 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028773 TCF7L
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF25 PTHR10373:SF25, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTF7L2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQB0
Secondary accession number(s): B4DRJ8
, B9X074, C6ZRJ8, C6ZRK0, E2GH14, E2GH19, E2GH20, E2GH24, E2GH25, E9PFH9, F8W742, F8W7T5, O00185, Q9NQB1, Q9NQB2, Q9NQB3, Q9NQB4, Q9NQB5, Q9NQB6, Q9NQB7, Q9ULC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: November 7, 2018
This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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