UniProtKB - Q9NQB0 (TF7L2_HUMAN)
Transcription factor 7-like 2
TCF7L2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 350 – 418 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- armadillo repeat domain binding Source: BHF-UCL
- beta-catenin binding Source: BHF-UCL
- DNA-binding transcription factor activity Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- gamma-catenin binding Source: BHF-UCL
- nuclear hormone receptor binding Source: BHF-UCL
- protein kinase binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- beta-catenin-TCF complex assembly Source: Reactome
- blood vessel development Source: BHF-UCL
- canonical Wnt signaling pathway Source: GO_Central
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- cell cycle arrest Source: BHF-UCL
- fat cell differentiation Source: BHF-UCL
- glucose homeostasis Source: BHF-UCL
- maintenance of DNA repeat elements Source: BHF-UCL
- myoblast fate commitment Source: BHF-UCL
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
- pancreas development Source: BHF-UCL
- positive regulation of epithelial cell proliferation Source: BHF-UCL
- positive regulation of heparan sulfate proteoglycan biosynthetic process Source: BHF-UCL
- positive regulation of insulin secretion Source: BHF-UCL
- positive regulation of protein binding Source: BHF-UCL
- positive regulation of protein export from nucleus Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of hormone metabolic process Source: BHF-UCL
- regulation of smooth muscle cell proliferation Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
- response to glucose Source: BHF-UCL
- Wnt signaling pathway, calcium modulating pathway Source: Reactome
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NQB0 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-4086398, Ca2+ pathway R-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265, Repression of WNT target genes R-HSA-5339700, Signaling by TCF7L2 mutants R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8951430, RUNX3 regulates WNT signaling |
SignaLinki | Q9NQB0 |
SIGNORi | Q9NQB0 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor 7-like 2Alternative name(s): HMG box transcription factor 4 T-cell-specific transcription factor 4 Short name: T-cell factor 4 Short name: TCF-4 Short name: hTCF-4 |
Gene namesi | Name:TCF7L2 Synonyms:TCF4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11641, TCF7L2 |
MIMi | 602228, gene |
neXtProti | NX_Q9NQB0 |
VEuPathDBi | HostDB:ENSG00000148737.15 |
Subcellular locationi
Nucleus
- PML body 3 Publications
Note: Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Nucleus
- beta-catenin-TCF complex Source: GO_Central
- beta-catenin-TCF7L2 complex Source: BHF-UCL
- catenin-TCF7L2 complex Source: GO_Central
- nucleoplasm Source: BHF-UCL
- nucleus Source: UniProtKB
- PML body Source: UniProtKB-SubCell
Other locations
- chromatin Source: BHF-UCL
- protein-DNA complex Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Diabetes mellitus, non-insulin-dependent (NIDDM)2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 10 – 11 | DD → AA: Reduces CTNNB1 binding. 1 Publication | 2 | |
Mutagenesisi | 16 | D → A: Abolishes CTNNB1 binding. 1 Publication | 1 | |
Mutagenesisi | 17 | E → A: Reduces CTNNB1 binding. 1 Publication | 1 | |
Mutagenesisi | 19 | I → A: Reduces transcription activation. 1 Publication | 1 | |
Mutagenesisi | 21 | F → A: Reduces transcription activation. 1 Publication | 1 | |
Mutagenesisi | 23 – 24 | DE → AA: Reduces CTNNB1 binding. 1 Publication | 2 | |
Mutagenesisi | 24 | E → A: Reduces CTNNB1 binding, and abolishes CTNNB1 binding; when associated with A-26; A-28 and A-29. 1 Publication | 1 | |
Mutagenesisi | 26 | E → A: Abolishes CTNNB1 binding; when associated with A-24; A-28 and A-29. 1 Publication | 1 | |
Mutagenesisi | 28 | E → A: Abolishes CTNNB1 binding; when associated with A-24; A-26 and A-29. 1 Publication | 1 | |
Mutagenesisi | 29 | E → A: Reduces CTNNB1 binding, and abolishes CTNNB1 binding; when associated with A-24; A-26 and A-28. 1 Publication | 1 | |
Mutagenesisi | 48 | L → A: Abolishes CTNNB1 binding. 1 Publication | 1 | |
Mutagenesisi | 201 | T → V: Reduced phosphorylation by NLK and enhanced DNA-binding; when associated with V-212. 1 Publication | 1 | |
Mutagenesisi | 212 | T → V: Reduced phosphorylation by NLK and enhanced DNA-binding; when associated with V-201. 1 Publication | 1 | |
Mutagenesisi | 320 | K → R: Loss of sumoylation. No effect on localization to nuclear bodies. 1 Publication | 1 | |
Mutagenesisi | 322 | E → A: Loss of sumoylation. 1 Publication | 1 |
Keywords - Diseasei
Diabetes mellitusOrganism-specific databases
DisGeNETi | 6934 |
MalaCardsi | TCF7L2 |
MIMi | 125853, phenotype |
OpenTargetsi | ENSG00000148737 |
PharmGKBi | PA36394 |
Miscellaneous databases
Pharosi | Q9NQB0, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3038511 |
Genetic variation databases
BioMutai | TCF7L2 |
DMDMi | 29337146 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048623 | 1 – 619 | Transcription factor 7-like 2Add BLAST | 619 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 201 | Phosphothreonine; by NLK1 Publication | 1 | |
Modified residuei | 212 | Phosphothreonine; by NLK1 Publication | 1 | |
Cross-linki | 320 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Cross-linki | 539 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9NQB0 |
MassIVEi | Q9NQB0 |
MaxQBi | Q9NQB0 |
PaxDbi | Q9NQB0 |
PeptideAtlasi | Q9NQB0 |
PRIDEi | Q9NQB0 |
ProteomicsDBi | 15216 29884 30005 82120 [Q9NQB0-1] 82121 [Q9NQB0-10] 82122 [Q9NQB0-2] 82123 [Q9NQB0-3] 82124 [Q9NQB0-4] 82125 [Q9NQB0-5] 82126 [Q9NQB0-6] 82127 [Q9NQB0-7] 82128 [Q9NQB0-8] 82129 [Q9NQB0-9] |
PTM databases
iPTMneti | Q9NQB0 |
PhosphoSitePlusi | Q9NQB0 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000148737, Expressed in lateral nuclear group of thalamus and 241 other tissues |
ExpressionAtlasi | Q9NQB0, baseline and differential |
Genevisiblei | Q9NQB0, HS |
Organism-specific databases
HPAi | ENSG00000148737, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TGFB1I1 (By similarity).
Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex (PubMed:9065401, PubMed:9916915, PubMed:10080941, PubMed:19816403, PubMed:28829046, PubMed:29739711, PubMed:17052462).
Interacts with EP300.
Interacts with NLK.
Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1.
Interacts with TNIK.
Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promZIPK/DAPK3oters, negatively modulating its transcriptional activity.
Interacts with ZIPK/DAPK3.
Interacts with XIAP/BIRC4 and TLE3.
Interacts with DDIT3/CHOP. The CTNNB1 and TCF7L2/TCF4 complex interacts with PML (isoform PML-4).
Identified in a complex with CTNNB1 and FERMT2.
Interacts with SPIN1 (PubMed:22258766, PubMed:24589551, PubMed:29061846).
Interacts with C11orf84/SPINDOC in a SPIN1-dependent manner (PubMed:29061846).
By similarity22 PublicationsBinary interactionsi
Hide detailsQ9NQB0
Isoform 10 [Q9NQB0-10]
GO - Molecular functioni
- armadillo repeat domain binding Source: BHF-UCL
- beta-catenin binding Source: BHF-UCL
- gamma-catenin binding Source: BHF-UCL
- nuclear hormone receptor binding Source: BHF-UCL
- protein kinase binding Source: UniProtKB
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112795, 173 interactors |
CORUMi | Q9NQB0 |
DIPi | DIP-36236N |
IntActi | Q9NQB0, 153 interactors |
MINTi | Q9NQB0 |
STRINGi | 9606.ENSP00000358404 |
Chemistry databases
BindingDBi | Q9NQB0 |
Miscellaneous databases
RNActi | Q9NQB0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NQB0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NQB0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | CTNNB1-bindingBy similarityAdd BLAST | 53 | |
Regioni | 201 – 395 | Mediates interaction with MAD2L21 PublicationAdd BLAST | 195 | |
Regioni | 459 – 505 | Promoter-specific activation domainAdd BLAST | 47 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 425 – 430 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 178 – 317 | Pro-richAdd BLAST | 140 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3248, Eukaryota |
GeneTreei | ENSGT00940000155535 |
HOGENOMi | CLU_013229_5_0_1 |
InParanoidi | Q9NQB0 |
OMAi | SLPPITX |
OrthoDBi | 807716at2759 |
PhylomeDBi | Q9NQB0 |
TreeFami | TF318448 |
Family and domain databases
DisProti | DP00175 |
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
IDEALi | IID00100 |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR024940, TCF/LEF |
PANTHERi | PTHR10373, PTHR10373, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
s (17+)i Sequence
Sequence statusi: Complete.
This entry describes 17 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 17 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ
160 170 180 190 200
YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP AHIVSNKVPV VQHPHHVHPL
210 220 230 240 250
TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS PYYPLSPGTV
260 270 280 290 300
GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SRFPPHMVPP
310 320 330 340 350
HHTLHTTGIP HPAIVTPTVK QESSQSDVGS LHSSKHQDSK KEEEKKKPHI
360 370 380 390 400
KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY
410 420 430 440 450
ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETNE HSECFLNPCL
460 470 480 490 500
SLPPITDLSA PKKCRARFGL DQQNNWCGPC RRKKKCVRYI QGEGSCLSPP
510 520 530 540 550
SSDGSLLDSP PPSPNLLGSP PRDAKSQTEQ TQPLSLSLKP DPLAHLSMMP
560 570 580 590 600
PPPALLLAEA THKASALCPN GALDLPPAAL QPAAPSSSIA QPSTSSLHSH
610
SSLAGTQPQP LSLVTKSLE
The sequence of this isoform differs from the canonical sequence as follows:
128-150: Missing.
260-263: Missing.
457-482: DLSAPKKCRARFGLDQQNNWCGPCRR → GEKKSAFATYKVKAAASAHPLQMEAY
483-619: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
128-150: Missing.
184-184: V → VSPLPCCTQGHDCQHFYPPSDFTVSTQVFRDMKRSHSLQKVGEPWCIE
440-465: EHSECFLNPCLSLPPITDLSAPKKCR → GEKKSAFATYKVKAAASAHPLQMEAY
466-619: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
128-150: Missing.
481-619: RRKKKCVRYI...PLSLVTKSLE → SL
The sequence of this isoform differs from the canonical sequence as follows:
128-150: Missing.
440-456: Missing.
457-478: DLSAPKKCRARFGLDQQNNWCG → DANTPKKCRALFGLDRQTLWCK
The sequence of this isoform differs from the canonical sequence as follows:
128-150: Missing.
440-465: EHSECFLNPCLSLPPITDLSAPKKCR → GEKKSAFATYKVKAAASAHPLQMEAY
466-619: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
128-150: Missing.
290-290: M → MSSFLS
440-465: EHSECFLNPCLSLPPITDLSAPKKCR → GEKKSAFATYKVKAAASAHPLQMEAY
466-619: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
128-150: Missing.
290-290: M → MSSFLS
440-456: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-6: MPQLNG → MSSFLS
7-290: Missing.
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5VVR7 | Q5VVR7_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-... | TCF7L2 | 455 | Annotation score: | ||
C6ZRJ7 | C6ZRJ7_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-... | TCF7L2 | 476 | Annotation score: | ||
C6ZRK5 | C6ZRK5_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_ex1-11-... | TCF7L2 hCG_40998 | 579 | Annotation score: | ||
A0A0A0MTL7 | A0A0A0MTL7_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 408 | Annotation score: | ||
E2GH26 | E2GH26_HUMAN | T-cell factor-4 variant L | TCF7L2 | 607 | Annotation score: | ||
A0A0D9SGH8 | A0A0D9SGH8_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 584 | Annotation score: | ||
Q5JRY3 | Q5JRY3_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 157 | Annotation score: | ||
Q5JRY5 | Q5JRY5_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 206 | Annotation score: | ||
C6ZRJ6 | C6ZRJ6_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,... | TCF7L2 | 534 | Annotation score: | ||
H0YEE5 | H0YEE5_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 108 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 – 121 | NGSL → KRSV in CAB97212 (PubMed:10919662).Curated | 4 | |
Sequence conflicti | 118 – 121 | NGSL → KRSV in CAB97213 (PubMed:10919662).Curated | 4 | |
Sequence conflicti | 167 | Q → R in ADK35180 (PubMed:21256126).Curated | 1 | |
Sequence conflicti | 226 | P → L in ADK35180 (PubMed:21256126).Curated | 1 | |
Sequence conflicti | 290 | M → V in CAA72166 (PubMed:9065401).Curated | 1 | |
Sequence conflicti | 331 | L → H in ACI28527 (PubMed:19602480).Curated | 1 | |
Sequence conflicti | 596 | S → W in CAA72166 (PubMed:9065401).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047126 | 346 | K → N1 PublicationCorresponds to variant dbSNP:rs2757884Ensembl. | 1 | |
Natural variantiVAR_035939 | 465 | R → C in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053748 | 1 – 6 | MPQLNG → MSSFLS in isoform 17. 1 Publication | 6 | |
Alternative sequenceiVSP_053749 | 7 – 290 | Missing in isoform 17. 1 PublicationAdd BLAST | 284 | |
Alternative sequenceiVSP_006962 | 128 – 150 | Missing in isoform 8, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15 and isoform 16. 5 PublicationsAdd BLAST | 23 | |
Alternative sequenceiVSP_045821 | 184 | V → VSPLPCCTQGHDCQHFYPPS DFTVSTQVFRDMKRSHSLQK VGEPWCIE in isoform 11. Curated | 1 | |
Alternative sequenceiVSP_006963 | 260 – 263 | Missing in isoform 10. 1 Publication | 4 | |
Alternative sequenceiVSP_053750 | 290 | M → MSSFLS in isoform 15 and isoform 16. 1 Publication | 1 | |
Alternative sequenceiVSP_006965 | 440 – 465 | EHSEC…PKKCR → GEKKSAFATYKVKAAASAHP LQMEAY in isoform 9, isoform 11, isoform 14 and isoform 15. 5 PublicationsAdd BLAST | 26 | |
Alternative sequenceiVSP_006964 | 440 – 456 | Missing in isoform 4, isoform 5, isoform 7, isoform 13 and isoform 16. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_006967 | 457 – 619 | DLSAP…TKSLE → GEKKSAFATYKVKAAASAHP LQMEAY in isoform 6. 1 PublicationAdd BLAST | 163 | |
Alternative sequenceiVSP_006968 | 457 – 482 | DLSAP…GPCRR → GEKKSAFATYKVKAAASAHP LQMEAY in isoform 10. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_006966 | 457 – 478 | DLSAP…NNWCG → DANTPKKCRALFGLDRQTLW CK in isoform 3, isoform 7 and isoform 13. 2 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_006969 | 466 – 619 | Missing in isoform 9, isoform 11, isoform 14 and isoform 15. 5 PublicationsAdd BLAST | 154 | |
Alternative sequenceiVSP_045822 | 481 – 619 | RRKKK…TKSLE → SL in isoform 12. 1 PublicationAdd BLAST | 139 | |
Alternative sequenceiVSP_006970 | 482 – 494 | RKKKC…IQGEG → CKYSKEVSGTVRA in isoform 2 and isoform 4. CuratedAdd BLAST | 13 | |
Alternative sequenceiVSP_006971 | 483 – 619 | Missing in isoform 10. 1 PublicationAdd BLAST | 137 | |
Alternative sequenceiVSP_006972 | 495 – 619 | Missing in isoform 2 and isoform 4. CuratedAdd BLAST | 125 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000352065; ENSP00000344823; ENSG00000148737 [Q9NQB0-12] ENST00000355717; ENSP00000347949; ENSG00000148737 [Q9NQB0-11] ENST00000355995; ENSP00000348274; ENSG00000148737 [Q9NQB0-1] ENST00000369397; ENSP00000358404; ENSG00000148737 [Q9NQB0-8] ENST00000538897; ENSP00000446172; ENSG00000148737 [Q9NQB0-6] ENST00000627217; ENSP00000486891; ENSG00000148737 [Q9NQB0-7] |
GeneIDi | 6934 |
KEGGi | hsa:6934 |
UCSCi | uc001lac.5, human [Q9NQB0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JDH | X-ray | 1.90 | B | 12-49 | [»] | |
1JPW | X-ray | 2.50 | D/E/F | 6-54 | [»] | |
2GL7 | X-ray | 2.60 | B/E | 1-53 | [»] | |
SMRi | Q9NQB0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112795, 173 interactors |
CORUMi | Q9NQB0 |
DIPi | DIP-36236N |
IntActi | Q9NQB0, 153 interactors |
MINTi | Q9NQB0 |
STRINGi | 9606.ENSP00000358404 |
Chemistry databases
BindingDBi | Q9NQB0 |
ChEMBLi | CHEMBL3038511 |
PTM databases
iPTMneti | Q9NQB0 |
PhosphoSitePlusi | Q9NQB0 |
Genetic variation databases
BioMutai | TCF7L2 |
DMDMi | 29337146 |
Proteomic databases
jPOSTi | Q9NQB0 |
MassIVEi | Q9NQB0 |
MaxQBi | Q9NQB0 |
PaxDbi | Q9NQB0 |
PeptideAtlasi | Q9NQB0 |
PRIDEi | Q9NQB0 |
ProteomicsDBi | 15216 29884 30005 82120 [Q9NQB0-1] 82121 [Q9NQB0-10] 82122 [Q9NQB0-2] 82123 [Q9NQB0-3] 82124 [Q9NQB0-4] 82125 [Q9NQB0-5] 82126 [Q9NQB0-6] 82127 [Q9NQB0-7] 82128 [Q9NQB0-8] 82129 [Q9NQB0-9] |
Protocols and materials databases
Antibodypediai | 31824, 472 antibodies |
Genome annotation databases
Ensembli | ENST00000352065; ENSP00000344823; ENSG00000148737 [Q9NQB0-12] ENST00000355717; ENSP00000347949; ENSG00000148737 [Q9NQB0-11] ENST00000355995; ENSP00000348274; ENSG00000148737 [Q9NQB0-1] ENST00000369397; ENSP00000358404; ENSG00000148737 [Q9NQB0-8] ENST00000538897; ENSP00000446172; ENSG00000148737 [Q9NQB0-6] ENST00000627217; ENSP00000486891; ENSG00000148737 [Q9NQB0-7] |
GeneIDi | 6934 |
KEGGi | hsa:6934 |
UCSCi | uc001lac.5, human [Q9NQB0-1] |
Organism-specific databases
CTDi | 6934 |
DisGeNETi | 6934 |
GeneCardsi | TCF7L2 |
HGNCi | HGNC:11641, TCF7L2 |
HPAi | ENSG00000148737, Low tissue specificity |
MalaCardsi | TCF7L2 |
MIMi | 125853, phenotype 602228, gene |
neXtProti | NX_Q9NQB0 |
OpenTargetsi | ENSG00000148737 |
PharmGKBi | PA36394 |
VEuPathDBi | HostDB:ENSG00000148737.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3248, Eukaryota |
GeneTreei | ENSGT00940000155535 |
HOGENOMi | CLU_013229_5_0_1 |
InParanoidi | Q9NQB0 |
OMAi | SLPPITX |
OrthoDBi | 807716at2759 |
PhylomeDBi | Q9NQB0 |
TreeFami | TF318448 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQB0 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-4086398, Ca2+ pathway R-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265, Repression of WNT target genes R-HSA-5339700, Signaling by TCF7L2 mutants R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8951430, RUNX3 regulates WNT signaling |
SignaLinki | Q9NQB0 |
SIGNORi | Q9NQB0 |
Miscellaneous databases
BioGRID-ORCSi | 6934, 68 hits in 1013 CRISPR screens |
ChiTaRSi | TCF7L2, human |
EvolutionaryTracei | Q9NQB0 |
GeneWikii | TCF7L2 |
GenomeRNAii | 6934 |
Pharosi | Q9NQB0, Tbio |
PROi | PR:Q9NQB0 |
RNActi | Q9NQB0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148737, Expressed in lateral nuclear group of thalamus and 241 other tissues |
ExpressionAtlasi | Q9NQB0, baseline and differential |
Genevisiblei | Q9NQB0, HS |
Family and domain databases
DisProti | DP00175 |
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
IDEALi | IID00100 |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR024940, TCF/LEF |
PANTHERi | PTHR10373, PTHR10373, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TF7L2_HUMAN | |
Accessioni | Q9NQB0Primary (citable) accession number: Q9NQB0 Secondary accession number(s): B4DRJ8 Q9ULC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | March 25, 2003 | |
Last modified: | April 7, 2021 | |
This is version 210 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families