Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transient receptor potential cation channel subfamily V member 5

Gene

TRPV5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).By similarity2 Publications

Enzyme regulationi

Activated by WNK3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi542Calcium; shared with neighboring subunitsBy similarity1

GO - Molecular functioni

  • calcium channel activity Source: UniProtKB
  • calmodulin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
SIGNORiQ9NQA5

Protein family/group databases

TCDBi1.A.4.2.10 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 5
Short name:
TrpV5
Alternative name(s):
Calcium transport protein 2
Short name:
CaT2
Epithelial calcium channel 11 Publication
Short name:
ECaC
Short name:
ECaC1
Osm-9-like TRP channel 3
Short name:
OTRPC3
Gene namesi
Name:TRPV5
Synonyms:ECAC11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000127412.6
HGNCiHGNC:3145 TRPV5
MIMi606679 gene
neXtProtiNX_Q9NQA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 327CytoplasmicBy similarityAdd BLAST327
Transmembranei328 – 348HelicalBy similarityAdd BLAST21
Topological domaini349 – 385ExtracellularBy similarityAdd BLAST37
Transmembranei386 – 408HelicalBy similarityAdd BLAST23
Topological domaini409 – 419CytoplasmicBy similarityAdd BLAST11
Transmembranei420 – 442HelicalBy similarityAdd BLAST23
Topological domaini443 – 448ExtracellularBy similarity6
Transmembranei449 – 469HelicalBy similarityAdd BLAST21
Topological domaini470 – 492CytoplasmicBy similarityAdd BLAST23
Transmembranei493 – 513HelicalBy similarityAdd BLAST21
Intramembranei524 – 544Pore-formingBy similarityAdd BLAST21
Transmembranei557 – 577HelicalBy similarityAdd BLAST21
Topological domaini578 – 729CytoplasmicBy similarityAdd BLAST152

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi358N → Q: Loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi56302
PharmGKBiPA35045

Chemistry databases

GuidetoPHARMACOLOGYi511

Polymorphism and mutation databases

BioMutaiTRPV5
DMDMi62901471

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153501 – 729Transient receptor potential cation channel subfamily V member 5Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi358N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei685PhosphothreonineBy similarity1
Modified residuei689PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NQA5
MaxQBiQ9NQA5
PaxDbiQ9NQA5
PeptideAtlasiQ9NQA5
PRIDEiQ9NQA5
ProteomicsDBi82119

PTM databases

iPTMnetiQ9NQA5
PhosphoSitePlusiQ9NQA5
SwissPalmiQ9NQA5

Expressioni

Tissue specificityi

Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.2 Publications

Gene expression databases

BgeeiENSG00000127412
CleanExiHS_TRPV5
ExpressionAtlasiQ9NQA5 baseline and differential
GenevisibleiQ9NQA5 HS

Organism-specific databases

HPAiHPA063175

Interactioni

Subunit structurei

Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (By similarity). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CALB1P059374EBI-751281,EBI-4286943

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121137, 22 interactors
IntActiQ9NQA5, 3 interactors
MINTiQ9NQA5
STRINGi9606.ENSP00000265310

Structurei

Secondary structure

1729
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi699 – 709Combined sources11
Beta strandi719 – 722Combined sources4

3D structure databases

ProteinModelPortaliQ9NQA5
SMRiQ9NQA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 74ANK 1Sequence analysisAdd BLAST31
Repeati78 – 107ANK 2Sequence analysisAdd BLAST30
Repeati116 – 145ANK 3Sequence analysisAdd BLAST30
Repeati162 – 191ANK 4Sequence analysisAdd BLAST30
Repeati195 – 228ANK 5Sequence analysisAdd BLAST34
Repeati239 – 268ANK 6Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni598 – 602Interaction with S100A10By similarity5
Regioni650 – 653Involved in Ca(2+)-dependent inactivationBy similarity4
Regioni700 – 729Involved in Ca(2+)-dependent inactivationBy similarityAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
HOGENOMiHOG000207344
HOVERGENiHBG061442
InParanoidiQ9NQA5
KOiK04974
PhylomeDBiQ9NQA5
TreeFamiTF314711

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008346 TRPV5
IPR008344 TRPV5/TRPV6
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF11 PTHR10582:SF11, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01415 ANKYRIN
PR01765 ECACCHANNEL
PR01767 ECACCHANNEL2
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGFLPKAEG PGSQLQKLLP SFLVREQDWD QHLDKLHMLQ QKRILESPLL
60 70 80 90 100
RASKENDLSV LRQLLLDCTC DVRQRGALGE TALHIAALYD NLEAALVLME
110 120 130 140 150
AAPELVFEPT TCEAFAGQTA LHIAVVNQNV NLVRALLTRR ASVSARATGT
160 170 180 190 200
AFRRSPRNLI YFGEHPLSFA ACVNSEEIVR LLIEHGADIR AQDSLGNTVL
210 220 230 240 250
HILILQPNKT FACQMYNLLL SYDGHGDHLQ PLDLVPNHQG LTPFKLAGVE
260 270 280 290 300
GNTVMFQHLM QKRRHIQWTY GPLTSILYDL TEIDSWGEEL SFLELVVSSD
310 320 330 340 350
KREARQILEQ TPVKELVSFK WNKYGRPYFC ILAALYLLYM ICFTTCCVYR
360 370 380 390 400
PLKFRGGNRT HSRDITILQQ KLLQEAYETR EDIIRLVGEL VSIVGAVIIL
410 420 430 440 450
LLEIPDIFRV GASRYFGKTI LGGPFHVIII TYASLVLVTM VMRLTNTNGE
460 470 480 490 500
VVPMSFALVL GWCSVMYFTR GFQMLGPFTI MIQKMIFGDL MRFCWLMAVV
510 520 530 540 550
ILGFASAFYI IFQTEDPTSL GQFYDYPMAL FTTFELFLTV IDAPANYDVD
560 570 580 590 600
LPFMFSIVNF AFAIIATLLM LNLFIAMMGD THWRVAQERD ELWRAQVVAT
610 620 630 640 650
TVMLERKLPR CLWPRSGICG CEFGLGDRWF LRVENHNDQN PLRVLRYVEV
660 670 680 690 700
FKNSDKEDDQ EHPSEKQPSG AESGTLARAS LALPTSSLSR TASQSSSHRG
710 720
WEILRQNTLG HLNLGLNLSE GDGEEVYHF
Length:729
Mass (Da):82,551
Last modified:March 1, 2002 - v2
Checksum:iA10FB80205FD0DBB
GO
Isoform 2 (identifier: Q9NQA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-381: EAYETRE → VILLRRG
     382-729: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):43,186
Checksum:iB84D5AF87D134ECC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0222478A → V1 PublicationCorresponds to variant dbSNP:rs4252372Ensembl.1
Natural variantiVAR_022248154R → H3 PublicationsCorresponds to variant dbSNP:rs4236480Ensembl.1
Natural variantiVAR_022249563A → T1 PublicationCorresponds to variant dbSNP:rs4252499Ensembl.1
Natural variantiVAR_022250712L → F1 PublicationCorresponds to variant dbSNP:rs4252509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057199375 – 381EAYETRE → VILLRRG in isoform 2. 1 Publication7
Alternative sequenceiVSP_057200382 – 729Missing in isoform 2. 1 PublicationAdd BLAST348

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271207 mRNA Translation: CAB96365.2
AF304464 mRNA Translation: AAL04015.1
AJ487965 mRNA Translation: CAD32312.2
AY206695 Genomic DNA Translation: AAO13488.1
AC245427 Genomic DNA No translation available.
CH236959 Genomic DNA Translation: EAL23777.1
CH471198 Genomic DNA Translation: EAW51896.1
BC034740 mRNA Translation: AAH34740.1
CCDSiCCDS5875.1 [Q9NQA5-1]
RefSeqiNP_062815.3, NM_019841.6
UniGeneiHs.283369

Genome annotation databases

EnsembliENST00000442623; ENSP00000406572; ENSG00000127412
GeneIDi56302
KEGGihsa:56302
UCSCiuc003wbz.3 human [Q9NQA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiTRPV5_HUMAN
AccessioniPrimary (citable) accession number: Q9NQA5
Secondary accession number(s): A4D2H7
, E9PBZ6, Q8N4C1, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2002
Last modified: July 18, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health