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Entry version 121 (11 Dec 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Protein C12orf4

Gene

C12orf4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mast cell degranulation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein C12orf4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C12orf4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000047621.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1184 C12orf4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616082 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQ89

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 66 (MRT66)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT66 patients have intellectual disability, delayed speech development, neuropsychiatric symptoms, and relatively normal life span.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081778328L → P in MRT66. 1 PublicationCorresponds to variant dbSNP:rs1468772495EnsemblClinVar.1
Natural variantiVAR_081779454 – 552Missing in MRT66. 1 PublicationAdd BLAST99

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
57102

MalaCards human disease database

More...
MalaCardsi
C12orf4
MIMi618221 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000047621

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88616 Autosomal recessive non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25505

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQ89 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C12orf4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153007

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898421 – 552Protein C12orf4Add BLAST552

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQ89

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQ89

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NQ89

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NQ89

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQ89

PeptideAtlas

More...
PeptideAtlasi
Q9NQ89

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQ89

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82107

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQ89

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQ89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000047621 Expressed in 220 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQ89 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQ89 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037871

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121368, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NQ89, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261250

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NQ89 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4506 Eukaryota
ENOG410XS4V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010229

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233884

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQ89

Identification of Orthologs from Complete Genome Data

More...
OMAi
EAMMGHQ

Database of Orthologous Groups

More...
OrthoDBi
743423at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQ89

TreeFam database of animal gene trees

More...
TreeFami
TF314243

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019311 DUF2362

The PANTHER Classification System

More...
PANTHERi
PTHR16525 PTHR16525, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10154 DUF2362, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NQ89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKNRERFCN REREFVYKFK VGSQCLELRV PLKFPVQENA SHLHGRLMLL
60 70 80 90 100
HSLPCFIEKD LKEALTQFIE EESLSDYDRD AEASLAAVKS GEVDLHQLAS
110 120 130 140 150
TWAKAYAETT LEHARPEEPS WDEDFADVYH DLIHSPASET LLNLEHNYFV
160 170 180 190 200
SISELIGERD VELKKLRERQ GIEMEKVMQE LGKSLTDQDV NSLAAQHFES
210 220 230 240 250
QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS SLSEEIKVQP
260 270 280 290 300
SQFRESVEAI GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK
310 320 330 340 350
HKRNHRSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC
360 370 380 390 400
QECTDFHFPR IEEQLEVVQQ VVLYARTQRR SKLKESLDSG NQNGGNDDKT
410 420 430 440 450
KNAERNYLNV LPGEFYITRH SNLSEIHVAF HLCVDDHVKS GNITARDPAI
460 470 480 490 500
MGLRNILKVC CTHDITTISI PLLLVHDMSE EMTIPWCLRR AELVFKCVKG
510 520 530 540 550
FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF RVSSTLTLTS

KH
Length:552
Mass (Da):63,801
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE183A979E3BA0F5E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGS6H0YGS6_HUMAN
Protein C12orf4
C12orf4
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXX6F5GXX6_HUMAN
Protein C12orf4
C12orf4
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H744F5H744_HUMAN
Protein C12orf4
C12orf4
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H271F5H271_HUMAN
Protein C12orf4
C12orf4
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24Q → R in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti156I → V in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti165K → E in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti245E → G in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti377T → P in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti465I → V in CAE46058 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081778328L → P in MRT66. 1 PublicationCorresponds to variant dbSNP:rs1468772495EnsemblClinVar.1
Natural variantiVAR_081779454 – 552Missing in MRT66. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ272205 mRNA Translation: CAC01126.1
AL834377 mRNA Translation: CAD39040.1
BX641128 mRNA Translation: CAE46058.1
CH471116 Genomic DNA Translation: EAW88845.1
CH471116 Genomic DNA Translation: EAW88846.1
BC016908 mRNA Translation: AAH16908.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8528.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291740.1, NM_001304811.1
NP_065107.1, NM_020374.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261250; ENSP00000261250; ENSG00000047621
ENST00000545746; ENSP00000439996; ENSG00000047621

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57102

UCSC genome browser

More...
UCSCi
uc001qms.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272205 mRNA Translation: CAC01126.1
AL834377 mRNA Translation: CAD39040.1
BX641128 mRNA Translation: CAE46058.1
CH471116 Genomic DNA Translation: EAW88845.1
CH471116 Genomic DNA Translation: EAW88846.1
BC016908 mRNA Translation: AAH16908.1
CCDSiCCDS8528.1
RefSeqiNP_001291740.1, NM_001304811.1
NP_065107.1, NM_020374.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121368, 5 interactors
IntActiQ9NQ89, 7 interactors
STRINGi9606.ENSP00000261250

PTM databases

iPTMnetiQ9NQ89
PhosphoSitePlusiQ9NQ89

Polymorphism and mutation databases

BioMutaiC12orf4
DMDMi71153007

Proteomic databases

EPDiQ9NQ89
jPOSTiQ9NQ89
MassIVEiQ9NQ89
MaxQBiQ9NQ89
PaxDbiQ9NQ89
PeptideAtlasiQ9NQ89
PRIDEiQ9NQ89
ProteomicsDBi82107

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57102

Genome annotation databases

EnsembliENST00000261250; ENSP00000261250; ENSG00000047621
ENST00000545746; ENSP00000439996; ENSG00000047621
GeneIDi57102
KEGGihsa:57102
UCSCiuc001qms.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57102
DisGeNETi57102
EuPathDBiHostDB:ENSG00000047621.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C12orf4
HGNCiHGNC:1184 C12orf4
HPAiHPA037871
MalaCardsiC12orf4
MIMi616082 gene
618221 phenotype
neXtProtiNX_Q9NQ89
OpenTargetsiENSG00000047621
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA25505

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4506 Eukaryota
ENOG410XS4V LUCA
GeneTreeiENSGT00390000010229
HOGENOMiHOG000233884
InParanoidiQ9NQ89
OMAiEAMMGHQ
OrthoDBi743423at2759
PhylomeDBiQ9NQ89
TreeFamiTF314243

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C12orf4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57102
PharosiQ9NQ89 Tdark

Protein Ontology

More...
PROi
PR:Q9NQ89
RNActiQ9NQ89 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000047621 Expressed in 220 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ9NQ89 baseline and differential
GenevisibleiQ9NQ89 HS

Family and domain databases

InterProiView protein in InterPro
IPR019311 DUF2362
PANTHERiPTHR16525 PTHR16525, 1 hit
PfamiView protein in Pfam
PF10154 DUF2362, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCL004_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQ89
Secondary accession number(s): D3DUQ8, Q6MZH5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: December 11, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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