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UniProtKB - Q9NQ86 (TRI36_HUMAN)

Entry version 173 (13 Nov 2019)
Sequence version 2 (30 Nov 2010)
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Protein

E3 ubiquitin-protein ligase TRIM36

Gene

TRIM36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri33 – 84RING-type; degeneratePROSITE-ProRule annotationAdd BLAST52
Zinc fingeri154 – 192B box-type 1PROSITE-ProRule annotationAdd BLAST39
Zinc fingeri207 – 249B box-type 2PROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM36 (EC:2.3.2.27By similarity)
Alternative name(s):
RING finger protein 98
RING-type E3 ubiquitin transferase TRIM36Curated
Tripartite motif-containing protein 36
Zinc-binding protein Rbcc728
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM36
Synonyms:RBCC728, RNF98
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16280 TRIM36

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609317 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NQ86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Anencephaly (ANPH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079581518D → N in ANPH; decreases protein stability; leads to microtubules disruption; exhibits multipolar spindles; exhibits abnormal cytokinesis. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		55521

MalaCards human disease database

More...MalaCardsi		TRIM36
MIMi206500 phenotype

Open Targets

More...OpenTargetsi		ENSG00000152503

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38111

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NQ86

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM36

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104034

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562521 – 728E3 ubiquitin-protein ligase TRIM36Add BLAST728

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NQ86

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NQ86

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NQ86

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NQ86

PeptideAtlas

More...PeptideAtlasi		Q9NQ86

PRoteomics IDEntifications database

More...PRIDEi		Q9NQ86

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20113
82103 [Q9NQ86-1]
82104 [Q9NQ86-2]
900

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NQ86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NQ86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis, prostate and brain (PubMed:15145053). Weakly expressed in kidney, lung and heart (PubMed:15145053). Expressed in fetal tissues (PubMed:28087737).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152503 Expressed in 160 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NQ86 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NQ86 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA061321

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CENPH.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120695, 19 interactors

Protein interaction database and analysis system

More...IntActi		Q9NQ86, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000282369

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini356 – 413COSPROSITE-ProRule annotationAdd BLAST58
Domaini419 – 510Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92
Domaini508 – 720B30.2/SPRYPROSITE-ProRule annotationAdd BLAST213

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili271 – 345Sequence analysisAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 84RING-type; degeneratePROSITE-ProRule annotationAdd BLAST52
Zinc fingeri154 – 192B box-type 1PROSITE-ProRule annotationAdd BLAST39
Zinc fingeri207 – 249B box-type 2PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ITFI Eukaryota
ENOG410Z6W7 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158373

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000119395

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NQ86

KEGG Orthology (KO)

More...KOi		K12013

Identification of Orthologs from Complete Genome Data

More...OMAi		MYCELCK

Database of Orthologous Groups

More...OrthoDBi		180330at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NQ86

TreeFam database of animal gene trees

More...TreeFami		TF315216

Family and domain databases

Conserved Domains Database

More...CDDi		cd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
cd12894 SPRY_PRY_TRIM36, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035727 SPRY/PRY_TRIM36
IPR027726 Trim36
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...PANTHERi		PTHR24099:SF18 PTHR24099:SF18, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQ86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH 
        60         70         80         90        100
SICHKCVKEL LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG 
       110        120        130        140        150
WKRNSLTPRT TVFPCPGCEH DVDLGERGIN GLFRNFTLET IVERYRQAAR 
       160        170        180        190        200
AATAIMCDLC KPPPQESTKS CMDCSASYCN ECFKIHHPWG TIKAQHEYVG 
       210        220        230        240        250
PTTNFRPKIL MCPEHETERI NMYCELCRRP VCHLCKLGGN HANHRVTTMS 
       260        270        280        290        300
SAYKTLKEKL SKDIDYLIGK ESQVKSQISE LNLLMKETEC NGERAKEEAI 
       310        320        330        340        350
THFEKLFEVL EERKSSVLKA IDSSKKLRLD KFQTQMEEYQ GLLENNGLVG 
       360        370        380        390        400
YAQEVLKETD QSCFVQTAKQ LHLRIQKATE SLKSFRPAAQ TSFEDYVVNT 
       410        420        430        440        450
SKQTELLGEL SFFSSGIDVP EINEEQSKVY NNALINWHHP EKDKADSYVL 
       460        470        480        490        500
EYRKINRDDE MSWNEIEVCG TSKIIQDLEN SSTYAFRVRA YKGSICSPCS 
       510        520        530        540        550
RELILHTPPA PVFSFLFDEK CGYNNEHLLL NLKRDRVESR AGFNLLLAAE 
       560        570        580        590        600
RIQVGYYTSL DYIIGDTGIT KGKHFWAFRV EPYSYLVKVG VASSDKLQEW 
       610        620        630        640        650
LRSPRDAVSP RYEQDSGHDS GSEDACFDSS QPFTLVTIGM QKFFIPKSPT 
       660        670        680        690        700
SSNEPENRVL PMPTSIGIFL DCDKGKVDFY DMDQMKCLYE RQVDCSHTLY 
       710        720 
PAFALMGSGG IQLEEPITAK YLEYQEDM
Length:728
Mass (Da):83,013
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D1B4F98325BD73C
GO
Isoform 2 (identifier: Q9NQ86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-60: VTIKNIEREL...SICHKCVKEL → MPDWRRGYRC...GNKSGKHFKT
     61-728: Missing.

Note: No experimental confirmation available.
Show »
Length:60
Mass (Da):6,742
Checksum:i5F14D56947E8AB29
GO
Isoform 3 (identifier: Q9NQ86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-61: VTIKNIEREL...ICHKCVKELL → ASAMGLQQTH...VGKQSLPRRT
     62-728: Missing.

Note: No experimental confirmation available.
Show »
Length:61
Mass (Da):6,702
Checksum:i1326D724A01FC532
GO
Isoform 4 (identifier: Q9NQ86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSESGEMSEFGYIMELIAKGK → MEGDGSDSP

Note: No experimental confirmation available.
Show »
Length:716
Mass (Da):81,570
Checksum:iD07682496F9897BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBG3E9PBG3_HUMAN
E3 ubiquitin-protein ligase TRIM36
TRIM36
573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAU9D6RAU9_HUMAN
E3 ubiquitin-protein ligase TRIM36
TRIM36
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti313R → G in BAH12340 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023197428K → R2 PublicationsCorresponds to variant dbSNP:rs79290430Ensembl.1
Natural variantiVAR_023198456N → S1 PublicationCorresponds to variant dbSNP:rs17137481Ensembl.1
Natural variantiVAR_079581518D → N in ANPH; decreases protein stability; leads to microtubules disruption; exhibits multipolar spindles; exhibits abnormal cytokinesis. 1 Publication1
Natural variantiVAR_020490678D → N4 PublicationsCorresponds to variant dbSNP:rs2974617Ensembl.1
Natural variantiVAR_057221725Q → E. Corresponds to variant dbSNP:rs3749745Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0538181 – 21MSESG…IAKGK → MEGDGSDSP in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_04579122 – 61VTIKN…VKELL → ASAMGLQQTHEHSRLTSKGG EARCPFEISEVGKQSLPRRT in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_04351122 – 60VTIKN…CVKEL → MPDWRRGYRCRQGCGKTTEL ATATDFSQTGNKSGKHFKT in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_04351261 – 728Missing in isoform 2. 1 PublicationAdd BLAST668
Alternative sequenceiVSP_04579262 – 728Missing in isoform 3. 1 PublicationAdd BLAST667

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ272269 mRNA Translation: CAB94831.1
BX460627 mRNA No translation available.
AK316422 mRNA Translation: BAH14793.1
AK296389 mRNA Translation: BAH12340.1
AC008494 Genomic DNA No translation available.
AC094104 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48972.1
BC045164 mRNA Translation: AAH45164.1
BC046096 mRNA Translation: AAH46096.1
BC130334 mRNA Translation: AAI30335.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34211.1 [Q9NQ86-2]
CCDS34212.1 [Q9NQ86-3]
CCDS4115.1 [Q9NQ86-1]
CCDS75287.1 [Q9NQ86-4]

NCBI Reference Sequences

More...RefSeqi		NP_001017397.1, NM_001017397.1 [Q9NQ86-2]
NP_001017398.1, NM_001017398.1 [Q9NQ86-3]
NP_001287681.1, NM_001300752.1
NP_001287688.1, NM_001300759.1 [Q9NQ86-4]
NP_061170.2, NM_018700.3 [Q9NQ86-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282369; ENSP00000282369; ENSG00000152503 [Q9NQ86-1]
ENST00000379617; ENSP00000368937; ENSG00000152503 [Q9NQ86-3]
ENST00000379618; ENSP00000368938; ENSG00000152503 [Q9NQ86-2]
ENST00000513154; ENSP00000423934; ENSG00000152503 [Q9NQ86-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55521

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55521

UCSC genome browser

More...UCSCi		uc003kqs.4 human [Q9NQ86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272269 mRNA Translation: CAB94831.1
BX460627 mRNA No translation available.
AK316422 mRNA Translation: BAH14793.1
AK296389 mRNA Translation: BAH12340.1
AC008494 Genomic DNA No translation available.
AC094104 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48972.1
BC045164 mRNA Translation: AAH45164.1
BC046096 mRNA Translation: AAH46096.1
BC130334 mRNA Translation: AAI30335.1
CCDSiCCDS34211.1 [Q9NQ86-2]
CCDS34212.1 [Q9NQ86-3]
CCDS4115.1 [Q9NQ86-1]
CCDS75287.1 [Q9NQ86-4]
RefSeqiNP_001017397.1, NM_001017397.1 [Q9NQ86-2]
NP_001017398.1, NM_001017398.1 [Q9NQ86-3]
NP_001287681.1, NM_001300752.1
NP_001287688.1, NM_001300759.1 [Q9NQ86-4]
NP_061170.2, NM_018700.3 [Q9NQ86-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi120695, 19 interactors
IntActiQ9NQ86, 14 interactors
STRINGi9606.ENSP00000282369

PTM databases

iPTMnetiQ9NQ86
PhosphoSitePlusiQ9NQ86

Polymorphism and mutation databases

BioMutaiTRIM36
DMDMi313104034

Proteomic databases

jPOSTiQ9NQ86
MassIVEiQ9NQ86
MaxQBiQ9NQ86
PaxDbiQ9NQ86
PeptideAtlasiQ9NQ86
PRIDEiQ9NQ86
ProteomicsDBi20113
82103 [Q9NQ86-1]
82104 [Q9NQ86-2]
900

Genome annotation databases

EnsembliENST00000282369; ENSP00000282369; ENSG00000152503 [Q9NQ86-1]
ENST00000379617; ENSP00000368937; ENSG00000152503 [Q9NQ86-3]
ENST00000379618; ENSP00000368938; ENSG00000152503 [Q9NQ86-2]
ENST00000513154; ENSP00000423934; ENSG00000152503 [Q9NQ86-4]
GeneIDi55521
KEGGihsa:55521
UCSCiuc003kqs.4 human [Q9NQ86-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55521
DisGeNETi55521

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM36
HGNCiHGNC:16280 TRIM36
HPAiHPA061321
MalaCardsiTRIM36
MIMi206500 phenotype
609317 gene
neXtProtiNX_Q9NQ86
OpenTargetsiENSG00000152503
PharmGKBiPA38111

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410ITFI Eukaryota
ENOG410Z6W7 LUCA
GeneTreeiENSGT00940000158373
HOGENOMiHOG000119395
InParanoidiQ9NQ86
KOiK12013
OMAiMYCELCK
OrthoDBi180330at2759
PhylomeDBiQ9NQ86
TreeFamiTF315216

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM36 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55521
PharosiQ9NQ86

Protein Ontology

More...PROi		PR:Q9NQ86

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152503 Expressed in 160 organ(s), highest expression level in sperm
ExpressionAtlasiQ9NQ86 baseline and differential
GenevisibleiQ9NQ86 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
cd12894 SPRY_PRY_TRIM36, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035727 SPRY/PRY_TRIM36
IPR027726 Trim36
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS
PANTHERiPTHR24099:SF18 PTHR24099:SF18, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI36_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQ86
Secondary accession number(s): A1L3Z1
, A6NDD0, B7Z3V4, B7ZAV7, E9PFI8, Q0P5Z9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 30, 2010
Last modified: November 13, 2019
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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