UniProtKB - Q9NQ84 (GPC5C_HUMAN)

BLAST

>sp|Q9NQ84|GPC5C_HUMAN G-protein coupled receptor family C group 5 member C OS=Homo sapiens OX=9606 GN=GPRC5C PE=1 SV=2
MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAG
IVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRR
FLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLV
RGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRK
HGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEV
SQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSG
YNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQ
AATPPKDGKNSQVFRNPYVWD

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History
Entry version 141 (12 Sep 2018)
Sequence version 2 (13 Apr 2004)
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Protein

G-protein coupled receptor family C group 5 member C

Gene

GPRC5C

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functionⁱ

G-protein coupled receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10783259

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10783259

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

TCDBⁱ	9.A.14.11.2 the g-protein-coupled receptor (gpcr) family

TCDBⁱ

9.A.14.11.2 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G-protein coupled receptor family C group 5 member C Alternative name(s): Retinoic acid-induced gene 3 protein Short name: RAIG-3
Gene namesⁱ	Name:GPRC5C Synonyms:RAIG3 ORF Names:PSEC0087
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170412.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13309 GPRC5C
MIMⁱ	605949 gene
neXtProtⁱ	NX_Q9NQ84

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 50	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	51 – 71	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	72 – 85	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	86 – 106	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	107 – 120	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	121 – 141	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	142 – 155	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	156 – 176	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	177 – 208	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	209 – 229	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	230 – 241	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	242 – 262	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	263 – 279	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	280 – 300	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	301 – 441	CytoplasmicSequence analysisAdd BLAST	141

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55890
Open Targets More...OpenTargetsⁱ	ENSG00000170412
PharmGKBⁱ	PA28939

Polymorphism and mutation databases

BioMutaⁱ	GPRC5C
DMDMⁱ	46396014

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000012967	24 – 441	G-protein coupled receptor family C group 5 member CAdd BLAST		418

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	191	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	344	PhosphoserineCombined sources	1
Modified residueⁱ	383	PhosphoserineCombined sources	1
Modified residueⁱ	403	PhosphoserineBy similarity	1
Modified residueⁱ	406	PhosphoserineBy similarity	1
Modified residueⁱ	414	PhosphotyrosineBy similarity	1
Modified residueⁱ	423	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NQ84
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NQ84
PaxDbⁱ	Q9NQ84
PeptideAtlas More...PeptideAtlasⁱ	Q9NQ84
PRIDEⁱ	Q9NQ84
ProteomicsDBⁱ	82101 82102 [Q9NQ84-2]

PTM databases

iPTMnetⁱ	Q9NQ84
PhosphoSitePlusⁱ	Q9NQ84
SwissPalmⁱ	Q9NQ84

Expressionⁱ

Tissue specificityⁱ

Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).2 Publications

Inductionⁱ

By all-trans retinoic acid (ATRA).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000170412 Expressed in 172 organ(s), highest expression level in body of stomach
CleanExⁱ	HS_GPRC5C
ExpressionAtlasⁱ	Q9NQ84 baseline and differential
Genevisibleⁱ	Q9NQ84 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029776

HPAⁱ

HPA029776

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120980, 35 interactors
IntActⁱ	Q9NQ84, 3 interactors
STRINGⁱ	9606.ENSP00000376403

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NQ84
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEI6 Eukaryota ENOG4110E9P LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055551
HOGENOMⁱ	HOG000116197
HOVERGENⁱ	HBG051794
InParanoidⁱ	Q9NQ84
KEGG Orthology (KO) More...KOⁱ	K04620
PhylomeDBⁱ	Q9NQ84
TreeFamⁱ	TF321410

Family and domain databases

InterProⁱ	View protein in InterPro IPR017978 GPCR_3_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit
PROSITEⁱ	View protein in PROSITE PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9NQ84-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIHKALVMC LGLPLFLFPG AWAQGHVPPG CSQGLNPLYY NLCDRSGAWG 
        60         70         80         90        100
IVLEAVAGAG IVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL 
       110        120        130        140        150
FCLVFACVVK PDFSTCASRR FLFGVLFAIC FSCLAAHVFA LNFLARKNHG 
       160        170        180        190        200
PRGWVIFTVA LLLTLVEVII NTEWLIITLV RGSGEGGPQG NSSAGWAVAS 
       210        220        230        240        250
PCAIANMDFV MALIYVMLLL LGAFLGAWPA LCGRYKRWRK HGVFVLLTTA 
       260        270        280        290        300
TSVAIWVVWI VMYTYGNKQH NSPTWDDPTL AIALAANAWA FVLFYVIPEV 
       310        320        330        340        350
SQVTKSSPEQ SYQGDMYPTR GVGYETILKE QKGQSMFVEN KAFSMDEPVA 
       360        370        380        390        400
AKRPVSPYSG YNGQLLTSVY QPTEMALMHK VPSEGAYDII LPRATANSQV 
       410        420        430        440 
MGSANSTLRA EDMYSAQSHQ AATPPKDGKN SQVFRNPYVW D

Length:441

Mass (Da):48,193

Last modified:April 13, 2004 - v2

Checksum:ⁱB255D9680328FE3D

Isoform 2 (identifier: Q9NQ84-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MGTQPEPGLGARM

« Hide

        10         20         30         40         50
MGTQPEPGLG ARMAIHKALV MCLGLPLFLF PGAWAQGHVP PGCSQGLNPL 
        60         70         80         90        100
YYNLCDRSGA WGIVLEAVAG AGIVTTFVLT IILVASLPFV QDTKKRSLLG 
       110        120        130        140        150
TQVFFLLGTL GLFCLVFACV VKPDFSTCAS RRFLFGVLFA ICFSCLAAHV 
       160        170        180        190        200
FALNFLARKN HGPRGWVIFT VALLLTLVEV IINTEWLIIT LVRGSGEGGP 
       210        220        230        240        250
QGNSSAGWAV ASPCAIANMD FVMALIYVML LLLGAFLGAW PALCGRYKRW 
       260        270        280        290        300
RKHGVFVLLT TATSVAIWVV WIVMYTYGNK QHNSPTWDDP TLAIALAANA 
       310        320        330        340        350
WAFVLFYVIP EVSQVTKSSP EQSYQGDMYP TRGVGYETIL KEQKGQSMFV 
       360        370        380        390        400
ENKAFSMDEP VAAKRPVSPY SGYNGQLLTS VYQPTEMALM HKVPSEGAYD 
       410        420        430        440        450
IILPRATANS QVMGSANSTL RAEDMYSAQS HQAATPPKDG KNSQVFRNPY 

VWD

Show »

Length:453

Mass (Da):49,389

Checksum:ⁱ232D2F2BCD64EE46

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
J3QQN3	J3QQN3_HUMAN	G-protein-coupled receptor family C... G-protein-coupled receptor family C group 5 member C	GPRC5C	145	Annotation score:
A0A0C4DFY5	A0A0C4DFY5_HUMAN	G-protein-coupled receptor family C... G-protein-coupled receptor family C group 5 member C	GPRC5C	486	Annotation score:
A8MXZ4	A8MXZ4_HUMAN	G-protein-coupled receptor family C... G-protein-coupled receptor family C group 5 member C	GPRC5C	462	Annotation score:
J3KTP8	J3KTP8_HUMAN	G-protein-coupled receptor family C... G-protein-coupled receptor family C group 5 member C	GPRC5C	355	Annotation score:
J3KRS9	J3KRS9_HUMAN	G-protein-coupled receptor family C... G-protein-coupled receptor family C group 5 member C	GPRC5C	150	Annotation score:
J9JIE0	J9JIE0_HUMAN	G-protein-coupled receptor family C... G-protein-coupled receptor family C group 5 member C	GPRC5C	126	Annotation score:
J3KSD6	J3KSD6_HUMAN	G-protein-coupled receptor family C... G-protein-coupled receptor family C group 5 member C	GPRC5C	153	Annotation score:

Sequence cautionⁱ

The sequence AAH16860 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAI10849 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAI25081 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAI25082 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAG54752 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAC00633 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	204	I → V in CAC00633 (PubMed:10945465).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037725	1	M → MGTQPEPGLGARM in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ276102 mRNA Translation: CAC00633.1 Different initiation. AF207989 mRNA Translation: AAF72870.1 BT007435 mRNA Translation: AAP36103.1 AK131210 mRNA Translation: BAG54752.1 Different initiation. AK075397 mRNA Translation: BAC11595.1 AB451470 mRNA Translation: BAG70284.1 AC079325 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89163.1 BC016860 mRNA Translation: AAH16860.2 Different initiation. BC110848 mRNA Translation: AAI10849.1 Different initiation. BC125080 mRNA Translation: AAI25081.1 Different initiation. BC125081 mRNA Translation: AAI25082.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42378.1 [Q9NQ84-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_061123.3, NM_018653.3 [Q9NQ84-2] NP_071319.2, NM_022036.2
UniGeneⁱ	Hs.446438

Genome annotation databases

Ensemblⁱ	ENST00000392629; ENSP00000376405; ENSG00000170412 [Q9NQ84-2]
GeneIDⁱ	55890
KEGGⁱ	hsa:55890
UCSC genome browser More...UCSCⁱ	uc002jkp.4 human [Q9NQ84-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQ84	G-protein-coupled receptor family C group 5 member C		HUMAN		126	UniRef100_Q9NQ84
UPI0007DC7DC2		HUMAN		541

Protein	Similar proteins		Species	Score	Length	Source
Q9NQ84	G-protein-coupled receptor family C group 5 member C		HUMAN		126	UniRef90_Q9NQ84
GPRC5C isoform 7		PONAB		560
Uncharacterized protein (Fragment)		MACMU		486
G protein-coupled receptor class C group 5 member C		MACFA		486
GPRC5C isoform 3 (Fragment)		PANTR		462
+69

Protein	Similar proteins		Species	Score	Length	Source
Q9NQ84	G-protein coupled receptor family C group 5 member C		RAT		441	UniRef50_Q9NQ84
G-protein coupled receptor family C group 5 member C		MOUSE		440
G-protein-coupled receptor family C group 5 member C		HUMAN		126
GPRC5C isoform 7		PONAB		560
Uncharacterized protein (Fragment)		MACMU		486
+288

Entry informationⁱ

Entry nameⁱ	GPC5C_HUMAN
Accessionⁱ	Q9NQ84Primary (citable) accession number: Q9NQ84 Secondary accession number(s): B5BUN4, Q2NL85, Q9NZG5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	April 13, 2004
	Last modified:	September 12, 2018
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NQ84 (GPC5C_HUMAN)

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G-protein coupled receptor family C group 5 member C

GPRC5C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ