UniProtKB - Q9NQ84 (GPC5C_HUMAN)
Protein
G-protein coupled receptor family C group 5 member C
Gene
GPRC5C
Organism
Homo sapiens (Human)
Status
Functioni
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: ProtInc
- protein kinase activator activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9NQ84 |
Protein family/group databases
TCDBi | 9.A.14.11.2, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor family C group 5 member CAlternative name(s): Retinoic acid-induced gene 3 protein Short name: RAIG-3 |
Gene namesi | Name:GPRC5C Synonyms:RAIG3 ORF Names:PSEC0087 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170412.16 |
HGNCi | HGNC:13309, GPRC5C |
MIMi | 605949, gene |
neXtProti | NX_Q9NQ84 |
Subcellular locationi
Plasma membrane
Other locations
Note: Localized in the plasma membrane and perinuclear vesicles.
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- intracellular membrane-bounded organelle Source: GO_Central
- receptor complex Source: MGI
- vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 50 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 51 – 71 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 72 – 85 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 86 – 106 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 120 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 121 – 141 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 142 – 155 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 156 – 176 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 208 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 209 – 229 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 230 – 241 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 242 – 262 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 263 – 279 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 280 – 300 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 301 – 441 | CytoplasmicSequence analysisAdd BLAST | 141 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55890 |
OpenTargetsi | ENSG00000170412 |
PharmGKBi | PA28939 |
Miscellaneous databases
Pharosi | Q9NQ84, Tdark |
Polymorphism and mutation databases
BioMutai | GPRC5C |
DMDMi | 46396014 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000012967 | 24 – 441 | G-protein coupled receptor family C group 5 member CAdd BLAST | 418 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 | |
Modified residuei | 383 | PhosphoserineCombined sources | 1 | |
Modified residuei | 403 | PhosphoserineBy similarity | 1 | |
Modified residuei | 406 | PhosphoserineBy similarity | 1 | |
Modified residuei | 414 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 423 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9NQ84 |
jPOSTi | Q9NQ84 |
MassIVEi | Q9NQ84 |
MaxQBi | Q9NQ84 |
PaxDbi | Q9NQ84 |
PeptideAtlasi | Q9NQ84 |
PRIDEi | Q9NQ84 |
ProteomicsDBi | 82101 [Q9NQ84-1] 82102 [Q9NQ84-2] |
PTM databases
GlyGeni | Q9NQ84, 1 site |
iPTMneti | Q9NQ84 |
PhosphoSitePlusi | Q9NQ84 |
SwissPalmi | Q9NQ84 |
Expressioni
Tissue specificityi
Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).2 Publications
Inductioni
By all-trans retinoic acid (ATRA).2 Publications
Gene expression databases
Bgeei | ENSG00000170412, Expressed in body of stomach and 190 other tissues |
ExpressionAtlasi | Q9NQ84, baseline and differential |
Genevisiblei | Q9NQ84, HS |
Organism-specific databases
HPAi | ENSG00000170412, Tissue enhanced (pancreas) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120980, 38 interactors |
IntActi | Q9NQ84, 33 interactors |
STRINGi | 9606.ENSP00000376403 |
Miscellaneous databases
RNActi | Q9NQ84, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQEH, Eukaryota |
GeneTreei | ENSGT00950000182961 |
HOGENOMi | CLU_044162_1_1_1 |
InParanoidi | Q9NQ84 |
OrthoDBi | 807909at2759 |
PhylomeDBi | Q9NQ84 |
TreeFami | TF321410 |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NQ84-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAIHKALVMC LGLPLFLFPG AWAQGHVPPG CSQGLNPLYY NLCDRSGAWG
60 70 80 90 100
IVLEAVAGAG IVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL
110 120 130 140 150
FCLVFACVVK PDFSTCASRR FLFGVLFAIC FSCLAAHVFA LNFLARKNHG
160 170 180 190 200
PRGWVIFTVA LLLTLVEVII NTEWLIITLV RGSGEGGPQG NSSAGWAVAS
210 220 230 240 250
PCAIANMDFV MALIYVMLLL LGAFLGAWPA LCGRYKRWRK HGVFVLLTTA
260 270 280 290 300
TSVAIWVVWI VMYTYGNKQH NSPTWDDPTL AIALAANAWA FVLFYVIPEV
310 320 330 340 350
SQVTKSSPEQ SYQGDMYPTR GVGYETILKE QKGQSMFVEN KAFSMDEPVA
360 370 380 390 400
AKRPVSPYSG YNGQLLTSVY QPTEMALMHK VPSEGAYDII LPRATANSQV
410 420 430 440
MGSANSTLRA EDMYSAQSHQ AATPPKDGKN SQVFRNPYVW D
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MXZ4 | A8MXZ4_HUMAN | G-protein-coupled receptor family C... | GPRC5C | 442 | Annotation score: | ||
J3QQN3 | J3QQN3_HUMAN | G-protein-coupled receptor family C... | GPRC5C | 145 | Annotation score: | ||
A0A0C4DFY5 | A0A0C4DFY5_HUMAN | G-protein-coupled receptor family C... | GPRC5C | 486 | Annotation score: | ||
J3KTP8 | J3KTP8_HUMAN | G-protein-coupled receptor family C... | GPRC5C | 355 | Annotation score: | ||
Q9BSP0 | Q9BSP0_HUMAN | G protein-coupled receptor, family ... | GPRC5C hCG_1775257 | 105 | Annotation score: | ||
J9JIE0 | J9JIE0_HUMAN | G-protein-coupled receptor family C... | GPRC5C | 126 | Annotation score: | ||
J3KSD6 | J3KSD6_HUMAN | G-protein-coupled receptor family C... | GPRC5C | 53 | Annotation score: |
Sequence cautioni
The sequence AAH16860 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI10849 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25081 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25082 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG54752 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC00633 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | I → V in CAC00633 (PubMed:10945465).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037725 | 1 | M → MGTQPEPGLGARM in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ276102 mRNA Translation: CAC00633.1 Different initiation. AF207989 mRNA Translation: AAF72870.1 BT007435 mRNA Translation: AAP36103.1 AK131210 mRNA Translation: BAG54752.1 Different initiation. AK075397 mRNA Translation: BAC11595.1 AB451470 mRNA Translation: BAG70284.1 AC079325 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89163.1 BC016860 mRNA Translation: AAH16860.2 Different initiation. BC110848 mRNA Translation: AAI10849.1 Different initiation. BC125080 mRNA Translation: AAI25081.1 Different initiation. BC125081 mRNA Translation: AAI25082.1 Different initiation. |
CCDSi | CCDS11699.1 [Q9NQ84-1] CCDS42378.1 [Q9NQ84-1] |
RefSeqi | NP_061123.3, NM_018653.3 [Q9NQ84-1] NP_071319.2, NM_022036.2 [Q9NQ84-1] |
Genome annotation databases
Ensembli | ENST00000392627; ENSP00000376403; ENSG00000170412 [Q9NQ84-1] ENST00000392629; ENSP00000376405; ENSG00000170412 [Q9NQ84-1] ENST00000652294; ENSP00000498839; ENSG00000170412 [Q9NQ84-2] |
GeneIDi | 55890 |
KEGGi | hsa:55890 |
UCSCi | uc002jkp.4, human [Q9NQ84-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ276102 mRNA Translation: CAC00633.1 Different initiation. AF207989 mRNA Translation: AAF72870.1 BT007435 mRNA Translation: AAP36103.1 AK131210 mRNA Translation: BAG54752.1 Different initiation. AK075397 mRNA Translation: BAC11595.1 AB451470 mRNA Translation: BAG70284.1 AC079325 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89163.1 BC016860 mRNA Translation: AAH16860.2 Different initiation. BC110848 mRNA Translation: AAI10849.1 Different initiation. BC125080 mRNA Translation: AAI25081.1 Different initiation. BC125081 mRNA Translation: AAI25082.1 Different initiation. |
CCDSi | CCDS11699.1 [Q9NQ84-1] CCDS42378.1 [Q9NQ84-1] |
RefSeqi | NP_061123.3, NM_018653.3 [Q9NQ84-1] NP_071319.2, NM_022036.2 [Q9NQ84-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120980, 38 interactors |
IntActi | Q9NQ84, 33 interactors |
STRINGi | 9606.ENSP00000376403 |
Protein family/group databases
TCDBi | 9.A.14.11.2, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9NQ84, 1 site |
iPTMneti | Q9NQ84 |
PhosphoSitePlusi | Q9NQ84 |
SwissPalmi | Q9NQ84 |
Polymorphism and mutation databases
BioMutai | GPRC5C |
DMDMi | 46396014 |
Proteomic databases
EPDi | Q9NQ84 |
jPOSTi | Q9NQ84 |
MassIVEi | Q9NQ84 |
MaxQBi | Q9NQ84 |
PaxDbi | Q9NQ84 |
PeptideAtlasi | Q9NQ84 |
PRIDEi | Q9NQ84 |
ProteomicsDBi | 82101 [Q9NQ84-1] 82102 [Q9NQ84-2] |
Protocols and materials databases
Antibodypediai | 31968, 235 antibodies |
DNASUi | 55890 |
Genome annotation databases
Ensembli | ENST00000392627; ENSP00000376403; ENSG00000170412 [Q9NQ84-1] ENST00000392629; ENSP00000376405; ENSG00000170412 [Q9NQ84-1] ENST00000652294; ENSP00000498839; ENSG00000170412 [Q9NQ84-2] |
GeneIDi | 55890 |
KEGGi | hsa:55890 |
UCSCi | uc002jkp.4, human [Q9NQ84-1] |
Organism-specific databases
CTDi | 55890 |
DisGeNETi | 55890 |
EuPathDBi | HostDB:ENSG00000170412.16 |
GeneCardsi | GPRC5C |
HGNCi | HGNC:13309, GPRC5C |
HPAi | ENSG00000170412, Tissue enhanced (pancreas) |
MIMi | 605949, gene |
neXtProti | NX_Q9NQ84 |
OpenTargetsi | ENSG00000170412 |
PharmGKBi | PA28939 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQEH, Eukaryota |
GeneTreei | ENSGT00950000182961 |
HOGENOMi | CLU_044162_1_1_1 |
InParanoidi | Q9NQ84 |
OrthoDBi | 807909at2759 |
PhylomeDBi | Q9NQ84 |
TreeFami | TF321410 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQ84 |
Miscellaneous databases
BioGRID-ORCSi | 55890, 4 hits in 843 CRISPR screens |
ChiTaRSi | GPRC5C, human |
GenomeRNAii | 55890 |
Pharosi | Q9NQ84, Tdark |
PROi | PR:Q9NQ84 |
RNActi | Q9NQ84, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170412, Expressed in body of stomach and 190 other tissues |
ExpressionAtlasi | Q9NQ84, baseline and differential |
Genevisiblei | Q9NQ84, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPC5C_HUMAN | |
Accessioni | Q9NQ84Primary (citable) accession number: Q9NQ84 Secondary accession number(s): B5BUN4, Q2NL85, Q9NZG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries