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Entry version 140 (13 Feb 2019)
Sequence version 2 (19 Jul 2004)
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Protein

Cartilage acidic protein 1

Gene

CRTAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cartilage acidic protein 1
Alternative name(s):
68 kDa chondrocyte-expressed protein
Short name:
CEP-68
ASPIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRTAC1
Synonyms:ASPIC1, CEP68
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000095713.13

Human Gene Nomenclature Database

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HGNCi
HGNC:14882 CRTAC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606276 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQ79

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55118

Open Targets

More...
OpenTargetsi
ENSG00000095713

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26899

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CRTAC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50400672

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000749728 – 661Cartilage acidic protein 1Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi563 ↔ 577Sequence analysis
Disulfide bondi570 ↔ 586Sequence analysis
Disulfide bondi592 ↔ 605Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi608O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi618O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi619O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi621O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi626O-linked (GalNAc...) threonineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NQ79

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NQ79

PeptideAtlas

More...
PeptideAtlasi
Q9NQ79

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQ79

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82098
82099 [Q9NQ79-2]
82100 [Q9NQ79-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NQ79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQ79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000095713 Expressed in 177 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NQ79 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NQ79 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008175

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120427, 24 interactors

Protein interaction database and analysis system

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IntActi
Q9NQ79, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000359629

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NQ79

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati46 – 88FG-GAP 1; atypicalAdd BLAST43
Repeati105 – 147FG-GAP 2; atypicalAdd BLAST43
Repeati283 – 333FG-GAP 3; atypicalAdd BLAST51
Repeati395 – 437FG-GAP 4; atypicalAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini559 – 605EGF-likeAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi622 – 639Ala-richAdd BLAST18

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHAW Eukaryota
ENOG410ZVH2 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013726

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051111

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NQ79

Identification of Orthologs from Complete Genome Data

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OMAi
YAIYIAN

Database of Orthologous Groups

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OrthoDBi
986490at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQ79

TreeFam database of animal gene trees

More...
TreeFami
TF333171

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027039 Crtac1
IPR001881 EGF-like_Ca-bd_dom
IPR018097 EGF_Ca-bd_CS
IPR011519 UnbV_ASPIC

The PANTHER Classification System

More...
PANTHERi
PTHR16026:SF4 PTHR16026:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645 EGF_CA, 1 hit
PF07593 UnbV_ASPIC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00179 EGF_CA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01187 EGF_CA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQ79-1) [UniParc]FASTAAdd to basket
Also known as: CRTAC1-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPSADPGMS RMLPFLLLLW FLPITEGSQR AEPMFTAVTN SVLPPDYDSN
60 70 80 90 100
PTQLNYGVAV TDVDHDGDFE IVVAGYNGPN LVLKYDRAQK RLVNIAVDER
110 120 130 140 150
SSPYYALRDR QGNAIGVTAC DIDGDGREEI YFLNTNNAFS GVATYTDKLF
160 170 180 190 200
KFRNNRWEDI LSDEVNVARG VASLFAGRSV ACVDRKGSGR YSIYIANYAY
210 220 230 240 250
GNVGPDALIE MDPEASDLSR GILALRDVAA EAGVSKYTGG RGVSVGPILS
260 270 280 290 300
SSASDIFCDN ENGPNFLFHN RGDGTFVDAA ASAGVDDPHQ HGRGVALADF
310 320 330 340 350
NRDGKVDIVY GNWNGPHRLY LQMSTHGKVR FRDIASPKFS MPSPVRTVIT
360 370 380 390 400
ADFDNDQELE IFFNNIAYRS SSANRLFRVI RREHGDPLIE ELNPGDALEP
410 420 430 440 450
EGRGTGGVVT DFDGDGMLDL ILSHGESMAQ PLSVFRGNQG FNNNWLRVVP
460 470 480 490 500
RTRFGAFARG AKVVLYTKKS GAHLRIIDGG SGYLCEMEPV AHFGLGKDEA
510 520 530 540 550
SSVEVTWPDG KMVSRNVASG EMNSVLEILY PRDEDTLQDP APLECGQGFS
560 570 580 590 600
QQENGHCMDT NECIQFPFVC PRDKPVCVNT YGSYRCRTNK KCSRGYEPNE
610 620 630 640 650
DGTACVGTLG QSPGPRPTTP TAAAATAAAA AAAGAATAAP VLVDGDLNLG
660
SVVKESCEPS C
Note: Shares an exon with the neighboring tail-to-tail oriented gene GOLGA7B.
Length:661
Mass (Da):71,421
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EF75321817F0D01
GO
Isoform 2 (identifier: Q9NQ79-2) [UniParc]FASTAAdd to basket
Also known as: CRTAC1-B

The sequence of this isoform differs from the canonical sequence as follows:
     607-645: GTLGQSPGPR...ATAAPVLVDG → AQVAFLGGYS...LGLCLQLYAL
     646-661: Missing.

Show »
Length:645
Mass (Da):70,434
Checksum:i815B2A4D3C5A321A
GO
Isoform 3 (identifier: Q9NQ79-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-661: CGQGFSQQEN...VVKESCEPSC → TPMNASSSHS...LELPLLHRSS

Note: No experimental confirmation available.
Show »
Length:628
Mass (Da):68,059
Checksum:i48AE68C4EB26DE40
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFP6A0A0C4DFP6_HUMAN
Cartilage acidic protein 1
CRTAC1
637Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T4F6Q5T4F6_HUMAN
Cartilage acidic protein 1
CRTAC1
524Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6C6H0Y6C6_HUMAN
Cartilage acidic protein 1
CRTAC1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34245 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91540 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB98268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB98269 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti454F → V in BAA91540 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048972253A → T. Corresponds to variant dbSNP:rs35853031Ensembl.1
Natural variantiVAR_048973569V → M. Corresponds to variant dbSNP:rs2297935Ensembl.1
Natural variantiVAR_061152658E → K. Corresponds to variant dbSNP:rs56007204Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010893545 – 661CGQGF…CEPSC → TPMNASSSHSCALETSPYVS TPMEATGAGPTRSAVGATSP TRMAQPAWGLSASHRAPAPP PPPLLLPLPLLLPLLELPLL HRSS in isoform 3. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_010894607 – 645GTLGQ…VLVDG → AQVAFLGGYSSAASRISEPL SRASYLSLGLGLCLQLYAL in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_010895646 – 661Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ276171 mRNA Translation: CAB98267.1
AJ276171 mRNA Translation: CAB98268.1 Different initiation.
AJ276171 mRNA Translation: CAB98269.1 Different initiation.
AK001182 mRNA Translation: BAA91540.1 Different initiation.
AK292084 mRNA Translation: BAF84773.1
AL139239 Genomic DNA No translation available.
AL358938 Genomic DNA No translation available.
AJ279016 mRNA Translation: CAC08451.1
AJ421515 mRNA Translation: CAD13394.1
BC034245 mRNA Translation: AAH34245.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31266.1 [Q9NQ79-1]
CCDS55723.1 [Q9NQ79-2]

NCBI Reference Sequences

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RefSeqi
NP_001193457.1, NM_001206528.2 [Q9NQ79-2]
NP_060528.3, NM_018058.6 [Q9NQ79-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.500736

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370591; ENSP00000359623; ENSG00000095713 [Q9NQ79-2]
ENST00000370597; ENSP00000359629; ENSG00000095713 [Q9NQ79-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55118

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55118

UCSC genome browser

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UCSCi
uc001kou.2 human [Q9NQ79-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276171 mRNA Translation: CAB98267.1
AJ276171 mRNA Translation: CAB98268.1 Different initiation.
AJ276171 mRNA Translation: CAB98269.1 Different initiation.
AK001182 mRNA Translation: BAA91540.1 Different initiation.
AK292084 mRNA Translation: BAF84773.1
AL139239 Genomic DNA No translation available.
AL358938 Genomic DNA No translation available.
AJ279016 mRNA Translation: CAC08451.1
AJ421515 mRNA Translation: CAD13394.1
BC034245 mRNA Translation: AAH34245.1 Different initiation.
CCDSiCCDS31266.1 [Q9NQ79-1]
CCDS55723.1 [Q9NQ79-2]
RefSeqiNP_001193457.1, NM_001206528.2 [Q9NQ79-2]
NP_060528.3, NM_018058.6 [Q9NQ79-1]
UniGeneiHs.500736

3D structure databases

ProteinModelPortaliQ9NQ79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120427, 24 interactors
IntActiQ9NQ79, 4 interactors
STRINGi9606.ENSP00000359629

PTM databases

iPTMnetiQ9NQ79
PhosphoSitePlusiQ9NQ79

Polymorphism and mutation databases

BioMutaiCRTAC1
DMDMi50400672

Proteomic databases

jPOSTiQ9NQ79
PaxDbiQ9NQ79
PeptideAtlasiQ9NQ79
PRIDEiQ9NQ79
ProteomicsDBi82098
82099 [Q9NQ79-2]
82100 [Q9NQ79-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55118
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370591; ENSP00000359623; ENSG00000095713 [Q9NQ79-2]
ENST00000370597; ENSP00000359629; ENSG00000095713 [Q9NQ79-1]
GeneIDi55118
KEGGihsa:55118
UCSCiuc001kou.2 human [Q9NQ79-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55118
DisGeNETi55118
EuPathDBiHostDB:ENSG00000095713.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CRTAC1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0035366
HGNCiHGNC:14882 CRTAC1
HPAiHPA008175
MIMi606276 gene
neXtProtiNX_Q9NQ79
OpenTargetsiENSG00000095713
PharmGKBiPA26899

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHAW Eukaryota
ENOG410ZVH2 LUCA
GeneTreeiENSGT00390000013726
HOVERGENiHBG051111
InParanoidiQ9NQ79
OMAiYAIYIAN
OrthoDBi986490at2759
PhylomeDBiQ9NQ79
TreeFamiTF333171

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CRTAC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55118

Protein Ontology

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PROi
PR:Q9NQ79

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000095713 Expressed in 177 organ(s), highest expression level in tendon
ExpressionAtlasiQ9NQ79 baseline and differential
GenevisibleiQ9NQ79 HS

Family and domain databases

InterProiView protein in InterPro
IPR027039 Crtac1
IPR001881 EGF-like_Ca-bd_dom
IPR018097 EGF_Ca-bd_CS
IPR011519 UnbV_ASPIC
PANTHERiPTHR16026:SF4 PTHR16026:SF4, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF07593 UnbV_ASPIC, 1 hit
SMARTiView protein in SMART
SM00179 EGF_CA, 1 hit
PROSITEiView protein in PROSITE
PS01187 EGF_CA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRAC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQ79
Secondary accession number(s): B1ALN4
, Q5T4F8, Q8N4H6, Q8TE52, Q9NQ78, Q9NQ80, Q9NW46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: February 13, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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