Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 171 (16 Oct 2019)
Sequence version 2 (10 Oct 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cas scaffolding protein family member 4

Gene

CASS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cas scaffolding protein family member 4
Alternative name(s):
HEF-like protein
HEF1-EFS-p130Cas-like protein
Short name:
HEPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASS4
Synonyms:C20orf32, HEFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15878 CASS4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQ75

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57091

NIAGADS Genomics Database

More...
NIAGADSi
ENSG00000087589

Open Targets

More...
OpenTargetsi
ENSG00000087589

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381095

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQ75

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASS4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23813906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794251 – 786Cas scaffolding protein family member 4Add BLAST786

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei200PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosines by SRC.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQ75

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NQ75

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NQ75

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQ75

PeptideAtlas

More...
PeptideAtlasi
Q9NQ75

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQ75

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82093 [Q9NQ75-1]
82094 [Q9NQ75-2]
82095 [Q9NQ75-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQ75

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQ75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000087589 Expressed in 90 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQ75 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034217

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SH3 domain) with PTK2/FAK1 (via C-terminus).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121359, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NQ75, 36 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353462

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1786
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQ75

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NQ75

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 73SH3PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi274 – 277Poly-Ser4
Compositional biasi373 – 429Ser-richAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAS family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG8H Eukaryota
ENOG410XSP8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111312

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQ75

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVSYKVP

Database of Orthologous Groups

More...
OrthoDBi
1086228at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQ75

TreeFam database of animal gene trees

More...
TreeFami
TF328782

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12000 SH3_CASS4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.830, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021901 CAS_C
IPR037362 CAS_fam
IPR035512 CASS4
IPR035744 CASS4_SH3
IPR014928 Serine_rich_dom
IPR038319 Serine_rich_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10654 PTHR10654, 2 hits
PTHR10654:SF19 PTHR10654:SF19, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12026 CAS_C, 1 hit
PF08824 Serine_rich, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9NQ75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGTGIMDCA PKALLARALY DNCPDCSDEL AFSRGDILTI LEQHVPESEG
60 70 80 90 100
WWKCLLHGRQ GLAPANRLQI LTEVAADRPC PPFLRGLEEA PASSEETYQV
110 120 130 140 150
PTLPRPPTPG PVYEQMRSWA EGPQPPTAQV YEFPDPPTSA RIICEKTLSF
160 170 180 190 200
PKQAILTLPR PVRASLPTLP SQVYDVPTQH RGPVVLKEPE KQQLYDIPAS
210 220 230 240 250
PKKAGLHPPD SQASGQGVPL ISVTTLRRGG YSTLPNPQKS EWIYDTPVSP
260 270 280 290 300
GKASVRNTPL TSFAEESRPH ALPSSSSTFY NPPSGRSRSL TPQLNNNVPM
310 320 330 340 350
QKKLSLPEIP SYGFLVPRGT FPLDEDVSYK VPSSFLIPRV EQQNTKPNIY
360 370 380 390 400
DIPKATSSVS QAGKELEKAK EVSENSAGHN SSWFSRRTTS PSPEPDRLSG
410 420 430 440 450
SSSDSRASIV SSCSTTSTDD SSSSSSEESA KELSLDLDVA KETVMALQHK
460 470 480 490 500
VVSSVAGLML FVSRKWRFRD YLEANIDAIH RSTDHIEESV REFLDFARGV
510 520 530 540 550
HGTACNLTDS NLQNRIRDQM QTISNSYRIL LETKESLDNR NWPLEVLVTD
560 570 580 590 600
SVQNSPDDLE RFVMVARMLP EDIKRFASIV IANGRLLFKR NCEKEETVQL
610 620 630 640 650
TPNAEFKCEK YIQPPQRETE SHQKSTPSTK QREDEHSSEL LKKNRANICG
660 670 680 690 700
QNPGPLIPQP SSQQTPERKP RLSEHCRLYF GALFKAISAF HGSLSSSQPA
710 720 730 740 750
EIITQSKLVI MVGQKLVDTL CMETQERDVR NEILRGSSHL CSLLKDVALA
760 770 780
TKNAVLTYPS PAALGHLQAE AEKLEQHTRQ FRGTLG
Length:786
Mass (Da):87,144
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E84CD7F60A361DB
GO
Isoform 2 (identifier: Q9NQ75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-786: NPGPLIPQPS...HTRQFRGTLG → VSSEFQVIEKGASIVTWSSGY

Note: No experimental confirmation available.
Show »
Length:672
Mass (Da):74,587
Checksum:i9100A597C52C415F
GO
Isoform 3 (identifier: Q9NQ75-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-651: Missing.

Note: No experimental confirmation available.
Show »
Length:349
Mass (Da):38,346
Checksum:i0DC83EBD13CF6839
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC00655 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti329Y → N in CAC00655 (Ref. 1) Curated1
Sequence conflicti350Missing in CAC00655 (Ref. 1) Curated1
Sequence conflicti488E → A in CAC00655 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054084491R → K. Corresponds to variant dbSNP:rs16979936Ensembl.1
Natural variantiVAR_054085629T → N. Corresponds to variant dbSNP:rs6069755Ensembl.1
Natural variantiVAR_054086660P → S1 PublicationCorresponds to variant dbSNP:rs35031530Ensembl.1
Natural variantiVAR_054087780Q → H. Corresponds to variant dbSNP:rs7272702Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003806215 – 651Missing in isoform 3. 1 PublicationAdd BLAST437
Alternative sequenceiVSP_003807652 – 786NPGPL…RGTLG → VSSEFQVIEKGASIVTWSSG Y in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ276678 mRNA Translation: CAC00655.1 Frameshift.
AK027760 mRNA Translation: BAB55351.1
AL121914 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75546.1
CH471077 Genomic DNA Translation: EAW75547.1
BC027951 mRNA Translation: AAH27951.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33492.1 [Q9NQ75-1]
CCDS54475.1 [Q9NQ75-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001157586.1, NM_001164114.1
NP_001157587.1, NM_001164115.1 [Q9NQ75-3]
NP_001157588.1, NM_001164116.1 [Q9NQ75-1]
NP_065089.2, NM_020356.3 [Q9NQ75-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360314; ENSP00000353462; ENSG00000087589 [Q9NQ75-1]
ENST00000434344; ENSP00000410027; ENSG00000087589 [Q9NQ75-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57091

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57091

UCSC genome browser

More...
UCSCi
uc002xxp.3 human [Q9NQ75-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276678 mRNA Translation: CAC00655.1 Frameshift.
AK027760 mRNA Translation: BAB55351.1
AL121914 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75546.1
CH471077 Genomic DNA Translation: EAW75547.1
BC027951 mRNA Translation: AAH27951.1
CCDSiCCDS33492.1 [Q9NQ75-1]
CCDS54475.1 [Q9NQ75-3]
RefSeqiNP_001157586.1, NM_001164114.1
NP_001157587.1, NM_001164115.1 [Q9NQ75-3]
NP_001157588.1, NM_001164116.1 [Q9NQ75-1]
NP_065089.2, NM_020356.3 [Q9NQ75-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRENMR-A14-71[»]
SMRiQ9NQ75
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121359, 2 interactors
IntActiQ9NQ75, 36 interactors
STRINGi9606.ENSP00000353462

PTM databases

iPTMnetiQ9NQ75
PhosphoSitePlusiQ9NQ75

Polymorphism and mutation databases

BioMutaiCASS4
DMDMi23813906

Proteomic databases

EPDiQ9NQ75
MassIVEiQ9NQ75
MaxQBiQ9NQ75
PaxDbiQ9NQ75
PeptideAtlasiQ9NQ75
PRIDEiQ9NQ75
ProteomicsDBi82093 [Q9NQ75-1]
82094 [Q9NQ75-2]
82095 [Q9NQ75-3]

Genome annotation databases

EnsembliENST00000360314; ENSP00000353462; ENSG00000087589 [Q9NQ75-1]
ENST00000434344; ENSP00000410027; ENSG00000087589 [Q9NQ75-3]
GeneIDi57091
KEGGihsa:57091
UCSCiuc002xxp.3 human [Q9NQ75-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57091
DisGeNETi57091

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CASS4
HGNCiHGNC:15878 CASS4
HPAiCAB034217
neXtProtiNX_Q9NQ75
NIAGADSiENSG00000087589
OpenTargetsiENSG00000087589
PharmGKBiPA162381095

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG8H Eukaryota
ENOG410XSP8 LUCA
GeneTreeiENSGT00950000183008
HOGENOMiHOG000111312
InParanoidiQ9NQ75
OMAiGVSYKVP
OrthoDBi1086228at2759
PhylomeDBiQ9NQ75
TreeFamiTF328782

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CASS4 human
EvolutionaryTraceiQ9NQ75

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57091
PharosiQ9NQ75

Protein Ontology

More...
PROi
PR:Q9NQ75

Gene expression databases

BgeeiENSG00000087589 Expressed in 90 organ(s), highest expression level in leukocyte
GenevisibleiQ9NQ75 HS

Family and domain databases

CDDicd12000 SH3_CASS4, 1 hit
Gene3Di1.20.120.830, 1 hit
InterProiView protein in InterPro
IPR021901 CAS_C
IPR037362 CAS_fam
IPR035512 CASS4
IPR035744 CASS4_SH3
IPR014928 Serine_rich_dom
IPR038319 Serine_rich_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10654 PTHR10654, 2 hits
PTHR10654:SF19 PTHR10654:SF19, 2 hits
PfamiView protein in Pfam
PF12026 CAS_C, 1 hit
PF08824 Serine_rich, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASS4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQ75
Secondary accession number(s): E1P5Z8
, Q5QPD6, Q96K09, Q9BYL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: October 16, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again