UniProtKB - Q9NQ66 (PLCB1_HUMAN)
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Gene
PLCB1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier.By similarity1 Publication
Miscellaneous
The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+1 PublicationEC:3.1.4.111 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 331 | PROSITE-ProRule annotation | 1 | |
Active sitei | 378 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- calmodulin binding Source: BHF-UCL
- enzyme binding Source: UniProtKB
- GTPase activator activity Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- lamin binding Source: Ensembl
- phosphatidylinositol-4,5-bisphosphate binding Source: BHF-UCL
- phosphatidylinositol phospholipase C activity Source: UniProtKB
GO - Biological processi
- activation of meiosis involved in egg activation Source: BHF-UCL
- cerebral cortex development Source: BHF-UCL
- fat cell differentiation Source: Ensembl
- G2/M transition of mitotic cell cycle Source: BHF-UCL
- glutamate receptor signaling pathway Source: BHF-UCL
- G protein-coupled acetylcholine receptor signaling pathway Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: Reactome
- inositol phosphate metabolic process Source: Reactome
- insulin-like growth factor receptor signaling pathway Source: BHF-UCL
- interleukin-12-mediated signaling pathway Source: BHF-UCL
- interleukin-15-mediated signaling pathway Source: BHF-UCL
- interleukin-1-mediated signaling pathway Source: BHF-UCL
- lipid catabolic process Source: UniProtKB-KW
- memory Source: BHF-UCL
- negative regulation of monocyte extravasation Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol metabolic process Source: UniProtKB
- positive regulation of acrosome reaction Source: BHF-UCL
- positive regulation of CD24 production Source: BHF-UCL
- positive regulation of developmental growth Source: BHF-UCL
- positive regulation of embryonic development Source: BHF-UCL
- positive regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
- positive regulation of interleukin-12 production Source: BHF-UCL
- positive regulation of JNK cascade Source: BHF-UCL
- positive regulation of myoblast differentiation Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- postsynaptic modulation of chemical synaptic transmission Source: Ensembl
- regulation of establishment of endothelial barrier Source: Ensembl
- regulation of fertilization Source: BHF-UCL
- regulation of G protein-coupled receptor signaling pathway Source: BHF-UCL
- regulation of retrograde trans-synaptic signaling by endocanabinoid Source: Ensembl
- signal transduction Source: UniProtKB
- Wnt signaling pathway, calcium modulating pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium |
Enzyme and pathway databases
BioCyci | MetaCyc:HS11935-MONOMER |
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | Q9NQ66 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors |
SignaLinki | Q9NQ66 |
SIGNORi | Q9NQ66 |
Chemistry databases
SwissLipidsi | SLP:000000662 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1Curated (EC:3.1.4.111 Publication)Alternative name(s): PLC-154 Phosphoinositide phospholipase C-beta-1 Phospholipase C-I Short name: PLC-I Phospholipase C-beta-1 Short name: PLC-beta-1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15917, PLCB1 |
MIMi | 607120, gene |
neXtProti | NX_Q9NQ66 |
VEuPathDBi | HostDB:ENSG00000182621.16 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus membrane By similarity
Note: Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.By similarity
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
- nuclear speck Source: BHF-UCL
- nucleus Source: UniProtKB
Other locations
- chromatin Source: BHF-UCL
- cytoplasm Source: UniProtKB
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
- postsynapse Source: GOC
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Developmental and epileptic encephalopathy 12 (DEE12)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG.
Related information in OMIMKeywords - Diseasei
EpilepsyOrganism-specific databases
DisGeNETi | 23236 |
MalaCardsi | PLCB1 |
MIMi | 613722, phenotype |
OpenTargetsi | ENSG00000182621 |
Orphaneti | 293181, Malignant migrating focal seizures of infancy 3451, West syndrome |
PharmGKBi | PA33384 |
Miscellaneous databases
Pharosi | Q9NQ66, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4034 |
Genetic variation databases
BioMutai | PLCB1 |
DMDMi | 12643814 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088486 | 1 – 1216 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1Add BLAST | 1216 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 17 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 236 | PhosphoserineBy similarity | 1 | |
Modified residuei | 417 | PhosphoserineBy similarity | 1 | |
Modified residuei | 509 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 511 | PhosphoserineBy similarity | 1 | |
Modified residuei | 582 | PhosphoserineBy similarity | 1 | |
Modified residuei | 887 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 978 | PhosphoserineBy similarity | 1 | |
Modified residuei | 987 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1199 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1200 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier. Palmitoylation by ZDHHC21 is stimulated by inflammation.By similarity
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | Q9NQ66 |
jPOSTi | Q9NQ66 |
MassIVEi | Q9NQ66 |
MaxQBi | Q9NQ66 |
PaxDbi | Q9NQ66 |
PeptideAtlasi | Q9NQ66 |
PRIDEi | Q9NQ66 |
ProteomicsDBi | 82087 [Q9NQ66-1] 82088 [Q9NQ66-2] |
PTM databases
iPTMneti | Q9NQ66 |
PhosphoSitePlusi | Q9NQ66 |
SwissPalmi | Q9NQ66 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182621, Expressed in endothelial cell and 230 other tissues |
ExpressionAtlasi | Q9NQ66, baseline and differential |
Genevisiblei | Q9NQ66, HS |
Organism-specific databases
HPAi | ENSG00000182621, Tissue enhanced (parathyroid) |
Interactioni
Subunit structurei
Interacts with DGKQ.
1 PublicationBinary interactionsi
Hide detailsQ9NQ66
GO - Molecular functioni
- calmodulin binding Source: BHF-UCL
- enzyme binding Source: UniProtKB
- identical protein binding Source: BHF-UCL
- lamin binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116841, 32 interactors |
CORUMi | Q9NQ66 |
IntActi | Q9NQ66, 14 interactors |
STRINGi | 9606.ENSP00000338185 |
Chemistry databases
BindingDBi | Q9NQ66 |
Miscellaneous databases
RNActi | Q9NQ66, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 316 – 467 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 152 | |
Domaini | 540 – 656 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 656 – 786 | C2PROSITE-ProRule annotationAdd BLAST | 131 |
Phylogenomic databases
eggNOGi | KOG1265, Eukaryota |
GeneTreei | ENSGT00940000155428 |
InParanoidi | Q9NQ66 |
OMAi | RDIAQIW |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q9NQ66 |
TreeFami | TF313216 |
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR028400, PLC-beta1 IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR009535, PLC-beta_CS IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF12, PTHR10336:SF12, 1 hit |
Pfami | View protein in Pfam PF06631, DUF1154, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All
Isoform A (identifier: Q9NQ66-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF
60 70 80 90 100
FFYWTDQNKE TELLDLSLVK DARCGRHAKA PKDPKLRELL DVGNIGRLEQ
110 120 130 140 150
RMITVVYGPD LVNISHLNLV AFQEEVAKEW TNEVFSLATN LLAQNMSRDA
160 170 180 190 200
FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA DRKRVETALE ACSLPSSRND
210 220 230 240 250
SIPQEDFTPE VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL TVDQMMDFIN
260 270 280 290 300
LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NNSLARKGQI SVDGFMRYLS
310 320 330 340 350
GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR
360 370 380 390 400
QVLLSGCRCV ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF
410 420 430 440 450
KTSPFPILLS FENHVDSPKQ QAKMAEYCRL IFGDALLMEP LEKYPLESGV
460 470 480 490 500
PLPSPMDLMY KILVKNKKKS HKSSEGSGKK KLSEQASNTY SDSSSMFEPS
510 520 530 540 550
SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM SNLVNYIQPV
560 570 580 590 600
KFESFEISKK RNKSFEMSSF VETKGLEQLT KSPVEFVEYN KMQLSRIYPK
610 620 630 640 650
GTRVDSSNYM PQLFWNAGCQ MVALNFQTMD LAMQINMGMY EYNGKSGYRL
660 670 680 690 700
KPEFMRRPDK HFDPFTEGIV DGIVANTLSV KIISGQFLSD KKVGTYVEVD
710 720 730 740 750
MFGLPVDTRR KAFKTKTSQG NAVNPVWEEE PIVFKKVVLP TLACLRIAVY
760 770 780 790 800
EEGGKFIGHR ILPVQAIRPG YHYICLRNER NQPLTLPAVF VYIEVKDYVP
810 820 830 840 850
DTYADVIEAL SNPIRYVNLM EQRAKQLAAL TLEDEEEVKK EADPGETPSE
860 870 880 890 900
APSEARTTPA ENGVNHTTTL TPKPPSQALH SQPAPGSVKA PAKTEDLIQS
910 920 930 940 950
VLTEVEAQTI EELKQQKSFV KLQKKHYKEM KDLVKRHHKK TTDLIKEHTT
960 970 980 990 1000
KYNEIQNDYL RRRAALEKSA KKDSKKKSEP SSPDHGSSTI EQDLAALDAE
1010 1020 1030 1040 1050
MTQKLIDLKD KQQQQLLNLR QEQYYSEKYQ KREHIKLLIQ KLTDVAEECQ
1060 1070 1080 1090 1100
NNQLKKLKEI CEKEKKELKK KMDKKRQEKI TEAKSKDKSQ MEEEKTEMIR
1110 1120 1130 1140 1150
SYIQEVVQYI KRLEEAQSKR QEKLVEKHKE IRQQILDEKP KLQVELEQEY
1160 1170 1180 1190 1200
QDKFKRLPLE ILEFVQEAMK GKISEDSNHG SAPLSLSSDP GKVNHKTPSS
1210
EELGGDIPGK EFDTPL
Computationally mapped potential isoform sequencesi
There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WT80 | A0A087WT80_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB1 | 1,136 | Annotation score: | ||
A0A087WW73 | A0A087WW73_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB1 | 1,093 | Annotation score: | ||
A0A1B0GWB6 | A0A1B0GWB6_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB1 | 1,072 | Annotation score: | ||
H0YCJ2 | H0YCJ2_HUMAN | Phosphoinositide phospholipase C | PLCB1 | 914 | Annotation score: | ||
A0A0D9SF51 | A0A0D9SF51_HUMAN | Phosphoinositide phospholipase C | PLCB1 | 960 | Annotation score: | ||
A0A0D9SG17 | A0A0D9SG17_HUMAN | Phosphoinositide phospholipase C | PLCB1 | 961 | Annotation score: | ||
A0A0D9SGI7 | A0A0D9SGI7_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB1 | 231 | Annotation score: | ||
A0A1B0GW62 | A0A1B0GW62_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB1 | 199 | Annotation score: | ||
Q8IV92 | Q8IV92_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB1 | 196 | Annotation score: | ||
B1AK73 | B1AK73_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB1 | 205 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BAA25507 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14641 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 34 | MAGAQ…KWDDD → MGSLQGIATKILIRILSDAL IRKETDLKS in AAF86613 (PubMed:10760467).CuratedAdd BLAST | 34 | |
Sequence conflicti | 189 | L → M in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 203 | P → L in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 216 | L → F in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 221 | P → L in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 266 | L → P in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 309 | P → T in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 320 | Q → R in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 352 | V → A in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 366 | K → R in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 393 | E → K in AAF86613 (PubMed:10760467).Curated | 1 | |
Sequence conflicti | 983 | P → S in CAB98143 (PubMed:11118617).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050541 | 854 | E → K. Corresponds to variant dbSNP:rs2076413Ensembl. | 1 | |
Natural variantiVAR_036547 | 907 | A → P in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004718 | 1142 – 1216 | LQVEL…FDTPL → GEGSSSFLSETCHEDPSVSP NFTPPNPQALKW in isoform B. 4 PublicationsAdd BLAST | 75 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ278313 mRNA Translation: CAB98142.1 AJ278314 mRNA Translation: CAB98143.1 AY004175 mRNA Translation: AAF86613.1 AB011153 mRNA Translation: BAA25507.3 Different initiation. AL031683 Genomic DNA No translation available. AL034551 Genomic DNA No translation available. AL049593 Genomic DNA No translation available. AL049632 Genomic DNA No translation available. AL050315 Genomic DNA No translation available. AL050323 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10372.1 CH471133 Genomic DNA Translation: EAX10373.1 CH471133 Genomic DNA Translation: EAX10374.1 CH471133 Genomic DNA Translation: EAX10376.1 BC069420 mRNA Translation: AAH69420.1 BC117231 mRNA Translation: AAI17232.1 AL137267 mRNA Translation: CAB70666.1 AK023689 mRNA Translation: BAB14641.1 Different initiation. |
CCDSi | CCDS13102.1 [Q9NQ66-1] CCDS13103.1 [Q9NQ66-2] |
RefSeqi | NP_056007.1, NM_015192.3 [Q9NQ66-1] NP_877398.1, NM_182734.2 [Q9NQ66-2] |
Genome annotation databases
Ensembli | ENST00000338037; ENSP00000338185; ENSG00000182621 [Q9NQ66-1] ENST00000378637; ENSP00000367904; ENSG00000182621 [Q9NQ66-2] ENST00000378641; ENSP00000367908; ENSG00000182621 [Q9NQ66-2] |
GeneIDi | 23236 |
KEGGi | hsa:23236 |
UCSCi | uc002wna.5, human [Q9NQ66-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ278313 mRNA Translation: CAB98142.1 AJ278314 mRNA Translation: CAB98143.1 AY004175 mRNA Translation: AAF86613.1 AB011153 mRNA Translation: BAA25507.3 Different initiation. AL031683 Genomic DNA No translation available. AL034551 Genomic DNA No translation available. AL049593 Genomic DNA No translation available. AL049632 Genomic DNA No translation available. AL050315 Genomic DNA No translation available. AL050323 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10372.1 CH471133 Genomic DNA Translation: EAX10373.1 CH471133 Genomic DNA Translation: EAX10374.1 CH471133 Genomic DNA Translation: EAX10376.1 BC069420 mRNA Translation: AAH69420.1 BC117231 mRNA Translation: AAI17232.1 AL137267 mRNA Translation: CAB70666.1 AK023689 mRNA Translation: BAB14641.1 Different initiation. |
CCDSi | CCDS13102.1 [Q9NQ66-1] CCDS13103.1 [Q9NQ66-2] |
RefSeqi | NP_056007.1, NM_015192.3 [Q9NQ66-1] NP_877398.1, NM_182734.2 [Q9NQ66-2] |
3D structure databases
SMRi | Q9NQ66 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116841, 32 interactors |
CORUMi | Q9NQ66 |
IntActi | Q9NQ66, 14 interactors |
STRINGi | 9606.ENSP00000338185 |
Chemistry databases
BindingDBi | Q9NQ66 |
ChEMBLi | CHEMBL4034 |
SwissLipidsi | SLP:000000662 |
PTM databases
iPTMneti | Q9NQ66 |
PhosphoSitePlusi | Q9NQ66 |
SwissPalmi | Q9NQ66 |
Genetic variation databases
BioMutai | PLCB1 |
DMDMi | 12643814 |
Proteomic databases
EPDi | Q9NQ66 |
jPOSTi | Q9NQ66 |
MassIVEi | Q9NQ66 |
MaxQBi | Q9NQ66 |
PaxDbi | Q9NQ66 |
PeptideAtlasi | Q9NQ66 |
PRIDEi | Q9NQ66 |
ProteomicsDBi | 82087 [Q9NQ66-1] 82088 [Q9NQ66-2] |
Protocols and materials databases
Antibodypediai | 3795, 267 antibodies |
Genome annotation databases
Ensembli | ENST00000338037; ENSP00000338185; ENSG00000182621 [Q9NQ66-1] ENST00000378637; ENSP00000367904; ENSG00000182621 [Q9NQ66-2] ENST00000378641; ENSP00000367908; ENSG00000182621 [Q9NQ66-2] |
GeneIDi | 23236 |
KEGGi | hsa:23236 |
UCSCi | uc002wna.5, human [Q9NQ66-1] |
Organism-specific databases
CTDi | 23236 |
DisGeNETi | 23236 |
GeneCardsi | PLCB1 |
HGNCi | HGNC:15917, PLCB1 |
HPAi | ENSG00000182621, Tissue enhanced (parathyroid) |
MalaCardsi | PLCB1 |
MIMi | 607120, gene 613722, phenotype |
neXtProti | NX_Q9NQ66 |
OpenTargetsi | ENSG00000182621 |
Orphaneti | 293181, Malignant migrating focal seizures of infancy 3451, West syndrome |
PharmGKBi | PA33384 |
VEuPathDBi | HostDB:ENSG00000182621.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1265, Eukaryota |
GeneTreei | ENSGT00940000155428 |
InParanoidi | Q9NQ66 |
OMAi | RDIAQIW |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q9NQ66 |
TreeFami | TF313216 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS11935-MONOMER |
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | Q9NQ66 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors |
SignaLinki | Q9NQ66 |
SIGNORi | Q9NQ66 |
Miscellaneous databases
BioGRID-ORCSi | 23236, 10 hits in 998 CRISPR screens |
ChiTaRSi | PLCB1, human |
GeneWikii | PLCB1 |
GenomeRNAii | 23236 |
Pharosi | Q9NQ66, Tbio |
PROi | PR:Q9NQ66 |
RNActi | Q9NQ66, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182621, Expressed in endothelial cell and 230 other tissues |
ExpressionAtlasi | Q9NQ66, baseline and differential |
Genevisiblei | Q9NQ66, HS |
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR028400, PLC-beta1 IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR009535, PLC-beta_CS IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF12, PTHR10336:SF12, 1 hit |
Pfami | View protein in Pfam PF06631, DUF1154, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCB1_HUMAN | |
Accessioni | Q9NQ66Primary (citable) accession number: Q9NQ66 Secondary accession number(s): D3DW12 Q9UM26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot