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UniProtKB - Q9NQ66 (PLCB1_HUMAN)

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Gene

PLCB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Miscellaneous

The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Ca2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei331PROSITE-ProRule annotation1
Active sitei378PROSITE-ProRule annotation1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium

Enzyme and pathway databases

BRENDAi3.1.4.11 2681
ReactomeiR-HSA-112043 PLC beta mediated events
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-500657 Presynaptic function of Kainate receptors
SignaLinkiQ9NQ66
SIGNORiQ9NQ66

Chemistry databases

SwissLipidsiSLP:000000662

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC:3.1.4.11)
Alternative name(s):
PLC-154
Phosphoinositide phospholipase C-beta-1
Phospholipase C-I
Short name:
PLC-I
Phospholipase C-beta-1
Short name:
PLC-beta-1
Gene namesi
Name:PLCB1
Synonyms:KIAA0581
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000182621.16
HGNCiHGNC:15917 PLCB1
MIMi607120 gene
neXtProtiNX_Q9NQ66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Epileptic encephalopathy, early infantile, 12 (EIEE12)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG.
See also OMIM:613722

Keywords - Diseasei

Epilepsy

Organism-specific databases

DisGeNETi23236
MalaCardsiPLCB1
MIMi613722 phenotype
OpenTargetsiENSG00000182621
Orphaneti293181 Malignant migrating partial seizures of infancy
3451 West syndrome
PharmGKBiPA33384

Chemistry databases

ChEMBLiCHEMBL4034

Polymorphism and mutation databases

DMDMi12643814

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000884861 – 12161-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1Add BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei509PhosphothreonineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei582PhosphoserineBy similarity1
Modified residuei887Phosphoserine; by PKCBy similarity1
Modified residuei978PhosphoserineBy similarity1
Modified residuei987PhosphoserineBy similarity1
Modified residuei1199PhosphoserineBy similarity1
Modified residuei1200PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NQ66
MaxQBiQ9NQ66
PaxDbiQ9NQ66
PeptideAtlasiQ9NQ66
PRIDEiQ9NQ66
ProteomicsDBi82087
82088 [Q9NQ66-2]

PTM databases

iPTMnetiQ9NQ66
PhosphoSitePlusiQ9NQ66
SwissPalmiQ9NQ66

Expressioni

Gene expression databases

BgeeiENSG00000182621 Expressed in 222 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ9NQ66 baseline and differential
GenevisibleiQ9NQ66 HS

Organism-specific databases

HPAiCAB004275
CAB005334
HPA034743
HPA057910

Interactioni

Subunit structurei

Interacts with DGKQ.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116841, 16 interactors
CORUMiQ9NQ66
IntActiQ9NQ66, 6 interactors
STRINGi9606.ENSP00000338185

Chemistry databases

BindingDBiQ9NQ66

Structurei

3D structure databases

ProteinModelPortaliQ9NQ66
SMRiQ9NQ66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 467PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST152
Domaini540 – 656PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini663 – 761C2PROSITE-ProRule annotationAdd BLAST99

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00760000118936
HOVERGENiHBG053609
InParanoidiQ9NQ66
KOiK05858
OMAiTVDLSMQ
OrthoDBiEOG091G00XL
PhylomeDBiQ9NQ66
TreeFamiTF313216

Family and domain databases

CDDicd13361 PH_PLC_beta, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR028400 PLC-beta1
IPR014815 PLC-beta_C
IPR009535 PLC-beta_CS
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF12 PTHR10336:SF12, 1 hit
PfamiView protein in Pfam
PF06631 DUF1154, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF08703 PLC-beta_C, 1 hit
PIRSFiPIRSF000956 PLC-beta, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9NQ66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF 
        60         70         80         90        100
FFYWTDQNKE TELLDLSLVK DARCGRHAKA PKDPKLRELL DVGNIGRLEQ 
       110        120        130        140        150
RMITVVYGPD LVNISHLNLV AFQEEVAKEW TNEVFSLATN LLAQNMSRDA 
       160        170        180        190        200
FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA DRKRVETALE ACSLPSSRND 
       210        220        230        240        250
SIPQEDFTPE VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL TVDQMMDFIN 
       260        270        280        290        300
LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NNSLARKGQI SVDGFMRYLS 
       310        320        330        340        350
GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR 
       360        370        380        390        400
QVLLSGCRCV ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF 
       410        420        430        440        450
KTSPFPILLS FENHVDSPKQ QAKMAEYCRL IFGDALLMEP LEKYPLESGV 
       460        470        480        490        500
PLPSPMDLMY KILVKNKKKS HKSSEGSGKK KLSEQASNTY SDSSSMFEPS 
       510        520        530        540        550
SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM SNLVNYIQPV 
       560        570        580        590        600
KFESFEISKK RNKSFEMSSF VETKGLEQLT KSPVEFVEYN KMQLSRIYPK 
       610        620        630        640        650
GTRVDSSNYM PQLFWNAGCQ MVALNFQTMD LAMQINMGMY EYNGKSGYRL 
       660        670        680        690        700
KPEFMRRPDK HFDPFTEGIV DGIVANTLSV KIISGQFLSD KKVGTYVEVD 
       710        720        730        740        750
MFGLPVDTRR KAFKTKTSQG NAVNPVWEEE PIVFKKVVLP TLACLRIAVY 
       760        770        780        790        800
EEGGKFIGHR ILPVQAIRPG YHYICLRNER NQPLTLPAVF VYIEVKDYVP 
       810        820        830        840        850
DTYADVIEAL SNPIRYVNLM EQRAKQLAAL TLEDEEEVKK EADPGETPSE 
       860        870        880        890        900
APSEARTTPA ENGVNHTTTL TPKPPSQALH SQPAPGSVKA PAKTEDLIQS 
       910        920        930        940        950
VLTEVEAQTI EELKQQKSFV KLQKKHYKEM KDLVKRHHKK TTDLIKEHTT 
       960        970        980        990       1000
KYNEIQNDYL RRRAALEKSA KKDSKKKSEP SSPDHGSSTI EQDLAALDAE 
      1010       1020       1030       1040       1050
MTQKLIDLKD KQQQQLLNLR QEQYYSEKYQ KREHIKLLIQ KLTDVAEECQ 
      1060       1070       1080       1090       1100
NNQLKKLKEI CEKEKKELKK KMDKKRQEKI TEAKSKDKSQ MEEEKTEMIR 
      1110       1120       1130       1140       1150
SYIQEVVQYI KRLEEAQSKR QEKLVEKHKE IRQQILDEKP KLQVELEQEY 
      1160       1170       1180       1190       1200
QDKFKRLPLE ILEFVQEAMK GKISEDSNHG SAPLSLSSDP GKVNHKTPSS 
      1210 
EELGGDIPGK EFDTPL
Length:1,216
Mass (Da):138,567
Last modified:October 1, 2000 - v1
Checksum:i6F4263D1A50C6FD1
GO
Isoform B (identifier: Q9NQ66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1142-1216: LQVELEQEYQ...IPGKEFDTPL → GEGSSSFLSETCHEDPSVSPNFTPPNPQALKW

Show »
Length:1,173
Mass (Da):133,703
Checksum:iB9DA88251A5769FB
GO

Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT80A0A087WT80_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCB1
1,136Annotation score:
A0A087WW73A0A087WW73_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCB1
1,093Annotation score:
A0A1B0GWB6A0A1B0GWB6_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCB1
1,072Annotation score:
H0YCJ2H0YCJ2_HUMAN
Phosphoinositide phospholipase C
PLCB1
914Annotation score:
A0A0D9SG17A0A0D9SG17_HUMAN
Phosphoinositide phospholipase C
PLCB1
961Annotation score:
A0A0D9SF51A0A0D9SF51_HUMAN
Phosphoinositide phospholipase C
PLCB1
960Annotation score:
A0A0D9SGI7A0A0D9SGI7_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCB1
231Annotation score:
A0A1B0GW62A0A1B0GW62_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCB1
199Annotation score:
Q8IV91Q8IV91_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCB1
41Annotation score:
A0A1B0GVT0A0A1B0GVT0_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCB1
87Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAA25507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14641 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 34MAGAQ…KWDDD → MGSLQGIATKILIRILSDAL IRKETDLKS in AAF86613 (PubMed:10760467).CuratedAdd BLAST34
Sequence conflicti189L → M in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti203P → L in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti216L → F in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti221P → L in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti266L → P in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti309P → T in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti320Q → R in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti352V → A in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti366K → R in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti393E → K in AAF86613 (PubMed:10760467).Curated1
Sequence conflicti983P → S in CAB98143 (PubMed:11118617).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050541854E → K. Corresponds to variant dbSNP:rs2076413Ensembl.1
Natural variantiVAR_036547907A → P in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0047181142 – 1216LQVEL…FDTPL → GEGSSSFLSETCHEDPSVSP NFTPPNPQALKW in isoform B. 4 PublicationsAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278313 mRNA Translation: CAB98142.1
AJ278314 mRNA Translation: CAB98143.1
AY004175 mRNA Translation: AAF86613.1
AB011153 mRNA Translation: BAA25507.3 Different initiation.
AL031683 Genomic DNA No translation available.
AL034551 Genomic DNA No translation available.
AL049593 Genomic DNA No translation available.
AL049632 Genomic DNA No translation available.
AL050315 Genomic DNA No translation available.
AL050323 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10372.1
CH471133 Genomic DNA Translation: EAX10373.1
CH471133 Genomic DNA Translation: EAX10374.1
CH471133 Genomic DNA Translation: EAX10376.1
BC069420 mRNA Translation: AAH69420.1
BC117231 mRNA Translation: AAI17232.1
AL137267 mRNA Translation: CAB70666.1
AK023689 mRNA Translation: BAB14641.1 Different initiation.
CCDSiCCDS13102.1 [Q9NQ66-1]
CCDS13103.1 [Q9NQ66-2]
RefSeqiNP_056007.1, NM_015192.3 [Q9NQ66-1]
NP_877398.1, NM_182734.2 [Q9NQ66-2]
UniGeneiHs.431173

Genome annotation databases

EnsembliENST00000338037; ENSP00000338185; ENSG00000182621 [Q9NQ66-1]
ENST00000378637; ENSP00000367904; ENSG00000182621 [Q9NQ66-2]
ENST00000378641; ENSP00000367908; ENSG00000182621 [Q9NQ66-2]
GeneIDi23236
KEGGihsa:23236
UCSCiuc002wna.5 human [Q9NQ66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278313 mRNA Translation: CAB98142.1
AJ278314 mRNA Translation: CAB98143.1
AY004175 mRNA Translation: AAF86613.1
AB011153 mRNA Translation: BAA25507.3 Different initiation.
AL031683 Genomic DNA No translation available.
AL034551 Genomic DNA No translation available.
AL049593 Genomic DNA No translation available.
AL049632 Genomic DNA No translation available.
AL050315 Genomic DNA No translation available.
AL050323 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10372.1
CH471133 Genomic DNA Translation: EAX10373.1
CH471133 Genomic DNA Translation: EAX10374.1
CH471133 Genomic DNA Translation: EAX10376.1
BC069420 mRNA Translation: AAH69420.1
BC117231 mRNA Translation: AAI17232.1
AL137267 mRNA Translation: CAB70666.1
AK023689 mRNA Translation: BAB14641.1 Different initiation.
CCDSiCCDS13102.1 [Q9NQ66-1]
CCDS13103.1 [Q9NQ66-2]
RefSeqiNP_056007.1, NM_015192.3 [Q9NQ66-1]
NP_877398.1, NM_182734.2 [Q9NQ66-2]
UniGeneiHs.431173

3D structure databases

ProteinModelPortaliQ9NQ66
SMRiQ9NQ66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116841, 16 interactors
CORUMiQ9NQ66
IntActiQ9NQ66, 6 interactors
STRINGi9606.ENSP00000338185

Chemistry databases

BindingDBiQ9NQ66
ChEMBLiCHEMBL4034
SwissLipidsiSLP:000000662

PTM databases

iPTMnetiQ9NQ66
PhosphoSitePlusiQ9NQ66
SwissPalmiQ9NQ66

Polymorphism and mutation databases

DMDMi12643814

Proteomic databases

EPDiQ9NQ66
MaxQBiQ9NQ66
PaxDbiQ9NQ66
PeptideAtlasiQ9NQ66
PRIDEiQ9NQ66
ProteomicsDBi82087
82088 [Q9NQ66-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338037; ENSP00000338185; ENSG00000182621 [Q9NQ66-1]
ENST00000378637; ENSP00000367904; ENSG00000182621 [Q9NQ66-2]
ENST00000378641; ENSP00000367908; ENSG00000182621 [Q9NQ66-2]
GeneIDi23236
KEGGihsa:23236
UCSCiuc002wna.5 human [Q9NQ66-1]

Organism-specific databases

CTDi23236
DisGeNETi23236
EuPathDBiHostDB:ENSG00000182621.16
GeneCardsiPLCB1
HGNCiHGNC:15917 PLCB1
HPAiCAB004275
CAB005334
HPA034743
HPA057910
MalaCardsiPLCB1
MIMi607120 gene
613722 phenotype
neXtProtiNX_Q9NQ66
OpenTargetsiENSG00000182621
Orphaneti293181 Malignant migrating partial seizures of infancy
3451 West syndrome
PharmGKBiPA33384
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00760000118936
HOVERGENiHBG053609
InParanoidiQ9NQ66
KOiK05858
OMAiTVDLSMQ
OrthoDBiEOG091G00XL
PhylomeDBiQ9NQ66
TreeFamiTF313216

Enzyme and pathway databases

BRENDAi3.1.4.11 2681
ReactomeiR-HSA-112043 PLC beta mediated events
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-500657 Presynaptic function of Kainate receptors
SignaLinkiQ9NQ66
SIGNORiQ9NQ66

Miscellaneous databases

ChiTaRSiPLCB1 human
GeneWikiiPLCB1
GenomeRNAii23236
PROiPR:Q9NQ66
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182621 Expressed in 222 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ9NQ66 baseline and differential
GenevisibleiQ9NQ66 HS

Family and domain databases

CDDicd13361 PH_PLC_beta, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR028400 PLC-beta1
IPR014815 PLC-beta_C
IPR009535 PLC-beta_CS
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF12 PTHR10336:SF12, 1 hit
PfamiView protein in Pfam
PF06631 DUF1154, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF08703 PLC-beta_C, 1 hit
PIRSFiPIRSF000956 PLC-beta, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLCB1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ66
Secondary accession number(s): D3DW12
, D3DW13, O60325, Q17RQ6, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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