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Protein

39S ribosomal protein L40, mitochondrial

Gene

MRPL40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L40, mitochondrial
Short name:
L40mt
Short name:
MRP-L40
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL401 Publication
Nuclear localization signal-containing protein deleted in velocardiofacial syndrome
Up-regulated in metastasis
Gene namesi
Name:MRPL40
Synonyms:NLVCF, URIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000185608.8
HGNCiHGNC:14491 MRPL40
MIMi605089 gene
neXtProtiNX_Q9NQ50

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185608
PharmGKBiPA30972

Polymorphism and mutation databases

BioMutaiMRPL40
DMDMi21263795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000003055847 – 20639S ribosomal protein L40, mitochondrialAdd BLAST160

Proteomic databases

EPDiQ9NQ50
MaxQBiQ9NQ50
PaxDbiQ9NQ50
PeptideAtlasiQ9NQ50
PRIDEiQ9NQ50
ProteomicsDBi82081
TopDownProteomicsiQ9NQ50

PTM databases

iPTMnetiQ9NQ50
PhosphoSitePlusiQ9NQ50

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000185608 Expressed in 241 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL40
GenevisibleiQ9NQ50 HS

Organism-specific databases

HPAiHPA006181

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL40 binds to the major groove of the anticodon stem of mt-tRNA(Val) in the central protuberance.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi122364, 76 interactors
CORUMiQ9NQ50
IntActiQ9NQ50, 21 interactors
MINTiQ9NQ50
STRINGi9606.ENSP00000333401

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NQ50
SMRiQ9NQ50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4778 Eukaryota
ENOG4111PQW LUCA
GeneTreeiENSGT00390000010239
HOGENOMiHOG000015976
HOVERGENiHBG044505
InParanoidiQ9NQ50
KOiK17421
OMAiRCLHTTP
OrthoDBiEOG091G0RI9
PhylomeDBiQ9NQ50
TreeFamiTF105982

Family and domain databases

InterProiView protein in InterPro
IPR039145 MRPL40
IPR019192 Ribosomal_L28/L40_mit
PANTHERiPTHR13359 PTHR13359, 1 hit
PfamiView protein in Pfam
PF09812 MRP-L28, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NQ50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL
60 70 80 90 100
RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFIT PLKFLDKARE
110 120 130 140 150
RPQVELTFEE TERRALLLKK WSLYKQQERK MERDTIRAML EAQQEALEEL
160 170 180 190 200
QLESPKLHAE AIKRDPNLFP FEKEGPHYTP PIPNYQPPEG RYNDITKVYT

QVEFKR
Length:206
Mass (Da):24,490
Last modified:October 1, 2000 - v1
Checksum:iAE6262A9A94B05FD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06180911L → P1 PublicationCorresponds to variant dbSNP:rs1128399Ensembl.1
Natural variantiVAR_016088129R → H1 PublicationCorresponds to variant dbSNP:rs7575Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034091 mRNA Translation: AAC70904.1
AJ295637 mRNA Translation: CAC00535.1
CR456532 mRNA Translation: CAG30418.1
AK123768 mRNA Translation: BAG53959.1
CH471176 Genomic DNA Translation: EAX03042.1
BC009707 mRNA Translation: AAH09707.1
CCDSiCCDS13760.1
RefSeqiNP_003767.2, NM_003776.3
UniGeneiHs.431307

Genome annotation databases

EnsembliENST00000333130; ENSP00000333401; ENSG00000185608
GeneIDi64976
KEGGihsa:64976
UCSCiuc002zpg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034091 mRNA Translation: AAC70904.1
AJ295637 mRNA Translation: CAC00535.1
CR456532 mRNA Translation: CAG30418.1
AK123768 mRNA Translation: BAG53959.1
CH471176 Genomic DNA Translation: EAX03042.1
BC009707 mRNA Translation: AAH09707.1
CCDSiCCDS13760.1
RefSeqiNP_003767.2, NM_003776.3
UniGeneiHs.431307

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4081-206[»]
3J9Melectron microscopy3.5081-206[»]
5OOLelectron microscopy3.0681-206[»]
5OOMelectron microscopy3.0381-206[»]
ProteinModelPortaliQ9NQ50
SMRiQ9NQ50
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122364, 76 interactors
CORUMiQ9NQ50
IntActiQ9NQ50, 21 interactors
MINTiQ9NQ50
STRINGi9606.ENSP00000333401

PTM databases

iPTMnetiQ9NQ50
PhosphoSitePlusiQ9NQ50

Polymorphism and mutation databases

BioMutaiMRPL40
DMDMi21263795

Proteomic databases

EPDiQ9NQ50
MaxQBiQ9NQ50
PaxDbiQ9NQ50
PeptideAtlasiQ9NQ50
PRIDEiQ9NQ50
ProteomicsDBi82081
TopDownProteomicsiQ9NQ50

Protocols and materials databases

DNASUi64976
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333130; ENSP00000333401; ENSG00000185608
GeneIDi64976
KEGGihsa:64976
UCSCiuc002zpg.4 human

Organism-specific databases

CTDi64976
EuPathDBiHostDB:ENSG00000185608.8
GeneCardsiMRPL40
HGNCiHGNC:14491 MRPL40
HPAiHPA006181
MIMi605089 gene
neXtProtiNX_Q9NQ50
OpenTargetsiENSG00000185608
PharmGKBiPA30972
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4778 Eukaryota
ENOG4111PQW LUCA
GeneTreeiENSGT00390000010239
HOGENOMiHOG000015976
HOVERGENiHBG044505
InParanoidiQ9NQ50
KOiK17421
OMAiRCLHTTP
OrthoDBiEOG091G0RI9
PhylomeDBiQ9NQ50
TreeFamiTF105982

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GeneWikiiMRPL40
GenomeRNAii64976
PROiPR:Q9NQ50
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185608 Expressed in 241 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL40
GenevisibleiQ9NQ50 HS

Family and domain databases

InterProiView protein in InterPro
IPR039145 MRPL40
IPR019192 Ribosomal_L28/L40_mit
PANTHERiPTHR13359 PTHR13359, 1 hit
PfamiView protein in Pfam
PF09812 MRP-L28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM40_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ50
Secondary accession number(s): B3KVZ7, O95134
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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