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Protein

A-kinase-interacting protein 1

Gene

AKIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.2 Publications

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase-interacting protein 1
Alternative name(s):
Breast cancer-associated gene 3 protein
PKA-interacting protein
Proline-rich protein BCA3
Gene namesi
Name:AKIP1
Synonyms:BCA3, C11orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166452.11
HGNCiHGNC:1170 AKIP1
MIMi609191 gene
neXtProtiNX_Q9NQ31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi56672
OpenTargetsiENSG00000166452
PharmGKBiPA25484

Polymorphism and mutation databases

BioMutaiAKIP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648571 – 210A-kinase-interacting protein 1Add BLAST210

Proteomic databases

MaxQBiQ9NQ31
PaxDbiQ9NQ31
PeptideAtlasiQ9NQ31
PRIDEiQ9NQ31
ProteomicsDBi82063
82064 [Q9NQ31-2]
82065 [Q9NQ31-3]

PTM databases

iPTMnetiQ9NQ31
PhosphoSitePlusiQ9NQ31

Expressioni

Tissue specificityi

Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.2 Publications

Gene expression databases

BgeeiENSG00000166452 Expressed in 204 organ(s), highest expression level in vagina
CleanExiHS_C11orf17
ExpressionAtlasiQ9NQ31 baseline and differential
GenevisibleiQ9NQ31 HS

Organism-specific databases

HPAiHPA061391

Interactioni

Subunit structurei

Interacts with PRKACA and RELA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKACAP176124EBI-517035,EBI-476586

Protein-protein interaction databases

BioGridi121180, 13 interactors
IntActiQ9NQ31, 5 interactors
STRINGi9606.ENSP00000310459

Structurei

3D structure databases

ProteinModelPortaliQ9NQ31
SMRiQ9NQ31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGJ9 Eukaryota
ENOG41114P0 LUCA
GeneTreeiENSGT00390000017064
HOVERGENiHBG030457
InParanoidiQ9NQ31
OMAiREERHPT
OrthoDBiEOG091G0W3L
PhylomeDBiQ9NQ31
TreeFamiTF337318

Family and domain databases

InterProiView protein in InterPro
IPR033214 AKIP1
PANTHERiPTHR14330 PTHR14330, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQ31-1) [UniParc]FASTAAdd to basket
Also known as: 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNCLAAAAL NGVDRRSLQR SARLALEVLE RAKRRAVDWH ALERPKGCMG
60 70 80 90 100
VLAREAPHLE KQPAAGPQRV LPGEREERPP TLSASFRTMA EFMDYTSSQC
110 120 130 140 150
GKYYSSVPEE GGATHVYRYH RGESKLHMCL DIGNGQRKDR KKTSLGPGGS
160 170 180 190 200
YQISEHAPEA SQPAENISKD LYIEVYPGTY SVTVGSNDLT KKTHVVAVDS
210
GQSVDLVFPV
Length:210
Mass (Da):23,114
Last modified:October 23, 2007 - v2
Checksum:iF00AA1F166C37967
GO
Isoform 2 (identifier: Q9NQ31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-163: Missing.

Show »
Length:183
Mass (Da):20,207
Checksum:i872DD878B01C513B
GO
Isoform 3 (identifier: Q9NQ31-3) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Show »
Length:183
Mass (Da):20,034
Checksum:iCF22CF64A41F33DF
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DGE2B4DGE2_HUMAN
A-kinase-interacting protein 1
AKIP1
195Annotation score:
E9PN38E9PN38_HUMAN
A-kinase-interacting protein 1
AKIP1
168Annotation score:
H0YCH8H0YCH8_HUMAN
A-kinase-interacting protein 1
AKIP1
151Annotation score:
E9PNI1E9PNI1_HUMAN
A-kinase-interacting protein 1
AKIP1
179Annotation score:
E9PPN7E9PPN7_HUMAN
A-kinase-interacting protein 1
AKIP1
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41A → T in BAC11537 (PubMed:15489334).Curated1
Sequence conflicti92F → S in BAC11537 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02156523R → K2 PublicationsCorresponds to variant dbSNP:rs1133833Ensembl.1
Natural variantiVAR_050688132I → T. Corresponds to variant dbSNP:rs35131475Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01327575 – 101Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_013276137 – 163Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493783 mRNA Translation: AAM12862.1
AF493784 mRNA Translation: AAM12863.1
AF493785 mRNA Translation: AAM12864.1
AF493786 Genomic DNA Translation: AAM12865.1
AF493786 Genomic DNA Translation: AAM12866.1
AF493786 Genomic DNA Translation: AAM12867.1
AF512007 mRNA Translation: AAM34785.1
AJ400877 Genomic DNA Translation: CAB92290.1
AK075308 mRNA Translation: BAC11537.1
BC030996 mRNA Translation: AAH30996.1
CCDSiCCDS55743.1 [Q9NQ31-2]
CCDS55744.1 [Q9NQ31-3]
CCDS7793.1 [Q9NQ31-1]
RefSeqiNP_001193575.1, NM_001206646.1 [Q9NQ31-3]
NP_001193576.1, NM_001206647.1 [Q9NQ31-2]
NP_001193577.1, NM_001206648.1
NP_065693.2, NM_020642.3 [Q9NQ31-1]
XP_016873500.1, XM_017018011.1 [Q9NQ31-1]
UniGeneiHs.131180

Genome annotation databases

EnsembliENST00000299576; ENSP00000299576; ENSG00000166452 [Q9NQ31-3]
ENST00000309357; ENSP00000310644; ENSG00000166452 [Q9NQ31-2]
ENST00000309377; ENSP00000310459; ENSG00000166452 [Q9NQ31-1]
ENST00000396648; ENSP00000379885; ENSG00000166452 [Q9NQ31-3]
ENST00000534147; ENSP00000431331; ENSG00000166452 [Q9NQ31-1]
GeneIDi56672
KEGGihsa:56672
UCSCiuc001mgx.4 human [Q9NQ31-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493783 mRNA Translation: AAM12862.1
AF493784 mRNA Translation: AAM12863.1
AF493785 mRNA Translation: AAM12864.1
AF493786 Genomic DNA Translation: AAM12865.1
AF493786 Genomic DNA Translation: AAM12866.1
AF493786 Genomic DNA Translation: AAM12867.1
AF512007 mRNA Translation: AAM34785.1
AJ400877 Genomic DNA Translation: CAB92290.1
AK075308 mRNA Translation: BAC11537.1
BC030996 mRNA Translation: AAH30996.1
CCDSiCCDS55743.1 [Q9NQ31-2]
CCDS55744.1 [Q9NQ31-3]
CCDS7793.1 [Q9NQ31-1]
RefSeqiNP_001193575.1, NM_001206646.1 [Q9NQ31-3]
NP_001193576.1, NM_001206647.1 [Q9NQ31-2]
NP_001193577.1, NM_001206648.1
NP_065693.2, NM_020642.3 [Q9NQ31-1]
XP_016873500.1, XM_017018011.1 [Q9NQ31-1]
UniGeneiHs.131180

3D structure databases

ProteinModelPortaliQ9NQ31
SMRiQ9NQ31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121180, 13 interactors
IntActiQ9NQ31, 5 interactors
STRINGi9606.ENSP00000310459

PTM databases

iPTMnetiQ9NQ31
PhosphoSitePlusiQ9NQ31

Polymorphism and mutation databases

BioMutaiAKIP1

Proteomic databases

MaxQBiQ9NQ31
PaxDbiQ9NQ31
PeptideAtlasiQ9NQ31
PRIDEiQ9NQ31
ProteomicsDBi82063
82064 [Q9NQ31-2]
82065 [Q9NQ31-3]

Protocols and materials databases

DNASUi56672
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299576; ENSP00000299576; ENSG00000166452 [Q9NQ31-3]
ENST00000309357; ENSP00000310644; ENSG00000166452 [Q9NQ31-2]
ENST00000309377; ENSP00000310459; ENSG00000166452 [Q9NQ31-1]
ENST00000396648; ENSP00000379885; ENSG00000166452 [Q9NQ31-3]
ENST00000534147; ENSP00000431331; ENSG00000166452 [Q9NQ31-1]
GeneIDi56672
KEGGihsa:56672
UCSCiuc001mgx.4 human [Q9NQ31-1]

Organism-specific databases

CTDi56672
DisGeNETi56672
EuPathDBiHostDB:ENSG00000166452.11
GeneCardsiAKIP1
H-InvDBiHIX0009428
HGNCiHGNC:1170 AKIP1
HPAiHPA061391
MIMi609191 gene
neXtProtiNX_Q9NQ31
OpenTargetsiENSG00000166452
PharmGKBiPA25484
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJ9 Eukaryota
ENOG41114P0 LUCA
GeneTreeiENSGT00390000017064
HOVERGENiHBG030457
InParanoidiQ9NQ31
OMAiREERHPT
OrthoDBiEOG091G0W3L
PhylomeDBiQ9NQ31
TreeFamiTF337318

Miscellaneous databases

ChiTaRSiAKIP1 human
GenomeRNAii56672
PROiPR:Q9NQ31
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166452 Expressed in 204 organ(s), highest expression level in vagina
CleanExiHS_C11orf17
ExpressionAtlasiQ9NQ31 baseline and differential
GenevisibleiQ9NQ31 HS

Family and domain databases

InterProiView protein in InterPro
IPR033214 AKIP1
PANTHERiPTHR14330 PTHR14330, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ31
Secondary accession number(s): Q8NBS2
, Q8TAC6, Q8TAD3, Q8TAE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 23, 2007
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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