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Protein

Endothelial cell-specific molecule 1

Gene

ESM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.1 Publication

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
  • regulation of cell growth Source: InterPro
  • sprouting angiogenesis Source: UniProtKB

Keywordsi

Biological processAngiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-specific molecule 1
Short name:
ESM-1
Gene namesi
Name:ESM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164283.12
HGNCiHGNC:3466 ESM1
MIMi601521 gene
neXtProtiNX_Q9NQ30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11082
OpenTargetsiENSG00000164283
PharmGKBiPA27883

Polymorphism and mutation databases

BioMutaiESM1
DMDMi13431509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001439420 – 184Endothelial cell-specific molecule 1Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156O-linked (Xyl...) (chondroitin sulfate) serine1 Publication1

Post-translational modificationi

May contain intrachain disulfide bonds.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiQ9NQ30
PeptideAtlasiQ9NQ30
PRIDEiQ9NQ30
ProteomicsDBi82061
82062 [Q9NQ30-2]

PTM databases

iPTMnetiQ9NQ30
PhosphoSitePlusiQ9NQ30

Expressioni

Tissue specificityi

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Inductioni

By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-4.

Gene expression databases

BgeeiENSG00000164283 Expressed in 95 organ(s), highest expression level in right lung
CleanExiHS_ESM1
ExpressionAtlasiQ9NQ30 baseline and differential
GenevisibleiQ9NQ30 HS

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116265, 1 interactor
IntActiQ9NQ30, 11 interactors
STRINGi9606.ENSP00000370812

Structurei

3D structure databases

ProteinModelPortaliQ9NQ30
SMRiQ9NQ30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 102IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IRWQ Eukaryota
ENOG4111J6S LUCA
GeneTreeiENSGT00390000018810
HOGENOMiHOG000273901
HOVERGENiHBG005610
InParanoidiQ9NQ30
OMAiAVDCPEH
OrthoDBiEOG091G0M9A
PhylomeDBiQ9NQ30

Family and domain databases

InterProiView protein in InterPro
IPR038850 ESM1
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
PANTHERiPTHR15428 PTHR15428, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQ30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSVLLLTTL LVPAHLVAAW SNNYAVDCPQ HCDSSECKSS PRCKRTVLDD
60 70 80 90 100
CGCCRVCAAG RGETCYRTVS GMDGMKCGPG LRCQPSNGED PFGEEFGICK
110 120 130 140 150
DCPYGTFGMD CRETCNCQSG ICDRGTGKCL KFPFFQYSVT KSSNRFVSLT
160 170 180
EHDMASGDGN IVREEVVKEN AAGSPVMRKW LNPR
Length:184
Mass (Da):20,095
Last modified:April 27, 2001 - v2
Checksum:i2AD15EDEC74BC8CE
GO
Isoform 2 (identifier: Q9NQ30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-150: Missing.

Show »
Length:134
Mass (Da):14,513
Checksum:i93F9A5E8396BD330
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R154M0R154_HUMAN
Endothelial cell-specific molecule ...
ESM1
89Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44K → E in AAH11989 (PubMed:15489334).Curated1
Sequence conflicti151Missing in CAB94771 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042631101 – 150Missing in isoform 2. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89426 mRNA Translation: CAA61597.1
AJ401091, AJ401092 Genomic DNA Translation: CAB94771.1
AJ973643 mRNA Translation: CAJ13737.1
AK300634 mRNA Translation: BAG62324.1
AK311817 mRNA Translation: BAG34760.1
AC010436 Genomic DNA No translation available.
AC034238 Genomic DNA No translation available.
BC011989 mRNA Translation: AAH11989.1
CCDSiCCDS3963.1 [Q9NQ30-1]
CCDS47206.1 [Q9NQ30-2]
RefSeqiNP_001129076.1, NM_001135604.1 [Q9NQ30-2]
NP_008967.1, NM_007036.4 [Q9NQ30-1]
UniGeneiHs.129944

Genome annotation databases

EnsembliENST00000381403; ENSP00000370810; ENSG00000164283 [Q9NQ30-2]
ENST00000381405; ENSP00000370812; ENSG00000164283 [Q9NQ30-1]
GeneIDi11082
KEGGihsa:11082
UCSCiuc003jpk.4 human [Q9NQ30-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89426 mRNA Translation: CAA61597.1
AJ401091, AJ401092 Genomic DNA Translation: CAB94771.1
AJ973643 mRNA Translation: CAJ13737.1
AK300634 mRNA Translation: BAG62324.1
AK311817 mRNA Translation: BAG34760.1
AC010436 Genomic DNA No translation available.
AC034238 Genomic DNA No translation available.
BC011989 mRNA Translation: AAH11989.1
CCDSiCCDS3963.1 [Q9NQ30-1]
CCDS47206.1 [Q9NQ30-2]
RefSeqiNP_001129076.1, NM_001135604.1 [Q9NQ30-2]
NP_008967.1, NM_007036.4 [Q9NQ30-1]
UniGeneiHs.129944

3D structure databases

ProteinModelPortaliQ9NQ30
SMRiQ9NQ30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116265, 1 interactor
IntActiQ9NQ30, 11 interactors
STRINGi9606.ENSP00000370812

PTM databases

iPTMnetiQ9NQ30
PhosphoSitePlusiQ9NQ30

Polymorphism and mutation databases

BioMutaiESM1
DMDMi13431509

Proteomic databases

PaxDbiQ9NQ30
PeptideAtlasiQ9NQ30
PRIDEiQ9NQ30
ProteomicsDBi82061
82062 [Q9NQ30-2]

Protocols and materials databases

DNASUi11082
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381403; ENSP00000370810; ENSG00000164283 [Q9NQ30-2]
ENST00000381405; ENSP00000370812; ENSG00000164283 [Q9NQ30-1]
GeneIDi11082
KEGGihsa:11082
UCSCiuc003jpk.4 human [Q9NQ30-1]

Organism-specific databases

CTDi11082
DisGeNETi11082
EuPathDBiHostDB:ENSG00000164283.12
GeneCardsiESM1
H-InvDBiHIX0004861
HGNCiHGNC:3466 ESM1
MIMi601521 gene
neXtProtiNX_Q9NQ30
OpenTargetsiENSG00000164283
PharmGKBiPA27883
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRWQ Eukaryota
ENOG4111J6S LUCA
GeneTreeiENSGT00390000018810
HOGENOMiHOG000273901
HOVERGENiHBG005610
InParanoidiQ9NQ30
OMAiAVDCPEH
OrthoDBiEOG091G0M9A
PhylomeDBiQ9NQ30

Miscellaneous databases

GeneWikiiESM1
GenomeRNAii11082
PROiPR:Q9NQ30
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164283 Expressed in 95 organ(s), highest expression level in right lung
CleanExiHS_ESM1
ExpressionAtlasiQ9NQ30 baseline and differential
GenevisibleiQ9NQ30 HS

Family and domain databases

InterProiView protein in InterPro
IPR038850 ESM1
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
PANTHERiPTHR15428 PTHR15428, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ30
Secondary accession number(s): B2R4G3
, Q15330, Q3V4E3, Q96ES3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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