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Protein

Putative RNA-binding protein Luc7-like 1

Gene

LUC7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mRNA binding Source: GO_Central
  • RS domain binding Source: Ensembl

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 1
Alternative name(s):
Putative SR protein LUC7B1
SR+89
Gene namesi
Name:LUC7L
Synonyms:LUC7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000007392.16
HGNCiHGNC:6723 LUC7L
MIMi607782 gene
neXtProtiNX_Q9NQ29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55692
OpenTargetsiENSG00000007392
PharmGKBiPA30485

Polymorphism and mutation databases

BioMutaiLUC7L
DMDMi47116932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872801 – 371Putative RNA-binding protein Luc7-like 1Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NQ29
MaxQBiQ9NQ29
PaxDbiQ9NQ29
PeptideAtlasiQ9NQ29
PRIDEiQ9NQ29
ProteomicsDBi82058
82059 [Q9NQ29-2]
82060 [Q9NQ29-3]

PTM databases

iPTMnetiQ9NQ29
PhosphoSitePlusiQ9NQ29

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000007392 Expressed in 217 organ(s), highest expression level in tendon
CleanExiHS_LUC7L
ExpressionAtlasiQ9NQ29 baseline and differential
GenevisibleiQ9NQ29 HS

Organism-specific databases

HPAiHPA056424
HPA069321

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120818, 131 interactors
IntActiQ9NQ29, 24 interactors
MINTiQ9NQ29
STRINGi9606.ENSP00000293872

Structurei

3D structure databases

ProteinModelPortaliQ9NQ29
SMRiQ9NQ29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 177Sequence analysisAdd BLAST91
Coiled coili218 – 259Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 362Arg/Ser-richAdd BLAST120

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiQ9NQ29
OMAiCPYDLFQ
OrthoDBiEOG091G0PSO
PhylomeDBiQ9NQ29
TreeFamiTF317607

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQ29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA
60 70 80 90 100
GTRMDLGECT KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR
110 120 130 140 150
TELAKKRLAE TQEEISAEVS AKAEKVHELN EEIGKLLAKA EQLGAEGNVD
160 170 180 190 200
ESQKILMEVE KVRAKKKEAE EEYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN QDRLRRREER
260 270 280 290 300
EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR
310 320 330 340 350
RHRSRSRSHS RGHRRASRDR SAKYKFSRER ASREESWESG RSERGPPDWR
360 370
LESSNGKMAS RRSEEKEAGE I
Length:371
Mass (Da):43,728
Last modified:October 1, 2000 - v1
Checksum:iC277F424F5F5659C
GO
Isoform 2 (identifier: Q9NQ29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-371: Missing.

Note: May be due to an intron retention.
Show »
Length:325
Mass (Da):38,405
Checksum:i35D03C10999A44B6
GO
Isoform 3 (identifier: Q9NQ29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRALLDQLMGTARD → MQM

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):41,929
Checksum:iB73044140DECCC9F
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZ09B8ZZ09_HUMAN
LUC7-like (S. cerevisiae)
LUC7L LA16c-OS12.1-012
84Annotation score:
A8MYV2A8MYV2_HUMAN
LUC7-like (S. cerevisiae), isoform ...
LUC7L hCG_22425, LA16c-OS12.1-007
272Annotation score:
B8ZZ10B8ZZ10_HUMAN
LUC7-like (S. cerevisiae)
LUC7L LA16c-OS12.1-015
182Annotation score:
B8ZZ08B8ZZ08_HUMAN
LUC7-like (S. cerevisiae)
LUC7L LA16c-OS12.1-016
170Annotation score:
B8ZZ12B8ZZ12_HUMAN
LUC7-like (S. cerevisiae)
LUC7L LA16c-OS12.1-020
32Annotation score:
H7C2U4H7C2U4_HUMAN
Putative RNA-binding protein Luc7-l...
LUC7L
60Annotation score:
F2Z322F2Z322_HUMAN
Putative RNA-binding protein Luc7-l...
LUC7L
55Annotation score:
F8WBC1F8WBC1_HUMAN
Putative RNA-binding protein Luc7-l...
LUC7L
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171E → V in AAK61218 (PubMed:11157797).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0102141 – 20MSAQA…GTARD → MQM in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_010215326 – 371Missing in isoform 2. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404326 mRNA Translation: CAB93981.1
AJ404326 mRNA Translation: CAB93982.1
AY005111 mRNA Translation: AAG22846.1
AE006462 Genomic DNA Translation: AAK61218.1
AK001093 mRNA Translation: BAA91500.1
Z69890, Z69706 Genomic DNA Translation: CAM26671.1
CH471112 Genomic DNA Translation: EAW85853.1
BC003194 mRNA Translation: AAH03194.1
BC065198 mRNA Translation: AAH65198.1
CCDSiCCDS10401.1 [Q9NQ29-2]
CCDS32348.1 [Q9NQ29-1]
RefSeqiNP_001307155.1, NM_001320226.1 [Q9NQ29-2]
NP_001317349.1, NM_001330420.1
NP_060502.1, NM_018032.4 [Q9NQ29-2]
NP_958815.1, NM_201412.2 [Q9NQ29-1]
UniGeneiHs.16803

Genome annotation databases

EnsembliENST00000293872; ENSP00000293872; ENSG00000007392 [Q9NQ29-1]
ENST00000337351; ENSP00000337507; ENSG00000007392 [Q9NQ29-2]
ENST00000397783; ENSP00000380885; ENSG00000007392 [Q9NQ29-2]
GeneIDi55692
KEGGihsa:55692
UCSCiuc002cga.2 human [Q9NQ29-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404326 mRNA Translation: CAB93981.1
AJ404326 mRNA Translation: CAB93982.1
AY005111 mRNA Translation: AAG22846.1
AE006462 Genomic DNA Translation: AAK61218.1
AK001093 mRNA Translation: BAA91500.1
Z69890, Z69706 Genomic DNA Translation: CAM26671.1
CH471112 Genomic DNA Translation: EAW85853.1
BC003194 mRNA Translation: AAH03194.1
BC065198 mRNA Translation: AAH65198.1
CCDSiCCDS10401.1 [Q9NQ29-2]
CCDS32348.1 [Q9NQ29-1]
RefSeqiNP_001307155.1, NM_001320226.1 [Q9NQ29-2]
NP_001317349.1, NM_001330420.1
NP_060502.1, NM_018032.4 [Q9NQ29-2]
NP_958815.1, NM_201412.2 [Q9NQ29-1]
UniGeneiHs.16803

3D structure databases

ProteinModelPortaliQ9NQ29
SMRiQ9NQ29
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120818, 131 interactors
IntActiQ9NQ29, 24 interactors
MINTiQ9NQ29
STRINGi9606.ENSP00000293872

PTM databases

iPTMnetiQ9NQ29
PhosphoSitePlusiQ9NQ29

Polymorphism and mutation databases

BioMutaiLUC7L
DMDMi47116932

Proteomic databases

EPDiQ9NQ29
MaxQBiQ9NQ29
PaxDbiQ9NQ29
PeptideAtlasiQ9NQ29
PRIDEiQ9NQ29
ProteomicsDBi82058
82059 [Q9NQ29-2]
82060 [Q9NQ29-3]

Protocols and materials databases

DNASUi55692
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293872; ENSP00000293872; ENSG00000007392 [Q9NQ29-1]
ENST00000337351; ENSP00000337507; ENSG00000007392 [Q9NQ29-2]
ENST00000397783; ENSP00000380885; ENSG00000007392 [Q9NQ29-2]
GeneIDi55692
KEGGihsa:55692
UCSCiuc002cga.2 human [Q9NQ29-1]

Organism-specific databases

CTDi55692
DisGeNETi55692
EuPathDBiHostDB:ENSG00000007392.16
GeneCardsiLUC7L
HGNCiHGNC:6723 LUC7L
HPAiHPA056424
HPA069321
MIMi607782 gene
neXtProtiNX_Q9NQ29
OpenTargetsiENSG00000007392
PharmGKBiPA30485
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiQ9NQ29
OMAiCPYDLFQ
OrthoDBiEOG091G0PSO
PhylomeDBiQ9NQ29
TreeFamiTF317607

Miscellaneous databases

ChiTaRSiLUC7L human
GeneWikiiLUC7L
GenomeRNAii55692
PROiPR:Q9NQ29
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007392 Expressed in 217 organ(s), highest expression level in tendon
CleanExiHS_LUC7L
ExpressionAtlasiQ9NQ29 baseline and differential
GenevisibleiQ9NQ29 HS

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLUC7L_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ29
Secondary accession number(s): B8ZZ13, Q96S32, Q9NPH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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