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Entry version 162 (22 Apr 2020)
Sequence version 1 (01 Oct 2000)
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Protein

SLAM family member 7

Gene

SLAMF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).By similarity5 Publications
Isoform 3 does not mediate any NK cell activation.

Miscellaneous

Proposed to be involved in systemic lupus erythematosus (SLE) disease process.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SLAM family member 7
Alternative name(s):
CD2 subset 1
CD2-like receptor-activating cytotoxic cells
Short name:
CRACC
Membrane protein FOAP-12
Novel Ly9
Protein 19A
CD_antigen: CD319
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLAMF7
Synonyms:CS1
ORF Names:UNQ576/PRO1138
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21394 SLAMF7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606625 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQ25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 226ExtracellularSequence analysisAdd BLAST204
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 335CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57823

Open Targets

More...
OpenTargetsi
ENSG00000026751

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134977110

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQ25 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3559386

Drug and drug target database

More...
DrugBanki
DB06317 Elotuzumab

DrugCentral

More...
DrugCentrali
Q9NQ25

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2850

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLAMF7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
66774034

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001496323 – 335SLAM family member 7Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi145 ↔ 215PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 195PROSITE-ProRule annotation
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQ25

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NQ25

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NQ25

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQ25

PeptideAtlas

More...
PeptideAtlasi
Q9NQ25

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQ25

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1858
4815
4826
5326
82055 [Q9NQ25-1]
82056 [Q9NQ25-2]
82057 [Q9NQ25-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NQ25-2 [Q9NQ25-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQ25

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQ25

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000026751 Expressed in dorsal plus ventral thalamus and 166 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQ25 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NQ25 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000026751 Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro); low affinity binding, the physiological relevance of the interaction is questioned.

Interacts with SH2D1B; in NK cells (PubMed:16339536).

Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NQ25
With#Exp.IntAct
itself2EBI-3916159,EBI-3916159

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121782, 16 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9NQ25

Protein interaction database and analysis system

More...
IntActi
Q9NQ25, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357022

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NQ25 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQ25

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 124Ig-like V-typeAdd BLAST102
Domaini131 – 206Ig-like C2-typeAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni278 – 296Interaction with FYN when phosphorylated at Tyr-284By similarityAdd BLAST19

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi302 – 307ITSMBy similarity6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).By similarity

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJW6 Eukaryota
ENOG41117FX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182746

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_069386_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQ25

KEGG Orthology (KO)

More...
KOi
K06733

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTCSMEQ

Database of Orthologous Groups

More...
OrthoDBi
990343at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQ25

TreeFam database of animal gene trees

More...
TreeFami
TF334964

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07686 V-set, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQ25-1) [UniParc]FASTAAdd to basket
Also known as: 19A, CS1-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSPTCLTL IYILWQLTGS AASGPVKELV GSVGGAVTFP LKSKVKQVDS
60 70 80 90 100
IVWTFNTTPL VTIQPEGGTI IVTQNRNRER VDFPDGGYSL KLSKLKKNDS
110 120 130 140 150
GIYYVGIYSS SLQQPSTQEY VLHVYEHLSK PKVTMGLQSN KNGTCVTNLT
160 170 180 190 200
CCMEHGEEDV IYTWKALGQA ANESHNGSIL PISWRWGESD MTFICVARNP
210 220 230 240 250
VSRNFSSPIL ARKLCEGAAD DPDSSMVLLC LLLVPLLLSL FVLGLFLWFL
260 270 280 290 300
KRERQEEYIE EKKRVDICRE TPNICPHSGE NTEYDTIPHT NRTILKEDPA
310 320 330
NTVYSTVEIP KKMENPHSLL TMPDTPRLFA YENVI
Length:335
Mass (Da):37,421
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD09ABBCFF74BE8D4
GO
Isoform 2 (identifier: Q9NQ25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-125: Missing.

Show »
Length:228
Mass (Da):25,831
Checksum:i2B01DB70E7BBFC14
GO
Isoform 3 (identifier: Q9NQ25-3) [UniParc]FASTAAdd to basket
Also known as: 19A24, CS1-S

The sequence of this isoform differs from the canonical sequence as follows:
     258-296: YIEEKKRVDI...IPHTNRTILK → NNPKGRSSKY...DARHTKAICL

Show »
Length:335
Mass (Da):37,026
Checksum:i3CD49C30FF3367B0
GO
Isoform 4 (identifier: Q9NQ25-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-165: HLSKPKVTMG...GEEDVIYTWK → NNPKGRSSKY...DARHTKAICL
     166-335: Missing.

Show »
Length:165
Mass (Da):17,945
Checksum:iE70079B2E27C5978
GO
Isoform 5 (identifier: Q9NQ25-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-335: YIEEKKRVDI...PRLFAYENVI → NNPKGRSSKY...DARHTKAICL

Show »
Length:296
Mass (Da):32,581
Checksum:iE85D277192494EEC
GO
Isoform 6 (identifier: Q9NQ25-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-256: Missing.

Show »
Length:204
Mass (Da):22,785
Checksum:iE7DEE14130014CD5
GO
Isoform 7 (identifier: Q9NQ25-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-125: Missing.
     217-256: Missing.

Show »
Length:188
Mass (Da):21,316
Checksum:i76BA8CF2C70B4663
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DW98B4DW98_HUMAN
SLAM family member 7
SLAMF7
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DVL7B4DVL7_HUMAN
SLAM family member 7
SLAMF7
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GND0R4GND0_HUMAN
SLAM family member 7
SLAMF7
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB76561 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135M → L in CAB81950 (PubMed:11802771).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049938175H → Y. Corresponds to variant dbSNP:rs35325048Ensembl.1
Natural variantiVAR_049939302T → M. Corresponds to variant dbSNP:rs2295617Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01378119 – 125Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST107
Alternative sequenceiVSP_055292126 – 256Missing in isoform 6. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_054540127 – 165HLSKP…IYTWK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_054541166 – 335Missing in isoform 4. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_055293217 – 256Missing in isoform 7. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_054542258 – 335YIEEK…YENVI → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 5. CuratedAdd BLAST78
Alternative sequenceiVSP_013782258 – 296YIEEK…RTILK → NNPKGRSSKYGLLHCGNTEK DGKSPLTAHDARHTKAICL in isoform 3. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF291815 mRNA Translation: AAK11549.1
AF390894 mRNA Translation: AAL26989.1
AJ271869 mRNA Translation: CAB76561.1 Frameshift.
AJ276429 mRNA Translation: CAB81950.2
AB027233 mRNA Translation: BAB61022.1
AY358512 mRNA Translation: AAQ88876.1
AK290706 mRNA Translation: BAF83395.1
AK298499 mRNA Translation: BAG60706.1
AK298548 mRNA Translation: BAG60745.1
AK301438 mRNA Translation: BAG62965.1
AL834424 mRNA Translation: CAD39085.1
AL121985 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52704.1
BC027867 mRNA Translation: AAH27867.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1209.1 [Q9NQ25-1]
CCDS60321.1 [Q9NQ25-5]
CCDS60322.1 [Q9NQ25-6]
CCDS60323.1 [Q9NQ25-4]
CCDS60324.1 [Q9NQ25-2]
CCDS60325.1 [Q9NQ25-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001269517.1, NM_001282588.1 [Q9NQ25-4]
NP_001269518.1, NM_001282589.1 [Q9NQ25-6]
NP_001269519.1, NM_001282590.1 [Q9NQ25-2]
NP_001269520.1, NM_001282591.1 [Q9NQ25-7]
NP_001269521.1, NM_001282592.1 [Q9NQ25-5]
NP_001269524.1, NM_001282595.1
NP_067004.3, NM_021181.4 [Q9NQ25-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359331; ENSP00000352281; ENSG00000026751 [Q9NQ25-5]
ENST00000368042; ENSP00000357021; ENSG00000026751 [Q9NQ25-2]
ENST00000368043; ENSP00000357022; ENSG00000026751 [Q9NQ25-1]
ENST00000441662; ENSP00000405605; ENSG00000026751 [Q9NQ25-6]
ENST00000444090; ENSP00000416592; ENSG00000026751 [Q9NQ25-4]
ENST00000458602; ENSP00000409965; ENSG00000026751 [Q9NQ25-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57823

UCSC genome browser

More...
UCSCi
uc001fwq.5 human [Q9NQ25-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291815 mRNA Translation: AAK11549.1
AF390894 mRNA Translation: AAL26989.1
AJ271869 mRNA Translation: CAB76561.1 Frameshift.
AJ276429 mRNA Translation: CAB81950.2
AB027233 mRNA Translation: BAB61022.1
AY358512 mRNA Translation: AAQ88876.1
AK290706 mRNA Translation: BAF83395.1
AK298499 mRNA Translation: BAG60706.1
AK298548 mRNA Translation: BAG60745.1
AK301438 mRNA Translation: BAG62965.1
AL834424 mRNA Translation: CAD39085.1
AL121985 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52704.1
BC027867 mRNA Translation: AAH27867.1
CCDSiCCDS1209.1 [Q9NQ25-1]
CCDS60321.1 [Q9NQ25-5]
CCDS60322.1 [Q9NQ25-6]
CCDS60323.1 [Q9NQ25-4]
CCDS60324.1 [Q9NQ25-2]
CCDS60325.1 [Q9NQ25-7]
RefSeqiNP_001269517.1, NM_001282588.1 [Q9NQ25-4]
NP_001269518.1, NM_001282589.1 [Q9NQ25-6]
NP_001269519.1, NM_001282590.1 [Q9NQ25-2]
NP_001269520.1, NM_001282591.1 [Q9NQ25-7]
NP_001269521.1, NM_001282592.1 [Q9NQ25-5]
NP_001269524.1, NM_001282595.1
NP_067004.3, NM_021181.4 [Q9NQ25-1]

3D structure databases

SMRiQ9NQ25
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121782, 16 interactors
ELMiQ9NQ25
IntActiQ9NQ25, 16 interactors
STRINGi9606.ENSP00000357022

Chemistry databases

ChEMBLiCHEMBL3559386
DrugBankiDB06317 Elotuzumab
DrugCentraliQ9NQ25
GuidetoPHARMACOLOGYi2850

PTM databases

iPTMnetiQ9NQ25
PhosphoSitePlusiQ9NQ25

Polymorphism and mutation databases

BioMutaiSLAMF7
DMDMi66774034

Proteomic databases

jPOSTiQ9NQ25
MassIVEiQ9NQ25
MaxQBiQ9NQ25
PaxDbiQ9NQ25
PeptideAtlasiQ9NQ25
PRIDEiQ9NQ25
ProteomicsDBi1858
4815
4826
5326
82055 [Q9NQ25-1]
82056 [Q9NQ25-2]
82057 [Q9NQ25-3]
TopDownProteomicsiQ9NQ25-2 [Q9NQ25-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9NQ25

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4220 496 antibodies

The DNASU plasmid repository

More...
DNASUi
57823

Genome annotation databases

EnsembliENST00000359331; ENSP00000352281; ENSG00000026751 [Q9NQ25-5]
ENST00000368042; ENSP00000357021; ENSG00000026751 [Q9NQ25-2]
ENST00000368043; ENSP00000357022; ENSG00000026751 [Q9NQ25-1]
ENST00000441662; ENSP00000405605; ENSG00000026751 [Q9NQ25-6]
ENST00000444090; ENSP00000416592; ENSG00000026751 [Q9NQ25-4]
ENST00000458602; ENSP00000409965; ENSG00000026751 [Q9NQ25-7]
GeneIDi57823
KEGGihsa:57823
UCSCiuc001fwq.5 human [Q9NQ25-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57823
DisGeNETi57823

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLAMF7
HGNCiHGNC:21394 SLAMF7
HPAiENSG00000026751 Tissue enhanced (blood, lymphoid tissue)
MIMi606625 gene
neXtProtiNX_Q9NQ25
OpenTargetsiENSG00000026751
PharmGKBiPA134977110

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJW6 Eukaryota
ENOG41117FX LUCA
GeneTreeiENSGT00950000182746
HOGENOMiCLU_069386_1_1_1
InParanoidiQ9NQ25
KOiK06733
OMAiLTCSMEQ
OrthoDBi990343at2759
PhylomeDBiQ9NQ25
TreeFamiTF334964

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLAMF7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57823
PharosiQ9NQ25 Tclin

Protein Ontology

More...
PROi
PR:Q9NQ25
RNActiQ9NQ25 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000026751 Expressed in dorsal plus ventral thalamus and 166 other tissues
ExpressionAtlasiQ9NQ25 baseline and differential
GenevisibleiQ9NQ25 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLAF7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQ25
Secondary accession number(s): A8K3U1
, B4DPU4, B4DPY3, B4DWA3, Q8N6Y8, Q8ND32, Q9NY08, Q9NY23
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 1, 2000
Last modified: April 22, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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