Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional repressor scratch 2

Gene

SCRT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 177C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 291C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor scratch 2
Alternative name(s):
Scratch homolog 2 zinc finger protein
Gene namesi
Name:SCRT2
ORF Names:FP7030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000215397.3
HGNCiHGNC:15952 SCRT2
neXtProtiNX_Q9NQ03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215397
PharmGKBiPA35016

Polymorphism and mutation databases

BioMutaiSCRT2
DMDMi46397045

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470381 – 307Transcriptional repressor scratch 2Add BLAST307

Proteomic databases

PaxDbiQ9NQ03
PeptideAtlasiQ9NQ03
PRIDEiQ9NQ03
ProteomicsDBi82051

PTM databases

iPTMnetiQ9NQ03
PhosphoSitePlusiQ9NQ03

Expressioni

Gene expression databases

BgeeiENSG00000215397 Expressed in 17 organ(s), highest expression level in cerebellum
CleanExiHS_SCRT2

Organism-specific databases

HPAiHPA067697

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000246104

Structurei

3D structure databases

ProteinModelPortaliQ9NQ03
SMRiQ9NQ03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 177C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 291C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiQ9NQ03
KOiK09219
OMAiAFFIMDG
OrthoDBiEOG091G0Q0V
PhylomeDBiQ9NQ03
TreeFamiTF315515

Family and domain databases

InterProiView protein in InterPro
IPR029794 SCRATCH1/2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44270 PTHR44270, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q9NQ03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSFLVKKI KGDGFQCSGV PAPTYHPLET AYVLPGARGP PGDNGYAPHR
60 70 80 90 100
LPPSSYDADQ KPGLELAPAE PAYPPAAPEE YSDPESPQSS LSARYFRGEA
110 120 130 140 150
AVTDSYSMDA FFISDGRSRR RRGGGGGDAG GSGDAGGAGG RAGRAGAQAG
160 170 180 190 200
GGHRHACAEC GKTYATSSNL SRHKQTHRSL DSQLARKCPT CGKAYVSMPA
210 220 230 240 250
LAMHLLTHNL RHKCGVCGKA FSRPWLLQGH MRSHTGEKPF GCAHCGKAFA
260 270 280 290 300
DRSNLRAHMQ THSAFKHYRC RQCDKSFALK SYLHKHCEAA CAKAAEPPPP

TPAGPAS
Length:307
Mass (Da):32,584
Last modified:April 13, 2004 - v3
Checksum:iE9328725903F9C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129025 mRNA Translation: AAM98768.1
AL121758 Genomic DNA No translation available.
CCDSiCCDS13006.1
RefSeqiNP_149120.1, NM_033129.3
UniGeneiHs.355284

Genome annotation databases

EnsembliENST00000246104; ENSP00000246104; ENSG00000215397
GeneIDi85508
KEGGihsa:85508
UCSCiuc002wec.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129025 mRNA Translation: AAM98768.1
AL121758 Genomic DNA No translation available.
CCDSiCCDS13006.1
RefSeqiNP_149120.1, NM_033129.3
UniGeneiHs.355284

3D structure databases

ProteinModelPortaliQ9NQ03
SMRiQ9NQ03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000246104

PTM databases

iPTMnetiQ9NQ03
PhosphoSitePlusiQ9NQ03

Polymorphism and mutation databases

BioMutaiSCRT2
DMDMi46397045

Proteomic databases

PaxDbiQ9NQ03
PeptideAtlasiQ9NQ03
PRIDEiQ9NQ03
ProteomicsDBi82051

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246104; ENSP00000246104; ENSG00000215397
GeneIDi85508
KEGGihsa:85508
UCSCiuc002wec.3 human

Organism-specific databases

CTDi85508
EuPathDBiHostDB:ENSG00000215397.3
GeneCardsiSCRT2
HGNCiHGNC:15952 SCRT2
HPAiHPA067697
neXtProtiNX_Q9NQ03
OpenTargetsiENSG00000215397
PharmGKBiPA35016
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiQ9NQ03
KOiK09219
OMAiAFFIMDG
OrthoDBiEOG091G0Q0V
PhylomeDBiQ9NQ03
TreeFamiTF315515

Miscellaneous databases

GenomeRNAii85508
PROiPR:Q9NQ03

Gene expression databases

BgeeiENSG00000215397 Expressed in 17 organ(s), highest expression level in cerebellum
CleanExiHS_SCRT2

Family and domain databases

InterProiView protein in InterPro
IPR029794 SCRATCH1/2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44270 PTHR44270, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSCRT2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: October 10, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again