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UniProtKB - Q9NQ03 (SCRT2_HUMAN)
Protein
Transcriptional repressor scratch 2
Gene
SCRT2
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 177 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 186 – 208 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 291 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- E-box binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of neuron migration Source: Ensembl
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NQ03 |
SignaLinki | Q9NQ03 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional repressor scratch 2Alternative name(s): Scratch homolog 2 zinc finger protein |
Gene namesi | Name:SCRT2 ORF Names:FP7030 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15952, SCRT2 |
neXtProti | NX_Q9NQ03 |
VEuPathDBi | HostDB:ENSG00000215397 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000215397 |
PharmGKBi | PA35016 |
Miscellaneous databases
Pharosi | Q9NQ03, Tdark |
Genetic variation databases
BioMutai | SCRT2 |
DMDMi | 46397045 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047038 | 1 – 307 | Transcriptional repressor scratch 2Add BLAST | 307 |
Proteomic databases
MassIVEi | Q9NQ03 |
PaxDbi | Q9NQ03 |
PeptideAtlasi | Q9NQ03 |
PRIDEi | Q9NQ03 |
ProteomicsDBi | 82051 |
PTM databases
iPTMneti | Q9NQ03 |
PhosphoSitePlusi | Q9NQ03 |
Expressioni
Gene expression databases
Bgeei | ENSG00000215397, Expressed in subventricular zone (inner) (primate) and 25 other tissues |
Organism-specific databases
HPAi | ENSG00000215397, Group enriched (brain, retina) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124568, 22 interactors |
STRINGi | 9606.ENSP00000246104 |
Miscellaneous databases
RNActi | Q9NQ03, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | SNAG domainBy similarityAdd BLAST | 20 | |
Regioni | 34 – 90 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 116 – 148 | DisorderedSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the snail C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 177 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 186 – 208 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 291 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154491 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | Q9NQ03 |
OMAi | HINNTYS |
OrthoDBi | 1332418at2759 |
PhylomeDBi | Q9NQ03 |
TreeFami | TF315515 |
Family and domain databases
InterProi | View protein in InterPro IPR029794, SCRATCH1/2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24388:SF81, PTHR24388:SF81, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
Q9NQ03-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRSFLVKKI KGDGFQCSGV PAPTYHPLET AYVLPGARGP PGDNGYAPHR
60 70 80 90 100
LPPSSYDADQ KPGLELAPAE PAYPPAAPEE YSDPESPQSS LSARYFRGEA
110 120 130 140 150
AVTDSYSMDA FFISDGRSRR RRGGGGGDAG GSGDAGGAGG RAGRAGAQAG
160 170 180 190 200
GGHRHACAEC GKTYATSSNL SRHKQTHRSL DSQLARKCPT CGKAYVSMPA
210 220 230 240 250
LAMHLLTHNL RHKCGVCGKA FSRPWLLQGH MRSHTGEKPF GCAHCGKAFA
260 270 280 290 300
DRSNLRAHMQ THSAFKHYRC RQCDKSFALK SYLHKHCEAA CAKAAEPPPP
TPAGPAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129025 mRNA Translation: AAM98768.1 AL121758 Genomic DNA No translation available. |
CCDSi | CCDS13006.1 |
RefSeqi | NP_149120.1, NM_033129.3 |
Genome annotation databases
Ensembli | ENST00000246104.7; ENSP00000246104.5; ENSG00000215397.4 |
GeneIDi | 85508 |
KEGGi | hsa:85508 |
MANE-Selecti | ENST00000246104.7; ENSP00000246104.5; NM_033129.4; NP_149120.1 |
UCSCi | uc002wec.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129025 mRNA Translation: AAM98768.1 AL121758 Genomic DNA No translation available. |
CCDSi | CCDS13006.1 |
RefSeqi | NP_149120.1, NM_033129.3 |
3D structure databases
AlphaFoldDBi | Q9NQ03 |
SMRi | Q9NQ03 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124568, 22 interactors |
STRINGi | 9606.ENSP00000246104 |
PTM databases
iPTMneti | Q9NQ03 |
PhosphoSitePlusi | Q9NQ03 |
Genetic variation databases
BioMutai | SCRT2 |
DMDMi | 46397045 |
Proteomic databases
MassIVEi | Q9NQ03 |
PaxDbi | Q9NQ03 |
PeptideAtlasi | Q9NQ03 |
PRIDEi | Q9NQ03 |
ProteomicsDBi | 82051 |
Protocols and materials databases
Antibodypediai | 23001, 38 antibodies from 12 providers |
DNASUi | 85508 |
Genome annotation databases
Ensembli | ENST00000246104.7; ENSP00000246104.5; ENSG00000215397.4 |
GeneIDi | 85508 |
KEGGi | hsa:85508 |
MANE-Selecti | ENST00000246104.7; ENSP00000246104.5; NM_033129.4; NP_149120.1 |
UCSCi | uc002wec.3, human |
Organism-specific databases
CTDi | 85508 |
GeneCardsi | SCRT2 |
HGNCi | HGNC:15952, SCRT2 |
HPAi | ENSG00000215397, Group enriched (brain, retina) |
neXtProti | NX_Q9NQ03 |
OpenTargetsi | ENSG00000215397 |
PharmGKBi | PA35016 |
VEuPathDBi | HostDB:ENSG00000215397 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154491 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | Q9NQ03 |
OMAi | HINNTYS |
OrthoDBi | 1332418at2759 |
PhylomeDBi | Q9NQ03 |
TreeFami | TF315515 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQ03 |
SignaLinki | Q9NQ03 |
Miscellaneous databases
BioGRID-ORCSi | 85508, 6 hits in 1087 CRISPR screens |
GenomeRNAii | 85508 |
Pharosi | Q9NQ03, Tdark |
PROi | PR:Q9NQ03 |
RNActi | Q9NQ03, protein |
Gene expression databases
Bgeei | ENSG00000215397, Expressed in subventricular zone (inner) (primate) and 25 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029794, SCRATCH1/2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24388:SF81, PTHR24388:SF81, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SCRT2_HUMAN | |
Accessioni | Q9NQ03Primary (citable) accession number: Q9NQ03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families