SCRT2

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	155 – 177	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	186 – 208	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	212 – 234	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 291	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: BHF-UCL
Inferred by curatorⁱ
- 21252910

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
regulation of neuron migration Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcriptional repressor scratch 2 Alternative name(s): Scratch homolog 2 zinc finger protein
Gene namesⁱ	Name:SCRT2 ORF Names:FP7030
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000215397.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15952 SCRT2
neXtProtⁱ	NX_Q9NQ03

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000215397
PharmGKBⁱ	PA35016

Polymorphism and mutation databases

BioMutaⁱ	SCRT2
DMDMⁱ	46397045

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047038	1 – 307	Transcriptional repressor scratch 2Add BLAST		307

Proteomic databases

PaxDbⁱ	Q9NQ03
PeptideAtlas More...PeptideAtlasⁱ	Q9NQ03
PRIDEⁱ	Q9NQ03
ProteomicsDBⁱ	82051

PTM databases

iPTMnetⁱ	Q9NQ03
PhosphoSitePlusⁱ	Q9NQ03

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000215397 Expressed in 17 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_SCRT2

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067697

HPAⁱ

HPA067697

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000246104

STRINGⁱ

9606.ENSP00000246104

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NQ03
SMRⁱ	Q9NQ03
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST		20

Sequence similaritiesⁱ

Belongs to the snail C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	155 – 177	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	186 – 208	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	212 – 234	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 291	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q9NQ03
KEGG Orthology (KO) More...KOⁱ	K09219
OMAⁱ	AFFIMDG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q9NQ03
TreeFamⁱ	TF315515

Family and domain databases

InterProⁱ	View protein in InterPro IPR029794 SCRATCH1/2 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44270 PTHR44270, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9NQ03-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRSFLVKKI KGDGFQCSGV PAPTYHPLET AYVLPGARGP PGDNGYAPHR 
        60         70         80         90        100
LPPSSYDADQ KPGLELAPAE PAYPPAAPEE YSDPESPQSS LSARYFRGEA 
       110        120        130        140        150
AVTDSYSMDA FFISDGRSRR RRGGGGGDAG GSGDAGGAGG RAGRAGAQAG 
       160        170        180        190        200
GGHRHACAEC GKTYATSSNL SRHKQTHRSL DSQLARKCPT CGKAYVSMPA 
       210        220        230        240        250
LAMHLLTHNL RHKCGVCGKA FSRPWLLQGH MRSHTGEKPF GCAHCGKAFA 
       260        270        280        290        300
DRSNLRAHMQ THSAFKHYRC RQCDKSFALK SYLHKHCEAA CAKAAEPPPP 

TPAGPAS

Length:307

Mass (Da):32,584

Last modified:April 13, 2004 - v3

Checksum:ⁱE9328725903F9C17

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY129025 mRNA Translation: AAM98768.1 AL121758 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13006.1
NCBI Reference Sequences More...RefSeqⁱ	NP_149120.1, NM_033129.3
UniGeneⁱ	Hs.355284

Genome annotation databases

Ensemblⁱ	ENST00000246104; ENSP00000246104; ENSG00000215397
GeneIDⁱ	85508
KEGGⁱ	hsa:85508
UCSC genome browser More...UCSCⁱ	uc002wec.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQ03	Scratch family transcriptional repressor 2		CALJA		308	UniRef90_Q9NQ03
transcriptional repressor scratch 2		Enhydra lutris kenyoni		308
Uncharacterized protein		Cebus capucinus imitator		307
transcriptional repressor scratch 2		DELLE		307
Uncharacterized protein		OTOGA		307
+34

Protein	Similar proteins		Species	Score	Length	Source
Q9NQ03	Transcriptional repressor scratch 1		HUMAN		348	UniRef50_Q9BWW7
Transcriptional repressor scratch 1		MOUSE		348
Uncharacterized protein		CERAT		348
Uncharacterized protein		PAPAN		348
Uncharacterized protein		CHLSB		348
+218

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY129025 mRNA Translation: AAM98768.1 AL121758 Genomic DNA No translation available.
CCDSⁱ	CCDS13006.1
RefSeqⁱ	NP_149120.1, NM_033129.3
UniGeneⁱ	Hs.355284

3D structure databases

ProteinModelPortalⁱ	Q9NQ03
SMRⁱ	Q9NQ03
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000246104

STRINGⁱ

9606.ENSP00000246104

PTM databases

iPTMnetⁱ	Q9NQ03
PhosphoSitePlusⁱ	Q9NQ03

Polymorphism and mutation databases

BioMutaⁱ	SCRT2
DMDMⁱ	46397045

Proteomic databases

PaxDbⁱ	Q9NQ03
PeptideAtlasⁱ	Q9NQ03
PRIDEⁱ	Q9NQ03
ProteomicsDBⁱ	82051

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000246104; ENSP00000246104; ENSG00000215397
GeneIDⁱ	85508
KEGGⁱ	hsa:85508
UCSCⁱ	uc002wec.3 human

Organism-specific databases

CTDⁱ	85508
EuPathDBⁱ	HostDB:ENSG00000215397.3
GeneCardsⁱ	SCRT2
HGNCⁱ	HGNC:15952 SCRT2
HPAⁱ	HPA067697
neXtProtⁱ	NX_Q9NQ03
OpenTargetsⁱ	ENSG00000215397
PharmGKBⁱ	PA35016
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q9NQ03
KOⁱ	K09219
OMAⁱ	AFFIMDG
OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q9NQ03
TreeFamⁱ	TF315515

Miscellaneous databases

GenomeRNAiⁱ	85508
Protein Ontology More...PROⁱ	PR:Q9NQ03

Gene expression databases

Bgeeⁱ	ENSG00000215397 Expressed in 17 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_SCRT2

Family and domain databases

InterProⁱ	View protein in InterPro IPR029794 SCRATCH1/2 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44270 PTHR44270, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCRT2_HUMAN
Accessionⁱ	Q9NQ03Primary (citable) accession number: Q9NQ03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	April 13, 2004
	Last modified:	October 10, 2018
	This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NQ03 (SCRT2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcriptional repressor scratch 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ