We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9NPY3 (C1QR1_HUMAN)
Protein
Complement component C1q receptor
Gene
CD93
Organism
Homo sapiens (Human)
Status
Functioni
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
Caution
Has been sometimes referred to as a collectin receptor.Curated
PubMed:11994479 reported that C1q is not a ligand for C1QR1.Curated
GO - Molecular functioni
- calcium ion binding Source: InterPro
- carbohydrate binding Source: UniProtKB-KW
- complement component C1q complex binding Source: UniProtKB
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- cell-cell adhesion Source: UniProtKB
- macrophage activation Source: UniProtKB
- phagocytosis Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Cell adhesion, Host-virus interaction |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q9NPY3 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9NPY3 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement component C1q receptorAlternative name(s): C1q/MBL/SPA receptor Short name: C1qR Short name: C1qR(p) Short name: C1qRp CDw93 Complement component 1 q subcomponent receptor 1 Matrix-remodeling-associated protein 4 CD_antigen: CD93 |
Gene namesi | Name:CD93 Synonyms:C1QR1, MXRA4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15855, CD93 |
MIMi | 120577, gene |
neXtProti | NX_Q9NPY3 |
VEuPathDBi | HostDB:ENSG00000125810 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: LIFEdb
Other locations
- cell surface Source: Ensembl
- ficolin-1-rich granule membrane Source: Reactome
- integral component of membrane Source: UniProtKB-KW
- secretory granule membrane Source: Reactome
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 580 | ExtracellularSequence analysisAdd BLAST | 557 | |
Transmembranei | 581 – 601 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 602 – 652 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 22918 |
OpenTargetsi | ENSG00000125810 |
PharmGKBi | PA25627 |
Miscellaneous databases
Pharosi | Q9NPY3, Tbio |
Genetic variation databases
BioMutai | CD93 |
DMDMi | 21759074 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000017367 | 22 – 652 | Complement component C1q receptorAdd BLAST | 631 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 141 ↔ 165 | PROSITE-ProRule annotation | ||
Disulfide bondi | 264 ↔ 275 | By similarity | ||
Disulfide bondi | 271 ↔ 285 | By similarity | ||
Disulfide bondi | 287 ↔ 300 | By similarity | ||
Disulfide bondi | 306 ↔ 317 | PROSITE-ProRule annotation | ||
Disulfide bondi | 311 ↔ 328 | PROSITE-ProRule annotation | ||
Glycosylationi | 325 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 330 ↔ 343 | By similarity | ||
Disulfide bondi | 349 ↔ 358 | PROSITE-ProRule annotation | ||
Disulfide bondi | 354 ↔ 367 | PROSITE-ProRule annotation | ||
Disulfide bondi | 369 ↔ 383 | By similarity | ||
Disulfide bondi | 389 ↔ 400 | PROSITE-ProRule annotation | ||
Disulfide bondi | 396 ↔ 409 | PROSITE-ProRule annotation | ||
Disulfide bondi | 411 ↔ 425 | PROSITE-ProRule annotation | ||
Disulfide bondi | 431 ↔ 443 | By similarity | ||
Disulfide bondi | 439 ↔ 452 | By similarity | ||
Disulfide bondi | 454 ↔ 467 | By similarity | ||
Modified residuei | 627 | PhosphoserineBy similarity | 1 | |
Modified residuei | 644 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
N- and O-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q9NPY3 |
MassIVEi | Q9NPY3 |
PaxDbi | Q9NPY3 |
PeptideAtlasi | Q9NPY3 |
PRIDEi | Q9NPY3 |
ProteomicsDBi | 82049 |
TopDownProteomicsi | Q9NPY3 |
PTM databases
GlyGeni | Q9NPY3, 3 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q9NPY3 |
PhosphoSitePlusi | Q9NPY3 |
Expressioni
Tissue specificityi
Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
Gene expression databases
Bgeei | ENSG00000125810, Expressed in visceral pleura and 230 other tissues |
Genevisiblei | Q9NPY3, HS |
Organism-specific databases
HPAi | ENSG00000125810, Tissue enhanced (placenta) |
Interactioni
Subunit structurei
Interacts with C1QBP; the association may represent a cell surface C1q receptor.
1 Publication(Microbial infection) Interacts with hepatitis virus C/HCV core protein.
1 PublicationGO - Molecular functioni
- complement component C1q complex binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116580, 28 interactors |
IntActi | Q9NPY3, 18 interactors |
STRINGi | 9606.ENSP00000246006 |
Miscellaneous databases
RNActi | Q9NPY3, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 174 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 143 | |
Domaini | 260 – 301 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 302 – 344 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 345 – 384 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 385 – 426 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 427 – 468 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 472 – 546 | DisorderedSequence analysisAdd BLAST | 75 | |
Regioni | 553 – 572 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 611 – 652 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 506 – 527 | Polar residuesSequence analysisAdd BLAST | 22 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUVB, Eukaryota |
GeneTreei | ENSGT00940000156996 |
HOGENOMi | CLU_027075_1_0_1 |
InParanoidi | Q9NPY3 |
OMAi | YTNWHKE |
OrthoDBi | 1174178at2759 |
PhylomeDBi | Q9NPY3 |
TreeFami | TF330714 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR026823, cEGF IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 1 hit PF07645, EGF_CA, 2 hits PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit SM00181, EGF, 5 hits SM00179, EGF_CA, 5 hits |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS50041, C_TYPE_LECTIN_2, 1 hit PS01186, EGF_2, 3 hits PS50026, EGF_3, 3 hits PS01187, EGF_CA, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9NPY3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATSMGLLLL LLLLLTQPGA GTGADTEAVV CVGTACYTAH SGKLSAAEAQ
60 70 80 90 100
NHCNQNGGNL ATVKSKEEAQ HVQRVLAQLL RREAALTARM SKFWIGLQRE
110 120 130 140 150
KGKCLDPSLP LKGFSWVGGG EDTPYSNWHK ELRNSCISKR CVSLLLDLSQ
160 170 180 190 200
PLLPSRLPKW SEGPCGSPGS PGSNIEGFVC KFSFKGMCRP LALGGPGQVT
210 220 230 240 250
YTTPFQTTSS SLEAVPFASA ANVACGEGDK DETQSHYFLC KEKAPDVFDW
260 270 280 290 300
GSSGPLCVSP KYGCNFNNGG CHQDCFEGGD GSFLCGCRPG FRLLDDLVTC
310 320 330 340 350
ASRNPCSSSP CRGGATCVLG PHGKNYTCRC PQGYQLDSSQ LDCVDVDECQ
360 370 380 390 400
DSPCAQECVN TPGGFRCECW VGYEPGGPGE GACQDVDECA LGRSPCAQGC
410 420 430 440 450
TNTDGSFHCS CEEGYVLAGE DGTQCQDVDE CVGPGGPLCD SLCFNTQGSF
460 470 480 490 500
HCGCLPGWVL APNGVSCTMG PVSLGPPSGP PDEEDKGEKE GSTVPRAATA
510 520 530 540 550
SPTRGPEGTP KATPTTSRPS LSSDAPITSA PLKMLAPSGS PGVWREPSIH
560 570 580 590 600
HATAASGPQE PAGGDSSVAT QNNDGTDGQK LLLFYILGTV VAILLLLALA
610 620 630 640 650
LGLLVYRKRR AKREEKKEKK PQNAADSYSW VPERAESRAM ENQYSPTPGT
DC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | T → V AA sequence (PubMed:9047234).Curated | 1 | |
Sequence conflicti | 36 | C → T AA sequence (PubMed:9047234).Curated | 1 | |
Sequence conflicti | 38 – 39 | TA → RI AA sequence (PubMed:9047234).Curated | 2 | |
Sequence conflicti | 155 | S → N in AAB53110 (PubMed:9047234).Curated | 1 | |
Sequence conflicti | 186 | G → A AA sequence (PubMed:9047234).Curated | 1 | |
Sequence conflicti | 492 | S → A AA sequence (PubMed:9047234).Curated | 1 | |
Sequence conflicti | 496 | R → Q AA sequence (PubMed:9047234).Curated | 1 | |
Sequence conflicti | 504 | R → G AA sequence (PubMed:9047234).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036400 | 220 | A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138932459Ensembl. | 1 | |
Natural variantiVAR_013573 | 318 | V → A1 Publication | 1 | |
Natural variantiVAR_050102 | 541 | P → S1 PublicationCorresponds to variant dbSNP:rs3746731Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U94333 mRNA Translation: AAB53110.1 AL118508 Genomic DNA No translation available. BC028075 mRNA Translation: AAH28075.1 |
CCDSi | CCDS13149.1 |
RefSeqi | NP_036204.2, NM_012072.3 |
Genome annotation databases
Ensembli | ENST00000246006; ENSP00000246006; ENSG00000125810 |
GeneIDi | 22918 |
KEGGi | hsa:22918 |
MANE-Selecti | ENST00000246006.5; ENSP00000246006.4; NM_012072.4; NP_036204.2 |
UCSCi | uc002wsv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U94333 mRNA Translation: AAB53110.1 AL118508 Genomic DNA No translation available. BC028075 mRNA Translation: AAH28075.1 |
CCDSi | CCDS13149.1 |
RefSeqi | NP_036204.2, NM_012072.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116580, 28 interactors |
IntActi | Q9NPY3, 18 interactors |
STRINGi | 9606.ENSP00000246006 |
PTM databases
GlyGeni | Q9NPY3, 3 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q9NPY3 |
PhosphoSitePlusi | Q9NPY3 |
Genetic variation databases
BioMutai | CD93 |
DMDMi | 21759074 |
Proteomic databases
jPOSTi | Q9NPY3 |
MassIVEi | Q9NPY3 |
PaxDbi | Q9NPY3 |
PeptideAtlasi | Q9NPY3 |
PRIDEi | Q9NPY3 |
ProteomicsDBi | 82049 |
TopDownProteomicsi | Q9NPY3 |
Protocols and materials databases
ABCDi | Q9NPY3, 1 sequenced antibody |
Antibodypediai | 2408, 558 antibodies from 33 providers |
DNASUi | 22918 |
Genome annotation databases
Ensembli | ENST00000246006; ENSP00000246006; ENSG00000125810 |
GeneIDi | 22918 |
KEGGi | hsa:22918 |
MANE-Selecti | ENST00000246006.5; ENSP00000246006.4; NM_012072.4; NP_036204.2 |
UCSCi | uc002wsv.4, human |
Organism-specific databases
CTDi | 22918 |
DisGeNETi | 22918 |
GeneCardsi | CD93 |
HGNCi | HGNC:15855, CD93 |
HPAi | ENSG00000125810, Tissue enhanced (placenta) |
MIMi | 120577, gene |
neXtProti | NX_Q9NPY3 |
OpenTargetsi | ENSG00000125810 |
PharmGKBi | PA25627 |
VEuPathDBi | HostDB:ENSG00000125810 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUVB, Eukaryota |
GeneTreei | ENSGT00940000156996 |
HOGENOMi | CLU_027075_1_0_1 |
InParanoidi | Q9NPY3 |
OMAi | YTNWHKE |
OrthoDBi | 1174178at2759 |
PhylomeDBi | Q9NPY3 |
TreeFami | TF330714 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPY3 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9NPY3 |
Miscellaneous databases
BioGRID-ORCSi | 22918, 10 hits in 1036 CRISPR screens |
GeneWikii | CD93 |
GenomeRNAii | 22918 |
Pharosi | Q9NPY3, Tbio |
PROi | PR:Q9NPY3 |
RNActi | Q9NPY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125810, Expressed in visceral pleura and 230 other tissues |
Genevisiblei | Q9NPY3, HS |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR026823, cEGF IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 1 hit PF07645, EGF_CA, 2 hits PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit SM00181, EGF, 5 hits SM00179, EGF_CA, 5 hits |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS50041, C_TYPE_LECTIN_2, 1 hit PS01186, EGF_2, 3 hits PS50026, EGF_3, 3 hits PS01187, EGF_CA, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | C1QR1_HUMAN | |
Accessioni | Q9NPY3Primary (citable) accession number: Q9NPY3 Secondary accession number(s): O00274 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2002 |
Last sequence update: | July 11, 2002 | |
Last modified: | February 23, 2022 | |
This is version 196 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot