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Entry version 137 (16 Oct 2019)
Sequence version 3 (05 Oct 2010)
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Protein

Synembryn-A

Gene

RIC8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synembryn-A
Alternative name(s):
Protein Ric-8A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIC8A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29550 RIC8A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609146 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPQ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000177963

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142671067

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9NPQ8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RIC8A

Domain mapping of disease mutations (DMDM)

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DMDMi
308153562

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002358901 – 531Synembryn-AAdd BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei436PhosphoserineCombined sources1
Modified residuei441PhosphothreonineCombined sources1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei502PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NPQ8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NPQ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NPQ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NPQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NPQ8

PeptideAtlas

More...
PeptideAtlasi
Q9NPQ8

PRoteomics IDEntifications database

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PRIDEi
Q9NPQ8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82040 [Q9NPQ8-1]
82041 [Q9NPQ8-2]
82042 [Q9NPQ8-3]
82043 [Q9NPQ8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NPQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NPQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177963 Expressed in 220 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NPQ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NPQ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB046012
HPA041491

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121946, 47 interactors

Protein interaction database and analysis system

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IntActi
Q9NPQ8, 38 interactors

Molecular INTeraction database

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MINTi
Q9NPQ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325941

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NPQ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synembryn family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4464 Eukaryota
ENOG410XSCJ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014700

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NPQ8

Identification of Orthologs from Complete Genome Data

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OMAi
NQEHSQS

Database of Orthologous Groups

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OrthoDBi
1110075at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NPQ8

TreeFam database of animal gene trees

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TreeFami
TF314907

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019318 Gua_nucleotide_exch_fac_Ric8
IPR008376 Synembryn

The PANTHER Classification System

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PANTHERi
PTHR12425 PTHR12425, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF10165 Ric8, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01802 SYNEMBRYN

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL
60 70 80 90 100
VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV
110 120 130 140 150
SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL
160 170 180 190 200
YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL
210 220 230 240 250
GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV DEEDAALYRH
260 270 280 290 300
LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST
310 320 330 340 350
EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK
360 370 380 390 400
FLKAQVLPPL RDVRTRPEVG EMLRNKLVRL MTHLDTDVKR VAAEFLFVLC
410 420 430 440 450
SESVPRFIKY TGYGNAAGLL AARGLMAGGR PEGQYSEDED TDTDEYKEAK
460 470 480 490 500
ASINPVTGRV EEKPPNPMEG MTEEQKEHEA MKLVTMFDKL SRNRVIQPMG
510 520 530
MSPRGHLTSL QDAMCETMEQ QLSSDPDSDP D
Length:531
Mass (Da):59,710
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BAF3E2791F6E021
GO
Isoform 2 (identifier: Q9NPQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: MEPRAVAEAV...FDDAQQEDRK → MMPNRRTGRW...WWSRSSPCPQ

Show »
Length:525
Mass (Da):58,943
Checksum:i823D0B28817F594D
GO
Isoform 3 (identifier: Q9NPQ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: A → AQGWPPP

Show »
Length:537
Mass (Da):60,372
Checksum:iC46E2F66B44DE40D
GO
Isoform 4 (identifier: Q9NPQ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: Missing.

Show »
Length:530
Mass (Da):59,612
Checksum:i46ED334ED07C9EA8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC88H0YC88_HUMAN
Synembryn-A
RIC8A
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE35H0YE35_HUMAN
Synembryn-A
RIC8A
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSI0E9PSI0_HUMAN
Synembryn-A
RIC8A
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMP0E9PMP0_HUMAN
Synembryn-A
RIC8A
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI04E9PI04_HUMAN
Synembryn-A
RIC8A
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEN0H0YEN0_HUMAN
Synembryn-A
RIC8A
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLE5E9PLE5_HUMAN
Synembryn-A
RIC8A
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14282 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14282 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15653 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55126 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48E → V in BAB55126 (PubMed:14702039).Curated1
Sequence conflicti405P → L in CAD98025 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0185071 – 44MEPRA…QEDRK → MMPNRRTGRWVLAQGVKGQG RVAPGRRAWWSRSSPCPQ in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_039849209Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_018508354A → AQGWPPP in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136935 mRNA Translation: CAB66869.1
AK022870 mRNA Translation: BAB14282.1 Sequence problems.
AK027090 mRNA Translation: BAB15653.1 Different initiation.
AK027461 mRNA Translation: BAB55126.1 Frameshift.
AL390088 mRNA Translation: CAB98211.1
BX538115 mRNA Translation: CAD98025.1
AC069287 Genomic DNA No translation available.
BC011821 mRNA Translation: AAH11821.2
BC111499 mRNA Translation: AAI11500.1
BC121807 mRNA Translation: AAI21808.1
BC121808 mRNA Translation: AAI21809.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS65982.1 [Q9NPQ8-1]
CCDS7690.1 [Q9NPQ8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001273063.1, NM_001286134.1 [Q9NPQ8-1]
NP_068751.4, NM_021932.5 [Q9NPQ8-3]
XP_016873596.1, XM_017018107.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3]
ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1]
ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
60626

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:60626

UCSC genome browser

More...
UCSCi
uc001lof.5 human [Q9NPQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136935 mRNA Translation: CAB66869.1
AK022870 mRNA Translation: BAB14282.1 Sequence problems.
AK027090 mRNA Translation: BAB15653.1 Different initiation.
AK027461 mRNA Translation: BAB55126.1 Frameshift.
AL390088 mRNA Translation: CAB98211.1
BX538115 mRNA Translation: CAD98025.1
AC069287 Genomic DNA No translation available.
BC011821 mRNA Translation: AAH11821.2
BC111499 mRNA Translation: AAI11500.1
BC121807 mRNA Translation: AAI21808.1
BC121808 mRNA Translation: AAI21809.1
CCDSiCCDS65982.1 [Q9NPQ8-1]
CCDS7690.1 [Q9NPQ8-3]
RefSeqiNP_001273063.1, NM_001286134.1 [Q9NPQ8-1]
NP_068751.4, NM_021932.5 [Q9NPQ8-3]
XP_016873596.1, XM_017018107.1

3D structure databases

SMRiQ9NPQ8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121946, 47 interactors
IntActiQ9NPQ8, 38 interactors
MINTiQ9NPQ8
STRINGi9606.ENSP00000325941

PTM databases

iPTMnetiQ9NPQ8
PhosphoSitePlusiQ9NPQ8

Polymorphism and mutation databases

BioMutaiRIC8A
DMDMi308153562

Proteomic databases

EPDiQ9NPQ8
jPOSTiQ9NPQ8
MassIVEiQ9NPQ8
MaxQBiQ9NPQ8
PaxDbiQ9NPQ8
PeptideAtlasiQ9NPQ8
PRIDEiQ9NPQ8
ProteomicsDBi82040 [Q9NPQ8-1]
82041 [Q9NPQ8-2]
82042 [Q9NPQ8-3]
82043 [Q9NPQ8-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
60626

Genome annotation databases

EnsembliENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3]
ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1]
ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2]
GeneIDi60626
KEGGihsa:60626
UCSCiuc001lof.5 human [Q9NPQ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
60626

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RIC8A
HGNCiHGNC:29550 RIC8A
HPAiCAB046012
HPA041491
MIMi609146 gene
neXtProtiNX_Q9NPQ8
OpenTargetsiENSG00000177963
PharmGKBiPA142671067

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4464 Eukaryota
ENOG410XSCJ LUCA
GeneTreeiENSGT00390000014700
InParanoidiQ9NPQ8
OMAiNQEHSQS
OrthoDBi1110075at2759
PhylomeDBiQ9NPQ8
TreeFamiTF314907

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RIC8A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RIC8A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
60626
PharosiQ9NPQ8

Protein Ontology

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PROi
PR:Q9NPQ8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177963 Expressed in 220 organ(s), highest expression level in testis
ExpressionAtlasiQ9NPQ8 baseline and differential
GenevisibleiQ9NPQ8 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019318 Gua_nucleotide_exch_fac_Ric8
IPR008376 Synembryn
PANTHERiPTHR12425 PTHR12425, 1 hit
PfamiView protein in Pfam
PF10165 Ric8, 1 hit
PRINTSiPR01802 SYNEMBRYN
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIC8A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPQ8
Secondary accession number(s): Q0P508
, Q2T9J1, Q7Z352, Q96EZ1, Q96SZ2, Q9H064, Q9H5H3, Q9H9E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: October 16, 2019
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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