RIC8A

Functionⁱ

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.By similarity1 Publication

GO - Molecular functionⁱ

G-protein alpha-subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTPase activator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
guanyl-nucleotide exchange factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
basement membrane organization Source: Ensembl
cell-cell adhesion involved in gastrulation Source: Ensembl
cell migration involved in gastrulation Source: Ensembl
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
in utero embryonic development Source: Ensembl
vasculature development Source: Ensembl
visual learning Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factor

Molecular function

Guanine-nucleotide releasing factor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synembryn-A Alternative name(s): Protein Ric-8A
Gene namesⁱ	Name:RIC8A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177963.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29550 RIC8A
MIMⁱ	609146 gene
neXtProtⁱ	NX_Q9NPQ8

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000177963
PharmGKBⁱ	PA142671067

Polymorphism and mutation databases

DMDMⁱ	308153562

DMDMⁱ

308153562

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000235890	1 – 531	Synembryn-AAdd BLAST		531

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	436	PhosphoserineCombined sources	1
Modified residueⁱ	441	PhosphothreonineCombined sources	1
Modified residueⁱ	443	PhosphothreonineBy similarity	1
Modified residueⁱ	502	PhosphoserineCombined sources	1
Modified residueⁱ	523	PhosphoserineCombined sources	1
Modified residueⁱ	524	PhosphoserineCombined sources	1
Modified residueⁱ	528	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NPQ8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NPQ8
PaxDbⁱ	Q9NPQ8
PeptideAtlas More...PeptideAtlasⁱ	Q9NPQ8
PRIDEⁱ	Q9NPQ8
ProteomicsDBⁱ	82040 82041 [Q9NPQ8-2] 82042 [Q9NPQ8-3] 82043 [Q9NPQ8-4]

PTM databases

iPTMnetⁱ	Q9NPQ8
PhosphoSitePlusⁱ	Q9NPQ8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177963 Expressed in 220 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q9NPQ8 baseline and differential
Genevisibleⁱ	Q9NPQ8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB046012 HPA041491

HPAⁱ

CAB046012
HPA041491

Interactionⁱ

Subunit structureⁱ

Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EFEMP1	Q12805	3	EBI-9091816,EBI-536772
NECAB2	Q7Z6G3-2	3	EBI-9091816,EBI-10172876
NUTM1	Q86Y26	3	EBI-9091816,EBI-10178410
RABAC1	Q9UI14	3	EBI-9091816,EBI-712367
SDCBP	O00560	3	EBI-9091816,EBI-727004
UBQLN1	Q9UMX0	3	EBI-717509,EBI-741480
UBQLN1	Q9UMX0-2	3	EBI-9091816,EBI-10173939

GO - Molecular functionⁱ

G-protein alpha-subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
guanyl-nucleotide exchange factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121946, 45 interactors
IntActⁱ	Q9NPQ8, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q9NPQ8
STRINGⁱ	9606.ENSP00000325941

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NPQ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the synembryn family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4464 Eukaryota ENOG410XSCJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014700
HOVERGENⁱ	HBG054867
InParanoidⁱ	Q9NPQ8
OMAⁱ	GMSPRGH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07N6
PhylomeDBⁱ	Q9NPQ8
TreeFamⁱ	TF314907

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR019318 Gua_nucleotide_exch_fac_Ric8 IPR008376 Synembryn
PANTHERⁱ	PTHR12425 PTHR12425, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10165 Ric8, 1 hit
PRINTSⁱ	PR01802 SYNEMBRYN
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NPQ8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL 
        60         70         80         90        100
VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV 
       110        120        130        140        150
SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL 
       160        170        180        190        200
YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL 
       210        220        230        240        250
GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV DEEDAALYRH 
       260        270        280        290        300
LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST 
       310        320        330        340        350
EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK 
       360        370        380        390        400
FLKAQVLPPL RDVRTRPEVG EMLRNKLVRL MTHLDTDVKR VAAEFLFVLC 
       410        420        430        440        450
SESVPRFIKY TGYGNAAGLL AARGLMAGGR PEGQYSEDED TDTDEYKEAK 
       460        470        480        490        500
ASINPVTGRV EEKPPNPMEG MTEEQKEHEA MKLVTMFDKL SRNRVIQPMG 
       510        520        530 
MSPRGHLTSL QDAMCETMEQ QLSSDPDSDP D

Length:531

Mass (Da):59,710

Last modified:October 5, 2010 - v3

Checksum:ⁱ2BAF3E2791F6E021

GO

Isoform 2 (identifier: Q9NPQ8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-44: MEPRAVAEAV...FDDAQQEDRK → MMPNRRTGRW...WWSRSSPCPQ

« Hide

        10         20         30         40         50
MMPNRRTGRW VLAQGVKGQG RVAPGRRAWW SRSSPCPQRL AELLVSVLEQ 
        60         70         80         90        100
GLPPSHRVIW LQSVRILSRD RNCLDPFTSR QSLQALACYA DISVSEGSVP 
       110        120        130        140        150
ESADMDVVLE SLKCLCNLVL SSPVAQMLAA EARLVVKLTE RVGLYRERSF 
       160        170        180        190        200
PHDVQFFDLR LLFLLTALRT DVRQQLFQEL KGVRLLTDTL ELTLGVTPEG 
       210        220        230        240        250
NPPPTLLPSQ ETERAMEILK VLFNITLDSI KGEVDEEDAA LYRHLGTLLR 
       260        270        280        290        300
HCVMIATAGD RTEEFHGHAV NLLGNLPLKC LDVLLTLEPH GDSTEFMGVN 
       310        320        330        340        350
MDVIRALLIF LEKRLHKTHR LKESVAPVLS VLTECARMHR PARKFLKAQV 
       360        370        380        390        400
LPPLRDVRTR PEVGEMLRNK LVRLMTHLDT DVKRVAAEFL FVLCSESVPR 
       410        420        430        440        450
FIKYTGYGNA AGLLAARGLM AGGRPEGQYS EDEDTDTDEY KEAKASINPV 
       460        470        480        490        500
TGRVEEKPPN PMEGMTEEQK EHEAMKLVTM FDKLSRNRVI QPMGMSPRGH 
       510        520 
LTSLQDAMCE TMEQQLSSDP DSDPD

Show »

Length:525

Mass (Da):58,943

Checksum:ⁱ823D0B28817F594D

GO

Isoform 3 (identifier: Q9NPQ8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
354-354: A → AQGWPPP

« Hide

        10         20         30         40         50
MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL 
        60         70         80         90        100
VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV 
       110        120        130        140        150
SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL 
       160        170        180        190        200
YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL 
       210        220        230        240        250
GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV DEEDAALYRH 
       260        270        280        290        300
LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST 
       310        320        330        340        350
EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK 
       360        370        380        390        400
FLKAQGWPPP QVLPPLRDVR TRPEVGEMLR NKLVRLMTHL DTDVKRVAAE 
       410        420        430        440        450
FLFVLCSESV PRFIKYTGYG NAAGLLAARG LMAGGRPEGQ YSEDEDTDTD 
       460        470        480        490        500
EYKEAKASIN PVTGRVEEKP PNPMEGMTEE QKEHEAMKLV TMFDKLSRNR 
       510        520        530 
VIQPMGMSPR GHLTSLQDAM CETMEQQLSS DPDSDPD

Show »

Length:537

Mass (Da):60,372

Checksum:ⁱC46E2F66B44DE40D

GO

Isoform 4 (identifier: Q9NPQ8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
209-209: Missing.

« Hide

        10         20         30         40         50
MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL 
        60         70         80         90        100
VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV 
       110        120        130        140        150
SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL 
       160        170        180        190        200
YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL 
       210        220        230        240        250
GVTPEGNPPT LLPSQETERA MEILKVLFNI TLDSIKGEVD EEDAALYRHL 
       260        270        280        290        300
GTLLRHCVMI ATAGDRTEEF HGHAVNLLGN LPLKCLDVLL TLEPHGDSTE 
       310        320        330        340        350
FMGVNMDVIR ALLIFLEKRL HKTHRLKESV APVLSVLTEC ARMHRPARKF 
       360        370        380        390        400
LKAQVLPPLR DVRTRPEVGE MLRNKLVRLM THLDTDVKRV AAEFLFVLCS 
       410        420        430        440        450
ESVPRFIKYT GYGNAAGLLA ARGLMAGGRP EGQYSEDEDT DTDEYKEAKA 
       460        470        480        490        500
SINPVTGRVE EKPPNPMEGM TEEQKEHEAM KLVTMFDKLS RNRVIQPMGM 
       510        520        530
SPRGHLTSLQ DAMCETMEQQ LSSDPDSDPD

Show »

Length:530

Mass (Da):59,612

Checksum:ⁱ46ED334ED07C9EA8

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PSI0	E9PSI0_HUMAN	Synembryn-A Synembryn-A	RIC8A	183	Annotation score:
H0YC88	H0YC88_HUMAN	Synembryn-A Synembryn-A	RIC8A	147	Annotation score:
E9PMP0	E9PMP0_HUMAN	Synembryn-A Synembryn-A	RIC8A	44	Annotation score:
E9PI04	E9PI04_HUMAN	Synembryn-A Synembryn-A	RIC8A	148	Annotation score:
H0YE35	H0YE35_HUMAN	Synembryn-A Synembryn-A	RIC8A	147	Annotation score:
H0YEN0	H0YEN0_HUMAN	Synembryn-A Synembryn-A	RIC8A	286	Annotation score:
E9PLE5	E9PLE5_HUMAN	Synembryn-A Synembryn-A	RIC8A	52	Annotation score:

Sequence cautionⁱ

The sequence BAB14282 differs from that shown. Reason: Frameshift at position 397.Curated

The sequence BAB14282 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB15653 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB55126 differs from that shown. Reason: Frameshift at position 48.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	48	E → V in BAB55126 (PubMed:14702039).Curated		1
Sequence conflictⁱ	405	P → L in CAD98025 (PubMed:17974005).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_018507	1 – 44	MEPRA…QEDRK → MMPNRRTGRWVLAQGVKGQG RVAPGRRAWWSRSSPCPQ in isoform 2. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_039849	209	Missing in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_018508	354	A → AQGWPPP in isoform 3. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136935 mRNA Translation: CAB66869.1 AK022870 mRNA Translation: BAB14282.1 Sequence problems. AK027090 mRNA Translation: BAB15653.1 Different initiation. AK027461 mRNA Translation: BAB55126.1 Frameshift. AL390088 mRNA Translation: CAB98211.1 BX538115 mRNA Translation: CAD98025.1 AC069287 Genomic DNA No translation available. BC011821 mRNA Translation: AAH11821.2 BC111499 mRNA Translation: AAI11500.1 BC121807 mRNA Translation: AAI21808.1 BC121808 mRNA Translation: AAI21809.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS65982.1 [Q9NPQ8-1] CCDS7690.1 [Q9NPQ8-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273063.1, NM_001286134.1 [Q9NPQ8-1] NP_068751.4, NM_021932.5 [Q9NPQ8-3] XP_016873596.1, XM_017018107.1
UniGeneⁱ	Hs.592292

Genome annotation databases

Ensemblⁱ	ENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3] ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1] ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2]
GeneIDⁱ	60626
KEGGⁱ	hsa:60626
UCSC genome browser More...UCSCⁱ	uc001lof.5 human [Q9NPQ8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NPQ8	Synembryn-A		MACFA		530	UniRef90_Q9NPQ8
Synembryn-A		PONAB		530
Isoform 3 of Synembryn-A		HUMAN		537
RIC8A isoform 1		PANTR		536
Uncharacterized protein		MACMU		536
+57

Protein	Similar proteins		Species	Score	Length	Source
Q9NPQ8	Synembryn-A		PONAB		530	UniRef50_Q9NPQ8
Synembryn-A		MACFA		530
Isoform 3 of Synembryn-A		HUMAN		537
RIC8A isoform 1		PANTR		536
Uncharacterized protein		NOMLE		536
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136935 mRNA Translation: CAB66869.1 AK022870 mRNA Translation: BAB14282.1 Sequence problems. AK027090 mRNA Translation: BAB15653.1 Different initiation. AK027461 mRNA Translation: BAB55126.1 Frameshift. AL390088 mRNA Translation: CAB98211.1 BX538115 mRNA Translation: CAD98025.1 AC069287 Genomic DNA No translation available. BC011821 mRNA Translation: AAH11821.2 BC111499 mRNA Translation: AAI11500.1 BC121807 mRNA Translation: AAI21808.1 BC121808 mRNA Translation: AAI21809.1
CCDSⁱ	CCDS65982.1 [Q9NPQ8-1] CCDS7690.1 [Q9NPQ8-3]
RefSeqⁱ	NP_001273063.1, NM_001286134.1 [Q9NPQ8-1] NP_068751.4, NM_021932.5 [Q9NPQ8-3] XP_016873596.1, XM_017018107.1
UniGeneⁱ	Hs.592292

3D structure databases

ProteinModelPortalⁱ	Q9NPQ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121946, 45 interactors
IntActⁱ	Q9NPQ8, 22 interactors
MINTⁱ	Q9NPQ8
STRINGⁱ	9606.ENSP00000325941

PTM databases

iPTMnetⁱ	Q9NPQ8
PhosphoSitePlusⁱ	Q9NPQ8

Polymorphism and mutation databases

DMDMⁱ	308153562

DMDMⁱ

308153562

Proteomic databases

EPDⁱ	Q9NPQ8
MaxQBⁱ	Q9NPQ8
PaxDbⁱ	Q9NPQ8
PeptideAtlasⁱ	Q9NPQ8
PRIDEⁱ	Q9NPQ8
ProteomicsDBⁱ	82040 82041 [Q9NPQ8-2] 82042 [Q9NPQ8-3] 82043 [Q9NPQ8-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	60626
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3] ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1] ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2]
GeneIDⁱ	60626
KEGGⁱ	hsa:60626
UCSCⁱ	uc001lof.5 human [Q9NPQ8-1]

Organism-specific databases

CTDⁱ	60626
EuPathDBⁱ	HostDB:ENSG00000177963.12
GeneCardsⁱ	RIC8A
HGNCⁱ	HGNC:29550 RIC8A
HPAⁱ	CAB046012 HPA041491
MIMⁱ	609146 gene
neXtProtⁱ	NX_Q9NPQ8
OpenTargetsⁱ	ENSG00000177963
PharmGKBⁱ	PA142671067
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4464 Eukaryota ENOG410XSCJ LUCA
GeneTreeⁱ	ENSGT00390000014700
HOVERGENⁱ	HBG054867
InParanoidⁱ	Q9NPQ8
OMAⁱ	GMSPRGH
OrthoDBⁱ	EOG091G07N6
PhylomeDBⁱ	Q9NPQ8
TreeFamⁱ	TF314907

Miscellaneous databases

ChiTaRSⁱ	RIC8A human
GeneWikiⁱ	RIC8A
GenomeRNAiⁱ	60626
Protein Ontology More...PROⁱ	PR:Q9NPQ8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177963 Expressed in 220 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q9NPQ8 baseline and differential
Genevisibleⁱ	Q9NPQ8 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR019318 Gua_nucleotide_exch_fac_Ric8 IPR008376 Synembryn
PANTHERⁱ	PTHR12425 PTHR12425, 1 hit
Pfamⁱ	View protein in Pfam PF10165 Ric8, 1 hit
PRINTSⁱ	PR01802 SYNEMBRYN
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RIC8A_HUMAN
Accessionⁱ	Q9NPQ8Primary (citable) accession number: Q9NPQ8 Secondary accession number(s): Q0P508 Q9H9E7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	October 5, 2010
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q9NPQ8 (RIC8A_HUMAN)

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Synembryn-A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ