UniProtKB - Q9NPQ8 (RIC8A_HUMAN)
Synembryn-A
RIC8A
Functioni
GO - Molecular functioni
- G-protein alpha-subunit binding Source: GO_Central
- GTPase activator activity Source: GO_Central
- guanyl-nucleotide exchange factor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
- basement membrane organization Source: Ensembl
- cell-cell adhesion involved in gastrulation Source: Ensembl
- cell migration involved in gastrulation Source: Ensembl
- G protein-coupled receptor signaling pathway Source: GO_Central
- in utero embryonic development Source: Ensembl
- vasculature development Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | Q9NPQ8 |
Names & Taxonomyi
Protein namesi | Recommended name: Synembryn-AAlternative name(s): Protein Ric-8A |
Gene namesi | Name:RIC8A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177963.12 |
HGNCi | HGNC:29550, RIC8A |
MIMi | 609146, gene |
neXtProti | NX_Q9NPQ8 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Other locations
- Cytoplasm By similarity
Note: Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 60626 |
OpenTargetsi | ENSG00000177963 |
PharmGKBi | PA142671067 |
Miscellaneous databases
Pharosi | Q9NPQ8, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4296100 |
Polymorphism and mutation databases
BioMutai | RIC8A |
DMDMi | 308153562 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000235890 | 1 – 531 | Synembryn-AAdd BLAST | 531 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 436 | PhosphoserineCombined sources | 1 | |
Modified residuei | 441 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 443 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 502 | PhosphoserineCombined sources | 1 | |
Modified residuei | 523 | PhosphoserineCombined sources | 1 | |
Modified residuei | 524 | PhosphoserineCombined sources | 1 | |
Modified residuei | 528 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NPQ8 |
jPOSTi | Q9NPQ8 |
MassIVEi | Q9NPQ8 |
MaxQBi | Q9NPQ8 |
PaxDbi | Q9NPQ8 |
PeptideAtlasi | Q9NPQ8 |
PRIDEi | Q9NPQ8 |
ProteomicsDBi | 82040 [Q9NPQ8-1] 82041 [Q9NPQ8-2] 82042 [Q9NPQ8-3] 82043 [Q9NPQ8-4] |
PTM databases
iPTMneti | Q9NPQ8 |
MetOSitei | Q9NPQ8 |
PhosphoSitePlusi | Q9NPQ8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177963, Expressed in testis and 233 other tissues |
ExpressionAtlasi | Q9NPQ8, baseline and differential |
Genevisiblei | Q9NPQ8, HS |
Organism-specific databases
HPAi | ENSG00000177963, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).
By similarityBinary interactionsi
Hide detailsQ9NPQ8
With | #Exp. | IntAct |
---|---|---|
UBQLN1 [Q9UMX0] | 4 | EBI-717509,EBI-741480 |
Isoform 4 [Q9NPQ8-4]
GO - Molecular functioni
- G-protein alpha-subunit binding Source: GO_Central
- guanyl-nucleotide exchange factor activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 121946, 54 interactors |
IntActi | Q9NPQ8, 39 interactors |
MINTi | Q9NPQ8 |
STRINGi | 9606.ENSP00000325941 |
Miscellaneous databases
RNActi | Q9NPQ8, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4464, Eukaryota |
GeneTreei | ENSGT00390000014700 |
HOGENOMi | CLU_018602_1_0_1 |
InParanoidi | Q9NPQ8 |
OMAi | NQEHSQS |
OrthoDBi | 1110075at2759 |
PhylomeDBi | Q9NPQ8 |
TreeFami | TF314907 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR019318, Gua_nucleotide_exch_fac_Ric8 IPR008376, Synembryn |
PANTHERi | PTHR12425, PTHR12425, 1 hit |
Pfami | View protein in Pfam PF10165, Ric8, 1 hit |
PRINTSi | PR01802, SYNEMBRYN |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL
60 70 80 90 100
VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV
110 120 130 140 150
SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL
160 170 180 190 200
YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL
210 220 230 240 250
GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV DEEDAALYRH
260 270 280 290 300
LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST
310 320 330 340 350
EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK
360 370 380 390 400
FLKAQVLPPL RDVRTRPEVG EMLRNKLVRL MTHLDTDVKR VAAEFLFVLC
410 420 430 440 450
SESVPRFIKY TGYGNAAGLL AARGLMAGGR PEGQYSEDED TDTDEYKEAK
460 470 480 490 500
ASINPVTGRV EEKPPNPMEG MTEEQKEHEA MKLVTMFDKL SRNRVIQPMG
510 520 530
MSPRGHLTSL QDAMCETMEQ QLSSDPDSDP D
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YC88 | H0YC88_HUMAN | Synembryn-A | RIC8A | 147 | Annotation score: | ||
H0YE35 | H0YE35_HUMAN | Synembryn-A | RIC8A | 147 | Annotation score: | ||
H0YEN0 | H0YEN0_HUMAN | Synembryn-A | RIC8A | 286 | Annotation score: | ||
E9PSI0 | E9PSI0_HUMAN | Synembryn-A | RIC8A | 183 | Annotation score: | ||
E9PMP0 | E9PMP0_HUMAN | Synembryn-A | RIC8A | 44 | Annotation score: | ||
E9PI04 | E9PI04_HUMAN | Synembryn-A | RIC8A | 148 | Annotation score: | ||
E9PLE5 | E9PLE5_HUMAN | Synembryn-A | RIC8A | 52 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | E → V in BAB55126 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 405 | P → L in CAD98025 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018507 | 1 – 44 | MEPRA…QEDRK → MMPNRRTGRWVLAQGVKGQG RVAPGRRAWWSRSSPCPQ in isoform 2. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_039849 | 209 | Missing in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_018508 | 354 | A → AQGWPPP in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136935 mRNA Translation: CAB66869.1 AK022870 mRNA Translation: BAB14282.1 Sequence problems. AK027090 mRNA Translation: BAB15653.1 Different initiation. AK027461 mRNA Translation: BAB55126.1 Frameshift. AL390088 mRNA Translation: CAB98211.1 BX538115 mRNA Translation: CAD98025.1 AC069287 Genomic DNA No translation available. BC011821 mRNA Translation: AAH11821.2 BC111499 mRNA Translation: AAI11500.1 BC121807 mRNA Translation: AAI21808.1 BC121808 mRNA Translation: AAI21809.1 |
CCDSi | CCDS65982.1 [Q9NPQ8-1] CCDS7690.1 [Q9NPQ8-3] |
RefSeqi | NP_001273063.1, NM_001286134.1 [Q9NPQ8-1] NP_068751.4, NM_021932.5 [Q9NPQ8-3] XP_016873596.1, XM_017018107.1 |
Genome annotation databases
Ensembli | ENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3] ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1] ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2] |
GeneIDi | 60626 |
KEGGi | hsa:60626 |
UCSCi | uc001lof.5, human [Q9NPQ8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136935 mRNA Translation: CAB66869.1 AK022870 mRNA Translation: BAB14282.1 Sequence problems. AK027090 mRNA Translation: BAB15653.1 Different initiation. AK027461 mRNA Translation: BAB55126.1 Frameshift. AL390088 mRNA Translation: CAB98211.1 BX538115 mRNA Translation: CAD98025.1 AC069287 Genomic DNA No translation available. BC011821 mRNA Translation: AAH11821.2 BC111499 mRNA Translation: AAI11500.1 BC121807 mRNA Translation: AAI21808.1 BC121808 mRNA Translation: AAI21809.1 |
CCDSi | CCDS65982.1 [Q9NPQ8-1] CCDS7690.1 [Q9NPQ8-3] |
RefSeqi | NP_001273063.1, NM_001286134.1 [Q9NPQ8-1] NP_068751.4, NM_021932.5 [Q9NPQ8-3] XP_016873596.1, XM_017018107.1 |
3D structure databases
SMRi | Q9NPQ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121946, 54 interactors |
IntActi | Q9NPQ8, 39 interactors |
MINTi | Q9NPQ8 |
STRINGi | 9606.ENSP00000325941 |
Chemistry databases
ChEMBLi | CHEMBL4296100 |
PTM databases
iPTMneti | Q9NPQ8 |
MetOSitei | Q9NPQ8 |
PhosphoSitePlusi | Q9NPQ8 |
Polymorphism and mutation databases
BioMutai | RIC8A |
DMDMi | 308153562 |
Proteomic databases
EPDi | Q9NPQ8 |
jPOSTi | Q9NPQ8 |
MassIVEi | Q9NPQ8 |
MaxQBi | Q9NPQ8 |
PaxDbi | Q9NPQ8 |
PeptideAtlasi | Q9NPQ8 |
PRIDEi | Q9NPQ8 |
ProteomicsDBi | 82040 [Q9NPQ8-1] 82041 [Q9NPQ8-2] 82042 [Q9NPQ8-3] 82043 [Q9NPQ8-4] |
Protocols and materials databases
Antibodypediai | 22381, 264 antibodies |
DNASUi | 60626 |
Genome annotation databases
Ensembli | ENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3] ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1] ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2] |
GeneIDi | 60626 |
KEGGi | hsa:60626 |
UCSCi | uc001lof.5, human [Q9NPQ8-1] |
Organism-specific databases
CTDi | 60626 |
DisGeNETi | 60626 |
EuPathDBi | HostDB:ENSG00000177963.12 |
GeneCardsi | RIC8A |
HGNCi | HGNC:29550, RIC8A |
HPAi | ENSG00000177963, Low tissue specificity |
MIMi | 609146, gene |
neXtProti | NX_Q9NPQ8 |
OpenTargetsi | ENSG00000177963 |
PharmGKBi | PA142671067 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4464, Eukaryota |
GeneTreei | ENSGT00390000014700 |
HOGENOMi | CLU_018602_1_0_1 |
InParanoidi | Q9NPQ8 |
OMAi | NQEHSQS |
OrthoDBi | 1110075at2759 |
PhylomeDBi | Q9NPQ8 |
TreeFami | TF314907 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPQ8 |
Miscellaneous databases
BioGRID-ORCSi | 60626, 58 hits in 843 CRISPR screens |
ChiTaRSi | RIC8A, human |
GeneWikii | RIC8A |
GenomeRNAii | 60626 |
Pharosi | Q9NPQ8, Tbio |
PROi | PR:Q9NPQ8 |
RNActi | Q9NPQ8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177963, Expressed in testis and 233 other tissues |
ExpressionAtlasi | Q9NPQ8, baseline and differential |
Genevisiblei | Q9NPQ8, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR019318, Gua_nucleotide_exch_fac_Ric8 IPR008376, Synembryn |
PANTHERi | PTHR12425, PTHR12425, 1 hit |
Pfami | View protein in Pfam PF10165, Ric8, 1 hit |
PRINTSi | PR01802, SYNEMBRYN |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIC8A_HUMAN | |
Accessioni | Q9NPQ8Primary (citable) accession number: Q9NPQ8 Secondary accession number(s): Q0P508 Q9H9E7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | October 5, 2010 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM