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UniProtKB - Q9NPQ8 (RIC8A_HUMAN)

Entry version 145 (10 Feb 2021)
Sequence version 3 (05 Oct 2010)
Previous versions | rss
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Protein

Synembryn-A

Gene

RIC8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NPQ8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synembryn-A
Alternative name(s):
Protein Ric-8A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIC8A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29550, RIC8A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609146, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPQ8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000177963.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		60626

Open Targets

More...OpenTargetsi		ENSG00000177963

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671067

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NPQ8, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4296100

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RIC8A

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153562

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002358901 – 531Synembryn-AAdd BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei436PhosphoserineCombined sources1
Modified residuei441PhosphothreonineCombined sources1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei502PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NPQ8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NPQ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NPQ8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NPQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPQ8

PeptideAtlas

More...PeptideAtlasi		Q9NPQ8

PRoteomics IDEntifications database

More...PRIDEi		Q9NPQ8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82040 [Q9NPQ8-1]
82041 [Q9NPQ8-2]
82042 [Q9NPQ8-3]
82043 [Q9NPQ8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NPQ8

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NPQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NPQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177963, Expressed in testis and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NPQ8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPQ8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000177963, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121946, 54 interactors

Protein interaction database and analysis system

More...IntActi		Q9NPQ8, 40 interactors

Molecular INTeraction database

More...MINTi		Q9NPQ8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000325941

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NPQ8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NPQ8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synembryn family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4464, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018602_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPQ8

Identification of Orthologs from Complete Genome Data

More...OMAi		NQEHSQS

Database of Orthologous Groups

More...OrthoDBi		1110075at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPQ8

TreeFam database of animal gene trees

More...TreeFami		TF314907

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR019318, Gua_nucleotide_exch_fac_Ric8
IPR008376, Synembryn

The PANTHER Classification System

More...PANTHERi		PTHR12425, PTHR12425, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10165, Ric8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01802, SYNEMBRYN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL 
        60         70         80         90        100
VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV 
       110        120        130        140        150
SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL 
       160        170        180        190        200
YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL 
       210        220        230        240        250
GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV DEEDAALYRH 
       260        270        280        290        300
LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST 
       310        320        330        340        350
EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK 
       360        370        380        390        400
FLKAQVLPPL RDVRTRPEVG EMLRNKLVRL MTHLDTDVKR VAAEFLFVLC 
       410        420        430        440        450
SESVPRFIKY TGYGNAAGLL AARGLMAGGR PEGQYSEDED TDTDEYKEAK 
       460        470        480        490        500
ASINPVTGRV EEKPPNPMEG MTEEQKEHEA MKLVTMFDKL SRNRVIQPMG 
       510        520        530 
MSPRGHLTSL QDAMCETMEQ QLSSDPDSDP D
Length:531
Mass (Da):59,710
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BAF3E2791F6E021
GO
Isoform 2 (identifier: Q9NPQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: MEPRAVAEAV...FDDAQQEDRK → MMPNRRTGRW...WWSRSSPCPQ

Show »
Length:525
Mass (Da):58,943
Checksum:i823D0B28817F594D
GO
Isoform 3 (identifier: Q9NPQ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: A → AQGWPPP

Show »
Length:537
Mass (Da):60,372
Checksum:iC46E2F66B44DE40D
GO
Isoform 4 (identifier: Q9NPQ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: Missing.

Show »
Length:530
Mass (Da):59,612
Checksum:i46ED334ED07C9EA8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC88H0YC88_HUMAN
Synembryn-A
RIC8A
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE35H0YE35_HUMAN
Synembryn-A
RIC8A
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEN0H0YEN0_HUMAN
Synembryn-A
RIC8A
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSI0E9PSI0_HUMAN
Synembryn-A
RIC8A
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMP0E9PMP0_HUMAN
Synembryn-A
RIC8A
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI04E9PI04_HUMAN
Synembryn-A
RIC8A
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLE5E9PLE5_HUMAN
Synembryn-A
RIC8A
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14282 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14282 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15653 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55126 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48E → V in BAB55126 (PubMed:14702039).Curated1
Sequence conflicti405P → L in CAD98025 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0185071 – 44MEPRA…QEDRK → MMPNRRTGRWVLAQGVKGQG RVAPGRRAWWSRSSPCPQ in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_039849209Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_018508354A → AQGWPPP in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136935 mRNA Translation: CAB66869.1
AK022870 mRNA Translation: BAB14282.1 Sequence problems.
AK027090 mRNA Translation: BAB15653.1 Different initiation.
AK027461 mRNA Translation: BAB55126.1 Frameshift.
AL390088 mRNA Translation: CAB98211.1
BX538115 mRNA Translation: CAD98025.1
AC069287 Genomic DNA No translation available.
BC011821 mRNA Translation: AAH11821.2
BC111499 mRNA Translation: AAI11500.1
BC121807 mRNA Translation: AAI21808.1
BC121808 mRNA Translation: AAI21809.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS65982.1 [Q9NPQ8-1]
CCDS7690.1 [Q9NPQ8-3]

NCBI Reference Sequences

More...RefSeqi		NP_001273063.1, NM_001286134.1 [Q9NPQ8-1]
NP_068751.4, NM_021932.5 [Q9NPQ8-3]
XP_016873596.1, XM_017018107.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3]
ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1]
ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		60626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:60626

UCSC genome browser

More...UCSCi		uc001lof.5, human [Q9NPQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136935 mRNA Translation: CAB66869.1
AK022870 mRNA Translation: BAB14282.1 Sequence problems.
AK027090 mRNA Translation: BAB15653.1 Different initiation.
AK027461 mRNA Translation: BAB55126.1 Frameshift.
AL390088 mRNA Translation: CAB98211.1
BX538115 mRNA Translation: CAD98025.1
AC069287 Genomic DNA No translation available.
BC011821 mRNA Translation: AAH11821.2
BC111499 mRNA Translation: AAI11500.1
BC121807 mRNA Translation: AAI21808.1
BC121808 mRNA Translation: AAI21809.1
CCDSiCCDS65982.1 [Q9NPQ8-1]
CCDS7690.1 [Q9NPQ8-3]
RefSeqiNP_001273063.1, NM_001286134.1 [Q9NPQ8-1]
NP_068751.4, NM_021932.5 [Q9NPQ8-3]
XP_016873596.1, XM_017018107.1

3D structure databases

SMRiQ9NPQ8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121946, 54 interactors
IntActiQ9NPQ8, 40 interactors
MINTiQ9NPQ8
STRINGi9606.ENSP00000325941

Chemistry databases

ChEMBLiCHEMBL4296100

PTM databases

iPTMnetiQ9NPQ8
MetOSiteiQ9NPQ8
PhosphoSitePlusiQ9NPQ8

Genetic variation databases

BioMutaiRIC8A
DMDMi308153562

Proteomic databases

EPDiQ9NPQ8
jPOSTiQ9NPQ8
MassIVEiQ9NPQ8
MaxQBiQ9NPQ8
PaxDbiQ9NPQ8
PeptideAtlasiQ9NPQ8
PRIDEiQ9NPQ8
ProteomicsDBi82040 [Q9NPQ8-1]
82041 [Q9NPQ8-2]
82042 [Q9NPQ8-3]
82043 [Q9NPQ8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22381, 264 antibodies

The DNASU plasmid repository

More...DNASUi		60626

Genome annotation databases

EnsembliENST00000325207; ENSP00000325941; ENSG00000177963 [Q9NPQ8-3]
ENST00000526104; ENSP00000432008; ENSG00000177963 [Q9NPQ8-1]
ENST00000527696; ENSP00000434833; ENSG00000177963 [Q9NPQ8-2]
GeneIDi60626
KEGGihsa:60626
UCSCiuc001lof.5, human [Q9NPQ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		60626
DisGeNETi60626

GeneCards: human genes, protein and diseases

More...GeneCardsi		RIC8A
HGNCiHGNC:29550, RIC8A
HPAiENSG00000177963, Low tissue specificity
MIMi609146, gene
neXtProtiNX_Q9NPQ8
OpenTargetsiENSG00000177963
PharmGKBiPA142671067
VEuPathDBiHostDB:ENSG00000177963.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4464, Eukaryota
GeneTreeiENSGT00390000014700
HOGENOMiCLU_018602_1_0_1
InParanoidiQ9NPQ8
OMAiNQEHSQS
OrthoDBi1110075at2759
PhylomeDBiQ9NPQ8
TreeFamiTF314907

Enzyme and pathway databases

PathwayCommonsiQ9NPQ8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		60626, 59 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RIC8A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RIC8A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		60626
PharosiQ9NPQ8, Tbio

Protein Ontology

More...PROi		PR:Q9NPQ8
RNActiQ9NPQ8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000177963, Expressed in testis and 233 other tissues
ExpressionAtlasiQ9NPQ8, baseline and differential
GenevisibleiQ9NPQ8, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR019318, Gua_nucleotide_exch_fac_Ric8
IPR008376, Synembryn
PANTHERiPTHR12425, PTHR12425, 1 hit
PfamiView protein in Pfam
PF10165, Ric8, 1 hit
PRINTSiPR01802, SYNEMBRYN
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIC8A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPQ8
Secondary accession number(s): Q0P508
, Q2T9J1, Q7Z352, Q96EZ1, Q96SZ2, Q9H064, Q9H5H3, Q9H9E7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: February 10, 2021
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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