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Entry version 163 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Inward rectifier potassium channel 16

Gene

KCNJ16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules (PubMed:24561201).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei161Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NPI9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-1296067, Potassium transport channels
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.2.1.11, the inward rectifier k(+) channel (irk-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inward rectifier potassium channel 16
Alternative name(s):
Inward rectifier K(+) channel Kir5.1
Potassium channel, inwardly rectifying subfamily J member 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNJ16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000153822.13

Human Gene Nomenclature Database

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HGNCi
HGNC:6262, KCNJ16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605722, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 70CytoplasmicBy similarityAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei71 – 95Helical; Name=M1By similarityAdd BLAST25
Topological domaini96 – 117ExtracellularBy similarityAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei118 – 129Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei130 – 136Pore-formingBy similarity7
Topological domaini137 – 145ExtracellularBy similarity9
Transmembranei146 – 167Helical; Name=M2By similarityAdd BLAST22
Topological domaini168 – 418CytoplasmicBy similarityAdd BLAST251

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3773

Open Targets

More...
OpenTargetsi
ENSG00000153822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30047

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NPI9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNJ16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13878562

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001549751 – 418Inward rectifier potassium channel 16Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei373PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NPI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NPI9

PeptideAtlas

More...
PeptideAtlasi
Q9NPI9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NPI9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82023

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NPI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153822, Expressed in adult mammalian kidney and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NPI9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NPI9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000153822, Tissue enhanced (kidney, parathyroid gland, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with Kir4.1/KCNJ10; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. As a heterodimer with KCNJ10, may interact with MAGI1; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (PubMed:24561201). May form heterodimers with Kir2.1/KCNJ2 (Probable).

1 Publication1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109975, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9NPI9, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9NPI9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000465295

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NPI9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NPI9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi131 – 136Selectivity filterBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3827, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222323

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022738_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NPI9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NPI9

TreeFam database of animal gene trees

More...
TreeFami
TF313676

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1400, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014756, Ig_E-set
IPR041647, IRK_C
IPR016449, K_chnl_inward-rec_Kir
IPR008061, K_chnl_inward-rec_Kir5
IPR013518, K_chnl_inward-rec_Kir_cyto
IPR040445, Kir_TM

The PANTHER Classification System

More...
PANTHERi
PTHR11767, PTHR11767, 1 hit
PTHR11767:SF24, PTHR11767:SF24, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01007, IRK, 1 hit
PF17655, IRK_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005465, GIRK_kir, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01678, KIR5CHANNEL
PR01320, KIRCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296, SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NPI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI
60 70 80 90 100
FGEWGSYVVD IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG
110 120 130 140 150
DLLNDPDITP CVDNVHSFTG AFLFSLETQT TIGYGYRCVT EECSVAVLMV
160 170 180 190 200
ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM
210 220 230 240 250
WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL VNDQIILVTP
260 270 280 290 300
VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV
310 320 330 340 350
PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ
360 370 380 390 400
LHIEKAPPVR ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET
410
PYQKALLTLN RISVESQM
Length:418
Mass (Da):47,949
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E241B4C15CBD264
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJR9K7EJR9_HUMAN
Inward rectifier potassium channel ...
KCNJ16 hCG_1643520
453Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPW9K7EPW9_HUMAN
Inward rectifier potassium channel ...
KCNJ16
457Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELL5K7ELL5_HUMAN
Inward rectifier potassium channel ...
KCNJ16
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKJ4K7EKJ4_HUMAN
Inward rectifier potassium channel ...
KCNJ16
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02451011I → V. Corresponds to variant dbSNP:rs9302912Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF179353 mRNA Translation: AAG09401.1
AF153814 Genomic DNA Translation: AAF73244.1
AF153815 mRNA Translation: AAF73238.1
AF153816 mRNA Translation: AAF73239.1
AF153817 mRNA Translation: AAF73240.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11687.1
CCDS74141.1

NCBI Reference Sequences

More...
RefSeqi
NP_001257351.1, NM_001270422.1
NP_001278551.1, NM_001291622.1
NP_001278552.1, NM_001291623.1
NP_001278553.1, NM_001291624.1
NP_001278554.1, NM_001291625.1
NP_061128.2, NM_018658.2
NP_733937.2, NM_170741.2
NP_733938.2, NM_170742.2
XP_011523083.1, XM_011524781.2
XP_016880102.1, XM_017024613.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283936; ENSP00000283936; ENSG00000153822
ENST00000392670; ENSP00000376438; ENSG00000153822
ENST00000392671; ENSP00000376439; ENSG00000153822
ENST00000589377; ENSP00000465967; ENSG00000153822
ENST00000615244; ENSP00000479817; ENSG00000153822

Database of genes from NCBI RefSeq genomes

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GeneIDi
3773

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3773

UCSC genome browser

More...
UCSCi
uc002jin.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179353 mRNA Translation: AAG09401.1
AF153814 Genomic DNA Translation: AAF73244.1
AF153815 mRNA Translation: AAF73238.1
AF153816 mRNA Translation: AAF73239.1
AF153817 mRNA Translation: AAF73240.1
CCDSiCCDS11687.1
CCDS74141.1
RefSeqiNP_001257351.1, NM_001270422.1
NP_001278551.1, NM_001291622.1
NP_001278552.1, NM_001291623.1
NP_001278553.1, NM_001291624.1
NP_001278554.1, NM_001291625.1
NP_061128.2, NM_018658.2
NP_733937.2, NM_170741.2
NP_733938.2, NM_170742.2
XP_011523083.1, XM_011524781.2
XP_016880102.1, XM_017024613.1

3D structure databases

SMRiQ9NPI9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109975, 1 interactor
IntActiQ9NPI9, 2 interactors
MINTiQ9NPI9
STRINGi9606.ENSP00000465295

Protein family/group databases

TCDBi1.A.2.1.11, the inward rectifier k(+) channel (irk-c) family

PTM databases

PhosphoSitePlusiQ9NPI9

Polymorphism and mutation databases

BioMutaiKCNJ16
DMDMi13878562

Proteomic databases

MassIVEiQ9NPI9
PaxDbiQ9NPI9
PeptideAtlasiQ9NPI9
PRIDEiQ9NPI9
ProteomicsDBi82023

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31886, 157 antibodies

The DNASU plasmid repository

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DNASUi
3773

Genome annotation databases

EnsembliENST00000283936; ENSP00000283936; ENSG00000153822
ENST00000392670; ENSP00000376438; ENSG00000153822
ENST00000392671; ENSP00000376439; ENSG00000153822
ENST00000589377; ENSP00000465967; ENSG00000153822
ENST00000615244; ENSP00000479817; ENSG00000153822
GeneIDi3773
KEGGihsa:3773
UCSCiuc002jin.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3773
DisGeNETi3773
EuPathDBiHostDB:ENSG00000153822.13

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNJ16
HGNCiHGNC:6262, KCNJ16
HPAiENSG00000153822, Tissue enhanced (kidney, parathyroid gland, thyroid gland)
MIMi605722, gene
neXtProtiNX_Q9NPI9
OpenTargetsiENSG00000153822
PharmGKBiPA30047

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3827, Eukaryota
GeneTreeiENSGT01010000222323
HOGENOMiCLU_022738_3_2_1
InParanoidiQ9NPI9
PhylomeDBiQ9NPI9
TreeFamiTF313676

Enzyme and pathway databases

PathwayCommonsiQ9NPI9
ReactomeiR-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-1296067, Potassium transport channels
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
3773, 6 hits in 841 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNJ16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3773
PharosiQ9NPI9, Tbio

Protein Ontology

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PROi
PR:Q9NPI9
RNActiQ9NPI9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000153822, Expressed in adult mammalian kidney and 158 other tissues
ExpressionAtlasiQ9NPI9, baseline and differential
GenevisibleiQ9NPI9, HS

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756, Ig_E-set
IPR041647, IRK_C
IPR016449, K_chnl_inward-rec_Kir
IPR008061, K_chnl_inward-rec_Kir5
IPR013518, K_chnl_inward-rec_Kir_cyto
IPR040445, Kir_TM
PANTHERiPTHR11767, PTHR11767, 1 hit
PTHR11767:SF24, PTHR11767:SF24, 1 hit
PfamiView protein in Pfam
PF01007, IRK, 1 hit
PF17655, IRK_C, 1 hit
PIRSFiPIRSF005465, GIRK_kir, 1 hit
PRINTSiPR01678, KIR5CHANNEL
PR01320, KIRCHANNEL
SUPFAMiSSF81296, SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCJ16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: December 2, 2020
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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