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UniProtKB - Q9NPI8 (FANCF_HUMAN)

Entry version 170 (25 May 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Fanconi anemia group F protein

Gene

FANCF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NPI8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6783310, Fanconi Anemia Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NPI8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NPI8

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q9NPI8, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi anemia group F protein
Short name:
Protein FACF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FANCF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3587, FANCF

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613897, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPI8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183161

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fanconi anemia complementation group F (FANCF)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi209L → R: Reduced monoubiquitination of FANCD2. 1 Publication1
Mutagenesisi251F → R: Reduced monoubiquitination of FANCD2. 1 Publication1
Mutagenesisi287Y → A: Strongly reduced monoubiquitination of FANCD2; when associated with A-289; A-339; A-341 and A-344. 1 Publication1
Mutagenesisi289L → A: Strongly reduced monoubiquitination of FANCD2; when associated with A-287; A-339; A-341 and A-344. 1 Publication1
Mutagenesisi339F → A: Strongly reduced monoubiquitination of FANCD2; when associated with A-287; A-289; A-341 and A-344. 1 Publication1
Mutagenesisi341V → A: Strongly reduced monoubiquitination of FANCD2; when associated with A-287; A-289; A-339 and A-344. 1 Publication1
Mutagenesisi344L → A: Strongly reduced monoubiquitination of FANCD2; when associated with A-287; A-289; A-339 and A-341. 1 Publication1

Keywords - Diseasei

Fanconi anemia

Organism-specific databases

DisGeNET

More...DisGeNETi		2188

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		FANCF

MalaCards human disease database

More...MalaCardsi		FANCF
MIMi603467, phenotype

Open Targets

More...OpenTargetsi		ENSG00000183161

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		84, Fanconi anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28001

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NPI8, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2157856

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FANCF

Domain mapping of disease mutations (DMDM)

More...DMDMi		23821547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000871881 – 374Fanconi anemia group F proteinAdd BLAST374

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NPI8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NPI8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NPI8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NPI8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPI8

PeptideAtlas

More...PeptideAtlasi		Q9NPI8

PRoteomics IDEntifications database

More...PRIDEi		Q9NPI8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82022

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NPI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NPI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183161, Expressed in forebrain and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NPI8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPI8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183161, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. In complex with FANCA, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108483, 22 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6263, Fanconi anemia ubiquitin ligase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NPI8

Protein interaction database and analysis system

More...IntActi		Q9NPI8, 12 interactors

Molecular INTeraction database

More...MINTi		Q9NPI8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000330875

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NPI8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NPI8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NPI8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NPI8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NPI8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S2Z3, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005623

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_770617_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPI8

Identification of Orthologs from Complete Genome Data

More...OMAi		LQWARYL

Database of Orthologous Groups

More...OrthoDBi		1404593at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPI8

TreeFam database of animal gene trees

More...TreeFami		TF332957

Family and domain databases

Database of protein disorder

More...DisProti		DP02782

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035428, FANCF
IPR038505, FANCF_C_sf

The PANTHER Classification System

More...PANTHERi		PTHR14449, PTHR14449, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11107, FANCF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NPI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLLQHLDR FSELLAVSST TYVSTWDPAT VRRALQWARY LRHIHRRFGR 
        60         70         80         90        100
HGPIRTALER RLHNQWRQEG GFGRGPVPGL ANFQALGHCD VLLSLRLLEN 
       110        120        130        140        150
RALGDAARYH LVQQLFPGPG VRDADEETLQ ESLARLARRR SAVHMLRFNG 
       160        170        180        190        200
YRENPNLQED SLMKTQAELL LERLQEVGKA EAERPARFLS SLWERLPQNN 
       210        220        230        240        250
FLKVIAVALL QPPLSRRPQE ELEPGIHKSP GEGSQVLVHW LLGNSEVFAA 
       260        270        280        290        300
FCRALPAGLL TLVTSRHPAL SPVYLGLLTD WGQRLHYDLQ KGIWVGTESQ 
       310        320        330        340        350
DVPWEELHNR FQSLCQAPPP LKDKVLTALE TCKAQDGDFE VPGLSIWTDL 
       360        370 
LLALRSGAFR KRQVLGLSAG LSSV
Length:374
Mass (Da):42,254
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F295CD1FBE6ED7D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050988295V → I. Corresponds to variant dbSNP:rs7103293EnsemblClinVar.1
Natural variantiVAR_022270320P → L1 PublicationCorresponds to variant dbSNP:rs45451294EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF181995 mRNA Translation: AAF26298.1
AF181994 mRNA Translation: AAF26297.1
AK023153 mRNA Translation: BAB14433.1
AY928335 Genomic DNA Translation: AAX09677.1
BC047028 mRNA Translation: AAH47028.1
BC093867 mRNA Translation: AAH93867.1
BC101807 mRNA Translation: AAI01808.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7857.1

NCBI Reference Sequences

More...RefSeqi		NP_073562.1, NM_022725.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327470.6; ENSP00000330875.3; ENSG00000183161.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2188

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000327470.6; ENSP00000330875.3; NM_022725.4; NP_073562.1

UCSC genome browser

More...UCSCi		uc001mql.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Fanconi Anemia Mutation Database
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181995 mRNA Translation: AAF26298.1
AF181994 mRNA Translation: AAF26297.1
AK023153 mRNA Translation: BAB14433.1
AY928335 Genomic DNA Translation: AAX09677.1
BC047028 mRNA Translation: AAH47028.1
BC093867 mRNA Translation: AAH93867.1
BC101807 mRNA Translation: AAI01808.1
CCDSiCCDS7857.1
RefSeqiNP_073562.1, NM_022725.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IQCX-ray2.40A156-357[»]
7KZPelectron microscopy3.10F1-374[»]
7KZQelectron microscopy4.20F1-374[»]
7KZRelectron microscopy4.20F1-374[»]
7KZSelectron microscopy4.20F1-374[»]
7KZTelectron microscopy4.20F1-374[»]
7KZVelectron microscopy4.20F1-374[»]
AlphaFoldDBiQ9NPI8
SMRiQ9NPI8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108483, 22 interactors
ComplexPortaliCPX-6263, Fanconi anemia ubiquitin ligase complex
CORUMiQ9NPI8
IntActiQ9NPI8, 12 interactors
MINTiQ9NPI8
STRINGi9606.ENSP00000330875

Chemistry databases

BindingDBiQ9NPI8
ChEMBLiCHEMBL2157856

Protein family/group databases

MoonDBiQ9NPI8, Predicted

PTM databases

iPTMnetiQ9NPI8
PhosphoSitePlusiQ9NPI8

Genetic variation databases

BioMutaiFANCF
DMDMi23821547

Proteomic databases

EPDiQ9NPI8
jPOSTiQ9NPI8
MassIVEiQ9NPI8
MaxQBiQ9NPI8
PaxDbiQ9NPI8
PeptideAtlasiQ9NPI8
PRIDEiQ9NPI8
ProteomicsDBi82022

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25340, 191 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		2188

Genome annotation databases

EnsembliENST00000327470.6; ENSP00000330875.3; ENSG00000183161.6
GeneIDi2188
KEGGihsa:2188
MANE-SelectiENST00000327470.6; ENSP00000330875.3; NM_022725.4; NP_073562.1
UCSCiuc001mql.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2188
DisGeNETi2188

GeneCards: human genes, protein and diseases

More...GeneCardsi		FANCF
GeneReviewsiFANCF
HGNCiHGNC:3587, FANCF
HPAiENSG00000183161, Low tissue specificity
MalaCardsiFANCF
MIMi603467, phenotype
613897, gene
neXtProtiNX_Q9NPI8
OpenTargetsiENSG00000183161
Orphaneti84, Fanconi anemia
PharmGKBiPA28001
VEuPathDBiHostDB:ENSG00000183161

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S2Z3, Eukaryota
GeneTreeiENSGT00390000005623
HOGENOMiCLU_770617_0_0_1
InParanoidiQ9NPI8
OMAiLQWARYL
OrthoDBi1404593at2759
PhylomeDBiQ9NPI8
TreeFamiTF332957

Enzyme and pathway databases

PathwayCommonsiQ9NPI8
ReactomeiR-HSA-6783310, Fanconi Anemia Pathway
SignaLinkiQ9NPI8
SIGNORiQ9NPI8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2188, 133 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FANCF, human
EvolutionaryTraceiQ9NPI8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FANCF

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2188
PharosiQ9NPI8, Tchem

Protein Ontology

More...PROi		PR:Q9NPI8
RNActiQ9NPI8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183161, Expressed in forebrain and 195 other tissues
ExpressionAtlasiQ9NPI8, baseline and differential
GenevisibleiQ9NPI8, HS

Family and domain databases

DisProtiDP02782
Gene3Di1.25.40.490, 1 hit
InterProiView protein in InterPro
IPR035428, FANCF
IPR038505, FANCF_C_sf
PANTHERiPTHR14449, PTHR14449, 1 hit
PfamiView protein in Pfam
PF11107, FANCF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFANCF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPI8
Secondary accession number(s): Q52LM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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