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Entry version 110 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Lysine-rich coiled-coil protein 1

Gene

KRCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-rich coiled-coil protein 1
Alternative name(s):
Cryptogenic hepatitis-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRCC1
Synonyms:CHBP2
ORF Names:BM-003, BM-044
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28039 KRCC1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPI7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000172086

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393681

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRCC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734308

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003063961 – 259Lysine-rich coiled-coil protein 1Add BLAST259

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NPI7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NPI7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NPI7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NPI7

PeptideAtlas

More...
PeptideAtlasi
Q9NPI7

PRoteomics IDEntifications database

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PRIDEi
Q9NPI7

ProteomicsDB human proteome resource

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ProteomicsDBi
82021

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NPI7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NPI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172086 Expressed in 226 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NPI7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NPI7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045618
HPA052666

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119466, 3 interactors

Database of interacting proteins

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DIPi
DIP-58940N

Protein interaction database and analysis system

More...
IntActi
Q9NPI7, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9NPI7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340083

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili169 – 249Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 239Lys-richAdd BLAST86

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IV81 Eukaryota
ENOG410Y3E0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162565

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113259

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NPI7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFTRDCF

Database of Orthologous Groups

More...
OrthoDBi
1288916at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NPI7

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NPI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKHSKKTYDS FQDELEDYIK VQKARGLEPK TCFRKMKGDY LETCGYKGEV
60 70 80 90 100
NSRPTYRMFD QRLPSETIQT YPRSCNIPQT VENRLPQWLP AHDSRLRLDS
110 120 130 140 150
LSYCQFTRDC FSEKPVPLNF NQQEYICGSH GVEHRVYKHF SSDNSTSTHQ
160 170 180 190 200
ASHKQIHQKR KRHPEEGREK SEEERSKHKR KKSCEEIDLD KHKSIQRKKT
210 220 230 240 250
EVEIETVHVS TEKLKNRKEK KSRDVVSKKE ERKRTKKKKE QGQERTEEEM

LWDQSILGF
Length:259
Mass (Da):30,980
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FD963D642683F01
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI07581 differs from that shown. Reason: Frameshift at position 183.Curated
The sequence ABN71577 differs from that shown. Reason: Frameshift at position 183.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF208845 mRNA Translation: AAF64259.1
AF217520 mRNA Translation: AAF67631.1
AC108479 Genomic DNA Translation: AAY24007.1
CH471215 Genomic DNA Translation: EAW77081.1
BC015927 mRNA Translation: AAH15927.1
BC107580 mRNA Translation: AAI07581.1 Frameshift.
EF413023 mRNA Translation: ABN71577.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2000.1

NCBI Reference Sequences

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RefSeqi
NP_001291455.1, NM_001304526.1
NP_057702.1, NM_016618.2
XP_016859781.1, XM_017004292.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347055; ENSP00000340083; ENSG00000172086

Database of genes from NCBI RefSeq genomes

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GeneIDi
51315

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51315

UCSC genome browser

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UCSCi
uc002sso.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208845 mRNA Translation: AAF64259.1
AF217520 mRNA Translation: AAF67631.1
AC108479 Genomic DNA Translation: AAY24007.1
CH471215 Genomic DNA Translation: EAW77081.1
BC015927 mRNA Translation: AAH15927.1
BC107580 mRNA Translation: AAI07581.1 Frameshift.
EF413023 mRNA Translation: ABN71577.1 Frameshift.
CCDSiCCDS2000.1
RefSeqiNP_001291455.1, NM_001304526.1
NP_057702.1, NM_016618.2
XP_016859781.1, XM_017004292.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119466, 3 interactors
DIPiDIP-58940N
IntActiQ9NPI7, 6 interactors
MINTiQ9NPI7
STRINGi9606.ENSP00000340083

PTM databases

iPTMnetiQ9NPI7
PhosphoSitePlusiQ9NPI7

Polymorphism and mutation databases

BioMutaiKRCC1
DMDMi74734308

Proteomic databases

EPDiQ9NPI7
jPOSTiQ9NPI7
MaxQBiQ9NPI7
PaxDbiQ9NPI7
PeptideAtlasiQ9NPI7
PRIDEiQ9NPI7
ProteomicsDBi82021

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51315
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347055; ENSP00000340083; ENSG00000172086
GeneIDi51315
KEGGihsa:51315
UCSCiuc002sso.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51315

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRCC1
HGNCiHGNC:28039 KRCC1
HPAiHPA045618
HPA052666
neXtProtiNX_Q9NPI7
OpenTargetsiENSG00000172086
PharmGKBiPA162393681

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IV81 Eukaryota
ENOG410Y3E0 LUCA
GeneTreeiENSGT00940000162565
HOGENOMiHOG000113259
InParanoidiQ9NPI7
OMAiQFTRDCF
OrthoDBi1288916at2759
PhylomeDBiQ9NPI7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRCC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51315

Protein Ontology

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PROi
PR:Q9NPI7

Gene expression databases

BgeeiENSG00000172086 Expressed in 226 organ(s), highest expression level in colon
ExpressionAtlasiQ9NPI7 baseline and differential
GenevisibleiQ9NPI7 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRCC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPI7
Secondary accession number(s): Q3B7J7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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