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Protein

mRNA-decapping enzyme 1A

Gene

DCP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.2 Publications

GO - Molecular functioni

  • enzyme activator activity Source: InterPro
  • hydrolase activity Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • kinesin binding Source: Ensembl
  • mRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

TCDBi3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme 1A (EC:3.-.-.-)
Alternative name(s):
Smad4-interacting transcriptional co-activator
Transcription factor SMIF
Gene namesi
Name:DCP1A
Synonyms:SMIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000272886.5
HGNCiHGNC:18714 DCP1A
MIMi607010 gene
neXtProtiNX_Q9NPI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20D → A: Lowers decapping activity. 1 Publication1
Mutagenesisi59R → A: Lowers decapping activity. 1 Publication1

Organism-specific databases

DisGeNETi55802
OpenTargetsiENSG00000272886
PharmGKBiPA134931379

Polymorphism and mutation databases

BioMutaiDCP1A
DMDMi296434475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896321 – 582mRNA-decapping enzyme 1AAdd BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei179PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei348PhosphothreonineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei376Asymmetric dimethylarginineCombined sources1
Modified residuei401PhosphothreonineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei528PhosphothreonineBy similarity1
Modified residuei531PhosphothreonineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NPI6
MaxQBiQ9NPI6
PeptideAtlasiQ9NPI6
PRIDEiQ9NPI6
ProteomicsDBi82020

PTM databases

iPTMnetiQ9NPI6
PhosphoSitePlusiQ9NPI6

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000272886 Expressed in 224 organ(s), highest expression level in oocyte
CleanExiHS_DCP1A
ExpressionAtlasiQ9NPI6 baseline and differential
GenevisibleiQ9NPI6 HS

Organism-specific databases

HPAiHPA013202

Interactioni

Subunit structurei

Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3 (PubMed:16364915). Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1 (PubMed:12515382). Interacts with DCP1B (PubMed:12417715). Interacts with DCP2 (PubMed:12417715). Interacts with DDX17 in an RNA-independent manner (PubMed:21876179). Interacts with PNRC2 (PubMed:19150429). Interacts with SMAD4 (PubMed:11836524). Interacts with UPF1 (PubMed:12417715). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258). Interacts with NBDY (PubMed:27918561).8 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120914, 58 interactors
CORUMiQ9NPI6
DIPiDIP-31292N
IntActiQ9NPI6, 40 interactors
MINTiQ9NPI6

Structurei

Secondary structure

1582
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NPI6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPI6

Family & Domainsi

Sequence similaritiesi

Belongs to the DCP1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000014855
HOVERGENiHBG051320
InParanoidiQ9NPI6
KOiK12610
OrthoDBiEOG091G0JB7
PhylomeDBiQ9NPI6

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010334 Dcp1
IPR031953 mRNA_decap_C
IPR011993 PH-like_dom_sf
PANTHERiPTHR16290 PTHR16290, 1 hit
PfamiView protein in Pfam
PF06058 DCP1, 1 hit
PF16741 mRNA_decap_C, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEALSRAGQE MSLAALKQHD PYITSIADLT GQVALYTFCP KANQWEKTDI
60 70 80 90 100
EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE PVNKDLEFQL HEPFLLYRNA
110 120 130 140 150
SLSIYSIWFY DKNDCHRIAK LMADVVEEET RRSQQAARDK QSPSQANGCS
160 170 180 190 200
DHRPIDILEM LSRAKDEYER NQMGDSNISS PGLQPSTQLS NLGSTETLEE
210 220 230 240 250
MPSGSQDKSA PSGHKHLTVE ELFGTSLPKE QPAVVGLDSE EMERLPGDAS
260 270 280 290 300
QKEPNSFLPF PFEQLGGAPQ SETLGVPSAA HHSVQPEITT PVLITPASIT
310 320 330 340 350
QSNEKHAPTY TIPLSPVLSP TLPAEAPTAQ VPPSLPRNST MMQAVKTTPR
360 370 380 390 400
QRSPLLNQPV PELSHASLIA NQSPFRAPLN VTNTAGTSLP SVDLLQKLRL
410 420 430 440 450
TPQHDQIQTQ PLGKGAMVAS FSPAAGQLAT PESFIEPPSK TAAARVAASA
460 470 480 490 500
SLSNMVLAPL QSMQQNQDPE VFVQPKVLSS AIPVAGAPLV TATTTAVSSV
510 520 530 540 550
LLAPSVFQQT VTRSSDLERK ASSPSPLTIG TPESQRKPSI ILSKSQLQDT
560 570 580
LIHLIKNDSS FLSTLHEVYL QVLTKNKDNH NL
Length:582
Mass (Da):63,278
Last modified:September 12, 2018 - v3
Checksum:i26480D0B10CE7C72
GO
Isoform 2 (identifier: Q9NPI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-208: Missing.

Note: No experimental confirmation available.
Show »
Length:544
Mass (Da):59,330
Checksum:i663A28831DCA1F25
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVE6A0A087WVE6_HUMAN
mRNA-decapping enzyme 1A
DCP1A
191Annotation score:
A0A087WT55A0A087WT55_HUMAN
mRNA-decapping enzyme 1A
DCP1A
260Annotation score:
A0A087WXD0A0A087WXD0_HUMAN
mRNA-decapping enzyme 1A
DCP1A
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti483P → Q in AC097015 (PubMed:16641997).1
Sequence conflicti483P → Q in AC112218 (PubMed:16641997).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057206171 – 208Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146651 mRNA Translation: AAN62763.1
AJ275986 mRNA Translation: CAB77023.1
AK001969 mRNA Translation: BAA92008.1
AK295205 mRNA Translation: BAG58201.1
AC097015 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
BC007439 mRNA Translation: AAH07439.1
CCDSiCCDS46847.2 [Q9NPI6-1]
CCDS74946.1 [Q9NPI6-2]
RefSeqiNP_001277133.1, NM_001290204.1 [Q9NPI6-2]
NP_001277134.1, NM_001290205.1
NP_001277135.1, NM_001290206.1
NP_001277136.1, NM_001290207.1
NP_060873.4, NM_018403.6 [Q9NPI6-1]
UniGeneiHs.476353

Genome annotation databases

EnsembliENST00000294241; ENSP00000476046; ENSG00000272886 [Q9NPI6-2]
ENST00000610213; ENSP00000476386; ENSG00000272886 [Q9NPI6-1]
GeneIDi55802
KEGGihsa:55802
UCSCiuc021wzk.3 human [Q9NPI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146651 mRNA Translation: AAN62763.1
AJ275986 mRNA Translation: CAB77023.1
AK001969 mRNA Translation: BAA92008.1
AK295205 mRNA Translation: BAG58201.1
AC097015 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
BC007439 mRNA Translation: AAH07439.1
CCDSiCCDS46847.2 [Q9NPI6-1]
CCDS74946.1 [Q9NPI6-2]
RefSeqiNP_001277133.1, NM_001290204.1 [Q9NPI6-2]
NP_001277134.1, NM_001290205.1
NP_001277135.1, NM_001290206.1
NP_001277136.1, NM_001290207.1
NP_060873.4, NM_018403.6 [Q9NPI6-1]
UniGeneiHs.476353

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WX3X-ray2.31A/B/C539-582[»]
4B6HX-ray2.60A/B1-130[»]
ProteinModelPortaliQ9NPI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120914, 58 interactors
CORUMiQ9NPI6
DIPiDIP-31292N
IntActiQ9NPI6, 40 interactors
MINTiQ9NPI6

Protein family/group databases

TCDBi3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetiQ9NPI6
PhosphoSitePlusiQ9NPI6

Polymorphism and mutation databases

BioMutaiDCP1A
DMDMi296434475

Proteomic databases

EPDiQ9NPI6
MaxQBiQ9NPI6
PeptideAtlasiQ9NPI6
PRIDEiQ9NPI6
ProteomicsDBi82020

Protocols and materials databases

DNASUi55802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294241; ENSP00000476046; ENSG00000272886 [Q9NPI6-2]
ENST00000610213; ENSP00000476386; ENSG00000272886 [Q9NPI6-1]
GeneIDi55802
KEGGihsa:55802
UCSCiuc021wzk.3 human [Q9NPI6-1]

Organism-specific databases

CTDi55802
DisGeNETi55802
EuPathDBiHostDB:ENSG00000272886.5
GeneCardsiDCP1A
HGNCiHGNC:18714 DCP1A
HPAiHPA013202
MIMi607010 gene
neXtProtiNX_Q9NPI6
OpenTargetsiENSG00000272886
PharmGKBiPA134931379
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000014855
HOVERGENiHBG051320
InParanoidiQ9NPI6
KOiK12610
OrthoDBiEOG091G0JB7
PhylomeDBiQ9NPI6

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiDCP1A human
EvolutionaryTraceiQ9NPI6
GeneWikiiDCP1A
GenomeRNAii55802
PROiPR:Q9NPI6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000272886 Expressed in 224 organ(s), highest expression level in oocyte
CleanExiHS_DCP1A
ExpressionAtlasiQ9NPI6 baseline and differential
GenevisibleiQ9NPI6 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010334 Dcp1
IPR031953 mRNA_decap_C
IPR011993 PH-like_dom_sf
PANTHERiPTHR16290 PTHR16290, 1 hit
PfamiView protein in Pfam
PF06058 DCP1, 1 hit
PF16741 mRNA_decap_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCP1A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPI6
Secondary accession number(s): B4DHN9, U3KQM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 12, 2018
Last modified: November 7, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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