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Protein

Interleukin-26

Gene

IL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.3 Publications

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cytokine-mediated signaling pathway Source: Reactome
  • negative regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of cytokine secretion Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of JAK-STAT cascade Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • positive regulation of stress-activated MAPK cascade Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ9NPH9
SIGNORiQ9NPH9

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-26
Short name:
IL-26
Alternative name(s):
Protein AK155
Gene namesi
Name:IL26
Synonyms:AK155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111536.4
HGNCiHGNC:17119 IL26
MIMi605679 gene
neXtProtiNX_Q9NPH9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55801
OpenTargetsiENSG00000111536
PharmGKBiPA29826

Polymorphism and mutation databases

BioMutaiIL26
DMDMi17366984

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001538722 – 171Interleukin-26Add BLAST150

Proteomic databases

PaxDbiQ9NPH9
PeptideAtlasiQ9NPH9
PRIDEiQ9NPH9
ProteomicsDBi82013

PTM databases

iPTMnetiQ9NPH9
PhosphoSitePlusiQ9NPH9

Expressioni

Tissue specificityi

Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).1 Publication

Inductioni

By Herpesvirus saimiri infection.

Gene expression databases

BgeeiENSG00000111536
CleanExiHS_IL26
GenevisibleiQ9NPH9 HS

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi120913, 1 interactor
STRINGi9606.ENSP00000229134

Structurei

3D structure databases

ProteinModelPortaliQ9NPH9
SMRiQ9NPH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW3K Eukaryota
ENOG410ZCBR LUCA
GeneTreeiENSGT00510000049242
HOGENOMiHOG000113042
InParanoidiQ9NPH9
KOiK05446
OMAiWIKKFLE
OrthoDBiEOG091G0OVX
PhylomeDBiQ9NPH9
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
PfamiView protein in Pfam
PF00726 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA
60 70 80 90 100
WLKATIPEDR IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ
110 120 130 140 150
GCKKIRFVED FHSLRQKLSH CISCASSARE MKSITRMKRI FYRIGNKGIY
160 170
KAISELDILL SWIKKLLESS Q
Length:171
Mass (Da):19,843
Last modified:October 1, 2000 - v1
Checksum:i31F6261E42B6ACC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251550, AJ251551 Genomic DNA Translation: CAB77049.1
AJ251549 mRNA Translation: CAB76942.1
AY509906 Genomic DNA Translation: AAR87776.1
BC066270 mRNA Translation: AAH66270.1
BC066271 mRNA Translation: AAH66271.1
CCDSiCCDS8981.1
RefSeqiNP_060872.1, NM_018402.1
UniGeneiHs.272350

Genome annotation databases

EnsembliENST00000229134; ENSP00000229134; ENSG00000111536
GeneIDi55801
KEGGihsa:55801
UCSCiuc001stx.2 human

Similar proteinsi

Entry informationi

Entry nameiIL26_HUMAN
AccessioniPrimary (citable) accession number: Q9NPH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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