IL26

Functionⁱ

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.3 Publications

GO - Molecular functionⁱ

cytokine activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 10729163
cytokine-mediated signaling pathway Source: Reactome
negative regulation of epithelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078
positive regulation of cytokine secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078
positive regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078
positive regulation of JAK-STAT cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078
positive regulation of protein kinase B signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078
positive regulation of stress-activated MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854691 Interleukin-20 family signaling
SignaLinkⁱ	Q9NPH9
SIGNORⁱ	Q9NPH9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-26 Short name: IL-26 Alternative name(s): Protein AK155
Gene namesⁱ	Name:IL26 Synonyms:AK155
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111536.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17119 IL26
MIMⁱ	605679 gene
neXtProtⁱ	NX_Q9NPH9

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55801
Open Targets More...OpenTargetsⁱ	ENSG00000111536
PharmGKBⁱ	PA29826

Polymorphism and mutation databases

BioMutaⁱ	IL26
DMDMⁱ	17366984

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000015387	22 – 171	Interleukin-26Add BLAST		150

Proteomic databases

PaxDbⁱ	Q9NPH9
PeptideAtlas More...PeptideAtlasⁱ	Q9NPH9
PRIDEⁱ	Q9NPH9
ProteomicsDBⁱ	82013

PTM databases

iPTMnetⁱ	Q9NPH9
PhosphoSitePlusⁱ	Q9NPH9

Expressionⁱ

Tissue specificityⁱ

Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).1 Publication

Inductionⁱ

By Herpesvirus saimiri infection.

Gene expression databases

Bgeeⁱ	ENSG00000111536 Expressed in 27 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_IL26
Genevisibleⁱ	Q9NPH9 HS

Interactionⁱ

Subunit structureⁱ

Homodimer.

GO - Molecular functionⁱ

cytokine activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18483078

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120913, 1 interactor
STRINGⁱ	9606.ENSP00000229134

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NPH9
SMRⁱ	Q9NPH9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-10 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IW3K Eukaryota ENOG410ZCBR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049242
HOGENOMⁱ	HOG000113042
InParanoidⁱ	Q9NPH9
KEGG Orthology (KO) More...KOⁱ	K05446
OMAⁱ	WIKKFLE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OVX
PhylomeDBⁱ	Q9NPH9
TreeFamⁱ	TF333253

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR020443 IL-10/19/20/22/24/26_fam IPR020423 IL-10_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00726 IL10, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9NPH9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA 
        60         70         80         90        100
WLKATIPEDR IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ 
       110        120        130        140        150
GCKKIRFVED FHSLRQKLSH CISCASSARE MKSITRMKRI FYRIGNKGIY 
       160        170 
KAISELDILL SWIKKLLESS Q

Length:171

Mass (Da):19,843

Last modified:October 1, 2000 - v1

Checksum:ⁱ31F6261E42B6ACC0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ251550, AJ251551 Genomic DNA Translation: CAB77049.1 AJ251549 mRNA Translation: CAB76942.1 AY509906 Genomic DNA Translation: AAR87776.1 BC066270 mRNA Translation: AAH66270.1 BC066271 mRNA Translation: AAH66271.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8981.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060872.1, NM_018402.1
UniGeneⁱ	Hs.272350

Genome annotation databases

Ensemblⁱ	ENST00000229134; ENSP00000229134; ENSG00000111536
GeneIDⁱ	55801
KEGGⁱ	hsa:55801
UCSC genome browser More...UCSCⁱ	uc001stx.2 human

Protein	Similar proteins		Species	Score	Length	Source
Q9NPH9	IL26 isoform 1		PANTR		171	UniRef100_Q9NPH9
Uncharacterized protein		PANPA		171
Interleukin 26		GORGO		171

Protein	Similar proteins		Species	Score	Length	Source
Q9NPH9	IL26 isoform 1		PANTR		171	UniRef90_Q9NPH9
Uncharacterized protein		PANPA		171
Interleukin 26		GORGO		171
Uncharacterized protein		PROCO		171
Uncharacterized protein		MACMU		171
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9NPH9	IL26 isoform 1		PANTR		171	UniRef50_Q9NPH9
Uncharacterized protein		PANPA		171
Interleukin 26		GORGO		171
Uncharacterized protein		COLAP		171
Uncharacterized protein		RHIBE		171
+77

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Interleukin-26 entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ251550, AJ251551 Genomic DNA Translation: CAB77049.1 AJ251549 mRNA Translation: CAB76942.1 AY509906 Genomic DNA Translation: AAR87776.1 BC066270 mRNA Translation: AAH66270.1 BC066271 mRNA Translation: AAH66271.1
CCDSⁱ	CCDS8981.1
RefSeqⁱ	NP_060872.1, NM_018402.1
UniGeneⁱ	Hs.272350

3D structure databases

ProteinModelPortalⁱ	Q9NPH9
SMRⁱ	Q9NPH9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120913, 1 interactor
STRINGⁱ	9606.ENSP00000229134

PTM databases

iPTMnetⁱ	Q9NPH9
PhosphoSitePlusⁱ	Q9NPH9

Polymorphism and mutation databases

BioMutaⁱ	IL26
DMDMⁱ	17366984

Proteomic databases

PaxDbⁱ	Q9NPH9
PeptideAtlasⁱ	Q9NPH9
PRIDEⁱ	Q9NPH9
ProteomicsDBⁱ	82013

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55801
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000229134; ENSP00000229134; ENSG00000111536
GeneIDⁱ	55801
KEGGⁱ	hsa:55801
UCSCⁱ	uc001stx.2 human

Organism-specific databases

CTDⁱ	55801
DisGeNETⁱ	55801
EuPathDBⁱ	HostDB:ENSG00000111536.4
GeneCardsⁱ	IL26
HGNCⁱ	HGNC:17119 IL26
MIMⁱ	605679 gene
neXtProtⁱ	NX_Q9NPH9
OpenTargetsⁱ	ENSG00000111536
PharmGKBⁱ	PA29826
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW3K Eukaryota ENOG410ZCBR LUCA
GeneTreeⁱ	ENSGT00510000049242
HOGENOMⁱ	HOG000113042
InParanoidⁱ	Q9NPH9
KOⁱ	K05446
OMAⁱ	WIKKFLE
OrthoDBⁱ	EOG091G0OVX
PhylomeDBⁱ	Q9NPH9
TreeFamⁱ	TF333253

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854691 Interleukin-20 family signaling
SignaLinkⁱ	Q9NPH9
SIGNORⁱ	Q9NPH9

Miscellaneous databases

GeneWikiⁱ	Interleukin_26
GenomeRNAiⁱ	55801
Protein Ontology More...PROⁱ	PR:Q9NPH9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111536 Expressed in 27 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_IL26
Genevisibleⁱ	Q9NPH9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR020443 IL-10/19/20/22/24/26_fam IPR020423 IL-10_CS
Pfamⁱ	View protein in Pfam PF00726 IL10, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL26_HUMAN
Accessionⁱ	Q9NPH9Primary (citable) accession number: Q9NPH9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NPH9 (IL26_HUMAN)

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Interleukin-26

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ