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Protein

Odorant-binding protein 2b

Gene

OBP2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably binds and transports small hydrophobic volatile molecules.

GO - Molecular functioni

  • odorant binding Source: UniProtKB
  • small molecule binding Source: InterPro

GO - Biological processi

  • chemosensory behavior Source: ProtInc
  • sensory perception of smell Source: UniProtKB

Keywordsi

Biological processOlfaction, Sensory transduction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant-binding protein 2b
Alternative name(s):
Odorant-binding protein IIb
Short name:
OBPIIb
Gene namesi
Name:OBP2B
ORF Names:UNQ653/PRO1283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171102.14
HGNCiHGNC:23381 OBP2B
MIMi604606 gene
neXtProtiNX_Q9NPH6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171102
PharmGKBiPA134883553

Polymorphism and mutation databases

BioMutaiOBP2B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000001793816 – 170Odorant-binding protein 2bAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 166By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NPH6
PeptideAtlasiQ9NPH6
PRIDEiQ9NPH6
ProteomicsDBi82010
82011 [Q9NPH6-2]
82012 [Q9NPH6-3]
TopDownProteomicsiQ9NPH6-2 [Q9NPH6-2]
Q9NPH6-3 [Q9NPH6-3]

PTM databases

iPTMnetiQ9NPH6
PhosphoSitePlusiQ9NPH6

Expressioni

Tissue specificityi

Strongly expressed in genital sphere organs such as the prostate and mammary glands.

Gene expression databases

BgeeiENSG00000171102 Expressed in 48 organ(s), highest expression level in prostate gland
CleanExiHS_OBP2B
ExpressionAtlasiQ9NPH6 baseline and differential
GenevisibleiQ9NPH6 HS

Interactioni

Protein-protein interaction databases

BioGridi119014, 1 interactor
STRINGi9606.ENSP00000361104

Structurei

3D structure databases

ProteinModelPortaliQ9NPH6
SMRiQ9NPH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZGJ Eukaryota
ENOG4111AYP LUCA
GeneTreeiENSGT00440000033563
HOGENOMiHOG000231562
HOVERGENiHBG101411
InParanoidiQ9NPH6
PhylomeDBiQ9NPH6
TreeFamiTF338197

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002450 von_Ebner_gland
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01175 VNEBNERGLAND
SUPFAMiSSF50814 SSF50814, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Ba (identifier: Q9NPH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS
60 70 80 90 100
PVKVTALGGG KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY
110 120 130 140 150
LQELPRRDHY IFYCKDQHHG GLLHMGKLVG RNSDTNREAL EEFKKLVQRK
160 170
GLSEEDIFTP LQTGSCVPEH
Length:170
Mass (Da):19,457
Last modified:October 1, 2000 - v1
Checksum:i344FBC37E70739C1
GO
Isoform Bb (identifier: Q9NPH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-170: YGGRKLMYLQ...LQTGSCVPEH → CLSAVEMDQI...GPAPHGKACG

Show »
Length:165
Mass (Da):18,292
Checksum:i3F867F5F12F1018E
GO
Isoform Bg (identifier: Q9NPH6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-170: ITGTWYVKAM...LQTGSCVPEH → EGGSVHPEEN...GPAPHGKACG

Show »
Length:85
Mass (Da):8,946
Checksum:i1F8189B2FFFA0B2E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J395C9J395_HUMAN
Odorant-binding protein 2b
OBP2B
220Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050177167V → I. Corresponds to variant dbSNP:rs11244035Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00313925 – 170ITGTW…CVPEH → EGGSVHPEENPDAEDGGAWQ IQRLWGQEAHIPAGAAQEGP LHLLLQRPAPWGPAPHGKAC G in isoform Bg. 1 PublicationAdd BLAST146
Alternative sequenceiVSP_00313893 – 170YGGRK…CVPEH → CLSAVEMDQITPALWEALAI DTLRKLRIGTRRPRIRWGQE AHVPAGAAQEGPLHLLLQRP APWGPAPHGKACG in isoform Bb. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251025 Genomic DNA Translation: CAB71322.1
AJ251026 mRNA Translation: CAB71323.1
AJ251027 mRNA Translation: CAB71324.1
AJ251028 mRNA Translation: CAB71325.1
AY358981 mRNA Translation: AAQ89340.1
AL732364 Genomic DNA No translation available.
BC096717 mRNA Translation: AAH96717.1
BC098125 mRNA Translation: AAH98125.1
BC098151 mRNA Translation: AAH98151.1
BC098340 mRNA Translation: AAH98340.1
CCDSiCCDS6961.1 [Q9NPH6-1]
RefSeqiNP_001275916.1, NM_001288987.1 [Q9NPH6-1]
NP_055396.1, NM_014581.3 [Q9NPH6-1]
UniGeneiHs.449629

Genome annotation databases

EnsembliENST00000372034; ENSP00000361104; ENSG00000171102 [Q9NPH6-1]
ENST00000473737; ENSP00000434927; ENSG00000171102 [Q9NPH6-2]
ENST00000618116; ENSP00000484615; ENSG00000171102 [Q9NPH6-1]
ENST00000627758; ENSP00000487521; ENSG00000280584 [Q9NPH6-1]
ENST00000628865; ENSP00000486108; ENSG00000280584 [Q9NPH6-1]
ENST00000630166; ENSP00000486815; ENSG00000280584 [Q9NPH6-2]
GeneIDi29989
KEGGihsa:29989
UCSCiuc004ccz.5 human [Q9NPH6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251025 Genomic DNA Translation: CAB71322.1
AJ251026 mRNA Translation: CAB71323.1
AJ251027 mRNA Translation: CAB71324.1
AJ251028 mRNA Translation: CAB71325.1
AY358981 mRNA Translation: AAQ89340.1
AL732364 Genomic DNA No translation available.
BC096717 mRNA Translation: AAH96717.1
BC098125 mRNA Translation: AAH98125.1
BC098151 mRNA Translation: AAH98151.1
BC098340 mRNA Translation: AAH98340.1
CCDSiCCDS6961.1 [Q9NPH6-1]
RefSeqiNP_001275916.1, NM_001288987.1 [Q9NPH6-1]
NP_055396.1, NM_014581.3 [Q9NPH6-1]
UniGeneiHs.449629

3D structure databases

ProteinModelPortaliQ9NPH6
SMRiQ9NPH6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119014, 1 interactor
STRINGi9606.ENSP00000361104

PTM databases

iPTMnetiQ9NPH6
PhosphoSitePlusiQ9NPH6

Polymorphism and mutation databases

BioMutaiOBP2B

Proteomic databases

PaxDbiQ9NPH6
PeptideAtlasiQ9NPH6
PRIDEiQ9NPH6
ProteomicsDBi82010
82011 [Q9NPH6-2]
82012 [Q9NPH6-3]
TopDownProteomicsiQ9NPH6-2 [Q9NPH6-2]
Q9NPH6-3 [Q9NPH6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372034; ENSP00000361104; ENSG00000171102 [Q9NPH6-1]
ENST00000473737; ENSP00000434927; ENSG00000171102 [Q9NPH6-2]
ENST00000618116; ENSP00000484615; ENSG00000171102 [Q9NPH6-1]
ENST00000627758; ENSP00000487521; ENSG00000280584 [Q9NPH6-1]
ENST00000628865; ENSP00000486108; ENSG00000280584 [Q9NPH6-1]
ENST00000630166; ENSP00000486815; ENSG00000280584 [Q9NPH6-2]
GeneIDi29989
KEGGihsa:29989
UCSCiuc004ccz.5 human [Q9NPH6-1]

Organism-specific databases

CTDi29989
EuPathDBiHostDB:ENSG00000171102.14
GeneCardsiOBP2B
HGNCiHGNC:23381 OBP2B
MIMi604606 gene
neXtProtiNX_Q9NPH6
OpenTargetsiENSG00000171102
PharmGKBiPA134883553
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZGJ Eukaryota
ENOG4111AYP LUCA
GeneTreeiENSGT00440000033563
HOGENOMiHOG000231562
HOVERGENiHBG101411
InParanoidiQ9NPH6
PhylomeDBiQ9NPH6
TreeFamiTF338197

Miscellaneous databases

GenomeRNAii29989
PROiPR:Q9NPH6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171102 Expressed in 48 organ(s), highest expression level in prostate gland
CleanExiHS_OBP2B
ExpressionAtlasiQ9NPH6 baseline and differential
GenevisibleiQ9NPH6 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002450 von_Ebner_gland
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01175 VNEBNERGLAND
SUPFAMiSSF50814 SSF50814, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOBP2B_HUMAN
AccessioniPrimary (citable) accession number: Q9NPH6
Secondary accession number(s): Q5VSP6, Q9NY51, Q9NY52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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