Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q9NPH5 (NOX4_HUMAN)

Entry version 164 (25 May 2022)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
Add a publicationFeedback
Protein

NADPH oxidase 4

Gene

NOX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.

Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by plumbagin (By similarity). Activated by phorbol 12-myristate 13-acetate (PMA). Activated by insulin. Inhibited by diphenylene iodonium.By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NPH5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3299685, Detoxification of Reactive Oxygen Species
R-HSA-9702518, STAT5 activation downstream of FLT3 ITD mutants
R-HSA-9703465, Signaling by FLT3 fusion proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NPH5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NPH5

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		5967, HsNOx04

Transport Classification Database

More...TCDBi		5.B.1.1.2, the phagocyte (gp91(phox)) nadph oxidase family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADPH oxidase 4 (EC:1.6.3.-)
Alternative name(s):
Kidney oxidase-1
Short name:
KOX-1
Kidney superoxide-producing NADPH oxidase
Renal NAD(P)H-oxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOX4
Synonyms:RENOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7891, NOX4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605261, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPH5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000086991

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 62ExtracellularSequence analysisAdd BLAST25
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 103CytoplasmicSequence analysisAdd BLAST20
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 154ExtracellularSequence analysisAdd BLAST30
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 188CytoplasmicSequence analysisAdd BLAST13
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 424ExtracellularSequence analysisAdd BLAST215
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 578CytoplasmicSequence analysisAdd BLAST133

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi304R → RGT: Partial loss of catalytic activity. No effect on CYBA localization. 1 Publication1
Mutagenesisi575 – 578Missing : Partial loss of catalytic activity. No effect on CYBA localization. 1 Publication4

Organism-specific databases

DisGeNET

More...DisGeNETi		50507

Open Targets

More...OpenTargetsi		ENSG00000086991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31692

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NPH5, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1250375

DrugCentral

More...DrugCentrali		Q9NPH5

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		3004

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NOX4

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276447

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002389801 – 578NADPH oxidase 4Add BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 3 and isoform 4 are N-glycosylated. Isoform 4 glycosylation is required for its proper function.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NPH5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPH5

PeptideAtlas

More...PeptideAtlasi		Q9NPH5

PRoteomics IDEntifications database

More...PRIDEi		Q9NPH5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		16922
82003 [Q9NPH5-1]
82004 [Q9NPH5-2]
82005 [Q9NPH5-3]
82006 [Q9NPH5-4]
82008 [Q9NPH5-6]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NPH5, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NPH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NPH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal kidney and fetal liver.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By 7-ketocholesterol (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000086991, Expressed in calcaneal tendon and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NPH5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPH5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000086991, Tissue enriched (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with protein disulfide isomerase (By similarity).

Interacts with, relocalizes and stabilizes CYBA/p22phox.

Interacts with TLR4.

Interacts with PPP1R15A (PubMed:26742780).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119078, 23 interactors

Protein interaction database and analysis system

More...IntActi		Q9NPH5, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263317

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NPH5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NPH5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NPH5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NPH5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 303Ferric oxidoreductaseAdd BLAST246
Domaini304 – 419FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni248 – 575Mediates interaction with TLR41 PublicationAdd BLAST328

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0039, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159621

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005646_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPH5

Identification of Orthologs from Complete Genome Data

More...OMAi		FIRGTHV

Database of Orthologous Groups

More...OrthoDBi		936110at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPH5

TreeFam database of animal gene trees

More...TreeFami		TF105354

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000778, Cyt_b245_heavy_chain
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR017938, Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00466, GP91PHOX

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51384, FAD_FR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML 
        60         70         80         90        100
GLGLCLSRAS ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK 
       110        120        130        140        150
SRTFHITCGV TICIFSGVHV AAHLVNALNF SVNYSEDFVE LNAARYRDED 
       160        170        180        190        200
PRKLLFTTVP GLTGVCMVVV LFLMITASTY AIRVSNYDIF WYTHNLFFVF 
       210        220        230        240        250
YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP EYFSEHFHEP 
       260        270        280        290        300
FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY 
       310        320        330        340        350
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE 
       360        370        380        390        400
NHPFTLTMCP TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ 
       410        420        430        440        450
SRNYPKLYID GPFGSPFEES LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK 
       460        470        480        490        500
PYKLRRLYFI WVCRDIQSFR WFADLLCMLH NKFWQENRPD YVNIQLYLSQ 
       510        520        530        540        550
TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK TVGVFCCGPN 
       560        570 
SLSKTLHKLS NQNNSYGTRF EYNKESFS
Length:578
Mass (Da):66,932
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD150A92CC71DD40D
GO
Isoform 2 (identifier: Q9NPH5-2) [UniParc]FASTAAdd to basket
Also known as: Nox4A

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Show »
Length:504
Mass (Da):58,410
Checksum:i5D1ECB62CB23ED47
GO
Isoform 3 (identifier: Q9NPH5-3) [UniParc]FASTAAdd to basket
Also known as: Nox4E

The sequence of this isoform differs from the canonical sequence as follows:
     52-358: Missing.
     407-446: Missing.

Show »
Length:231
Mass (Da):27,625
Checksum:i548F872E16DC4D37
GO
Isoform 4 (identifier: Q9NPH5-4) [UniParc]FASTAAdd to basket
Also known as: 28 kDa, Nox4D

The sequence of this isoform differs from the canonical sequence as follows:
     52-358: Missing.

Show »
Length:271
Mass (Da):31,812
Checksum:i9C889BAAB7E531A2
GO
Isoform 5 (identifier: Q9NPH5-5) [UniParc]FASTAAdd to basket
Also known as: Nox4C

The sequence of this isoform differs from the canonical sequence as follows:
     211-224: GLLKYQTNLDTHPP → VQLKPKQHLGFILK
     225-578: Missing.

Show »
Length:224
Mass (Da):25,761
Checksum:i27E3A0B6890E2A67
GO
Isoform 6 (identifier: Q9NPH5-6) [UniParc]FASTAAdd to basket
Also known as: Nox4B

The sequence of this isoform differs from the canonical sequence as follows:
     407-446: Missing.

Show »
Length:538
Mass (Da):62,745
Checksum:i2E541C48425EF25B
GO
Isoform 7 (identifier: Q9NPH5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-54: LGL → ELS
     55-578: Missing.

Show »
Length:54
Mass (Da):6,516
Checksum:i2392A10568021769
GO
Isoform 8 (identifier: Q9NPH5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:554
Mass (Da):64,102
Checksum:iD7469DB8BCE92821
GO
Isoform 9 (identifier: Q9NPH5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     407-446: Missing.

Show »
Length:514
Mass (Da):59,915
Checksum:i5FFB5AA1DBE790B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR43E9PR43_HUMAN
NADPH oxidase 4
NOX4
391Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPP2E9PPP2_HUMAN
NADPH oxidase 4
NOX4
553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI95E9PI95_HUMAN
NADPH oxidase 4
NOX4
342Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti286W → C in BAH12756 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047114315M → I7 PublicationsCorresponds to variant dbSNP:rs317139Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0190521 – 74Missing in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_0538261 – 24Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_01905352 – 358Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST307
Alternative sequenceiVSP_01905452 – 54LGL → ELS in isoform 7. 1 Publication3
Alternative sequenceiVSP_01905555 – 578Missing in isoform 7. 1 PublicationAdd BLAST524
Alternative sequenceiVSP_019056211 – 224GLLKY…DTHPP → VQLKPKQHLGFILK in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_019057225 – 578Missing in isoform 5. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_019058407 – 446Missing in isoform 3, isoform 6 and isoform 9. 3 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF261943 mRNA Translation: AAF87572.1
AF254621 mRNA Translation: AAF68973.1
AB041035 mRNA Translation: BAA95695.1
AY288918 mRNA Translation: AAP41109.1
AJ704725 mRNA Translation: CAG28807.1
AJ704726 mRNA Translation: CAG28808.1
AJ704727 mRNA Translation: CAG28809.1
AJ704728 mRNA Translation: CAG28810.1
AJ704729 mRNA Translation: CAG28811.1
AK291830 mRNA Translation: BAF84519.1
AK298323 mRNA Translation: BAH12756.1
AP003400 Genomic DNA No translation available.
AP001815 Genomic DNA No translation available.
AP002404 Genomic DNA No translation available.
BC040105 mRNA Translation: AAH40105.1
BC051371 mRNA Translation: AAH51371.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44695.1 [Q9NPH5-6]
CCDS44696.1 [Q9NPH5-8]
CCDS73361.1 [Q9NPH5-9]
CCDS8285.1 [Q9NPH5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001137308.1, NM_001143836.2 [Q9NPH5-6]
NP_001137309.1, NM_001143837.1 [Q9NPH5-8]
NP_001278855.1, NM_001291926.1 [Q9NPH5-2]
NP_001278856.1, NM_001291927.1
NP_001287924.1, NM_001300995.1 [Q9NPH5-9]
NP_058627.1, NM_016931.4 [Q9NPH5-1]
XP_011541159.1, XM_011542857.2 [Q9NPH5-8]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263317.9; ENSP00000263317.4; ENSG00000086991.13
ENST00000343727.9; ENSP00000344747.5; ENSG00000086991.13 [Q9NPH5-8]
ENST00000375979.7; ENSP00000365146.3; ENSG00000086991.13 [Q9NPH5-4]
ENST00000393282.2; ENSP00000376961.2; ENSG00000086991.13 [Q9NPH5-7]
ENST00000424319.5; ENSP00000412446.1; ENSG00000086991.13 [Q9NPH5-8]
ENST00000527956.5; ENSP00000433797.1; ENSG00000086991.13 [Q9NPH5-8]
ENST00000529343.5; ENSP00000435474.1; ENSG00000086991.13 [Q9NPH5-5]
ENST00000531342.5; ENSP00000435039.1; ENSG00000086991.13 [Q9NPH5-3]
ENST00000532825.5; ENSP00000434924.1; ENSG00000086991.13 [Q9NPH5-9]
ENST00000534731.5; ENSP00000436892.1; ENSG00000086991.13 [Q9NPH5-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		50507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:50507

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000263317.9; ENSP00000263317.4; NM_016931.5; NP_058627.2

UCSC genome browser

More...UCSCi		uc001pct.4, human [Q9NPH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261943 mRNA Translation: AAF87572.1
AF254621 mRNA Translation: AAF68973.1
AB041035 mRNA Translation: BAA95695.1
AY288918 mRNA Translation: AAP41109.1
AJ704725 mRNA Translation: CAG28807.1
AJ704726 mRNA Translation: CAG28808.1
AJ704727 mRNA Translation: CAG28809.1
AJ704728 mRNA Translation: CAG28810.1
AJ704729 mRNA Translation: CAG28811.1
AK291830 mRNA Translation: BAF84519.1
AK298323 mRNA Translation: BAH12756.1
AP003400 Genomic DNA No translation available.
AP001815 Genomic DNA No translation available.
AP002404 Genomic DNA No translation available.
BC040105 mRNA Translation: AAH40105.1
BC051371 mRNA Translation: AAH51371.1
CCDSiCCDS44695.1 [Q9NPH5-6]
CCDS44696.1 [Q9NPH5-8]
CCDS73361.1 [Q9NPH5-9]
CCDS8285.1 [Q9NPH5-1]
RefSeqiNP_001137308.1, NM_001143836.2 [Q9NPH5-6]
NP_001137309.1, NM_001143837.1 [Q9NPH5-8]
NP_001278855.1, NM_001291926.1 [Q9NPH5-2]
NP_001278856.1, NM_001291927.1
NP_001287924.1, NM_001300995.1 [Q9NPH5-9]
NP_058627.1, NM_016931.4 [Q9NPH5-1]
XP_011541159.1, XM_011542857.2 [Q9NPH5-8]

3D structure databases

AlphaFoldDBiQ9NPH5
SMRiQ9NPH5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119078, 23 interactors
IntActiQ9NPH5, 3 interactors
STRINGi9606.ENSP00000263317

Chemistry databases

BindingDBiQ9NPH5
ChEMBLiCHEMBL1250375
DrugCentraliQ9NPH5
GuidetoPHARMACOLOGYi3004

Protein family/group databases

PeroxiBasei5967, HsNOx04
TCDBi5.B.1.1.2, the phagocyte (gp91(phox)) nadph oxidase family

PTM databases

GlyGeniQ9NPH5, 2 sites
iPTMnetiQ9NPH5
PhosphoSitePlusiQ9NPH5

Genetic variation databases

BioMutaiNOX4
DMDMi212276447

Proteomic databases

MassIVEiQ9NPH5
PaxDbiQ9NPH5
PeptideAtlasiQ9NPH5
PRIDEiQ9NPH5
ProteomicsDBi16922
82003 [Q9NPH5-1]
82004 [Q9NPH5-2]
82005 [Q9NPH5-3]
82006 [Q9NPH5-4]
82008 [Q9NPH5-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17747, 633 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		50507

Genome annotation databases

EnsembliENST00000263317.9; ENSP00000263317.4; ENSG00000086991.13
ENST00000343727.9; ENSP00000344747.5; ENSG00000086991.13 [Q9NPH5-8]
ENST00000375979.7; ENSP00000365146.3; ENSG00000086991.13 [Q9NPH5-4]
ENST00000393282.2; ENSP00000376961.2; ENSG00000086991.13 [Q9NPH5-7]
ENST00000424319.5; ENSP00000412446.1; ENSG00000086991.13 [Q9NPH5-8]
ENST00000527956.5; ENSP00000433797.1; ENSG00000086991.13 [Q9NPH5-8]
ENST00000529343.5; ENSP00000435474.1; ENSG00000086991.13 [Q9NPH5-5]
ENST00000531342.5; ENSP00000435039.1; ENSG00000086991.13 [Q9NPH5-3]
ENST00000532825.5; ENSP00000434924.1; ENSG00000086991.13 [Q9NPH5-9]
ENST00000534731.5; ENSP00000436892.1; ENSG00000086991.13 [Q9NPH5-6]
GeneIDi50507
KEGGihsa:50507
MANE-SelectiENST00000263317.9; ENSP00000263317.4; NM_016931.5; NP_058627.2
UCSCiuc001pct.4, human [Q9NPH5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		50507
DisGeNETi50507

GeneCards: human genes, protein and diseases

More...GeneCardsi		NOX4
HGNCiHGNC:7891, NOX4
HPAiENSG00000086991, Tissue enriched (kidney)
MIMi605261, gene
neXtProtiNX_Q9NPH5
OpenTargetsiENSG00000086991
PharmGKBiPA31692
VEuPathDBiHostDB:ENSG00000086991

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0039, Eukaryota
GeneTreeiENSGT00940000159621
HOGENOMiCLU_005646_3_1_1
InParanoidiQ9NPH5
OMAiFIRGTHV
OrthoDBi936110at2759
PhylomeDBiQ9NPH5
TreeFamiTF105354

Enzyme and pathway databases

PathwayCommonsiQ9NPH5
ReactomeiR-HSA-3299685, Detoxification of Reactive Oxygen Species
R-HSA-9702518, STAT5 activation downstream of FLT3 ITD mutants
R-HSA-9703465, Signaling by FLT3 fusion proteins
SignaLinkiQ9NPH5
SIGNORiQ9NPH5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		50507, 12 hits in 1076 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NOX4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NOX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		50507
PharosiQ9NPH5, Tchem

Protein Ontology

More...PROi		PR:Q9NPH5
RNActiQ9NPH5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000086991, Expressed in calcaneal tendon and 144 other tissues
ExpressionAtlasiQ9NPH5, baseline and differential
GenevisibleiQ9NPH5, HS

Family and domain databases

Gene3Di3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR000778, Cyt_b245_heavy_chain
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR017938, Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
PRINTSiPR00466, GP91PHOX
SUPFAMiSSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384, FAD_FR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPH5
Secondary accession number(s): A8K715
, B7Z520, E7EMD7, Q5K3R4, Q5K3R5, Q5K3R6, Q5K3R8, Q7Z7G3, Q86V92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 4, 2008
Last modified: May 25, 2022
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again