Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 receptor accessory protein

Gene

IL1RAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).By similarity2 Publications2 Publications
Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).By similarity1 Publication
Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014826 Interleukin-36 pathway
R-HSA-9014843 Interleukin-33 signaling
R-HSA-9020702 Interleukin-1 signaling
SignaLinkiQ9NPH3
SIGNORiQ9NPH3

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor accessory protein
Short name:
IL-1 receptor accessory protein
Short name:
IL-1RAcP
Alternative name(s):
Interleukin-1 receptor 3
Short name:
IL-1R-3
Short name:
IL-1R3
Gene namesi
Name:IL1RAP
Synonyms:C3orf13, IL1R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196083.9
HGNCiHGNC:5995 IL1RAP
MIMi602626 gene
neXtProtiNX_Q9NPH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 367ExtracellularSequence analysisAdd BLAST347
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 570CytoplasmicSequence analysisAdd BLAST182

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3556
OpenTargetsiENSG00000196083
PharmGKBiPA29811

Chemistry databases

GuidetoPHARMACOLOGYi1897

Polymorphism and mutation databases

BioMutaiIL1RAP
DMDMi34222652

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001545021 – 570Interleukin-1 receptor accessory proteinAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122PROSITE-ProRule annotation1 Publication
Disulfide bondi47 ↔ 114PROSITE-ProRule annotation1 Publication
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi111N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation1 Publication
Disulfide bondi160 ↔ 212PROSITE-ProRule annotation1 Publication
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi266 ↔ 332PROSITE-ProRule annotation1 Publication
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei557PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NPH3
MaxQBiQ9NPH3
PeptideAtlasiQ9NPH3
PRIDEiQ9NPH3
ProteomicsDBi81999
82000 [Q9NPH3-2]
82001 [Q9NPH3-3]
82002 [Q9NPH3-5]

PTM databases

GlyConnecti1425
iPTMnetiQ9NPH3
PhosphoSitePlusiQ9NPH3

Expressioni

Tissue specificityi

Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).7 Publications

Inductioni

Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment.2 Publications

Gene expression databases

BgeeiENSG00000196083 Expressed in 175 organ(s), highest expression level in liver
CleanExiHS_IL1RAP
ExpressionAtlasiQ9NPH3 baseline and differential
GenevisibleiQ9NPH3 HS

Organism-specific databases

HPAiHPA035293

Interactioni

Subunit structurei

The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Isoform 4 interacts with IL1R1 in a interleukin-1-dependent manner. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).By similarity1 Publication4 Publications

Protein-protein interaction databases

BioGridi109771, 20 interactors
DIPiDIP-33487N
IntActiQ9NPH3, 12 interactors
MINTiQ9NPH3

Structurei

Secondary structure

1570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NPH3
SMRiQ9NPH3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPH3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 128Ig-like C2-type 1Add BLAST108
Domaini141 – 230Ig-like C2-type 2Add BLAST90
Domaini242 – 348Ig-like C2-type 3Add BLAST107
Domaini403 – 549TIRPROSITE-ProRule annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 85Essential for interaction with PTPRDBy similarityAdd BLAST17

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119071
HOGENOMiHOG000092977
HOVERGENiHBG104298
InParanoidiQ9NPH3
KOiK04723
OMAiYGVQKIT
OrthoDBiEOG091G0GXW
PhylomeDBiQ9NPH3
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS50104 TIR, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPH3-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound IL-1RAcP, mIL-1RAcP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF
60 70 80 90 100
EHFLKFNYST AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW
110 120 130 140 150
FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY
160 170 180 190 200
IEYGIQRITC PNVDGYFPSS VKPTITWYMG CYKIQNFNNV IPEGMNLSFL
210 220 230 240 250
IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA VPPVIHSPND
260 270 280 290 300
HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE
310 320 330 340 350
SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK
360 370 380 390 400
VPAPRYTVEL ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL
410 420 430 440 450
DGKEYDIYVS YARNAEEEEF VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV
460 470 480 490 500
TDETLSFIQK SRRLLVVLSP NYVLQGTQAL LELKAGLENM ASRGNINVIL
510 520 530 540 550
VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK QLQVAMPVKK
560 570
SPRRSSSDEQ GLSYSSLKNV
Length:570
Mass (Da):65,418
Last modified:August 22, 2003 - v2
Checksum:i5F47F8D0ECA98B8A
GO
Isoform 2 (identifier: Q9NPH3-2) [UniParc]FASTAAdd to basket
Also known as: Soluble IL-1RAcP, sIL-1RAcP

The sequence of this isoform differs from the canonical sequence as follows:
     351-356: VPAPRY → GNRCGQ
     357-570: Missing.

Show »
Length:356
Mass (Da):41,019
Checksum:i39B72452C458A1C3
GO
Isoform 3 (identifier: Q9NPH3-3) [UniParc]FASTAAdd to basket
Also known as: Soluble IL-1RAcP-beta, sIL-1RAcP-beta

The sequence of this isoform differs from the canonical sequence as follows:
     302-570: ISHSRTEDET...GLSYSSLKNV → ASSKIHSGTG...PILPGSFWNR

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:346
Mass (Da):39,743
Checksum:i6F13B34E6763E062
GO
Isoform 4 (identifier: Q9NPH3-5) [UniParc]FASTAAdd to basket
Also known as: AcPb, mIL-1RAcP687

The sequence of this isoform differs from the canonical sequence as follows:
     449-570: IVTDETLSFI...GLSYSSLKNV → NTVEAVFDFI...LSNNNDFYIL

Show »
Length:687
Mass (Da):78,603
Checksum:i5489237C18503D4C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1D9C9J1D9_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
145Annotation score:
C9JT28C9JT28_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
113Annotation score:
C9J9W1C9J9W1_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
215Annotation score:
H7C3W4H7C3W4_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
193Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053383473V → M. Corresponds to variant dbSNP:rs34661910Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008052302 – 570ISHSR…SLKNV → ASSKIHSGTGLWFWSHSPAS GDSHCCLPCLLARDGPILPG SFWNR in isoform 3. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_008050351 – 356VPAPRY → GNRCGQ in isoform 2. 3 Publications6
Alternative sequenceiVSP_008051357 – 570Missing in isoform 2. 3 PublicationsAdd BLAST214
Alternative sequenceiVSP_041256449 – 570IVTDE…SLKNV → NTVEAVFDFIQRSRRMIVVL SPDYVTEKSISMLEFKLGVM CQNSIATKLIVVEYRPLEHP HPGILQLKESVSFVSWKGEK SKHSGSKFWKALRLALPLRS LSASSGWNESCSSQSDISLD HVQRRRSRLKEPPELQSSER AAGSPPAPGTMSKHRGKSSA TCRCCVTYCEGENHLRNKSR AEIHNQPQWETHLCKPVPQE SETQWIQNGTRLEPPAPQIS ALALHHFTDLSNNNDFYIL in isoform 4. 2 PublicationsAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029213 mRNA Translation: AAB84059.1
AB006537 mRNA Translation: BAA25421.1
AF167343 mRNA Translation: AAF71687.1
AF167340
, AF167335, AF167336, AF167337, AF167338, AF167339 Genomic DNA Translation: AAF71688.1
AF167342
, AF167335, AF167336, AF167337, AF167338, AF167339, AF167340, AF167341 Genomic DNA Translation: AAF71689.1
AF538730 mRNA Translation: AAQ01755.1
AF538731 mRNA Translation: AAQ01756.1
AF538732 mRNA Translation: AAQ01757.1
AF538733 mRNA Translation: AAQ01758.1
AF538734 mRNA Translation: AAQ01759.1
AF487335 mRNA Translation: AAO49451.1
EF591790 mRNA Translation: ABU90811.1
FJ998418 mRNA Translation: ACR82488.1
AC008249 Genomic DNA No translation available.
AC108747 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78100.1
CH471052 Genomic DNA Translation: EAW78102.1
BC053621 mRNA Translation: AAH53621.1
AF016261 Genomic DNA Translation: AAC39609.1
CCDSiCCDS3298.1 [Q9NPH3-1]
CCDS46982.1 [Q9NPH3-2]
CCDS54696.1 [Q9NPH3-5]
RefSeqiNP_001161400.1, NM_001167928.1 [Q9NPH3-1]
NP_001161401.1, NM_001167929.1 [Q9NPH3-1]
NP_001161402.1, NM_001167930.1 [Q9NPH3-2]
NP_001161403.1, NM_001167931.1 [Q9NPH3-5]
NP_002173.1, NM_002182.3 [Q9NPH3-1]
NP_608273.1, NM_134470.3 [Q9NPH3-2]
UniGeneiHs.478673

Genome annotation databases

EnsembliENST00000072516; ENSP00000072516; ENSG00000196083 [Q9NPH3-1]
ENST00000317757; ENSP00000314807; ENSG00000196083 [Q9NPH3-5]
ENST00000342550; ENSP00000345829; ENSG00000196083 [Q9NPH3-3]
ENST00000412504; ENSP00000412053; ENSG00000196083 [Q9NPH3-1]
ENST00000413869; ENSP00000416296; ENSG00000196083 [Q9NPH3-3]
ENST00000422485; ENSP00000409352; ENSG00000196083 [Q9NPH3-2]
ENST00000422940; ENSP00000387371; ENSG00000196083 [Q9NPH3-2]
ENST00000439062; ENSP00000401132; ENSG00000196083 [Q9NPH3-1]
ENST00000443369; ENSP00000408893; ENSG00000196083 [Q9NPH3-5]
ENST00000447382; ENSP00000390541; ENSG00000196083 [Q9NPH3-1]
GeneIDi3556
KEGGihsa:3556
UCSCiuc003fsk.4 human [Q9NPH3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029213 mRNA Translation: AAB84059.1
AB006537 mRNA Translation: BAA25421.1
AF167343 mRNA Translation: AAF71687.1
AF167340
, AF167335, AF167336, AF167337, AF167338, AF167339 Genomic DNA Translation: AAF71688.1
AF167342
, AF167335, AF167336, AF167337, AF167338, AF167339, AF167340, AF167341 Genomic DNA Translation: AAF71689.1
AF538730 mRNA Translation: AAQ01755.1
AF538731 mRNA Translation: AAQ01756.1
AF538732 mRNA Translation: AAQ01757.1
AF538733 mRNA Translation: AAQ01758.1
AF538734 mRNA Translation: AAQ01759.1
AF487335 mRNA Translation: AAO49451.1
EF591790 mRNA Translation: ABU90811.1
FJ998418 mRNA Translation: ACR82488.1
AC008249 Genomic DNA No translation available.
AC108747 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78100.1
CH471052 Genomic DNA Translation: EAW78102.1
BC053621 mRNA Translation: AAH53621.1
AF016261 Genomic DNA Translation: AAC39609.1
CCDSiCCDS3298.1 [Q9NPH3-1]
CCDS46982.1 [Q9NPH3-2]
CCDS54696.1 [Q9NPH3-5]
RefSeqiNP_001161400.1, NM_001167928.1 [Q9NPH3-1]
NP_001161401.1, NM_001167929.1 [Q9NPH3-1]
NP_001161402.1, NM_001167930.1 [Q9NPH3-2]
NP_001161403.1, NM_001167931.1 [Q9NPH3-5]
NP_002173.1, NM_002182.3 [Q9NPH3-1]
NP_608273.1, NM_134470.3 [Q9NPH3-2]
UniGeneiHs.478673

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4OX-ray3.30B21-350[»]
4DEPX-ray3.10C/F21-367[»]
ProteinModelPortaliQ9NPH3
SMRiQ9NPH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109771, 20 interactors
DIPiDIP-33487N
IntActiQ9NPH3, 12 interactors
MINTiQ9NPH3

Chemistry databases

GuidetoPHARMACOLOGYi1897

PTM databases

GlyConnecti1425
iPTMnetiQ9NPH3
PhosphoSitePlusiQ9NPH3

Polymorphism and mutation databases

BioMutaiIL1RAP
DMDMi34222652

Proteomic databases

EPDiQ9NPH3
MaxQBiQ9NPH3
PeptideAtlasiQ9NPH3
PRIDEiQ9NPH3
ProteomicsDBi81999
82000 [Q9NPH3-2]
82001 [Q9NPH3-3]
82002 [Q9NPH3-5]

Protocols and materials databases

DNASUi3556
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000072516; ENSP00000072516; ENSG00000196083 [Q9NPH3-1]
ENST00000317757; ENSP00000314807; ENSG00000196083 [Q9NPH3-5]
ENST00000342550; ENSP00000345829; ENSG00000196083 [Q9NPH3-3]
ENST00000412504; ENSP00000412053; ENSG00000196083 [Q9NPH3-1]
ENST00000413869; ENSP00000416296; ENSG00000196083 [Q9NPH3-3]
ENST00000422485; ENSP00000409352; ENSG00000196083 [Q9NPH3-2]
ENST00000422940; ENSP00000387371; ENSG00000196083 [Q9NPH3-2]
ENST00000439062; ENSP00000401132; ENSG00000196083 [Q9NPH3-1]
ENST00000443369; ENSP00000408893; ENSG00000196083 [Q9NPH3-5]
ENST00000447382; ENSP00000390541; ENSG00000196083 [Q9NPH3-1]
GeneIDi3556
KEGGihsa:3556
UCSCiuc003fsk.4 human [Q9NPH3-1]

Organism-specific databases

CTDi3556
DisGeNETi3556
EuPathDBiHostDB:ENSG00000196083.9
GeneCardsiIL1RAP
HGNCiHGNC:5995 IL1RAP
HPAiHPA035293
MIMi602626 gene
neXtProtiNX_Q9NPH3
OpenTargetsiENSG00000196083
PharmGKBiPA29811
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119071
HOGENOMiHOG000092977
HOVERGENiHBG104298
InParanoidiQ9NPH3
KOiK04723
OMAiYGVQKIT
OrthoDBiEOG091G0GXW
PhylomeDBiQ9NPH3
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014826 Interleukin-36 pathway
R-HSA-9014843 Interleukin-33 signaling
R-HSA-9020702 Interleukin-1 signaling
SignaLinkiQ9NPH3
SIGNORiQ9NPH3

Miscellaneous databases

ChiTaRSiIL1RAP human
EvolutionaryTraceiQ9NPH3
GeneWikiiIL1RAP
GenomeRNAii3556
PROiPR:Q9NPH3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196083 Expressed in 175 organ(s), highest expression level in liver
CleanExiHS_IL1RAP
ExpressionAtlasiQ9NPH3 baseline and differential
GenevisibleiQ9NPH3 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL1AP_HUMAN
AccessioniPrimary (citable) accession number: Q9NPH3
Secondary accession number(s): B1NLD0
, D3DNW0, O14915, Q86WJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again