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Entry version 160 (22 Apr 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Inositol-3-phosphate synthase 1

Gene

ISYNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.57 mM for 6-phosphate1 Publication
  2. KM=8 µM for NAD1 Publication

    pH dependencei

    Optimum pH is 8.0.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: myo-inositol biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. Inositol-3-phosphate synthase 1 (ISYNA1)
    2. Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase, Inositol-1-monophosphatase (IMPA1), Inositol monophosphatase 1 (IMPA1), Inositol monophosphatase 2 (IMPA2), Inositol-1-monophosphatase (IMPA1)
    This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • inositol-3-phosphate synthase activity Source: CACAO

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase
    Biological processInositol biosynthesis, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
    LigandNAD

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q9NPH2

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00823;UER00787

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Inositol-3-phosphate synthase 1 (EC:5.5.1.4)
    Short name:
    IPS 1
    Alternative name(s):
    Myo-inositol 1-phosphate synthase
    Short name:
    MI-1-P synthase
    Short name:
    MIP synthase
    Short name:
    hIPS
    Myo-inositol 1-phosphate synthase A1
    Short name:
    hINO1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ISYNA1
    Synonyms:INO1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:29821 ISYNA1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    611670 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NPH2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    51477

    Open Targets

    More...
    OpenTargetsi
    ENSG00000105655

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA164721116

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9NPH2 Tbio

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB01840 2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate
    DB04516 2-Deoxy-Glucitol-6-Phosphate
    DB09462 Glycerin

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ISYNA1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74734304

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003246281 – 558Inositol-3-phosphate synthase 1Add BLAST558

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-227
    CPTAC-228

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9NPH2

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9NPH2

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9NPH2

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NPH2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NPH2

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NPH2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NPH2

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    34039
    81997 [Q9NPH2-1]
    81998 [Q9NPH2-2]

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00549569

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NPH2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NPH2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon.1 Publication

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By glucose and lovastain. Up-regulation is prevented by mevalonic acid, farnesol, and geranylgeraniol. Up-regulated by E2F1.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000105655 Expressed in right testis and 208 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NPH2 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NPH2 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000105655 Tissue enhanced (testis)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Show more details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    119562, 42 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NPH2, 11 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000337746

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q9NPH2 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NPH2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0693 Eukaryota
    COG1260 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000018395

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_021486_2_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NPH2

    KEGG Orthology (KO)

    More...
    KOi
    K01858

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EGWDNID

    Database of Orthologous Groups

    More...
    OrthoDBi
    451916at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NPH2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300382

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002587 Myo-inos-1-P_Synthase
    IPR013021 Myo-inos-1-P_Synthase_GAPDH
    IPR036291 NAD(P)-bd_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11510 PTHR11510, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01658 Inos-1-P_synth, 1 hit
    PF07994 NAD_binding_5, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF015578 Myoinos-ppht_syn, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51735 SSF51735, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NPH2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEAAAQFFVE SPDVVYGPEA IEAQYEYRTT RVSREGGVLK VHPTSTRFTF
    60 70 80 90 100
    RTARQVPRLG VMLVGWGGNN GSTLTAAVLA NRLRLSWPTR SGRKEANYYG
    110 120 130 140 150
    SLTQAGTVSL GLDAEGQEVF VPFSAVLPMV APNDLVFDGW DISSLNLAEA
    160 170 180 190 200
    MRRAKVLDWG LQEQLWPHME ALRPRPSVYI PEFIAANQSA RADNLIPGSR
    210 220 230 240 250
    AQQLEQIRRD IRDFRSSAGL DKVIVLWTAN TERFCEVIPG LNDTAENLLR
    260 270 280 290 300
    TIELGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LAWQHRVFVG
    310 320 330 340 350
    GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG ENLSAPLQFR
    360 370 380 390 400
    SKEVSKSNVV DDMVQSNPVL YTPGEEPDHC VVIKYVPYVG DSKRALDEYT
    410 420 430 440 450
    SELMLGGTNT LVLHNTCEDS LLAAPIMLDL ALLTELCQRV SFCTDMDPEP
    460 470 480 490 500
    QTFHPVLSLL SFLFKAPLVP PGSPVVNALF RQRSCIENIL RACVGLPPQN
    510 520 530 540 550
    HMLLEHKMER PGPSLKRVGP VAATYPMLNK KGPVPAATNG CTGDANGHLQ

    EEPPMPTT
    Length:558
    Mass (Da):61,068
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A1009D941A5F87D
    GO
    Isoform 2 (identifier: Q9NPH2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-128: Missing.

    Show »
    Length:430
    Mass (Da):47,146
    Checksum:i8C21453E5B3E4D88
    GO
    Isoform 3 (identifier: Q9NPH2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         40-93: Missing.

    Show »
    Length:504
    Mass (Da):55,136
    Checksum:i84D7E719BBB98135
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3QS51J3QS51_HUMAN
    Inositol-3-phosphate synthase 1
    ISYNA1
    233Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KRH4J3KRH4_HUMAN
    Inositol-3-phosphate synthase 1
    ISYNA1
    177Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QRY0J3QRY0_HUMAN
    Inositol-3-phosphate synthase 1
    ISYNA1
    148Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QLD7J3QLD7_HUMAN
    Inositol-3-phosphate synthase 1
    ISYNA1
    182Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QRH1J3QRH1_HUMAN
    Inositol-3-phosphate synthase 1
    ISYNA1
    151Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QKW9J3QKW9_HUMAN
    Inositol-3-phosphate synthase 1
    ISYNA1
    46Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAP97151 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17G → S in AAP97151 (Ref. 3) Curated1
    Sequence conflicti35E → K in AAP97151 (Ref. 3) Curated1
    Sequence conflicti57P → T in AAP97151 (Ref. 3) Curated1
    Sequence conflicti82R → Q in AAP97151 (Ref. 3) Curated1
    Sequence conflicti91Missing in AAP97151 (Ref. 3) Curated1
    Sequence conflicti155K → N in AAG35698 (PubMed:12941308).Curated1
    Sequence conflicti193D → N in AAP97151 (Ref. 3) Curated1
    Sequence conflicti368P → Q in AAH66902 (PubMed:15489334).Curated1
    Sequence conflicti392S → G in AAH66902 (PubMed:15489334).Curated1
    Sequence conflicti414H → R in BAG52493 (PubMed:14702039).Curated1
    Sequence conflicti471P → R in AAH66902 (PubMed:15489334).Curated1
    Sequence conflicti514S → C in BAA91626 (PubMed:14702039).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0323241 – 128Missing in isoform 2. 1 PublicationAdd BLAST128
    Alternative sequenceiVSP_04606540 – 93Missing in isoform 3. 1 PublicationAdd BLAST54

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF207640 mRNA Translation: AAG35698.1
    AF220530 mRNA Translation: AAF26444.1
    AF220259 AF220258 Genomic DNA Translation: AAF26739.1
    AF086921 mRNA Translation: AAP97151.1 Frameshift.
    AK001325 mRNA Translation: BAA91626.1
    AK021526 mRNA Translation: BAB13837.1
    AK092179 mRNA Translation: BAG52493.1
    AL137749 mRNA Translation: CAB70904.1
    AC008397 Genomic DNA No translation available.
    CH471106 Genomic DNA Translation: EAW84703.1
    CH471106 Genomic DNA Translation: EAW84705.1
    BC004320 mRNA Translation: AAH04320.1
    BC018952 mRNA Translation: AAH18952.1
    BC066902 mRNA Translation: AAH66902.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12379.1 [Q9NPH2-1]
    CCDS54234.1 [Q9NPH2-3]
    CCDS62603.1 [Q9NPH2-2]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T46317

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001164409.1, NM_001170938.1 [Q9NPH2-3]
    NP_001240318.1, NM_001253389.1 [Q9NPH2-2]
    NP_057452.1, NM_016368.4 [Q9NPH2-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000338128; ENSP00000337746; ENSG00000105655 [Q9NPH2-1]
    ENST00000457269; ENSP00000415458; ENSG00000105655 [Q9NPH2-3]
    ENST00000578963; ENSP00000475677; ENSG00000105655 [Q9NPH2-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    51477

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:51477

    UCSC genome browser

    More...
    UCSCi
    uc002nja.3 human [Q9NPH2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF207640 mRNA Translation: AAG35698.1
    AF220530 mRNA Translation: AAF26444.1
    AF220259 AF220258 Genomic DNA Translation: AAF26739.1
    AF086921 mRNA Translation: AAP97151.1 Frameshift.
    AK001325 mRNA Translation: BAA91626.1
    AK021526 mRNA Translation: BAB13837.1
    AK092179 mRNA Translation: BAG52493.1
    AL137749 mRNA Translation: CAB70904.1
    AC008397 Genomic DNA No translation available.
    CH471106 Genomic DNA Translation: EAW84703.1
    CH471106 Genomic DNA Translation: EAW84705.1
    BC004320 mRNA Translation: AAH04320.1
    BC018952 mRNA Translation: AAH18952.1
    BC066902 mRNA Translation: AAH66902.1
    CCDSiCCDS12379.1 [Q9NPH2-1]
    CCDS54234.1 [Q9NPH2-3]
    CCDS62603.1 [Q9NPH2-2]
    PIRiT46317
    RefSeqiNP_001164409.1, NM_001170938.1 [Q9NPH2-3]
    NP_001240318.1, NM_001253389.1 [Q9NPH2-2]
    NP_057452.1, NM_016368.4 [Q9NPH2-1]

    3D structure databases

    SMRiQ9NPH2
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi119562, 42 interactors
    IntActiQ9NPH2, 11 interactors
    STRINGi9606.ENSP00000337746

    Chemistry databases

    DrugBankiDB01840 2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate
    DB04516 2-Deoxy-Glucitol-6-Phosphate
    DB09462 Glycerin

    PTM databases

    iPTMnetiQ9NPH2
    PhosphoSitePlusiQ9NPH2

    Polymorphism and mutation databases

    BioMutaiISYNA1
    DMDMi74734304

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00549569

    Proteomic databases

    CPTACiCPTAC-227
    CPTAC-228
    EPDiQ9NPH2
    jPOSTiQ9NPH2
    MassIVEiQ9NPH2
    MaxQBiQ9NPH2
    PaxDbiQ9NPH2
    PeptideAtlasiQ9NPH2
    PRIDEiQ9NPH2
    ProteomicsDBi34039
    81997 [Q9NPH2-1]
    81998 [Q9NPH2-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    28044 88 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    51477

    Genome annotation databases

    EnsembliENST00000338128; ENSP00000337746; ENSG00000105655 [Q9NPH2-1]
    ENST00000457269; ENSP00000415458; ENSG00000105655 [Q9NPH2-3]
    ENST00000578963; ENSP00000475677; ENSG00000105655 [Q9NPH2-2]
    GeneIDi51477
    KEGGihsa:51477
    UCSCiuc002nja.3 human [Q9NPH2-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    51477
    DisGeNETi51477

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ISYNA1
    HGNCiHGNC:29821 ISYNA1
    HPAiENSG00000105655 Tissue enhanced (testis)
    MIMi611670 gene
    neXtProtiNX_Q9NPH2
    OpenTargetsiENSG00000105655
    PharmGKBiPA164721116

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0693 Eukaryota
    COG1260 LUCA
    GeneTreeiENSGT00390000018395
    HOGENOMiCLU_021486_2_1_1
    InParanoidiQ9NPH2
    KOiK01858
    OMAiEGWDNID
    OrthoDBi451916at2759
    PhylomeDBiQ9NPH2
    TreeFamiTF300382

    Enzyme and pathway databases

    UniPathwayiUPA00823;UER00787
    ReactomeiR-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
    SIGNORiQ9NPH2

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ISYNA1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    51477
    PharosiQ9NPH2 Tbio

    Protein Ontology

    More...
    PROi
    PR:Q9NPH2
    RNActiQ9NPH2 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000105655 Expressed in right testis and 208 other tissues
    ExpressionAtlasiQ9NPH2 baseline and differential
    GenevisibleiQ9NPH2 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002587 Myo-inos-1-P_Synthase
    IPR013021 Myo-inos-1-P_Synthase_GAPDH
    IPR036291 NAD(P)-bd_dom_sf
    PANTHERiPTHR11510 PTHR11510, 1 hit
    PfamiView protein in Pfam
    PF01658 Inos-1-P_synth, 1 hit
    PF07994 NAD_binding_5, 1 hit
    PIRSFiPIRSF015578 Myoinos-ppht_syn, 1 hit
    SUPFAMiSSF51735 SSF51735, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINO1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPH2
    Secondary accession number(s): B3KRT1
    , G5E9U0, Q6NXT5, Q7Z525, Q9BT65, Q9H2Y2, Q9NSU0, Q9NVW7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 1, 2000
    Last modified: April 22, 2020
    This is version 160 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
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