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Protein

Lysophosphatidic acid phosphatase type 6

Gene

ACP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.2 Publications

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated
Was originally reported to be located in the mitochondrion, but the evidence seems to be weak and contradictory with the presence of a cleaved signal sequence.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei59Nucleophile1 Publication1
Active sitei335Proton donor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483166 Synthesis of PA

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001294

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase 6, lysophosphatidic
Acid phosphatase-like protein 1
PACPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACP6
Synonyms:ACPL1, LPAP
ORF Names:UNQ205/PRO231
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162836.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29609 ACP6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611471 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPH0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58R → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi59H → A: Abolishes enzyme activity. 2 Publications1
Mutagenesisi62R → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi106Y → F: Decreases enzyme activity. 1 Publication1
Mutagenesisi110Y → F: Decreases enzyme activity. 1
Mutagenesisi168R → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi257A → F or L: Decreases enzyme activity by interfering with water access to the active site cavity. 1 Publication1
Mutagenesisi257A → W: Abolishes enzyme activity by interfering with water access to the active site cavity. 1 Publication1
Mutagenesisi285S → W: Decreases activity toward substrates with medium and long aliphatic chains, but not toward substrates with short aliphatic chains. 1 Publication1
Mutagenesisi289L → W: Decreases activity toward substrates with medium and long aliphatic chains, but not toward substrates with short aliphatic chains. 1 Publication1
Mutagenesisi334H → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi335D → A: Abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51205

Open Targets

More...
OpenTargetsi
ENSG00000162836

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134930830

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373268

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 32Mitochondrion1 PublicationAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002396533 – 428Lysophosphatidic acid phosphatase type 6Add BLAST396

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NPH0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NPH0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NPH0

PeptideAtlas

More...
PeptideAtlasi
Q9NPH0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NPH0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81995
81996 [Q9NPH0-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q9NPH0

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NPH0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NPH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced with the differentiation from myoblast to myotube.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162836 Expressed in 199 organ(s), highest expression level in right uterine tube

CleanEx database of gene expression profiles

More...
CleanExi
HS_ACP6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NPH0 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028560

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119378, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NPH0, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358241

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JOBX-ray2.17A33-428[»]
4JOCX-ray2.21A33-428[»]
4JODX-ray2.21A33-428[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NPH0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NPH0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 168Substrate bindingBy similarityAdd BLAST111

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3720 Eukaryota
ENOG410ZVBQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290692

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079458

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NPH0

KEGG Orthology (KO)

More...
KOi
K14395

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVKEGMG

Database of Orthologous Groups

More...
OrthoDBi
1221585at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NPH0

TreeFam database of animal gene trees

More...
TreeFami
TF318821

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07061 HP_HAP_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1240, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00328 His_Phos_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53254 SSF53254, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGQ CPVDRSLLKL
60 70 80 90 100
KMVQVVFRHG ARSPLKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP
110 120 130 140 150
KPYSPYDSQY HETTLKGGMF AGQLTKVGMQ QMFALGERLR KNYVEDIPFL
160 170 180 190 200
SPTFNPQEVF IRSTNIFRNL ESTRCLLAGL FQCQKEGPII IHTDEADSEV
210 220 230 240 250
LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG IDSSDKVDFF
260 270 280 290 300
ILLDNVAAEQ AHNLPSCPML KRFARMIEQR AVDTSLYILP KEDRESLQMA
310 320 330 340 350
VGPFLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTFIP LLMTLGIFDH
360 370 380 390 400
KWPPFAVDLT MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN
410 420
AMSVYTLSPE KYHALCSQTQ VMEVGNEE
Length:428
Mass (Da):48,886
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CA08CFD1BB44BFA
GO
Isoform 2 (identifier: Q9NPH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-271: AHNLPSCPMLK → EKMGSCRFHGS
     272-428: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):30,790
Checksum:iFF6FF0AFF8D01144
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS36A0A0A0MS36_HUMAN
Lysophosphatidic acid phosphatase t...
ACP6
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYU6A0A087WYU6_HUMAN
Lysophosphatidic acid phosphatase t...
ACP6
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW36A0A087WW36_HUMAN
Lysophosphatidic acid phosphatase t...
ACP6
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ71V9GZ71_HUMAN
Lysophosphatidic acid phosphatase t...
ACP6
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWB7A0A087WWB7_HUMAN
Lysophosphatidic acid phosphatase t...
ACP6
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA89311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD92485 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti428E → D in CAG33382 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022678316M → V. Corresponds to variant dbSNP:rs6593795Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014121261 – 271AHNLPSCPMLK → EKMGSCRFHGS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_014122272 – 428Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB031478 mRNA Translation: BAA89311.1 Different initiation.
AB030039 mRNA Translation: BAA94309.2
KJ534759 mRNA Translation: AHW56399.1
AY358552 mRNA Translation: AAQ88916.1
AK000657 mRNA Translation: BAA91310.1
AB209248 mRNA Translation: BAD92485.1 Different initiation.
AC241644 Genomic DNA No translation available.
AC242628 Genomic DNA No translation available.
AL359207 Genomic DNA Translation: CAI15199.1
CH471223 Genomic DNA Translation: EAW50931.1
BC009965 mRNA Translation: AAH09965.1
BC034686 mRNA Translation: AAH34686.1
CR457101 mRNA Translation: CAG33382.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS928.1 [Q9NPH0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_057445.4, NM_016361.4 [Q9NPH0-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.562154

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000487562; ENSP00000481777; ENSG00000162836 [Q9NPH0-2]
ENST00000583509; ENSP00000463574; ENSG00000162836 [Q9NPH0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51205

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51205

UCSC genome browser

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UCSCi
uc001epr.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031478 mRNA Translation: BAA89311.1 Different initiation.
AB030039 mRNA Translation: BAA94309.2
KJ534759 mRNA Translation: AHW56399.1
AY358552 mRNA Translation: AAQ88916.1
AK000657 mRNA Translation: BAA91310.1
AB209248 mRNA Translation: BAD92485.1 Different initiation.
AC241644 Genomic DNA No translation available.
AC242628 Genomic DNA No translation available.
AL359207 Genomic DNA Translation: CAI15199.1
CH471223 Genomic DNA Translation: EAW50931.1
BC009965 mRNA Translation: AAH09965.1
BC034686 mRNA Translation: AAH34686.1
CR457101 mRNA Translation: CAG33382.1
CCDSiCCDS928.1 [Q9NPH0-1]
RefSeqiNP_057445.4, NM_016361.4 [Q9NPH0-1]
UniGeneiHs.562154

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JOBX-ray2.17A33-428[»]
4JOCX-ray2.21A33-428[»]
4JODX-ray2.21A33-428[»]
ProteinModelPortaliQ9NPH0
SMRiQ9NPH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119378, 22 interactors
IntActiQ9NPH0, 10 interactors
STRINGi9606.ENSP00000358241

Chemistry databases

SwissLipidsiSLP:000001294

PTM databases

DEPODiQ9NPH0
iPTMnetiQ9NPH0
PhosphoSitePlusiQ9NPH0

Polymorphism and mutation databases

BioMutaiACP6
DMDMi317373268

Proteomic databases

EPDiQ9NPH0
jPOSTiQ9NPH0
PaxDbiQ9NPH0
PeptideAtlasiQ9NPH0
PRIDEiQ9NPH0
ProteomicsDBi81995
81996 [Q9NPH0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51205
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000487562; ENSP00000481777; ENSG00000162836 [Q9NPH0-2]
ENST00000583509; ENSP00000463574; ENSG00000162836 [Q9NPH0-1]
GeneIDi51205
KEGGihsa:51205
UCSCiuc001epr.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51205
DisGeNETi51205
EuPathDBiHostDB:ENSG00000162836.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ACP6

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0000989
HGNCiHGNC:29609 ACP6
HPAiHPA028560
MIMi611471 gene
neXtProtiNX_Q9NPH0
OpenTargetsiENSG00000162836
PharmGKBiPA134930830

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3720 Eukaryota
ENOG410ZVBQ LUCA
GeneTreeiENSGT00940000158408
HOGENOMiHOG000290692
HOVERGENiHBG079458
InParanoidiQ9NPH0
KOiK14395
OMAiKVKEGMG
OrthoDBi1221585at2759
PhylomeDBiQ9NPH0
TreeFamiTF318821

Enzyme and pathway databases

ReactomeiR-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACP6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ACP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51205

Protein Ontology

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PROi
PR:Q9NPH0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162836 Expressed in 199 organ(s), highest expression level in right uterine tube
CleanExiHS_ACP6
ExpressionAtlasiQ9NPH0 baseline and differential

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPA6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPH0
Secondary accession number(s): Q59G61
, Q5T490, Q6IAQ3, Q7LG81, Q9UIG6, X5D289
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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