UniProtKB - Q9NPG8 (ZDHC4_HUMAN)
Protein
Palmitoyltransferase ZDHHC4
Gene
ZDHHC4
Organism
Homo sapiens (Human)
Status
Functioni
Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D2 dopamine receptor DRD2.1 Publication
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 179 | S-palmitoyl cysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein-cysteine S-palmitoyltransferase activity Source: GO_Central
GO - Biological processi
- peptidyl-L-cysteine S-palmitoylation Source: GO_Central
- protein targeting to membrane Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.3.1.225, 2681 |
PathwayCommonsi | Q9NPG8 |
Names & Taxonomyi
Protein namesi | Recommended name: Palmitoyltransferase ZDHHC4Curated (EC:2.3.1.2251 Publication)Alternative name(s): Zinc finger DHHC domain-containing protein 4Imported Short name: DHHC-4 Zinc finger protein 374 |
Gene namesi | ORF Names:DC1, UNQ5787/PRO19576 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18471, ZDHHC4 |
neXtProti | NX_Q9NPG8 |
VEuPathDBi | HostDB:ENSG00000136247.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 2 | Lumenal1 Publication | 2 | |
Transmembranei | 3 – 23 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 24 – 67 | Cytoplasmic1 PublicationAdd BLAST | 44 | |
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 99 | Lumenal1 PublicationAdd BLAST | 11 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 192 | Cytoplasmic1 PublicationAdd BLAST | 72 | |
Transmembranei | 193 – 213 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 214 – 255 | Lumenal1 PublicationAdd BLAST | 42 | |
Transmembranei | 256 – 276 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 277 – 344 | Cytoplasmic1 PublicationAdd BLAST | 68 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 340 | R → A: Does not affect localization to the endoplasmic reticulum. 1 Publication | 1 | |
Mutagenesisi | 341 | K → A: Does not affect localization to the endoplasmic reticulum. 1 Publication | 1 | |
Mutagenesisi | 342 | K → A: Impaired localization to the endoplasmic reticulum. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55146 |
OpenTargetsi | ENSG00000136247 |
PharmGKBi | PA38337 |
Miscellaneous databases
Pharosi | Q9NPG8, Tdark |
Genetic variation databases
BioMutai | ZDHHC4 |
DMDMi | 28202108 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212865 | 1 – 344 | Palmitoyltransferase ZDHHC4Add BLAST | 344 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
EPDi | Q9NPG8 |
jPOSTi | Q9NPG8 |
MassIVEi | Q9NPG8 |
MaxQBi | Q9NPG8 |
PaxDbi | Q9NPG8 |
PeptideAtlasi | Q9NPG8 |
PRIDEi | Q9NPG8 |
ProteomicsDBi | 81994 |
PTM databases
iPTMneti | Q9NPG8 |
PhosphoSitePlusi | Q9NPG8 |
SwissPalmi | Q9NPG8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136247, Expressed in pancreas and 209 other tissues |
ExpressionAtlasi | Q9NPG8, baseline and differential |
Genevisiblei | Q9NPG8, HS |
Organism-specific databases
HPAi | ENSG00000136247, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9NPG8
With | #Exp. | IntAct |
---|---|---|
CLDND1 [Q9NY35] | 3 | EBI-20009624,EBI-4319704 |
TUSC5 [A5PKU2] | 3 | EBI-20009624,EBI-11988865 |
Protein-protein interaction databases
BioGRIDi | 120449, 3 interactors |
IntActi | Q9NPG8, 3 interactors |
MINTi | Q9NPG8 |
STRINGi | 9606.ENSP00000379934 |
Miscellaneous databases
RNActi | Q9NPG8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 199 | DHHCPROSITE-ProRule annotationAdd BLAST | 51 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 341 – 344 | Di-lysine motif1 Publication | 4 |
Domaini
The C-terminal di-lysine motif confers endoplasmic reticulum localization.1 Publication
The DHHC domain is required for palmitoyltransferase activity.By similarity
Sequence similaritiesi
Belongs to the DHHC palmitoyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1312, Eukaryota |
GeneTreei | ENSGT00920000149163 |
HOGENOMi | CLU_042181_4_0_1 |
InParanoidi | Q9NPG8 |
OMAi | CKYSGQQ |
OrthoDBi | 445686at2759 |
PhylomeDBi | Q9NPG8 |
TreeFami | TF330931 |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
PROSITEi | View protein in PROSITE PS50216, DHHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NPG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ
60 70 80 90 100
RAVHGLLHYL FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY
110 120 130 140 150
LLLPYLLLGV NLFFFTLTCG TNPGIITKAN ELLFLHVYEF DEVMFPKNVR
160 170 180 190 200
CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV WVNNCIGAWN IRYFLIYVLT
210 220 230 240 250
LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM DTVFLIQYLF
260 270 280 290 300
LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
310 320 330 340
CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J5I9 | C9J5I9_HUMAN | Palmitoyltransferase ZDHHC4 | ZDHHC4 | 165 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 | L → P in BAD97252 (Ref. 6) Curated | 1 | |
Sequence conflicti | 244 | F → I in CAB66609 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 244 | F → I in CAG38542 (Ref. 4) Curated | 1 | |
Sequence conflicti | 276 | F → S in CAB66609 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 276 | F → S in CAG38542 (Ref. 4) Curated | 1 | |
Sequence conflicti | 294 | D → V in CAB66609 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 294 | D → V in CAG38542 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023832 | 53 | V → M1 PublicationCorresponds to variant dbSNP:rs11559146Ensembl. | 1 | |
Natural variantiVAR_036260 | 104 | P → S in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF201931 mRNA Translation: AAF86867.1 AL136674 mRNA Translation: CAB66609.1 AY359090 mRNA Translation: AAQ89448.1 CR533511 mRNA Translation: CAG38542.1 AK001341 mRNA Translation: BAA91636.1 AK223532 mRNA Translation: BAD97252.1 AC079742 Genomic DNA No translation available. CH236963 Genomic DNA Translation: EAL23725.1 CH878731 Genomic DNA Translation: EAW55023.1 BC001239 mRNA Translation: AAH01239.1 |
CCDSi | CCDS5352.1 |
RefSeqi | NP_001127859.1, NM_001134387.1 NP_001127860.1, NM_001134388.1 NP_001127861.1, NM_001134389.1 NP_060576.1, NM_018106.3 XP_005249850.1, XM_005249793.2 XP_005249851.1, XM_005249794.3 XP_005249852.1, XM_005249795.2 XP_005249853.1, XM_005249796.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF201931 mRNA Translation: AAF86867.1 AL136674 mRNA Translation: CAB66609.1 AY359090 mRNA Translation: AAQ89448.1 CR533511 mRNA Translation: CAG38542.1 AK001341 mRNA Translation: BAA91636.1 AK223532 mRNA Translation: BAD97252.1 AC079742 Genomic DNA No translation available. CH236963 Genomic DNA Translation: EAL23725.1 CH878731 Genomic DNA Translation: EAW55023.1 BC001239 mRNA Translation: AAH01239.1 |
CCDSi | CCDS5352.1 |
RefSeqi | NP_001127859.1, NM_001134387.1 NP_001127860.1, NM_001134388.1 NP_001127861.1, NM_001134389.1 NP_060576.1, NM_018106.3 XP_005249850.1, XM_005249793.2 XP_005249851.1, XM_005249794.3 XP_005249852.1, XM_005249795.2 XP_005249853.1, XM_005249796.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120449, 3 interactors |
IntActi | Q9NPG8, 3 interactors |
MINTi | Q9NPG8 |
STRINGi | 9606.ENSP00000379934 |
PTM databases
iPTMneti | Q9NPG8 |
PhosphoSitePlusi | Q9NPG8 |
SwissPalmi | Q9NPG8 |
Genetic variation databases
BioMutai | ZDHHC4 |
DMDMi | 28202108 |
Proteomic databases
EPDi | Q9NPG8 |
jPOSTi | Q9NPG8 |
MassIVEi | Q9NPG8 |
MaxQBi | Q9NPG8 |
PaxDbi | Q9NPG8 |
PeptideAtlasi | Q9NPG8 |
PRIDEi | Q9NPG8 |
ProteomicsDBi | 81994 |
Protocols and materials databases
Antibodypediai | 24908, 46 antibodies |
DNASUi | 55146 |
Genome annotation databases
Organism-specific databases
CTDi | 55146 |
DisGeNETi | 55146 |
GeneCardsi | ZDHHC4 |
HGNCi | HGNC:18471, ZDHHC4 |
HPAi | ENSG00000136247, Low tissue specificity |
neXtProti | NX_Q9NPG8 |
OpenTargetsi | ENSG00000136247 |
PharmGKBi | PA38337 |
VEuPathDBi | HostDB:ENSG00000136247.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1312, Eukaryota |
GeneTreei | ENSGT00920000149163 |
HOGENOMi | CLU_042181_4_0_1 |
InParanoidi | Q9NPG8 |
OMAi | CKYSGQQ |
OrthoDBi | 445686at2759 |
PhylomeDBi | Q9NPG8 |
TreeFami | TF330931 |
Enzyme and pathway databases
BRENDAi | 2.3.1.225, 2681 |
PathwayCommonsi | Q9NPG8 |
Miscellaneous databases
BioGRID-ORCSi | 55146, 1 hit in 878 CRISPR screens |
ChiTaRSi | ZDHHC4, human |
GeneWikii | ZDHHC4 |
GenomeRNAii | 55146 |
Pharosi | Q9NPG8, Tdark |
PROi | PR:Q9NPG8 |
RNActi | Q9NPG8, protein |
Gene expression databases
Bgeei | ENSG00000136247, Expressed in pancreas and 209 other tissues |
ExpressionAtlasi | Q9NPG8, baseline and differential |
Genevisiblei | Q9NPG8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
PROSITEi | View protein in PROSITE PS50216, DHHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZDHC4_HUMAN | |
Accessioni | Q9NPG8Primary (citable) accession number: Q9NPG8 Secondary accession number(s): A4D2N9 Q9H0R9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM