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Entry version 143 (31 Jul 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Ubinuclein-1

Gene

UBN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubinuclein-1
Alternative name(s):
HIRA-binding protein
Protein VT4
Ubiquitously expressed nuclear protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12506 UBN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609771 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPG3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi138F → E: Strongly diminishes interaction with HIRA; when associated with E-139 and L-140. 1
Mutagenesisi139I → E: Strongly diminishes interaction with HIRA; when associated with E-138 and L-140. 1
Mutagenesisi140D → L: Strongly diminishes interaction with HIRA; when associated with E-138 and L-139. 1
Mutagenesisi160F → E: Strongly diminishes interaction with HIRA. 1 Publication1
Mutagenesisi162I → E: Strongly diminishes interaction with HIRA. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
29855

Open Targets

More...
OpenTargetsi
ENSG00000118900

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37153

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242836

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000657121 – 1134Ubinuclein-1Add BLAST1134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei166PhosphothreonineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei222N6-acetyllysineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NPG3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NPG3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NPG3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NPG3

PeptideAtlas

More...
PeptideAtlasi
Q9NPG3

PRoteomics IDEntifications database

More...
PRIDEi
Q9NPG3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81991 [Q9NPG3-1]
81992 [Q9NPG3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NPG3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NPG3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Also expressed in numerous tumors and cancer cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118900 Expressed in 238 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NPG3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NPG3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA061029
HPA069045

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1.

Interacts with HIRA (via WD repeat domain); the interaction is direct.

Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.

3 Publications

(Microbial infection)

Interacts with Epstein-Barr virus BZLF1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HIRAP5419810EBI-2880187,EBI-372342

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118934, 39 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NPG3

Protein interaction database and analysis system

More...
IntActi
Q9NPG3, 13 interactors

Molecular INTeraction database

More...
MINTi
Q9NPG3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379894

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NPG3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 166Sufficient for interaction with HIRA1 PublicationAdd BLAST166

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili479 – 542Sequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi181 – 261Lys-richAdd BLAST81
Compositional biasi862 – 1042Ser-richAdd BLAST181

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubinuclein family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPMD Eukaryota
ENOG410XREY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158857

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154753

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NPG3

KEGG Orthology (KO)

More...
KOi
K17492

Identification of Orthologs from Complete Genome Data

More...
OMAi
VNKLQGP

Database of Orthologous Groups

More...
OrthoDBi
469344at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NPG3

TreeFam database of animal gene trees

More...
TreeFami
TF326088

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014840 HRD
IPR026936 Ubinuclein-1
IPR026947 UBN_middle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR21669:SF12 PTHR21669:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08729 HUN, 1 hit
PF14075 UBN_AB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEPHRVQFT SLPGSLNPAF LKKSRKEEAG AGEQHQDCEP AAAAVRITLT
60 70 80 90 100
LFEPDHKRCP EFFYPELVKN IRGKVKGLQP GDKKKDLSDP FNDEEKERHK
110 120 130 140 150
VEALARKFEE KYGGKKRRKD RIQDLIDMGY GYDESDSFID NSEAYDELVP
160 170 180 190 200
ASLTTKYGGF YINSGTLQFR QASESEDDFI KEKKKKSPKK RKLKEGGEKI
210 220 230 240 250
KKKKKDDTYD KEKKSKKSKF SKAGFTALNA SKEKKKKKYS GALSVKEMLK
260 270 280 290 300
KFQKEKEAQK KREEEHKPVA VPSAEAQGLR ELEGASDPLL SLFGSTSDND
310 320 330 340 350
LLQAATAMDS LTDLDLEHLL SESPEGSPFR DMDDGSDSLG VGLDQEFRQP
360 370 380 390 400
SSLPEGLPAP LEKRVKELAQ AARAAEGESR QKFFTQDING ILLDIEAQTR
410 420 430 440 450
ELSSQVRSGV YAYLASFLPC SKDALLKRAR KLHLYEQGGR LKEPLQKLKE
460 470 480 490 500
AIGRAMPEQM AKYQDECQAH TQAKVAKMLE EEKDKEQRDR ICSDEEEDEE
510 520 530 540 550
KGGRRIMGPR KKFQWNDEIR ELLCQVVKIK LESQDLERNN KAQAWEDCVK
560 570 580 590 600
GFLDAEVKPL WPKGWMQART LFKESRRGHG HLTSILAKKK VMAPSKIKVK
610 620 630 640 650
ESSTKPDKKV SVPSGQIGGP IALPSDHQTG GLSIGASSRE LPSQASGGLA
660 670 680 690 700
NPPPVNLEDS LDEDLIRNPA SSVEAVSKEL AALNSRAAGN SEFTLPAPSK
710 720 730 740 750
APAEKVGGVL CTEEKRNFAK PSPSAPPPAS SLQSPLNFLA EQALALGQSS
760 770 780 790 800
QEKKPESSGY KELSCQAPLN KGLPEVHQSK AKHHSLPRTS HGPQVAVPVP
810 820 830 840 850
GPQVKVFHAG TQQQKNFTPP SPFANKLQGP KASPTQCHRS LLQLVKTAAK
860 870 880 890 900
GQGFHPSAPA TSGGLSASSS SSHKTPASSS SALSHPAKPH SVSSAGSSYK
910 920 930 940 950
NNPFASSISK HGVSSGSSSS GGTPVQSSVS GSLVPGIQPP SVGQATSRPV
960 970 980 990 1000
PSSAGKKMPV SQKLTLVAPP GGPNGDSSGG TQGVAKLLTS PSLKPSAVSS
1010 1020 1030 1040 1050
VTSSTSLSKG ASGTVLLAGS SLMASPYKSS SPKLSGAMSS NSLGIITPVP
1060 1070 1080 1090 1100
IPVHVLSFSA DSSAKAGVSK DAIVTGPAPG SFHHGLGHSL LAGLHSSPPH
1110 1120 1130
AAPLPHAAVP THIPQSLPGA SQLHGKGPAV PRKL
Length:1,134
Mass (Da):121,520
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DE68C63D4E8E01B
GO
Isoform 2 (identifier: Q9NPG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1119: Missing.

Show »
Length:1,104
Mass (Da):118,554
Checksum:iB3F257D8DB385A2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJT1K7EJT1_HUMAN
Ubinuclein-1
UBN1
312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQR1K7EQR1_HUMAN
Ubinuclein-1
UBN1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESM4K7ESM4_HUMAN
Ubinuclein-1
UBN1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER78K7ER78_HUMAN
Ubinuclein-1
UBN1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119K → N in BAH13219 (PubMed:14702039).Curated1
Sequence conflicti276A → V in AAF31755 (PubMed:10725330).Curated1
Sequence conflicti276A → V in AAF31756 (PubMed:10725330).Curated1
Sequence conflicti277Q → H in BAH13219 (PubMed:14702039).Curated1
Sequence conflicti718F → L in AAF31755 (PubMed:10725330).Curated1
Sequence conflicti718F → L in AAF31756 (PubMed:10725330).Curated1
Sequence conflicti945A → P in AAF31755 (PubMed:10725330).Curated1
Sequence conflicti945A → P in AAF31756 (PubMed:10725330).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051465435Y → C. Corresponds to variant dbSNP:rs35103368Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0369711090 – 1119Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF108460 mRNA Translation: AAF31755.1
AF108461 mRNA Translation: AAF31756.1
AF108459
, AF108454, AF108455, AF108456, AF108457, AF108458 Genomic DNA Translation: AAF34869.1
AK300131 mRNA Translation: BAH13219.1
AC020663 Genomic DNA No translation available.
AC027687 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85249.1
CH471112 Genomic DNA Translation: EAW85250.1
U19346 mRNA Translation: AAA64188.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10525.1 [Q9NPG3-1]
CCDS73822.1 [Q9NPG3-2]

Protein sequence database of the Protein Information Resource

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PIRi
G01628

NCBI Reference Sequences

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RefSeqi
NP_001072982.1, NM_001079514.2 [Q9NPG3-1]
NP_001275585.1, NM_001288656.1 [Q9NPG3-2]
XP_016878678.1, XM_017023189.1 [Q9NPG3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262376; ENSP00000262376; ENSG00000118900 [Q9NPG3-1]
ENST00000396658; ENSP00000379894; ENSG00000118900 [Q9NPG3-1]
ENST00000590769; ENSP00000468740; ENSG00000118900 [Q9NPG3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29855

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29855

UCSC genome browser

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UCSCi
uc002cyb.5 human [Q9NPG3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108460 mRNA Translation: AAF31755.1
AF108461 mRNA Translation: AAF31756.1
AF108459
, AF108454, AF108455, AF108456, AF108457, AF108458 Genomic DNA Translation: AAF34869.1
AK300131 mRNA Translation: BAH13219.1
AC020663 Genomic DNA No translation available.
AC027687 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85249.1
CH471112 Genomic DNA Translation: EAW85250.1
U19346 mRNA Translation: AAA64188.1
CCDSiCCDS10525.1 [Q9NPG3-1]
CCDS73822.1 [Q9NPG3-2]
PIRiG01628
RefSeqiNP_001072982.1, NM_001079514.2 [Q9NPG3-1]
NP_001275585.1, NM_001288656.1 [Q9NPG3-2]
XP_016878678.1, XM_017023189.1 [Q9NPG3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZBJX-ray2.25D122-148[»]
SMRiQ9NPG3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi118934, 39 interactors
CORUMiQ9NPG3
IntActiQ9NPG3, 13 interactors
MINTiQ9NPG3
STRINGi9606.ENSP00000379894

PTM databases

iPTMnetiQ9NPG3
PhosphoSitePlusiQ9NPG3

Polymorphism and mutation databases

BioMutaiUBN1
DMDMi116242836

Proteomic databases

EPDiQ9NPG3
jPOSTiQ9NPG3
MaxQBiQ9NPG3
PaxDbiQ9NPG3
PeptideAtlasiQ9NPG3
PRIDEiQ9NPG3
ProteomicsDBi81991 [Q9NPG3-1]
81992 [Q9NPG3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262376; ENSP00000262376; ENSG00000118900 [Q9NPG3-1]
ENST00000396658; ENSP00000379894; ENSG00000118900 [Q9NPG3-1]
ENST00000590769; ENSP00000468740; ENSG00000118900 [Q9NPG3-2]
GeneIDi29855
KEGGihsa:29855
UCSCiuc002cyb.5 human [Q9NPG3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29855
DisGeNETi29855

GeneCards: human genes, protein and diseases

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GeneCardsi
UBN1
HGNCiHGNC:12506 UBN1
HPAiHPA061029
HPA069045
MIMi609771 gene
neXtProtiNX_Q9NPG3
OpenTargetsiENSG00000118900
PharmGKBiPA37153

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPMD Eukaryota
ENOG410XREY LUCA
GeneTreeiENSGT00940000158857
HOGENOMiHOG000154753
InParanoidiQ9NPG3
KOiK17492
OMAiVNKLQGP
OrthoDBi469344at2759
PhylomeDBiQ9NPG3
TreeFamiTF326088

Enzyme and pathway databases

ReactomeiR-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UBN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29855

Protein Ontology

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PROi
PR:Q9NPG3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118900 Expressed in 238 organ(s), highest expression level in blood
ExpressionAtlasiQ9NPG3 baseline and differential
GenevisibleiQ9NPG3 HS

Family and domain databases

InterProiView protein in InterPro
IPR014840 HRD
IPR026936 Ubinuclein-1
IPR026947 UBN_middle_dom
PANTHERiPTHR21669:SF12 PTHR21669:SF12, 1 hit
PfamiView protein in Pfam
PF08729 HUN, 1 hit
PF14075 UBN_AB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPG3
Secondary accession number(s): B7Z6D3
, D3DUE8, Q13079, Q9P1P7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 17, 2006
Last modified: July 31, 2019
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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