UniProtKB - Q9NPF8 (ADAP2_HUMAN)
Protein
Arf-GAP with dual PH domain-containing protein 2
Gene
ADAP2
Organism
Homo sapiens (Human)
Status
Functioni
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.Curated1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 25 – 48 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- inositol 1,3,4,5 tetrakisphosphate binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
- phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- protein-macromolecule adaptor activity Source: UniProtKB
GO - Biological processi
- heart development Source: UniProtKB
- inositol lipid-mediated signaling Source: MGI
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NPF8 |
Names & Taxonomyi
Protein namesi | Recommended name: Arf-GAP with dual PH domain-containing protein 2Alternative name(s): Centaurin-alpha-2 Short name: Cnt-a2 |
Gene namesi | Name:ADAP2 Synonyms:CENTA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16487, ADAP2 |
MIMi | 608635, gene |
neXtProti | NX_Q9NPF8 |
VEuPathDBi | HostDB:ENSG00000184060.10 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Note: Constitutively associated with the plasma membrane. Excluded from the nucleus.
Mitochondrion
- mitochondrial envelope Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55803 |
OpenTargetsi | ENSG00000184060 |
PharmGKBi | PA26405 |
Miscellaneous databases
Pharosi | Q9NPF8, Tbio |
Genetic variation databases
BioMutai | ADAP2 |
DMDMi | 27923749 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074206 | 1 – 381 | Arf-GAP with dual PH domain-containing protein 2Add BLAST | 381 |
Proteomic databases
jPOSTi | Q9NPF8 |
MassIVEi | Q9NPF8 |
PaxDbi | Q9NPF8 |
PeptideAtlasi | Q9NPF8 |
PRIDEi | Q9NPF8 |
ProteomicsDBi | 81987 [Q9NPF8-1] 81988 [Q9NPF8-2] |
PTM databases
iPTMneti | Q9NPF8 |
PhosphoSitePlusi | Q9NPF8 |
Expressioni
Tissue specificityi
Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow.1 Publication
Gene expression databases
Bgeei | ENSG00000184060, Expressed in layer of synovial tissue and 222 other tissues |
ExpressionAtlasi | Q9NPF8, baseline and differential |
Genevisiblei | Q9NPF8, HS |
Organism-specific databases
HPAi | ENSG00000184060, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NPF8
With | #Exp. | IntAct |
---|---|---|
IKBKG [Q9Y6K9] | 2 | EBI-718895,EBI-81279 |
Protein-protein interaction databases
BioGRIDi | 120915, 13 interactors |
IntActi | Q9NPF8, 5 interactors |
STRINGi | 9606.ENSP00000329468 |
Miscellaneous databases
RNActi | Q9NPF8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 131 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 132 – 233 | PH 1PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 255 – 361 | PH 2PROSITE-ProRule annotationAdd BLAST | 107 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 25 – 48 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0703, Eukaryota |
GeneTreei | ENSGT00940000156498 |
InParanoidi | Q9NPF8 |
OrthoDBi | 1274375at2759 |
PhylomeDBi | Q9NPF8 |
TreeFami | TF324540 |
Family and domain databases
CDDi | cd13252, PH1_ADAP, 1 hit cd01251, PH2_ADAP, 1 hit |
Gene3Di | 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR011993, PH-like_dom_sf IPR037849, PH1_ADAP IPR037851, PH2_ADAP IPR001849, PH_domain |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit PF00169, PH, 2 hits |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NPF8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDRERNKKR LLELLRAPDT GNAHCADCGA ADPDWASYKL GIFICLNCCG
60 70 80 90 100
VHRNFPDISR VKSVRLDFWD DSIVEFMIHN GNLRVKAKFE ARVPAFYYIP
110 120 130 140 150
QANDCLVLKE QWIRAKYERR EFMADGETIS LPGNREGFLW KRGRDNSQFL
160 170 180 190 200
RRKFVLLARE GLLKYFTKEQ GKSPKAVISI KDLNATFQTE KIGHPHGLQI
210 220 230 240 250
TYRRDGHTRN LFVYHESGKE IVDWFNALRA ARLQYLKMAF PELPESELVP
260 270 280 290 300
FLTRNYLKQG FMEKTGPKQK EPFKKRWFAL DCHERRLLYY KNPLDAFEQG
310 320 330 340 350
QVFLGNKEQG YEAYEDLPKG IRGNRWKAGL TIVTPERRFV LTCPSEKEQQ
360 370 380
EWLESLRGVL SSPLTPLNRL TASTESGRSS R
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ2V6Q1 | Q2V6Q1_HUMAN | Arf-GAP with dual PH domain-contain... | ADAP2 CENTA2 | 387 | Annotation score: | ||
J3QRD3 | J3QRD3_HUMAN | Arf-GAP with dual PH domain-contain... | ADAP2 | 333 | Annotation score: | ||
K7ENT1 | K7ENT1_HUMAN | Arf-GAP with dual PH domain-contain... | ADAP2 | 114 | Annotation score: | ||
J3KT70 | J3KT70_HUMAN | Arf-GAP with dual PH domain-contain... | ADAP2 | 84 | Annotation score: | ||
J3QRA6 | J3QRA6_HUMAN | Arf-GAP with dual PH domain-contain... | ADAP2 | 106 | Annotation score: | ||
J3QLP8 | J3QLP8_HUMAN | Arf-GAP with dual PH domain-contain... | ADAP2 | 145 | Annotation score: | ||
J3KST1 | J3KST1_HUMAN | Arf-GAP with dual PH domain-contain... | ADAP2 | 98 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | L → P in CAC40651 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011180 | 269 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ238994 mRNA Translation: CAB88383.1 AJ272195 mRNA Translation: CAB77266.1 AJ242782 mRNA Translation: CAC40651.1 BC033758 mRNA Translation: AAH33758.1 |
CCDSi | CCDS11261.1 [Q9NPF8-1] |
RefSeqi | NP_001333643.1, NM_001346714.1 [Q9NPF8-2] NP_060874.1, NM_018404.2 [Q9NPF8-1] |
Genome annotation databases
Ensembli | ENST00000330889; ENSP00000329468; ENSG00000184060 [Q9NPF8-1] |
GeneIDi | 55803 |
KEGGi | hsa:55803 |
UCSCi | uc002hfx.4, human [Q9NPF8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ238994 mRNA Translation: CAB88383.1 AJ272195 mRNA Translation: CAB77266.1 AJ242782 mRNA Translation: CAC40651.1 BC033758 mRNA Translation: AAH33758.1 |
CCDSi | CCDS11261.1 [Q9NPF8-1] |
RefSeqi | NP_001333643.1, NM_001346714.1 [Q9NPF8-2] NP_060874.1, NM_018404.2 [Q9NPF8-1] |
3D structure databases
SMRi | Q9NPF8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120915, 13 interactors |
IntActi | Q9NPF8, 5 interactors |
STRINGi | 9606.ENSP00000329468 |
PTM databases
iPTMneti | Q9NPF8 |
PhosphoSitePlusi | Q9NPF8 |
Genetic variation databases
BioMutai | ADAP2 |
DMDMi | 27923749 |
Proteomic databases
jPOSTi | Q9NPF8 |
MassIVEi | Q9NPF8 |
PaxDbi | Q9NPF8 |
PeptideAtlasi | Q9NPF8 |
PRIDEi | Q9NPF8 |
ProteomicsDBi | 81987 [Q9NPF8-1] 81988 [Q9NPF8-2] |
Protocols and materials databases
Antibodypediai | 26908, 179 antibodies |
DNASUi | 55803 |
Genome annotation databases
Ensembli | ENST00000330889; ENSP00000329468; ENSG00000184060 [Q9NPF8-1] |
GeneIDi | 55803 |
KEGGi | hsa:55803 |
UCSCi | uc002hfx.4, human [Q9NPF8-1] |
Organism-specific databases
CTDi | 55803 |
DisGeNETi | 55803 |
GeneCardsi | ADAP2 |
HGNCi | HGNC:16487, ADAP2 |
HPAi | ENSG00000184060, Low tissue specificity |
MIMi | 608635, gene |
neXtProti | NX_Q9NPF8 |
OpenTargetsi | ENSG00000184060 |
PharmGKBi | PA26405 |
VEuPathDBi | HostDB:ENSG00000184060.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0703, Eukaryota |
GeneTreei | ENSGT00940000156498 |
InParanoidi | Q9NPF8 |
OrthoDBi | 1274375at2759 |
PhylomeDBi | Q9NPF8 |
TreeFami | TF324540 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPF8 |
Miscellaneous databases
BioGRID-ORCSi | 55803, 9 hits in 984 CRISPR screens |
ChiTaRSi | ADAP2, human |
GeneWikii | CENTA2 |
GenomeRNAii | 55803 |
Pharosi | Q9NPF8, Tbio |
PROi | PR:Q9NPF8 |
RNActi | Q9NPF8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184060, Expressed in layer of synovial tissue and 222 other tissues |
ExpressionAtlasi | Q9NPF8, baseline and differential |
Genevisiblei | Q9NPF8, HS |
Family and domain databases
CDDi | cd13252, PH1_ADAP, 1 hit cd01251, PH2_ADAP, 1 hit |
Gene3Di | 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR011993, PH-like_dom_sf IPR037849, PH1_ADAP IPR037851, PH2_ADAP IPR001849, PH_domain |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit PF00169, PH, 2 hits |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAP2_HUMAN | |
Accessioni | Q9NPF8Primary (citable) accession number: Q9NPF8 Secondary accession number(s): Q8N4Q6, Q96SD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 27, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot