Interleukin-23 subunit alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• interleukin-23 receptor binding Source: Ensembl

GO - Biological processⁱ

• cytokine-mediated signaling pathway Source: Reactome
• defense response to Gram-negative bacterium Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.7

    "Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development."
    Smits H.H., van Beelen A.J., Hessle C., Westland R., de Jong E., Soeteman E., Wold A., Wierenga E.A., Kapsenberg M.L.
    Eur. J. Immunol. 34:1371-1380(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS ONE 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• defense response to virus Source: UniProtKB-KW
• inflammatory response Source: UniProtKB-KW
• innate immune response Source: UniProtKB-KW
• interleukin-23-mediated signaling pathway Source: Reactome
• negative regulation of interleukin-10 production Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.12

    "IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production."
    Vaknin-Dembinsky A., Balashov K., Weiner H.L.
    J. Immunol. 176:7768-7774(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of activated T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
    Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T., Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J.

    , Abrams J.S., Moore K.W., Rennick D.M., de Waal-Malefyt R., Hannum C., Bazan J.F., Kastelein R.A.
    Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IL12B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• positive regulation of activation of Janus kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
• positive regulation of defense response to virus by host Source: BHF-UCLInferred from direct assayⁱ
  • Ref.6

    "Regulation of virus-induced IL-12 and IL-23 expression in human macrophages."
    Pirhonen J., Matikainen S., Julkunen I.
    J. Immunol. 169:5673-5678(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCLInferred from direct assayⁱ
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS ONE 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."
    Hoeve M.A., Savage N.D., de Boer T., Langenberg D.M., de Waal Malefyt R., Ottenhoff T.H., Verreck F.A.
    Eur. J. Immunol. 36:661-670(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-gamma production Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
    Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T., Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J.

    , Abrams J.S., Moore K.W., Rennick D.M., de Waal-Malefyt R., Hannum C., Bazan J.F., Kastelein R.A.
    Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IL12B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • "IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats."
    Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., Kotake S.
    Arthritis Res. Ther. 9:R96-R96(2007) [PubMed] [Europe PMC] [Abstract]
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS ONE 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-10 production Source: BHF-UCLInferred from direct assayⁱ
  • "ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells."
    Wassink L., Vieira P.L., Smits H.H., Kingsbury G.A., Coyle A.J., Kapsenberg M.L., Wierenga E.A.
    J. Immunol. 173:1779-1786(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-12 production Source: BHF-UCLInferred from direct assayⁱ
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS ONE 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-17 production Source: BHF-UCLInferred from direct assayⁱ
  • "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."
    Hoeve M.A., Savage N.D., de Boer T., Langenberg D.M., de Waal Malefyt R., Ottenhoff T.H., Verreck F.A.
    Eur. J. Immunol. 36:661-670(2006) [PubMed] [Europe PMC] [Abstract]
  • Ref.12

    "IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production."
    Vaknin-Dembinsky A., Balashov K., Weiner H.L.
    J. Immunol. 176:7768-7774(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
  • "IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats."
    Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., Kotake S.
    Arthritis Res. Ther. 9:R96-R96(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of memory T cell differentiation Source: BHF-UCL
• positive regulation of natural killer cell activation Source: BHF-UCLInferred by curatorⁱ
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS ONE 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of natural killer cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int. Immunol. 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil chemotaxis Source: Ensembl
• positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity."
    Fukuda M., Ehara M., Suzuki S., Ohmori Y., Sakashita H.
    Int. J. Oncol. 36:1355-1365(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NK T cell activation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int. Immunol. 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NK T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int. Immunol. 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoclast differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats."
    Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., Kotake S.
    Arthritis Res. Ther. 9:R96-R96(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
• positive regulation of T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
• positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
• positive regulation of T-helper 17 type immune response Source: BHF-UCL
• positive regulation of T-helper 1 type immune response Source: BHF-UCLInferred from direct assayⁱ
  • Ref.7

    "Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development."
    Smits H.H., van Beelen A.J., Hessle C., Westland R., de Jong E., Soeteman E., Wold A., Wierenga E.A., Kapsenberg M.L.
    Eur. J. Immunol. 34:1371-1380(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of tissue remodeling Source: BHF-UCLInferred by curatorⁱ
  • "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."
    Hoeve M.A., Savage N.D., de Boer T., Langenberg D.M., de Waal Malefyt R., Ottenhoff T.H., Verreck F.A.
    Eur. J. Immunol. 36:661-670(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of tumor necrosis factor production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.12

    "IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production."
    Vaknin-Dembinsky A., Balashov K., Weiner H.L.
    J. Immunol. 176:7768-7774(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int. Immunol. 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
• T cell proliferation Source: Ensembl
• tissue remodeling Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

        10         20         30         40         50
MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL 
        60         70         80         90        100
VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY 
       110        120        130        140        150
EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL 
       160        170        180 
SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP