Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-23 subunit alpha

Gene

IL23A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.3 Publications

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • defense response to Gram-negative bacterium Source: BHF-UCL
  • defense response to virus Source: UniProtKB-KW
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • interleukin-23-mediated signaling pathway Source: Reactome
  • negative regulation of interleukin-10 production Source: BHF-UCL
  • positive regulation of activated T cell proliferation Source: BHF-UCL
  • positive regulation of activation of Janus kinase activity Source: BHF-UCL
  • positive regulation of defense response to virus by host Source: BHF-UCL
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of interferon-gamma production Source: BHF-UCL
  • positive regulation of interleukin-10 production Source: BHF-UCL
  • positive regulation of interleukin-12 production Source: BHF-UCL
  • positive regulation of interleukin-17 production Source: BHF-UCL
  • positive regulation of memory T cell differentiation Source: BHF-UCL
  • positive regulation of natural killer cell activation Source: BHF-UCL
  • positive regulation of natural killer cell proliferation Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: Ensembl
  • positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
  • positive regulation of NK T cell activation Source: BHF-UCL
  • positive regulation of NK T cell proliferation Source: BHF-UCL
  • positive regulation of osteoclast differentiation Source: BHF-UCL
  • positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
  • positive regulation of T cell proliferation Source: BHF-UCL
  • positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
  • positive regulation of T-helper 17 type immune response Source: BHF-UCL
  • positive regulation of T-helper 1 type immune response Source: BHF-UCL
  • positive regulation of tissue remodeling Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • positive regulation of tumor necrosis factor production Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
  • regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
  • T cell proliferation Source: Ensembl
  • tissue remodeling Source: UniProtKB-KW

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-9020933 Interleukin-23 signaling
SignaLinkiQ9NPF7
SIGNORiQ9NPF7

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
Gene namesi
Name:IL23A
Synonyms:SGRF
ORF Names:UNQ2498/PRO5798
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000110944.8
HGNCiHGNC:15488 IL23A
MIMi605580 gene
neXtProtiNX_Q9NPF7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51561
OpenTargetsiENSG00000110944
PharmGKBiPA29824

Chemistry databases

ChEMBLiCHEMBL3580502
DrugBankiDB05459 Briakinumab
DB05679 Ustekinumab

Polymorphism and mutation databases

BioMutaiIL23A
DMDMi74761641

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000025948820 – 189Interleukin-23 subunit alphaAdd BLAST170

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NPF7
PeptideAtlasiQ9NPF7
PRIDEiQ9NPF7
ProteomicsDBi81986

Expressioni

Tissue specificityi

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).2 Publications

Developmental stagei

Expressed by newborns dendritic cells.1 Publication

Inductioni

Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.7 Publications

Gene expression databases

BgeeiENSG00000110944
CleanExiHS_IL23A
GenevisibleiQ9NPF7 HS

Organism-specific databases

HPAiHPA001554

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119611, 7 interactors
ComplexPortaliCPX-3290 Interleukin-23 complex
CPX-383 Interleukin-23-receptor complex
IntActiQ9NPF7, 4 interactors
STRINGi9606.ENSP00000228534

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 46Combined sources17
Turni49 – 51Combined sources3
Turni53 – 56Combined sources4
Helixi61 – 67Combined sources7
Helixi73 – 75Combined sources3
Helixi79 – 85Combined sources7
Helixi87 – 104Combined sources18
Helixi107 – 110Combined sources4
Beta strandi111 – 113Combined sources3
Helixi120 – 135Combined sources16
Beta strandi136 – 138Combined sources3
Helixi155 – 186Combined sources32

3D structure databases

ProteinModelPortaliQ9NPF7
SMRiQ9NPF7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPF7

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGBY Eukaryota
ENOG411142Q LUCA
GeneTreeiENSGT00390000006482
HOGENOMiHOG000048728
HOVERGENiHBG081786
InParanoidiQ9NPF7
KOiK05426
OMAiPMGHVDL
OrthoDBiEOG091G0Q9J
PhylomeDBiQ9NPF7
TreeFamiTF337234

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010831 IL-23_alpha
PANTHERiPTHR15947 PTHR15947, 1 hit
PfamiView protein in Pfam
PF16649 IL23, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL
60 70 80 90 100
VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY
110 120 130 140 150
EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL
160 170 180
SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP
Length:189
Mass (Da):20,730
Last modified:October 1, 2000 - v1
Checksum:i51B5C0F188EC1B9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122G → A in AAG37232 (PubMed:11114383).Curated1
Sequence conflicti147I → M in AAH66267 (PubMed:15489334).Curated1
Sequence conflicti168S → N in AAH66267 (PubMed:15489334).Curated1
Sequence conflicti173V → A in AAH66269 (PubMed:15489334).Curated1
Sequence conflicti189P → L in AAH66269 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301620 mRNA Translation: AAG37232.1
AB030000 mRNA Translation: BAA93686.1
AB030001 Genomic DNA Translation: BAA93687.1
AY359083 mRNA Translation: AAQ89442.1
BC066267 mRNA Translation: AAH66267.1
BC066268 mRNA Translation: AAH66268.1
BC066269 mRNA Translation: AAH66269.1
BC067511 mRNA Translation: AAH67511.1
BC067512 mRNA Translation: AAH67512.1
BC067513 mRNA Translation: AAH67513.1
CCDSiCCDS8916.1
RefSeqiNP_057668.1, NM_016584.2
XP_011536779.1, XM_011538477.2
UniGeneiHs.382212
Hs.98309

Genome annotation databases

EnsembliENST00000228534; ENSP00000228534; ENSG00000110944
GeneIDi51561
KEGGihsa:51561
UCSCiuc001sla.4 human

Similar proteinsi

Entry informationi

Entry nameiIL23A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPF7
Secondary accession number(s): Q6NZ80, Q6NZ82, Q9H2A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health