Interleukin-23 subunit alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• interleukin-23 receptor binding Source: Ensembl

GO - Biological processⁱ

• defense response to Gram-negative bacterium Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.7

    "Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development."
    Smits H.H., van Beelen A.J., Hessle C., Westland R., de Jong E., Soeteman E., Wold A., Wierenga E.A., Kapsenberg M.L.
    Eur. J. Immunol. 34:1371-1380(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS One 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• defense response to virus Source: UniProtKB-KW
• immune response Source: ComplexPortal <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int Immunol 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: UniProtKB-KW
• innate immune response Source: UniProtKB-KW
• negative regulation of interleukin-10 production Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.12

    "IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production."
    Vaknin-Dembinsky A., Balashov K., Weiner H.L.
    J. Immunol. 176:7768-7774(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of activated T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
    Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T., Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J.

    , Abrams J.S., Moore K.W., Rennick D.M., de Waal-Malefyt R., Hannum C., Bazan J.F., Kastelein R.A.
    Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IL12B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• positive regulation of activation of Janus kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
• positive regulation of defense response to virus by host Source: BHF-UCLInferred from direct assayⁱ
  • Ref.6

    "Regulation of virus-induced IL-12 and IL-23 expression in human macrophages."
    Pirhonen J., Matikainen S., Julkunen I.
    J. Immunol. 169:5673-5678(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCLInferred from direct assayⁱ
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS One 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: BHF-UCLInferred by curatorⁱ
  • "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."
    Hoeve M.A., Savage N.D., de Boer T., Langenberg D.M., de Waal Malefyt R., Ottenhoff T.H., Verreck F.A.
    Eur J Immunol 36:661-670(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-gamma production Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
    Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T., Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J.

    , Abrams J.S., Moore K.W., Rennick D.M., de Waal-Malefyt R., Hannum C., Bazan J.F., Kastelein R.A.
    Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IL12B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • "IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats."
    Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., Kotake S.
    Arthritis Res Ther 9:R96-R96(2007) [PubMed] [Europe PMC] [Abstract]
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS One 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-10 production Source: BHF-UCLInferred from direct assayⁱ
  • "ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells."
    Wassink L., Vieira P.L., Smits H.H., Kingsbury G.A., Coyle A.J., Kapsenberg M.L., Wierenga E.A.
    J Immunol 173:1779-1786(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-12 production Source: BHF-UCLInferred from direct assayⁱ
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS One 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-17 production Source: BHF-UCLInferred from direct assayⁱ
  • "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."
    Hoeve M.A., Savage N.D., de Boer T., Langenberg D.M., de Waal Malefyt R., Ottenhoff T.H., Verreck F.A.
    Eur J Immunol 36:661-670(2006) [PubMed] [Europe PMC] [Abstract]
  • Ref.12

    "IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production."
    Vaknin-Dembinsky A., Balashov K., Weiner H.L.
    J. Immunol. 176:7768-7774(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
  • "IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats."
    Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., Kotake S.
    Arthritis Res Ther 9:R96-R96(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of memory T cell differentiation Source: BHF-UCL
• positive regulation of natural killer cell activation Source: BHF-UCLInferred by curatorⁱ
  • "Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    PLoS One 4:e8396-e8396(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of natural killer cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int Immunol 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil chemotaxis Source: Ensembl
• positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity."
    Fukuda M., Ehara M., Suzuki S., Ohmori Y., Sakashita H.
    Int J Oncol 36:1355-1365(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NK T cell activation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int Immunol 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NK T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int Immunol 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoclast differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats."
    Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., Kotake S.
    Arthritis Res Ther 9:R96-R96(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortalInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
• positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
• positive regulation of T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
• positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
• positive regulation of T-helper 17 type immune response Source: ComplexPortalInferred from direct assayⁱ
  • "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."
    Hoeve M.A., Savage N.D., de Boer T., Langenberg D.M., de Waal Malefyt R., Ottenhoff T.H., Verreck F.A.
    Eur J Immunol 36:661-670(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T-helper 1 type immune response Source: BHF-UCLInferred from direct assayⁱ
  • Ref.7

    "Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development."
    Smits H.H., van Beelen A.J., Hessle C., Westland R., de Jong E., Soeteman E., Wold A., Wierenga E.A., Kapsenberg M.L.
    Eur. J. Immunol. 34:1371-1380(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of tissue remodeling Source: BHF-UCLInferred by curatorⁱ
  • "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."
    Hoeve M.A., Savage N.D., de Boer T., Langenberg D.M., de Waal Malefyt R., Ottenhoff T.H., Verreck F.A.
    Eur J Immunol 36:661-670(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of tumor necrosis factor production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.12

    "IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production."
    Vaknin-Dembinsky A., Balashov K., Weiner H.L.
    J. Immunol. 176:7768-7774(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
  • "IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12."
    van de Wetering D., de Paus R.A., van Dissel J.T., van de Vosse E.
    Int Immunol 21:145-153(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCLInferred from direct assayⁱ
  • Ref.5

    "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
    Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M.

    , Kastelein R.A., de Waal Malefyt R., Moore K.W.
    J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH IL12RB1 AND IL23R.
• T cell proliferation Source: Ensembl
• tissue remodeling Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• interleukin-23 receptor binding Source: Ensembl

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL 
        60         70         80         90        100
VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY 
       110        120        130        140        150
EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL 
       160        170        180 
SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP             

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 12
   Human chromosome 12: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families