UniProtKB - Q9NPF7 (IL23A_HUMAN)
Interleukin-23 subunit alpha
IL23A
Functioni
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383).
Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:32474165, PubMed:29287995, PubMed:33606986).
This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369).
In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165).
Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044).
7 PublicationsGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- interleukin-23 receptor binding Source: Ensembl
GO - Biological processi
- defense response to Gram-negative bacterium Source: BHF-UCL
- defense response to virus Source: UniProtKB-KW
- immune response Source: ComplexPortal
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- negative regulation of interleukin-10 production Source: BHF-UCL
- positive regulation of activated T cell proliferation Source: BHF-UCL
- positive regulation of activation of Janus kinase activity Source: BHF-UCL
- positive regulation of defense response to virus by host Source: BHF-UCL
- positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of interferon-gamma production Source: BHF-UCL
- positive regulation of interleukin-10 production Source: BHF-UCL
- positive regulation of interleukin-12 production Source: BHF-UCL
- positive regulation of interleukin-17 production Source: BHF-UCL
- positive regulation of memory T cell differentiation Source: BHF-UCL
- positive regulation of natural killer cell activation Source: BHF-UCL
- positive regulation of natural killer cell proliferation Source: BHF-UCL
- positive regulation of neutrophil chemotaxis Source: Ensembl
- positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
- positive regulation of NK T cell activation Source: BHF-UCL
- positive regulation of NK T cell proliferation Source: BHF-UCL
- positive regulation of osteoclast differentiation Source: BHF-UCL
- positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
- positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
- positive regulation of T cell proliferation Source: BHF-UCL
- positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
- positive regulation of T-helper 17 type immune response Source: ComplexPortal
- positive regulation of T-helper 1 type immune response Source: BHF-UCL
- positive regulation of tissue remodeling Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of tumor necrosis factor production Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- T cell proliferation Source: Ensembl
- tissue remodeling Source: UniProtKB-KW
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling |
Enzyme and pathway databases
PathwayCommonsi | Q9NPF7 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9020933, Interleukin-23 signaling |
SignaLinki | Q9NPF7 |
SIGNORi | Q9NPF7 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-23 subunit alphaShort name: IL-23 subunit alpha Short name: IL-23-A Alternative name(s): Interleukin-23 subunit p19 Short name: IL-23p19 |
Gene namesi | Name:IL23A Synonyms:SGRF ORF Names:UNQ2498/PRO5798 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15488, IL23A |
MIMi | 605580, gene |
neXtProti | NX_Q9NPF7 |
VEuPathDBi | HostDB:ENSG00000110944 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Note: Secreted upon association with IL12B.
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- interleukin-23 complex Source: BHF-UCL
Plasma Membrane
- interleukin-23 receptor complex Source: ComplexPortal
- plasma membrane Source: ComplexPortal
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 51561 |
OpenTargetsi | ENSG00000110944 |
PharmGKBi | PA29824 |
Miscellaneous databases
Pharosi | Q9NPF7, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364154 |
DrugBanki | DB05459, Briakinumab DB11834, Guselkumab DB14762, Risankizumab DB14004, Tildrakizumab DB05679, Ustekinumab |
DrugCentrali | Q9NPF7 |
Genetic variation databases
BioMutai | IL23A |
DMDMi | 74761641 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000259488 | 20 – 189 | Interleukin-23 subunit alphaAdd BLAST | 170 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 73 | Interchain (with C-119 in IL12A)2 Publications | ||
Disulfide bondi | 77 ↔ 89 | 3 Publications |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q9NPF7 |
PaxDbi | Q9NPF7 |
PeptideAtlasi | Q9NPF7 |
PRIDEi | Q9NPF7 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000110944, Expressed in testis and 125 other tissues |
Genevisiblei | Q9NPF7, HS |
Organism-specific databases
HPAi | ENSG00000110944, Tissue enriched (urinary) |
Interactioni
Subunit structurei
Binary interactionsi
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- interleukin-23 receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 119611, 9 interactors |
ComplexPortali | CPX-3290, Interleukin-23 complex CPX-383, Interleukin-23-receptor complex |
IntActi | Q9NPF7, 6 interactors |
STRINGi | 9606.ENSP00000228534 |
Miscellaneous databases
RNActi | Q9NPF7, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9NPF7 |
SMRi | Q9NPF7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NPF7 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502STAQ, Eukaryota |
GeneTreei | ENSGT01040000240626 |
HOGENOMi | CLU_122915_0_0_1 |
InParanoidi | Q9NPF7 |
OMAi | WARCQQL |
OrthoDBi | 1344829at2759 |
PhylomeDBi | Q9NPF7 |
TreeFami | TF337234 |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR010831, IL-23_alpha |
PANTHERi | PTHR15947, PTHR15947, 1 hit |
Pfami | View protein in Pfam PF16649, IL23, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL
60 70 80 90 100
VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY
110 120 130 140 150
EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL
160 170 180
SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 122 | G → A in AAG37232 (PubMed:11114383).Curated | 1 | |
Sequence conflicti | 147 | I → M in AAH66267 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 168 | S → N in AAH66267 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 173 | V → A in AAH66269 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 189 | P → L in AAH66269 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF301620 mRNA Translation: AAG37232.1 AB030000 mRNA Translation: BAA93686.1 AB030001 Genomic DNA Translation: BAA93687.1 AY359083 mRNA Translation: AAQ89442.1 BC066267 mRNA Translation: AAH66267.1 BC066268 mRNA Translation: AAH66268.1 BC066269 mRNA Translation: AAH66269.1 BC067511 mRNA Translation: AAH67511.1 BC067512 mRNA Translation: AAH67512.1 BC067513 mRNA Translation: AAH67513.1 |
CCDSi | CCDS8916.1 |
RefSeqi | NP_057668.1, NM_016584.2 XP_011536779.1, XM_011538477.2 |
Genome annotation databases
Ensembli | ENST00000228534.6; ENSP00000228534.4; ENSG00000110944.9 |
GeneIDi | 51561 |
KEGGi | hsa:51561 |
MANE-Selecti | ENST00000228534.6; ENSP00000228534.4; NM_016584.3; NP_057668.1 |
UCSCi | uc001sla.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF301620 mRNA Translation: AAG37232.1 AB030000 mRNA Translation: BAA93686.1 AB030001 Genomic DNA Translation: BAA93687.1 AY359083 mRNA Translation: AAQ89442.1 BC066267 mRNA Translation: AAH66267.1 BC066268 mRNA Translation: AAH66268.1 BC066269 mRNA Translation: AAH66269.1 BC067511 mRNA Translation: AAH67511.1 BC067512 mRNA Translation: AAH67512.1 BC067513 mRNA Translation: AAH67513.1 |
CCDSi | CCDS8916.1 |
RefSeqi | NP_057668.1, NM_016584.2 XP_011536779.1, XM_011538477.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3D85 | X-ray | 1.90 | C | 20-189 | [»] | |
3D87 | X-ray | 2.90 | A/C | 20-189 | [»] | |
3DUH | X-ray | 2.30 | C/D | 20-189 | [»] | |
3QWR | X-ray | 3.25 | B | 20-189 | [»] | |
4GRW | X-ray | 2.55 | A/C | 1-189 | [»] | |
5MJ3 | X-ray | 1.74 | B | 20-189 | [»] | |
5MJ4 | X-ray | 3.40 | B | 20-189 | [»] | |
5MXA | X-ray | 2.50 | B | 1-189 | [»] | |
5MZV | X-ray | 2.80 | B | 1-189 | [»] | |
5NJD | X-ray | 3.90 | B/D/F/H/J/L | 1-189 | [»] | |
6UIB | X-ray | 2.74 | A | 20-189 | [»] | |
6WDQ | X-ray | 3.40 | B | 28-189 | [»] | |
AlphaFoldDBi | Q9NPF7 | |||||
SMRi | Q9NPF7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119611, 9 interactors |
ComplexPortali | CPX-3290, Interleukin-23 complex CPX-383, Interleukin-23-receptor complex |
IntActi | Q9NPF7, 6 interactors |
STRINGi | 9606.ENSP00000228534 |
Chemistry databases
ChEMBLi | CHEMBL2364154 |
DrugBanki | DB05459, Briakinumab DB11834, Guselkumab DB14762, Risankizumab DB14004, Tildrakizumab DB05679, Ustekinumab |
DrugCentrali | Q9NPF7 |
Genetic variation databases
BioMutai | IL23A |
DMDMi | 74761641 |
Proteomic databases
MassIVEi | Q9NPF7 |
PaxDbi | Q9NPF7 |
PeptideAtlasi | Q9NPF7 |
PRIDEi | Q9NPF7 |
Protocols and materials databases
ABCDi | Q9NPF7, 22 sequenced antibodies |
Antibodypediai | 803, 837 antibodies from 38 providers |
DNASUi | 51561 |
Genome annotation databases
Ensembli | ENST00000228534.6; ENSP00000228534.4; ENSG00000110944.9 |
GeneIDi | 51561 |
KEGGi | hsa:51561 |
MANE-Selecti | ENST00000228534.6; ENSP00000228534.4; NM_016584.3; NP_057668.1 |
UCSCi | uc001sla.4, human |
Organism-specific databases
CTDi | 51561 |
DisGeNETi | 51561 |
GeneCardsi | IL23A |
HGNCi | HGNC:15488, IL23A |
HPAi | ENSG00000110944, Tissue enriched (urinary) |
MIMi | 605580, gene |
neXtProti | NX_Q9NPF7 |
OpenTargetsi | ENSG00000110944 |
PharmGKBi | PA29824 |
VEuPathDBi | HostDB:ENSG00000110944 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502STAQ, Eukaryota |
GeneTreei | ENSGT01040000240626 |
HOGENOMi | CLU_122915_0_0_1 |
InParanoidi | Q9NPF7 |
OMAi | WARCQQL |
OrthoDBi | 1344829at2759 |
PhylomeDBi | Q9NPF7 |
TreeFami | TF337234 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPF7 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9020933, Interleukin-23 signaling |
SignaLinki | Q9NPF7 |
SIGNORi | Q9NPF7 |
Miscellaneous databases
BioGRID-ORCSi | 51561, 12 hits in 1024 CRISPR screens |
EvolutionaryTracei | Q9NPF7 |
GeneWikii | Interleukin_23 |
GenomeRNAii | 51561 |
Pharosi | Q9NPF7, Tclin |
PROi | PR:Q9NPF7 |
RNActi | Q9NPF7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110944, Expressed in testis and 125 other tissues |
Genevisiblei | Q9NPF7, HS |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR010831, IL-23_alpha |
PANTHERi | PTHR15947, PTHR15947, 1 hit |
Pfami | View protein in Pfam PF16649, IL23, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL23A_HUMAN | |
Accessioni | Q9NPF7Primary (citable) accession number: Q9NPF7 Secondary accession number(s): Q6NZ80, Q6NZ82, Q9H2A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families