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UniProtKB - Q9NPF7 (IL23A_HUMAN)

Protein

Interleukin-23 subunit alpha

Gene

IL23A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-23 receptor binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020933 Interleukin-23 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NPF7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NPF7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL23A
Synonyms:SGRF
ORF Names:UNQ2498/PRO5798
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000110944.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:15488 IL23A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605580 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPF7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51561

Open Targets

More...OpenTargetsi		ENSG00000110944

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29824

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3580502

Drug and drug target database

More...DrugBanki		DB05459 Briakinumab
DB05679 Ustekinumab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL23A

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025948820 – 189Interleukin-23 subunit alphaAdd BLAST170

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPF7

PeptideAtlas

More...PeptideAtlasi		Q9NPF7

PRoteomics IDEntifications database

More...PRIDEi		Q9NPF7

ProteomicsDB human proteome resource

More...ProteomicsDBi		81986

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed by newborns dendritic cells.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.7 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110944 Expressed in 106 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...CleanExi		HS_IL23A

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPF7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA001554

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119611, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3290 Interleukin-23 complex
CPX-383 Interleukin-23-receptor complex

Protein interaction database and analysis system

More...IntActi		Q9NPF7, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000228534

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9NPF7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NPF7

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NPF7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IGBY Eukaryota
ENOG411142Q LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006482

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000048728

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG081786

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPF7

KEGG Orthology (KO)

More...KOi		K05426

Identification of Orthologs from Complete Genome Data

More...OMAi		PMGHVDL

Database of Orthologous Groups

More...OrthoDBi		EOG091G0Q9J

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPF7

TreeFam database of animal gene trees

More...TreeFami		TF337234

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010831 IL-23_alpha

The PANTHER Classification System

More...PANTHERi		PTHR15947 PTHR15947, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16649 IL23, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47266 SSF47266, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NPF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL 
        60         70         80         90        100
VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY 
       110        120        130        140        150
EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL 
       160        170        180 
SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP
Length:189
Mass (Da):20,730
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51B5C0F188EC1B9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti122G → A in AAG37232 (PubMed:11114383).Curated1
Sequence conflicti147I → M in AAH66267 (PubMed:15489334).Curated1
Sequence conflicti168S → N in AAH66267 (PubMed:15489334).Curated1
Sequence conflicti173V → A in AAH66269 (PubMed:15489334).Curated1
Sequence conflicti189P → L in AAH66269 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF301620 mRNA Translation: AAG37232.1
AB030000 mRNA Translation: BAA93686.1
AB030001 Genomic DNA Translation: BAA93687.1
AY359083 mRNA Translation: AAQ89442.1
BC066267 mRNA Translation: AAH66267.1
BC066268 mRNA Translation: AAH66268.1
BC066269 mRNA Translation: AAH66269.1
BC067511 mRNA Translation: AAH67511.1
BC067512 mRNA Translation: AAH67512.1
BC067513 mRNA Translation: AAH67513.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8916.1

NCBI Reference Sequences

More...RefSeqi		NP_057668.1, NM_016584.2
XP_011536779.1, XM_011538477.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.382212
Hs.98309

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000228534; ENSP00000228534; ENSG00000110944

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51561

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51561

UCSC genome browser

More...UCSCi		uc001sla.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301620 mRNA Translation: AAG37232.1
AB030000 mRNA Translation: BAA93686.1
AB030001 Genomic DNA Translation: BAA93687.1
AY359083 mRNA Translation: AAQ89442.1
BC066267 mRNA Translation: AAH66267.1
BC066268 mRNA Translation: AAH66268.1
BC066269 mRNA Translation: AAH66269.1
BC067511 mRNA Translation: AAH67511.1
BC067512 mRNA Translation: AAH67512.1
BC067513 mRNA Translation: AAH67513.1
CCDSiCCDS8916.1
RefSeqiNP_057668.1, NM_016584.2
XP_011536779.1, XM_011538477.2
UniGeneiHs.382212
Hs.98309

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D85X-ray1.90C20-189[»]
3D87X-ray2.90A/C20-189[»]
3DUHX-ray2.30C/D20-189[»]
3QWRX-ray3.25B20-189[»]
4GRWX-ray2.55A/C1-189[»]
5MJ3X-ray1.74B20-189[»]
5MJ4X-ray3.40B20-189[»]
5MXAX-ray2.50B1-189[»]
5MZVX-ray2.80B1-189[»]
5NJDX-ray3.90B/D/F/H/J/L1-189[»]
ProteinModelPortaliQ9NPF7
SMRiQ9NPF7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119611, 7 interactors
ComplexPortaliCPX-3290 Interleukin-23 complex
CPX-383 Interleukin-23-receptor complex
IntActiQ9NPF7, 4 interactors
STRINGi9606.ENSP00000228534

Chemistry databases

ChEMBLiCHEMBL3580502
DrugBankiDB05459 Briakinumab
DB05679 Ustekinumab

Polymorphism and mutation databases

BioMutaiIL23A
DMDMi74761641

Proteomic databases

PaxDbiQ9NPF7
PeptideAtlasiQ9NPF7
PRIDEiQ9NPF7
ProteomicsDBi81986

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51561
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228534; ENSP00000228534; ENSG00000110944
GeneIDi51561
KEGGihsa:51561
UCSCiuc001sla.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51561
DisGeNETi51561
EuPathDBiHostDB:ENSG00000110944.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL23A
HGNCiHGNC:15488 IL23A
HPAiHPA001554
MIMi605580 gene
neXtProtiNX_Q9NPF7
OpenTargetsiENSG00000110944
PharmGKBiPA29824

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IGBY Eukaryota
ENOG411142Q LUCA
GeneTreeiENSGT00390000006482
HOGENOMiHOG000048728
HOVERGENiHBG081786
InParanoidiQ9NPF7
KOiK05426
OMAiPMGHVDL
OrthoDBiEOG091G0Q9J
PhylomeDBiQ9NPF7
TreeFamiTF337234

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020933 Interleukin-23 signaling
SignaLinkiQ9NPF7
SIGNORiQ9NPF7

Miscellaneous databases

EvolutionaryTraceiQ9NPF7

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Interleukin_23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51561

Protein Ontology

More...PROi		PR:Q9NPF7

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110944 Expressed in 106 organ(s), highest expression level in testis
CleanExiHS_IL23A
GenevisibleiQ9NPF7 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010831 IL-23_alpha
PANTHERiPTHR15947 PTHR15947, 1 hit
PfamiView protein in Pfam
PF16649 IL23, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL23A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPF7
Secondary accession number(s): Q6NZ80, Q6NZ82, Q9H2A5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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