IL23A

Functionⁱ

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.3 Publications

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
interleukin-23 receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytokine-mediated signaling pathway Source: Reactome
defense response to Gram-negative bacterium
Source: BHF-UCL
Inferred from direct assayⁱ
- 15114670
- 20027291
defense response to virus Source: UniProtKB-KW
inflammatory response Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
interleukin-23-mediated signaling pathway Source: Reactome
negative regulation of interleukin-10 production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16751425
positive regulation of activated T cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 11114383
positive regulation of activation of Janus kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 12023369
positive regulation of defense response to virus by host
Source: BHF-UCL
Inferred from direct assayⁱ
- 12421946
positive regulation of granulocyte macrophage colony-stimulating factor production
Source: BHF-UCL
Inferred from direct assayⁱ
- 20027291
positive regulation of inflammatory response
Source: BHF-UCL
Inferred by curatorⁱ
- 16482511
positive regulation of interferon-gamma production
Source: BHF-UCL
Inferred from direct assayⁱ
positive regulation of interleukin-10 production
Source: BHF-UCL
Inferred from direct assayⁱ
- 15265908
positive regulation of interleukin-12 production
Source: BHF-UCL
Inferred from direct assayⁱ
- 20027291
positive regulation of interleukin-17 production
Source: BHF-UCL
Inferred from direct assayⁱ
positive regulation of memory T cell differentiation Source: BHF-UCL
positive regulation of natural killer cell activation
Source: BHF-UCL
Inferred by curatorⁱ
- 20027291
positive regulation of natural killer cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19088061
positive regulation of neutrophil chemotaxis Source: Ensembl
positive regulation of NIK/NF-kappaB signaling
Source: BHF-UCL
Traceable author statementⁱ
- 20428758
positive regulation of NK T cell activation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19088061
positive regulation of NK T cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19088061
positive regulation of osteoclast differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17888176
positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
positive regulation of T cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 12023369
positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
positive regulation of T-helper 17 type immune response Source: BHF-UCL
positive regulation of T-helper 1 type immune response
Source: BHF-UCL
Inferred from direct assayⁱ
- 15114670
positive regulation of tissue remodeling
Source: BHF-UCL
Inferred by curatorⁱ
- 16482511
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of tumor necrosis factor production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16751425
positive regulation of tyrosine phosphorylation of STAT protein
Source: BHF-UCL
Inferred from direct assayⁱ
- 12023369
- 19088061
regulation of tyrosine phosphorylation of STAT protein
Source: BHF-UCL
Inferred from direct assayⁱ
- 12023369
T cell proliferation Source: Ensembl
tissue remodeling Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-9020933 Interleukin-23 signaling
SignaLinkⁱ	Q9NPF7
SIGNORⁱ	Q9NPF7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-23 subunit alpha Short name: IL-23 subunit alpha Short name: IL-23-A Alternative name(s): Interleukin-23 subunit p19 Short name: IL-23p19
Gene namesⁱ	Name:IL23A Synonyms:SGRF ORF Names:UNQ2498/PRO5798
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110944.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15488 IL23A
MIMⁱ	605580 gene
neXtProtⁱ	NX_Q9NPF7

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51561
Open Targets More...OpenTargetsⁱ	ENSG00000110944
PharmGKBⁱ	PA29824

Chemistry databases

ChEMBLⁱ	CHEMBL3580502
Drug and drug target database More...DrugBankⁱ	DB05459 Briakinumab DB05679 Ustekinumab

Polymorphism and mutation databases

BioMutaⁱ	IL23A
DMDMⁱ	74761641

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000259488	20 – 189	Interleukin-23 subunit alphaAdd BLAST		170

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q9NPF7
PeptideAtlas More...PeptideAtlasⁱ	Q9NPF7
PRIDEⁱ	Q9NPF7
ProteomicsDBⁱ	81986

Expressionⁱ

Tissue specificityⁱ

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).2 Publications

Developmental stageⁱ

Expressed by newborns dendritic cells.1 Publication

Inductionⁱ

Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.7 Publications

Gene expression databases

Bgeeⁱ	ENSG00000110944
CleanExⁱ	HS_IL23A
Genevisibleⁱ	Q9NPF7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001554

HPAⁱ

HPA001554

Interactionⁱ

Subunit structureⁱ

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL12B	P29460	4	EBI-2481154,EBI-1029614
PEX19	P40855	5	EBI-2481154,EBI-594747

Show more details

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
interleukin-23 receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119611, 7 interactors
ComplexPortalⁱ	CPX-3290 Interleukin-23 complex CPX-383 Interleukin-23-receptor complex
IntActⁱ	Q9NPF7, 4 interactors
STRINGⁱ	9606.ENSP00000228534

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	30 – 46	Combined sources	17
Turnⁱ	49 – 51	Combined sources	3
Turnⁱ	53 – 56	Combined sources	4
Helixⁱ	61 – 67	Combined sources	7
Helixⁱ	73 – 75	Combined sources	3
Helixⁱ	79 – 85	Combined sources	7
Helixⁱ	87 – 104	Combined sources	18
Helixⁱ	107 – 110	Combined sources	4
Beta strandⁱ	111 – 113	Combined sources	3
Helixⁱ	120 – 135	Combined sources	16
Beta strandⁱ	136 – 138	Combined sources	3
Helixⁱ	155 – 186	Combined sources	32

3D structure databases

ProteinModelPortalⁱ	Q9NPF7
SMRⁱ	Q9NPF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9NPF7

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-6 superfamily.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IGBY Eukaryota ENOG411142Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006482
HOGENOMⁱ	HOG000048728
HOVERGENⁱ	HBG081786
InParanoidⁱ	Q9NPF7
KEGG Orthology (KO) More...KOⁱ	K05426
OMAⁱ	PMGHVDL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q9J
PhylomeDBⁱ	Q9NPF7
TreeFamⁱ	TF337234

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR010831 IL-23_alpha
PANTHERⁱ	PTHR15947 PTHR15947, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16649 IL23, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9NPF7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL 
        60         70         80         90        100
VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY 
       110        120        130        140        150
EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL 
       160        170        180 
SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP

Length:189

Mass (Da):20,730

Last modified:October 1, 2000 - v1

Checksum:ⁱ51B5C0F188EC1B9F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	122	G → A in AAG37232 (PubMed:11114383).Curated	1
Sequence conflictⁱ	147	I → M in AAH66267 (PubMed:15489334).Curated	1
Sequence conflictⁱ	168	S → N in AAH66267 (PubMed:15489334).Curated	1
Sequence conflictⁱ	173	V → A in AAH66269 (PubMed:15489334).Curated	1
Sequence conflictⁱ	189	P → L in AAH66269 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF301620 mRNA Translation: AAG37232.1 AB030000 mRNA Translation: BAA93686.1 AB030001 Genomic DNA Translation: BAA93687.1 AY359083 mRNA Translation: AAQ89442.1 BC066267 mRNA Translation: AAH66267.1 BC066268 mRNA Translation: AAH66268.1 BC066269 mRNA Translation: AAH66269.1 BC067511 mRNA Translation: AAH67511.1 BC067512 mRNA Translation: AAH67512.1 BC067513 mRNA Translation: AAH67513.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8916.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057668.1, NM_016584.2 XP_011536779.1, XM_011538477.2
UniGeneⁱ	Hs.382212 Hs.98309

Genome annotation databases

Ensemblⁱ	ENST00000228534; ENSP00000228534; ENSG00000110944
GeneIDⁱ	51561
KEGGⁱ	hsa:51561
UCSC genome browser More...UCSCⁱ	uc001sla.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9NPF7	IL23A isoform 3		PANTR		189
Interleukin 23 subunit alpha		PANPA		189
UPI00052E48D1		HUMAN		198
UPI00094DFD80		HUMAN		179
UPI0000E5FF09		HUMAN		170

Protein	Similar proteins		Species	Score	Length
Q9NPF7	IL23A isoform 3		PANTR		189
Interleukin 23 subunit alpha		PANPA		189
UPI00052E48D1		HUMAN		198
Interleukin 23 subunit alpha		COLAP		200
Interleukin 23 subunit alpha		PROCO		190
+25

Protein	Similar proteins		Species	Score	Length
Q9NPF7	IL23A isoform 3		PANTR		189
Interleukin 23 subunit alpha		PANPA		189
UPI00052E48D1		HUMAN		198
Interleukin 23 subunit alpha		COLAP		200
Interleukin 23 subunit alpha		PROCO		190
+123

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF301620 mRNA Translation: AAG37232.1 AB030000 mRNA Translation: BAA93686.1 AB030001 Genomic DNA Translation: BAA93687.1 AY359083 mRNA Translation: AAQ89442.1 BC066267 mRNA Translation: AAH66267.1 BC066268 mRNA Translation: AAH66268.1 BC066269 mRNA Translation: AAH66269.1 BC067511 mRNA Translation: AAH67511.1 BC067512 mRNA Translation: AAH67512.1 BC067513 mRNA Translation: AAH67513.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8916.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057668.1, NM_016584.2 XP_011536779.1, XM_011538477.2
UniGeneⁱ	Hs.382212 Hs.98309

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3D85	X-ray	1.90	C	20-189	[»]
	3D87	X-ray	2.90	A/C	20-189	[»]
	3DUH	X-ray	2.30	C/D	20-189	[»]
	3QWR	X-ray	3.25	B	20-189	[»]
	4GRW	X-ray	2.55	A/C	1-189	[»]
	5MJ3	X-ray	1.74	B	20-189	[»]
	5MJ4	X-ray	3.40	B	20-189	[»]
	5MXA	X-ray	2.50	B	1-189	[»]
	5MZV	X-ray	2.80	B	1-189	[»]
	5NJD	X-ray	3.90	B/D/F/H/J/L	1-189	[»]
ProteinModelPortalⁱ	Q9NPF7
SMRⁱ	Q9NPF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119611, 7 interactors
ComplexPortalⁱ	CPX-3290 Interleukin-23 complex CPX-383 Interleukin-23-receptor complex
IntActⁱ	Q9NPF7, 4 interactors
STRINGⁱ	9606.ENSP00000228534

Chemistry databases

ChEMBLⁱ	CHEMBL3580502
Drug and drug target database More...DrugBankⁱ	DB05459 Briakinumab DB05679 Ustekinumab

Polymorphism and mutation databases

BioMutaⁱ	IL23A
DMDMⁱ	74761641

Proteomic databases

PaxDbⁱ	Q9NPF7
PeptideAtlas More...PeptideAtlasⁱ	Q9NPF7
PRIDEⁱ	Q9NPF7
ProteomicsDBⁱ	81986

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51561
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000228534; ENSP00000228534; ENSG00000110944
GeneIDⁱ	51561
KEGGⁱ	hsa:51561
UCSC genome browser More...UCSCⁱ	uc001sla.4 human

Organism-specific databases

CTDⁱ	51561
DisGeNET More...DisGeNETⁱ	51561
EuPathDBⁱ	HostDB:ENSG00000110944.8
GeneCardsⁱ	IL23A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15488 IL23A
Human Protein Atlas More...HPAⁱ	HPA001554
MIMⁱ	605580 gene
neXtProtⁱ	NX_Q9NPF7
Open Targets More...OpenTargetsⁱ	ENSG00000110944
PharmGKBⁱ	PA29824
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGBY Eukaryota ENOG411142Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006482
HOGENOMⁱ	HOG000048728
HOVERGENⁱ	HBG081786
InParanoidⁱ	Q9NPF7
KEGG Orthology (KO) More...KOⁱ	K05426
OMAⁱ	PMGHVDL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q9J
PhylomeDBⁱ	Q9NPF7
TreeFamⁱ	TF337234

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-9020933 Interleukin-23 signaling
SignaLinkⁱ	Q9NPF7
SIGNORⁱ	Q9NPF7

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NPF7
GeneWikiⁱ	Interleukin_23
GenomeRNAiⁱ	51561
Protein Ontology More...PROⁱ	PR:Q9NPF7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110944
CleanExⁱ	HS_IL23A
Genevisibleⁱ	Q9NPF7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR010831 IL-23_alpha
PANTHERⁱ	PTHR15947 PTHR15947, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16649 IL23, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL23A_HUMAN
Accessionⁱ	Q9NPF7Primary (citable) accession number: Q9NPF7 Secondary accession number(s): Q6NZ80, Q6NZ82, Q9H2A5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	October 1, 2000
	Last modified:	July 18, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9NPF7 (IL23A_HUMAN)

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Interleukin-23 subunit alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ