UniProtKB - Q9NPE3 (NOP10_HUMAN)
H/ACA ribonucleoprotein complex subunit 3
NOP10
Functioni
GO - Molecular functioni
- box H/ACA snoRNA binding Source: BHF-UCL
- RNA binding Source: BHF-UCL
- telomerase RNA binding Source: BHF-UCL
GO - Biological processi
- positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
- pseudouridine synthesis Source: UniProtKB
- rRNA pseudouridine synthesis Source: GO_Central
- snoRNA guided rRNA pseudouridine synthesis Source: Ensembl
- snRNA pseudouridine synthesis Source: GO_Central
- telomere maintenance via telomerase Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein |
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q9NPE3 |
Reactomei | R-HSA-171319, Telomere Extension By Telomerase R-HSA-6790901, rRNA modification in the nucleus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: H/ACA ribonucleoprotein complex subunit 3Alternative name(s): Nucleolar protein 10 Nucleolar protein family A member 3 snoRNP protein NOP10 |
Gene namesi | Name:NOP10 Synonyms:NOLA3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14378, NOP10 |
MIMi | 606471, gene |
neXtProti | NX_Q9NPE3 |
VEuPathDBi | HostDB:ENSG00000182117.5 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
- Cajal body 1 Publication
Note: Also localized to Cajal bodies (coiled bodies).
Nucleus
- box H/ACA scaRNP complex Source: BHF-UCL
- box H/ACA snoRNP complex Source: BHF-UCL
- box H/ACA telomerase RNP complex Source: BHF-UCL
- nuclear body Source: HPA
- nucleoplasm Source: Reactome
- telomerase holoenzyme complex Source: UniProtKB
Other locations
- sno(s)RNA-containing ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Dyskeratosis congenita, autosomal recessive, 1 (DKCB1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043725 | 34 | R → W in DKCB1. 1 PublicationCorresponds to variant dbSNP:rs121908092EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Dyskeratosis congenitaOrganism-specific databases
DisGeNETi | 55505 |
GeneReviewsi | NOP10 |
MalaCardsi | NOP10 |
MIMi | 224230, phenotype |
OpenTargetsi | ENSG00000182117 |
Orphaneti | 1775, Dyskeratosis congenita |
PharmGKBi | PA164723973 |
Miscellaneous databases
Pharosi | Q9NPE3, Tbio |
Genetic variation databases
BioMutai | NOP10 |
DMDMi | 54036209 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149001 | 1 – 64 | H/ACA ribonucleoprotein complex subunit 3Add BLAST | 64 |
Proteomic databases
EPDi | Q9NPE3 |
jPOSTi | Q9NPE3 |
MassIVEi | Q9NPE3 |
MaxQBi | Q9NPE3 |
PaxDbi | Q9NPE3 |
PeptideAtlasi | Q9NPE3 |
PRIDEi | Q9NPE3 |
ProteomicsDBi | 81979 |
TopDownProteomicsi | Q9NPE3 |
PTM databases
iPTMneti | Q9NPE3 |
MetOSitei | Q9NPE3 |
PhosphoSitePlusi | Q9NPE3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182117, Expressed in oocyte and 239 other tissues |
ExpressionAtlasi | Q9NPE3, baseline and differential |
Genevisiblei | Q9NPE3, HS |
Organism-specific databases
HPAi | ENSG00000182117, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit (PubMed:11074001). The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1 (PubMed:11074001). The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate (PubMed:16601202). During assembly, the complex contains NAF1 instead of GAR1/NOLA1 (PubMed:11074001, PubMed:16601202). The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs (PubMed:11074001, PubMed:16601202). Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2 (PubMed:11074001, PubMed:16601202). Associates with NOLC1/NOPP140 (PubMed:11074001, PubMed:16601202). H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4 (PubMed:11074001, PubMed:16601202). This is mediated by interaction between GAR1 and SMN1 or SMN2 (PubMed:11074001, PubMed:16601202). The SMN complex may be required for correct assembly of the H/ACA snoRNP complex (PubMed:11074001, PubMed:16601202).
Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC) (PubMed:19179534, PubMed:20351177, PubMed:29695869). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1 (PubMed:19179534).
5 PublicationsBinary interactionsi
Hide detailsQ9NPE3
With | #Exp. | IntAct |
---|---|---|
CABP2 [Q9NPB3] | 3 | EBI-1642169,EBI-12011224 |
MEOX2 [Q6FHY5] | 3 | EBI-1642169,EBI-16439278 |
NHP2 [Q9NX24] | 11 | EBI-1642169,EBI-1050064 |
Protein-protein interaction databases
BioGRIDi | 120685, 51 interactors |
ComplexPortali | CPX-265, Telomerase holoenzyme complex |
CORUMi | Q9NPE3 |
DIPi | DIP-40092N |
IntActi | Q9NPE3, 30 interactors |
MINTi | Q9NPE3 |
STRINGi | 9606.ENSP00000332198 |
Miscellaneous databases
RNActi | Q9NPE3, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3503, Eukaryota |
GeneTreei | ENSGT00390000012563 |
HOGENOMi | CLU_184680_1_0_1 |
InParanoidi | Q9NPE3 |
OMAi | HLMYTLG |
OrthoDBi | 1628018at2759 |
PhylomeDBi | Q9NPE3 |
TreeFami | TF300211 |
Family and domain databases
Gene3Di | 2.20.28.40, 1 hit |
InterProi | View protein in InterPro IPR007264, H/ACA_rnp_Nop10 IPR036756, H/ACA_rnp_Nop10_sf |
PANTHERi | PTHR13305, PTHR13305, 1 hit |
Pfami | View protein in Pfam PF04135, Nop10p, 1 hit |
SUPFAMi | SSF144210, SSF144210, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MFLQYYLNEQ GDRVYTLKKF DPMGQQTCSA HPARFSPDDK YSRHRITIKK
60
RFKVLMTQQP RPVL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YM60 | H0YM60_HUMAN | H/ACA ribonucleoprotein complex sub... | NOP10 | 36 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043725 | 34 | R → W in DKCB1. 1 PublicationCorresponds to variant dbSNP:rs121908092EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB043103 Genomic DNA Translation: BAA96107.1 AB043104 mRNA Translation: BAA96133.1 BC008886 mRNA Translation: AAH08886.1 BC063023 mRNA Translation: AAH63023.1 |
CCDSi | CCDS10037.1 |
RefSeqi | NP_061118.1, NM_018648.3 |
Genome annotation databases
Ensembli | ENST00000328848; ENSP00000332198; ENSG00000182117 |
GeneIDi | 55505 |
KEGGi | hsa:55505 |
UCSCi | uc001zie.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB043103 Genomic DNA Translation: BAA96107.1 AB043104 mRNA Translation: BAA96133.1 BC008886 mRNA Translation: AAH08886.1 BC063023 mRNA Translation: AAH63023.1 |
CCDSi | CCDS10037.1 |
RefSeqi | NP_061118.1, NM_018648.3 |
3D structure databases
SMRi | Q9NPE3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120685, 51 interactors |
ComplexPortali | CPX-265, Telomerase holoenzyme complex |
CORUMi | Q9NPE3 |
DIPi | DIP-40092N |
IntActi | Q9NPE3, 30 interactors |
MINTi | Q9NPE3 |
STRINGi | 9606.ENSP00000332198 |
PTM databases
iPTMneti | Q9NPE3 |
MetOSitei | Q9NPE3 |
PhosphoSitePlusi | Q9NPE3 |
Genetic variation databases
BioMutai | NOP10 |
DMDMi | 54036209 |
Proteomic databases
EPDi | Q9NPE3 |
jPOSTi | Q9NPE3 |
MassIVEi | Q9NPE3 |
MaxQBi | Q9NPE3 |
PaxDbi | Q9NPE3 |
PeptideAtlasi | Q9NPE3 |
PRIDEi | Q9NPE3 |
ProteomicsDBi | 81979 |
TopDownProteomicsi | Q9NPE3 |
Protocols and materials databases
Antibodypediai | 41964, 56 antibodies |
Genome annotation databases
Ensembli | ENST00000328848; ENSP00000332198; ENSG00000182117 |
GeneIDi | 55505 |
KEGGi | hsa:55505 |
UCSCi | uc001zie.2, human |
Organism-specific databases
CTDi | 55505 |
DisGeNETi | 55505 |
GeneCardsi | NOP10 |
GeneReviewsi | NOP10 |
HGNCi | HGNC:14378, NOP10 |
HPAi | ENSG00000182117, Tissue enhanced (blood) |
MalaCardsi | NOP10 |
MIMi | 224230, phenotype 606471, gene |
neXtProti | NX_Q9NPE3 |
OpenTargetsi | ENSG00000182117 |
Orphaneti | 1775, Dyskeratosis congenita |
PharmGKBi | PA164723973 |
VEuPathDBi | HostDB:ENSG00000182117.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3503, Eukaryota |
GeneTreei | ENSGT00390000012563 |
HOGENOMi | CLU_184680_1_0_1 |
InParanoidi | Q9NPE3 |
OMAi | HLMYTLG |
OrthoDBi | 1628018at2759 |
PhylomeDBi | Q9NPE3 |
TreeFami | TF300211 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPE3 |
Reactomei | R-HSA-171319, Telomere Extension By Telomerase R-HSA-6790901, rRNA modification in the nucleus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 55505, 662 hits in 1002 CRISPR screens |
ChiTaRSi | NOP10, human |
GenomeRNAii | 55505 |
Pharosi | Q9NPE3, Tbio |
PROi | PR:Q9NPE3 |
RNActi | Q9NPE3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182117, Expressed in oocyte and 239 other tissues |
ExpressionAtlasi | Q9NPE3, baseline and differential |
Genevisiblei | Q9NPE3, HS |
Family and domain databases
Gene3Di | 2.20.28.40, 1 hit |
InterProi | View protein in InterPro IPR007264, H/ACA_rnp_Nop10 IPR036756, H/ACA_rnp_Nop10_sf |
PANTHERi | PTHR13305, PTHR13305, 1 hit |
Pfami | View protein in Pfam PF04135, Nop10p, 1 hit |
SUPFAMi | SSF144210, SSF144210, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOP10_HUMAN | |
Accessioni | Q9NPE3Primary (citable) accession number: Q9NPE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families