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Protein

Neuritin

Gene

NRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
SIGNORiQ9NPD7

Names & Taxonomyi

Protein namesi
Recommended name:
Neuritin
Gene namesi
Name:NRN1
Synonyms:NRN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124785.8
HGNCiHGNC:17972 NRN1
MIMi607409 gene
neXtProtiNX_Q9NPD7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi51299
OpenTargetsiENSG00000124785
PharmGKBiPA38477

Polymorphism and mutation databases

BioMutaiNRN1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000026251228 – 116NeuritinAdd BLAST89
PropeptideiPRO_0000262513117 – 142Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi116GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9NPD7
PeptideAtlasiQ9NPD7
PRIDEiQ9NPD7
ProteomicsDBi81975

PTM databases

iPTMnetiQ9NPD7
PhosphoSitePlusiQ9NPD7

Expressioni

Gene expression databases

BgeeiENSG00000124785 Expressed in 203 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_NRN1
ExpressionAtlasiQ9NPD7 baseline and differential
GenevisibleiQ9NPD7 HS

Interactioni

Subunit structurei

Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Protein-protein interaction databases

BioGridi119450, 28 interactors
STRINGi9606.ENSP00000244766

Structurei

3D structure databases

ProteinModelPortaliQ9NPD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXWR Eukaryota
ENOG410YHS3 LUCA
GeneTreeiENSGT00530000063853
HOGENOMiHOG000059601
HOVERGENiHBG052772
InParanoidiQ9NPD7
OMAiFHSCATT
PhylomeDBiQ9NPD7
TreeFamiTF332589

Family and domain databases

InterProiView protein in InterPro
IPR026144 Neuritin_fam
PANTHERiPTHR15902 PTHR15902, 1 hit
PfamiView protein in Pfam
PF15056 NRN1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NPD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA
60 70 80 90 100
NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN
110 120 130 140
LNIQGSLFEL CGSGNGAAGS LLPAFPVLLV SLSAALATWL SF
Length:142
Mass (Da):15,333
Last modified:October 1, 2000 - v1
Checksum:i6C3C3DAC8D6392E6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWT2A0A087WWT2_HUMAN
Neuritin
NRN1
168Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48 – 49SM → TW in AAP97232 (Ref. 3) Curated2
Sequence conflicti55 – 56GL → AW in AAP97232 (Ref. 3) Curated2
Sequence conflicti113 – 115SGN → RAT in AAP97232 (Ref. 3) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136631 mRNA Translation: AAF62371.1
AF114833 mRNA Translation: AAP97232.1
AL136307 Genomic DNA No translation available.
AK314095 mRNA Translation: BAG36790.1
CH471087 Genomic DNA Translation: EAW55184.1
BC002683 mRNA Translation: AAH02683.1
BC042019 mRNA Translation: AAH42019.1
CCDSiCCDS4495.1
RefSeqiNP_001265639.1, NM_001278710.1
NP_001265640.1, NM_001278711.1
NP_057672.1, NM_016588.2
UniGeneiHs.103291

Genome annotation databases

EnsembliENST00000244766; ENSP00000244766; ENSG00000124785
ENST00000616243; ENSP00000484055; ENSG00000124785
GeneIDi51299
KEGGihsa:51299
UCSCiuc003mwu.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136631 mRNA Translation: AAF62371.1
AF114833 mRNA Translation: AAP97232.1
AL136307 Genomic DNA No translation available.
AK314095 mRNA Translation: BAG36790.1
CH471087 Genomic DNA Translation: EAW55184.1
BC002683 mRNA Translation: AAH02683.1
BC042019 mRNA Translation: AAH42019.1
CCDSiCCDS4495.1
RefSeqiNP_001265639.1, NM_001278710.1
NP_001265640.1, NM_001278711.1
NP_057672.1, NM_016588.2
UniGeneiHs.103291

3D structure databases

ProteinModelPortaliQ9NPD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119450, 28 interactors
STRINGi9606.ENSP00000244766

PTM databases

iPTMnetiQ9NPD7
PhosphoSitePlusiQ9NPD7

Polymorphism and mutation databases

BioMutaiNRN1

Proteomic databases

PaxDbiQ9NPD7
PeptideAtlasiQ9NPD7
PRIDEiQ9NPD7
ProteomicsDBi81975

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244766; ENSP00000244766; ENSG00000124785
ENST00000616243; ENSP00000484055; ENSG00000124785
GeneIDi51299
KEGGihsa:51299
UCSCiuc003mwu.4 human

Organism-specific databases

CTDi51299
DisGeNETi51299
EuPathDBiHostDB:ENSG00000124785.8
GeneCardsiNRN1
HGNCiHGNC:17972 NRN1
MIMi607409 gene
neXtProtiNX_Q9NPD7
OpenTargetsiENSG00000124785
PharmGKBiPA38477
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXWR Eukaryota
ENOG410YHS3 LUCA
GeneTreeiENSGT00530000063853
HOGENOMiHOG000059601
HOVERGENiHBG052772
InParanoidiQ9NPD7
OMAiFHSCATT
PhylomeDBiQ9NPD7
TreeFamiTF332589

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
SIGNORiQ9NPD7

Miscellaneous databases

ChiTaRSiNRN1 human
GenomeRNAii51299
PROiPR:Q9NPD7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124785 Expressed in 203 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_NRN1
ExpressionAtlasiQ9NPD7 baseline and differential
GenevisibleiQ9NPD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR026144 Neuritin_fam
PANTHERiPTHR15902 PTHR15902, 1 hit
PfamiView protein in Pfam
PF15056 NRN1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NPD7
Secondary accession number(s): B2RA93, Q7Z4Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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