UniProtKB - Q9NPD5 (SO1B3_HUMAN)
Solute carrier organic anion transporter family member 1B3
SLCO1B3
Functioni
Mediates the Na+-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
1 PublicationGO - Molecular functioni
- bile acid transmembrane transporter activity Source: GO_Central
- organic anion transmembrane transporter activity Source: ProtInc
- sodium-independent organic anion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- bile acid and bile salt transport Source: GO_Central
- heme catabolic process Source: Reactome
- organic anion transport Source: ProtInc
- sodium-independent organic anion transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NPD5 |
Reactomei | R-HSA-159418, Recycling of bile acids and salts R-HSA-189483, Heme degradation R-HSA-5619058, Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-879518, Transport of organic anions |
Protein family/group databases
TCDBi | 2.A.60.1.12, the organo anion transporter (oat) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier organic anion transporter family member 1B3Alternative name(s): Liver-specific organic anion transporter 2 Short name: LST-2 Organic anion transporter 8 Organic anion-transporting polypeptide 8 Short name: OATP-8 Solute carrier family 21 member 8 |
Gene namesi | Name:SLCO1B3 Synonyms:LST2, OATP1B3, OATP8, SLC21A8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10961, SLCO1B3 |
MIMi | 605495, gene |
neXtProti | NX_Q9NPD5 |
VEuPathDBi | HostDB:ENSG00000111700 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB-SubCell
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 49 – 67 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 68 – 88 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 94 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 95 – 119 | Helical; Name=3Sequence analysisAdd BLAST | 25 | |
Topological domaini | 120 – 168 | ExtracellularSequence analysisAdd BLAST | 49 | |
Transmembranei | 169 – 197 | Helical; Name=4Sequence analysisAdd BLAST | 29 | |
Topological domaini | 198 – 216 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 217 – 237 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 238 – 255 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 256 – 280 | Helical; Name=6Sequence analysisAdd BLAST | 25 | |
Topological domaini | 281 – 331 | CytoplasmicSequence analysisAdd BLAST | 51 | |
Transmembranei | 332 – 353 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 354 – 373 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 374 – 397 | Helical; Name=8Sequence analysisAdd BLAST | 24 | |
Topological domaini | 398 – 401 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 402 – 425 | Helical; Name=9Sequence analysisAdd BLAST | 24 | |
Topological domaini | 426 – 537 | ExtracellularSequence analysisAdd BLAST | 112 | |
Transmembranei | 538 – 560 | Helical; Name=10Sequence analysisAdd BLAST | 23 | |
Topological domaini | 561 – 569 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 570 – 595 | Helical; Name=11Sequence analysisAdd BLAST | 26 | |
Topological domaini | 596 – 629 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 630 – 647 | Helical; Name=12Sequence analysisAdd BLAST | 18 | |
Topological domaini | 648 – 695 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Hyperbilirubinemia, Rotor type (HBLRR)1 Publication
Organism-specific databases
DisGeNETi | 28234 |
GeneReviewsi | SLCO1B3 |
MalaCardsi | SLCO1B3 |
MIMi | 237450, phenotype |
OpenTargetsi | ENSG00000111700 ENSG00000257046 |
Orphaneti | 3111, Rotor syndrome |
PharmGKBi | PA35844 |
Miscellaneous databases
Pharosi | Q9NPD5, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1743121 |
DrugBanki | DB06403, Ambrisentan DB11586, Asunaprevir DB05016, Ataluren DB01072, Atazanavir DB01076, Atorvastatin DB11817, Baricitinib DB00394, Beclomethasone dipropionate DB15719, Belantamab mafodotin DB11936, Bempedoic acid DB00188, Bortezomib DB06772, Cabazitaxel DB00520, Caspofungin DB08862, Cholecystokinin DB02659, Cholic Acid DB01211, Clarithromycin DB00257, Clotrimazole DB09065, Cobicistat DB05239, Cobimetinib DB00286, Conjugated estrogens DB00091, Cyclosporine DB08912, Dabrafenib DB09102, Daclatasvir DB12941, Darolutamide DB00975, Dipyridamole DB01248, Docetaxel DB05928, Dovitinib DB08861, DPDPE DB04855, Dronedarone DB15444, Elexacaftor DB09038, Empagliflozin DB13874, Enasidenib DB00199, Erythromycin DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01590, Everolimus DB12500, Fedratinib DB00950, Fexofenadine DB01095, Fluvastatin DB11796, Fostemsavir DB08884, Gadoxetic acid DB01241, Gemfibrozil DB06749, Ginsenoside Rb1 DB06750, Ginsenoside Rg1 DB13879, Glecaprevir DB02691, Glycocholic acid DB11575, Grazoprevir DB09054, Idelalisib DB11757, Istradefylline DB00602, Ivermectin DB12070, Letermovir DB08855, Leukotriene C4 DB13153, Levomenol DB13139, Levosalbutamol DB00451, Levothyroxine DB00279, Liothyronine DB01583, Liotrix DB06448, Lonafarnib DB01601, Lopinavir DB00227, Lovastatin DB12674, Lurbinectedin DB00563, Methotrexate DB00834, Mifepristone DB00688, Mycophenolate mofetil DB01149, Nefazodone DB00220, Nelfinavir DB01051, Novobiocin DB00646, Nystatin DB00275, Olmesartan DB01092, Ouabain DB01229, Paclitaxel DB13154, Parachlorophenol DB09297, Paritaprevir DB12978, Pexidartinib DB13878, Pibrentasvir DB01132, Pioglitazone DB08860, Pitavastatin DB15822, Pralsetinib DB01708, Prasterone DB05804, Prasterone sulfate DB00175, Pravastatin DB00396, Progesterone DB00481, Raloxifene DB14761, Remdesivir DB11855, Revefenacin DB01045, Rifampicin DB11753, Rifamycin DB08864, Rilpivirine DB12457, Rimegepant DB00503, Ritonavir DB06176, Romidepsin DB01098, Rosuvastatin DB12332, Rucaparib DB09292, Sacubitril DB11362, Selexipag DB11942, Selinexor DB09298, Silibinin DB06290, Simeprevir DB00641, Simvastatin DB09142, Sincalide DB00795, Sulfasalazine DB04348, Taurocholic acid DB09137, Technetium Tc-99m mebrofenin DB00976, Telithromycin DB09299, Tenofovir alafenamide DB00624, Testosterone DB13946, Testosterone undecanoate DB00932, Tipranavir DB06137, Tirbanibulin DB14962, Trastuzumab deruxtecan DB15328, Ubrogepant DB00177, Valsartan DB11869, Valspodar DB11613, Velpatasvir DB00541, Vincristine DB12026, Voxilaprevir |
DrugCentrali | Q9NPD5 |
GuidetoPHARMACOLOGYi | 1221 |
Genetic variation databases
BioMutai | SLCO1B3 |
DMDMi | 27734563 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191053 | 1 – 702 | Solute carrier organic anion transporter family member 1B3Add BLAST | 702 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 293 | PhosphoserineBy similarity | 1 | |
Modified residuei | 295 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 445 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 459 ↔ 489 | PROSITE-ProRule annotation | ||
Disulfide bondi | 465 ↔ 485 | PROSITE-ProRule annotation | ||
Disulfide bondi | 474 ↔ 506 | PROSITE-ProRule annotation | ||
Glycosylationi | 503 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 516 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 683 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q9NPD5 |
PaxDbi | Q9NPD5 |
PeptideAtlasi | Q9NPD5 |
PRIDEi | Q9NPD5 |
ProteomicsDBi | 62988 81974 [Q9NPD5-1] |
PTM databases
GlyGeni | Q9NPD5, 8 sites, 1 N-linked glycan (2 sites) |
iPTMneti | Q9NPD5 |
PhosphoSitePlusi | Q9NPD5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000111700, Expressed in liver and 88 other tissues |
ExpressionAtlasi | Q9NPD5, baseline and differential |
Genevisiblei | Q9NPD5, HS |
Organism-specific databases
HPAi | ENSG00000111700, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 118182, 9 interactors |
STRINGi | 9606.ENSP00000261196 |
Chemistry databases
BindingDBi | Q9NPD5 |
Miscellaneous databases
RNActi | Q9NPD5, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 453 – 508 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 56 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3626, Eukaryota |
GeneTreei | ENSGT01040000240481 |
HOGENOMi | CLU_008954_4_0_1 |
InParanoidi | Q9NPD5 |
OMAi | IANFMIA |
PhylomeDBi | Q9NPD5 |
TreeFami | TF317540 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004156, OATP |
PANTHERi | PTHR11388, PTHR11388, 1 hit |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit PF03137, OATP, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00805, oat, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI
60 70 80 90 100
SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF
160 170 180 190 200
NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA
210 220 230 240 250
KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK
260 270 280 290 300
DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK
310 320 330 340 350
TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS
360 370 380 390 400
SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF
410 420 430 440 450
KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS
460 470 480 490 500
HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV
510 520 530 540 550
FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT
560 570 580 590 600
GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM
610 620 630 640 650
KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK
660 670 680 690 700
FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA
AN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YGG9 | H0YGG9_HUMAN | Solute carrier organic anion transp... | SLCO1B3 | 479 | Annotation score: | ||
F5H8K0 | F5H8K0_HUMAN | Solute carrier organic anion transp... | SLCO1B3 | 291 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024645 | 112 | S → A. Corresponds to variant dbSNP:rs4149117EnsemblClinVar. | 1 | |
Natural variantiVAR_053672 | 233 | M → I. Corresponds to variant dbSNP:rs7311358EnsemblClinVar. | 1 | |
Natural variantiVAR_062150 | 256 | G → A. Corresponds to variant dbSNP:rs60140950EnsemblClinVar. | 1 | |
Natural variantiVAR_036410 | 292 | I → M in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_053673 | 560 | V → A. Corresponds to variant dbSNP:rs12299012EnsemblClinVar. | 1 | |
Natural variantiVAR_036411 | 647 | M → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs556554798Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056615 | 622 – 664 | GRVYL…DNERK → GIVQPELKALAIGFHSMIMR SLGGILVPIYFGALIDTTCM KWSTNSCGARGACRIYNSTY LGRAFFGLKVALIFPVLVLL TVFIFVVRKKSHGKDTKVLE NERQ in isoform 2. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_056616 | 676 – 677 | NG → DS in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_056617 | 685 – 702 | GTDSK…NAAAN → EEQ in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ400763 , AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA Translation: CAB97008.1 AJ251506 mRNA Translation: CAB96997.1 AF187815 mRNA Translation: AAG43445.1 AY257471 mRNA Translation: AAP81212.1 AY442326 mRNA Translation: AAS01768.1 AC011604 Genomic DNA No translation available. AC087309 Genomic DNA No translation available. |
CCDSi | CCDS8684.1 [Q9NPD5-1] |
RefSeqi | NP_062818.1, NM_019844.3 [Q9NPD5-1] |
Genome annotation databases
Ensembli | ENST00000261196; ENSP00000261196; ENSG00000111700 ENST00000381545; ENSP00000370956; ENSG00000111700 |
GeneIDi | 28234 |
KEGGi | hsa:28234 |
MANE-Selecti | ENST00000381545.8; ENSP00000370956.4; NM_019844.4; NP_062818.1 |
UCSCi | uc001rel.5, human [Q9NPD5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ400763 , AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA Translation: CAB97008.1 AJ251506 mRNA Translation: CAB96997.1 AF187815 mRNA Translation: AAG43445.1 AY257471 mRNA Translation: AAP81212.1 AY442326 mRNA Translation: AAS01768.1 AC011604 Genomic DNA No translation available. AC087309 Genomic DNA No translation available. |
CCDSi | CCDS8684.1 [Q9NPD5-1] |
RefSeqi | NP_062818.1, NM_019844.3 [Q9NPD5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 118182, 9 interactors |
STRINGi | 9606.ENSP00000261196 |
Chemistry databases
BindingDBi | Q9NPD5 |
ChEMBLi | CHEMBL1743121 |
DrugBanki | DB06403, Ambrisentan DB11586, Asunaprevir DB05016, Ataluren DB01072, Atazanavir DB01076, Atorvastatin DB11817, Baricitinib DB00394, Beclomethasone dipropionate DB15719, Belantamab mafodotin DB11936, Bempedoic acid DB00188, Bortezomib DB06772, Cabazitaxel DB00520, Caspofungin DB08862, Cholecystokinin DB02659, Cholic Acid DB01211, Clarithromycin DB00257, Clotrimazole DB09065, Cobicistat DB05239, Cobimetinib DB00286, Conjugated estrogens DB00091, Cyclosporine DB08912, Dabrafenib DB09102, Daclatasvir DB12941, Darolutamide DB00975, Dipyridamole DB01248, Docetaxel DB05928, Dovitinib DB08861, DPDPE DB04855, Dronedarone DB15444, Elexacaftor DB09038, Empagliflozin DB13874, Enasidenib DB00199, Erythromycin DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01590, Everolimus DB12500, Fedratinib DB00950, Fexofenadine DB01095, Fluvastatin DB11796, Fostemsavir DB08884, Gadoxetic acid DB01241, Gemfibrozil DB06749, Ginsenoside Rb1 DB06750, Ginsenoside Rg1 DB13879, Glecaprevir DB02691, Glycocholic acid DB11575, Grazoprevir DB09054, Idelalisib DB11757, Istradefylline DB00602, Ivermectin DB12070, Letermovir DB08855, Leukotriene C4 DB13153, Levomenol DB13139, Levosalbutamol DB00451, Levothyroxine DB00279, Liothyronine DB01583, Liotrix DB06448, Lonafarnib DB01601, Lopinavir DB00227, Lovastatin DB12674, Lurbinectedin DB00563, Methotrexate DB00834, Mifepristone DB00688, Mycophenolate mofetil DB01149, Nefazodone DB00220, Nelfinavir DB01051, Novobiocin DB00646, Nystatin DB00275, Olmesartan DB01092, Ouabain DB01229, Paclitaxel DB13154, Parachlorophenol DB09297, Paritaprevir DB12978, Pexidartinib DB13878, Pibrentasvir DB01132, Pioglitazone DB08860, Pitavastatin DB15822, Pralsetinib DB01708, Prasterone DB05804, Prasterone sulfate DB00175, Pravastatin DB00396, Progesterone DB00481, Raloxifene DB14761, Remdesivir DB11855, Revefenacin DB01045, Rifampicin DB11753, Rifamycin DB08864, Rilpivirine DB12457, Rimegepant DB00503, Ritonavir DB06176, Romidepsin DB01098, Rosuvastatin DB12332, Rucaparib DB09292, Sacubitril DB11362, Selexipag DB11942, Selinexor DB09298, Silibinin DB06290, Simeprevir DB00641, Simvastatin DB09142, Sincalide DB00795, Sulfasalazine DB04348, Taurocholic acid DB09137, Technetium Tc-99m mebrofenin DB00976, Telithromycin DB09299, Tenofovir alafenamide DB00624, Testosterone DB13946, Testosterone undecanoate DB00932, Tipranavir DB06137, Tirbanibulin DB14962, Trastuzumab deruxtecan DB15328, Ubrogepant DB00177, Valsartan DB11869, Valspodar DB11613, Velpatasvir DB00541, Vincristine DB12026, Voxilaprevir |
DrugCentrali | Q9NPD5 |
GuidetoPHARMACOLOGYi | 1221 |
Protein family/group databases
TCDBi | 2.A.60.1.12, the organo anion transporter (oat) family |
PTM databases
GlyGeni | Q9NPD5, 8 sites, 1 N-linked glycan (2 sites) |
iPTMneti | Q9NPD5 |
PhosphoSitePlusi | Q9NPD5 |
Genetic variation databases
BioMutai | SLCO1B3 |
DMDMi | 27734563 |
Proteomic databases
MassIVEi | Q9NPD5 |
PaxDbi | Q9NPD5 |
PeptideAtlasi | Q9NPD5 |
PRIDEi | Q9NPD5 |
ProteomicsDBi | 62988 81974 [Q9NPD5-1] |
Protocols and materials databases
Antibodypediai | 12268, 234 antibodies from 22 providers |
DNASUi | 28234 |
Genome annotation databases
Ensembli | ENST00000261196; ENSP00000261196; ENSG00000111700 ENST00000381545; ENSP00000370956; ENSG00000111700 |
GeneIDi | 28234 |
KEGGi | hsa:28234 |
MANE-Selecti | ENST00000381545.8; ENSP00000370956.4; NM_019844.4; NP_062818.1 |
UCSCi | uc001rel.5, human [Q9NPD5-1] |
Organism-specific databases
CTDi | 28234 |
DisGeNETi | 28234 |
GeneCardsi | SLCO1B3 |
GeneReviewsi | SLCO1B3 |
HGNCi | HGNC:10961, SLCO1B3 |
HPAi | ENSG00000111700, Tissue enriched (liver) |
MalaCardsi | SLCO1B3 |
MIMi | 237450, phenotype 605495, gene |
neXtProti | NX_Q9NPD5 |
OpenTargetsi | ENSG00000111700 ENSG00000257046 |
Orphaneti | 3111, Rotor syndrome |
PharmGKBi | PA35844 |
VEuPathDBi | HostDB:ENSG00000111700 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3626, Eukaryota |
GeneTreei | ENSGT01040000240481 |
HOGENOMi | CLU_008954_4_0_1 |
InParanoidi | Q9NPD5 |
OMAi | IANFMIA |
PhylomeDBi | Q9NPD5 |
TreeFami | TF317540 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPD5 |
Reactomei | R-HSA-159418, Recycling of bile acids and salts R-HSA-189483, Heme degradation R-HSA-5619058, Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-879518, Transport of organic anions |
Miscellaneous databases
BioGRID-ORCSi | 28234, 5 hits in 1031 CRISPR screens |
ChiTaRSi | SLCO1B3, human |
GeneWikii | SLCO1B3 |
GenomeRNAii | 28234 |
Pharosi | Q9NPD5, Tchem |
PROi | PR:Q9NPD5 |
RNActi | Q9NPD5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111700, Expressed in liver and 88 other tissues |
ExpressionAtlasi | Q9NPD5, baseline and differential |
Genevisiblei | Q9NPD5, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004156, OATP |
PANTHERi | PTHR11388, PTHR11388, 1 hit |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit PF03137, OATP, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00805, oat, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SO1B3_HUMAN | |
Accessioni | Q9NPD5Primary (citable) accession number: Q9NPD5 Secondary accession number(s): E7EMT8, Q5JAR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families