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Protein

Solute carrier organic anion transporter family member 1B3

Gene

SLCO1B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.1 Publication

GO - Molecular functioni

  • bile acid transmembrane transporter activity Source: GO_Central
  • organic anion transmembrane transporter activity Source: ProtInc
  • sodium-independent organic anion transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.12 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B3
Alternative name(s):
Liver-specific organic anion transporter 2
Short name:
LST-2
Organic anion transporter 8
Organic anion-transporting polypeptide 8
Short name:
OATP-8
Solute carrier family 21 member 8
Gene namesi
Name:SLCO1B3
Synonyms:LST2, OATP1B3, OATP8, SLC21A8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111700.12
HGNCiHGNC:10961 SLCO1B3
MIMi605495 gene
neXtProtiNX_Q9NPD5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini49 – 67ExtracellularSequence analysisAdd BLAST19
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 94CytoplasmicSequence analysis6
Transmembranei95 – 119Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini120 – 168ExtracellularSequence analysisAdd BLAST49
Transmembranei169 – 197Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini198 – 216CytoplasmicSequence analysisAdd BLAST19
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 255ExtracellularSequence analysisAdd BLAST18
Transmembranei256 – 280Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini281 – 331CytoplasmicSequence analysisAdd BLAST51
Transmembranei332 – 353Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini354 – 373ExtracellularSequence analysisAdd BLAST20
Transmembranei374 – 397Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini398 – 401CytoplasmicSequence analysis4
Transmembranei402 – 425Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini426 – 537ExtracellularSequence analysisAdd BLAST112
Transmembranei538 – 560Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini561 – 569CytoplasmicSequence analysis9
Transmembranei570 – 595Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini596 – 629ExtracellularSequence analysisAdd BLAST34
Transmembranei630 – 647Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini648 – 695CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
See also OMIM:237450

Organism-specific databases

DisGeNETi28234
GeneReviewsiSLCO1B3
MalaCardsiSLCO1B3
MIMi237450 phenotype
OpenTargetsiENSG00000111700
ENSG00000257046
Orphaneti3111 Rotor syndrome
PharmGKBiPA35844

Chemistry databases

ChEMBLiCHEMBL1743121
DrugBankiDB06403 Ambrisentan
DB01076 Atorvastatin
DB06772 Cabazitaxel
DB00520 Caspofungin
DB08862 Cholecystokinin
DB02659 Cholic Acid
DB01211 Clarithromycin
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB08912 Dabrafenib
DB09102 Daclatasvir
DB05804 dehydroepiandrosterone sulfate
DB00390 Digoxin
DB01248 Docetaxel
DB00783 Estradiol
DB00950 Fexofenadine
DB01095 Fluvastatin
DB08884 Gadoxetic acid
DB11575 Grazoprevir
DB09054 Idelalisib
DB13153 Levomenol
DB13139 Levosalbutamol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB02691 N-Cholylglycine
DB00275 Olmesartan
DB01092 Ouabain
DB01229 Paclitaxel
DB13154 Parachlorophenol
DB01132 Pioglitazone
DB08860 Pitavastatin
DB00175 Pravastatin
DB01045 Rifampicin
DB08864 Rilpivirine
DB06176 Romidepsin
DB01098 Rosuvastatin
DB09292 Sacubitril
DB11362 Selexipag
DB04348 Taurocholic Acid
DB09137 Technetium Tc 99m Mebrofenin
DB00177 Valsartan
GuidetoPHARMACOLOGYi1221

Polymorphism and mutation databases

BioMutaiSLCO1B3
DMDMi27734563

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910531 – 702Solute carrier organic anion transporter family member 1B3Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei293PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
Glycosylationi503N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei683PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NPD5
PeptideAtlasiQ9NPD5
PRIDEiQ9NPD5
ProteomicsDBi81974

PTM databases

iPTMnetiQ9NPD5
PhosphoSitePlusiQ9NPD5

Expressioni

Tissue specificityi

Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

Gene expression databases

BgeeiENSG00000111700 Expressed in 62 organ(s), highest expression level in liver
CleanExiHS_SLCO1B3
ExpressionAtlasiQ9NPD5 baseline and differential
GenevisibleiQ9NPD5 HS

Organism-specific databases

HPAiHPA004943
HPA050892

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261196

Chemistry databases

BindingDBiQ9NPD5

Structurei

3D structure databases

ProteinModelPortaliQ9NPD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 508Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9NPD5
KOiK05043
OMAiCNLDMQD
OrthoDBiEOG091G08QD
PhylomeDBiQ9NPD5
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI
60 70 80 90 100
SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF
160 170 180 190 200
NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA
210 220 230 240 250
KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK
260 270 280 290 300
DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK
310 320 330 340 350
TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS
360 370 380 390 400
SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF
410 420 430 440 450
KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS
460 470 480 490 500
HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV
510 520 530 540 550
FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT
560 570 580 590 600
GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM
610 620 630 640 650
KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK
660 670 680 690 700
FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA

AN
Length:702
Mass (Da):77,403
Last modified:October 1, 2000 - v1
Checksum:i6D2AE371D782C7FB
GO
Isoform 2 (identifier: Q9NPD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-664: GRVYLGLSIA...DTKASDNERK → GIVQPELKAL...DTKVLENERQ
     676-677: NG → DS
     685-702: GTDSKTCNLDMQDNAAAN → EEQ

Show »
Length:748
Mass (Da):82,544
Checksum:i09A644194BDE3B85
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H8K0F5H8K0_HUMAN
Solute carrier organic anion transp...
SLCO1B3
291Annotation score:
H0YGG9H0YGG9_HUMAN
Solute carrier organic anion transp...
SLCO1B3
479Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024645112S → A. Corresponds to variant dbSNP:rs4149117EnsemblClinVar.1
Natural variantiVAR_053672233M → I. Corresponds to variant dbSNP:rs7311358EnsemblClinVar.1
Natural variantiVAR_062150256G → A. Corresponds to variant dbSNP:rs60140950EnsemblClinVar.1
Natural variantiVAR_036410292I → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053673560V → A. Corresponds to variant dbSNP:rs12299012Ensembl.1
Natural variantiVAR_036411647M → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs556554798Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056615622 – 664GRVYL…DNERK → GIVQPELKALAIGFHSMIMR SLGGILVPIYFGALIDTTCM KWSTNSCGARGACRIYNSTY LGRAFFGLKVALIFPVLVLL TVFIFVVRKKSHGKDTKVLE NERQ in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_056616676 – 677NG → DS in isoform 2. 1 Publication2
Alternative sequenceiVSP_056617685 – 702GTDSK…NAAAN → EEQ in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400763
, AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA Translation: CAB97008.1
AJ251506 mRNA Translation: CAB96997.1
AF187815 mRNA Translation: AAG43445.1
AY257471 mRNA Translation: AAP81212.1
AY442326 mRNA Translation: AAS01768.1
AC011604 Genomic DNA No translation available.
AC087309 Genomic DNA No translation available.
CCDSiCCDS8684.1 [Q9NPD5-1]
RefSeqiNP_062818.1, NM_019844.3 [Q9NPD5-1]
UniGeneiHs.504966

Genome annotation databases

EnsembliENST00000261196; ENSP00000261196; ENSG00000111700 [Q9NPD5-1]
ENST00000381545; ENSP00000370956; ENSG00000111700 [Q9NPD5-1]
GeneIDi28234
KEGGihsa:28234
UCSCiuc001rel.5 human [Q9NPD5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400763
, AJ400764, AJ400765, AJ400766, AJ400767, AJ400768, AJ400769, AJ400770, AJ400771, AJ400772, AJ400773, AJ400774, AJ400775, AJ400776 Genomic DNA Translation: CAB97008.1
AJ251506 mRNA Translation: CAB96997.1
AF187815 mRNA Translation: AAG43445.1
AY257471 mRNA Translation: AAP81212.1
AY442326 mRNA Translation: AAS01768.1
AC011604 Genomic DNA No translation available.
AC087309 Genomic DNA No translation available.
CCDSiCCDS8684.1 [Q9NPD5-1]
RefSeqiNP_062818.1, NM_019844.3 [Q9NPD5-1]
UniGeneiHs.504966

3D structure databases

ProteinModelPortaliQ9NPD5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261196

Chemistry databases

BindingDBiQ9NPD5
ChEMBLiCHEMBL1743121
DrugBankiDB06403 Ambrisentan
DB01076 Atorvastatin
DB06772 Cabazitaxel
DB00520 Caspofungin
DB08862 Cholecystokinin
DB02659 Cholic Acid
DB01211 Clarithromycin
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB08912 Dabrafenib
DB09102 Daclatasvir
DB05804 dehydroepiandrosterone sulfate
DB00390 Digoxin
DB01248 Docetaxel
DB00783 Estradiol
DB00950 Fexofenadine
DB01095 Fluvastatin
DB08884 Gadoxetic acid
DB11575 Grazoprevir
DB09054 Idelalisib
DB13153 Levomenol
DB13139 Levosalbutamol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB02691 N-Cholylglycine
DB00275 Olmesartan
DB01092 Ouabain
DB01229 Paclitaxel
DB13154 Parachlorophenol
DB01132 Pioglitazone
DB08860 Pitavastatin
DB00175 Pravastatin
DB01045 Rifampicin
DB08864 Rilpivirine
DB06176 Romidepsin
DB01098 Rosuvastatin
DB09292 Sacubitril
DB11362 Selexipag
DB04348 Taurocholic Acid
DB09137 Technetium Tc 99m Mebrofenin
DB00177 Valsartan
GuidetoPHARMACOLOGYi1221

Protein family/group databases

TCDBi2.A.60.1.12 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ9NPD5
PhosphoSitePlusiQ9NPD5

Polymorphism and mutation databases

BioMutaiSLCO1B3
DMDMi27734563

Proteomic databases

PaxDbiQ9NPD5
PeptideAtlasiQ9NPD5
PRIDEiQ9NPD5
ProteomicsDBi81974

Protocols and materials databases

DNASUi28234
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261196; ENSP00000261196; ENSG00000111700 [Q9NPD5-1]
ENST00000381545; ENSP00000370956; ENSG00000111700 [Q9NPD5-1]
GeneIDi28234
KEGGihsa:28234
UCSCiuc001rel.5 human [Q9NPD5-1]

Organism-specific databases

CTDi28234
DisGeNETi28234
EuPathDBiHostDB:ENSG00000111700.12
GeneCardsiSLCO1B3
GeneReviewsiSLCO1B3
HGNCiHGNC:10961 SLCO1B3
HPAiHPA004943
HPA050892
MalaCardsiSLCO1B3
MIMi237450 phenotype
605495 gene
neXtProtiNX_Q9NPD5
OpenTargetsiENSG00000111700
ENSG00000257046
Orphaneti3111 Rotor syndrome
PharmGKBiPA35844
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9NPD5
KOiK05043
OMAiCNLDMQD
OrthoDBiEOG091G08QD
PhylomeDBiQ9NPD5
TreeFamiTF317540

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions

Miscellaneous databases

ChiTaRSiSLCO1B3 human
GeneWikiiSLCO1B3
GenomeRNAii28234
PROiPR:Q9NPD5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111700 Expressed in 62 organ(s), highest expression level in liver
CleanExiHS_SLCO1B3
ExpressionAtlasiQ9NPD5 baseline and differential
GenevisibleiQ9NPD5 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSO1B3_HUMAN
AccessioniPrimary (citable) accession number: Q9NPD5
Secondary accession number(s): E7EMT8, Q5JAR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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