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UniProtKB - Q9NPD5 (SO1B3_HUMAN)

Entry version 170 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Solute carrier organic anion transporter family member 1B3

Gene

SLCO1B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the Na+-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NPD5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-159418, Recycling of bile acids and salts
R-HSA-189483, Heme degradation
R-HSA-5619058, Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518, Transport of organic anions

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.60.1.12, the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B3
Alternative name(s):
Liver-specific organic anion transporter 2
Short name:
LST-2
Organic anion transporter 8
Organic anion-transporting polypeptide 8
Short name:
OATP-8
Solute carrier family 21 member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO1B3
Synonyms:LST2, OATP1B3, OATP8, SLC21A8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000111700.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:10961, SLCO1B3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605495, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPD5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 48Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini49 – 67ExtracellularSequence analysisAdd BLAST19
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 94CytoplasmicSequence analysis6
Transmembranei95 – 119Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini120 – 168ExtracellularSequence analysisAdd BLAST49
Transmembranei169 – 197Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini198 – 216CytoplasmicSequence analysisAdd BLAST19
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 255ExtracellularSequence analysisAdd BLAST18
Transmembranei256 – 280Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini281 – 331CytoplasmicSequence analysisAdd BLAST51
Transmembranei332 – 353Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini354 – 373ExtracellularSequence analysisAdd BLAST20
Transmembranei374 – 397Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini398 – 401CytoplasmicSequence analysis4
Transmembranei402 – 425Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini426 – 537ExtracellularSequence analysisAdd BLAST112
Transmembranei538 – 560Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini561 – 569CytoplasmicSequence analysis9
Transmembranei570 – 595Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini596 – 629ExtracellularSequence analysisAdd BLAST34
Transmembranei630 – 647Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini648 – 695CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		28234

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		SLCO1B3

MalaCards human disease database

More...MalaCardsi		SLCO1B3
MIMi237450, phenotype

Open Targets

More...OpenTargetsi		ENSG00000111700
ENSG00000257046

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3111, Rotor syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35844

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NPD5, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1743121

Drug and drug target database

More...DrugBanki		DB06403, Ambrisentan
DB11586, Asunaprevir
DB05016, Ataluren
DB01072, Atazanavir
DB01076, Atorvastatin
DB11817, Baricitinib
DB00394, Beclomethasone dipropionate
DB11936, Bempedoic acid
DB06772, Cabazitaxel
DB00520, Caspofungin
DB08862, Cholecystokinin
DB02659, Cholic Acid
DB01211, Clarithromycin
DB00257, Clotrimazole
DB09065, Cobicistat
DB05239, Cobimetinib
DB00286, Conjugated estrogens
DB00091, Cyclosporine
DB08912, Dabrafenib
DB09102, Daclatasvir
DB12941, Darolutamide
DB00975, Dipyridamole
DB01248, Docetaxel
DB05928, Dovitinib
DB08861, DPDPE
DB04855, Dronedarone
DB15444, Elexacaftor
DB13874, Enasidenib
DB00199, Erythromycin
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB01590, Everolimus
DB12500, Fedratinib
DB00950, Fexofenadine
DB01095, Fluvastatin
DB08884, Gadoxetic acid
DB01241, Gemfibrozil
DB06749, Ginsenoside Rb1
DB06750, Ginsenoside Rg1
DB13879, Glecaprevir
DB02691, Glycocholic acid
DB11575, Grazoprevir
DB09054, Idelalisib
DB11757, Istradefylline
DB00602, Ivermectin
DB12070, Letermovir
DB08855, Leukotriene C4
DB13153, Levomenol
DB13139, Levosalbutamol
DB00451, Levothyroxine
DB00279, Liothyronine
DB01583, Liotrix
DB01601, Lopinavir
DB00227, Lovastatin
DB00563, Methotrexate
DB00834, Mifepristone
DB00688, Mycophenolate mofetil
DB01149, Nefazodone
DB00220, Nelfinavir
DB01051, Novobiocin
DB00646, Nystatin
DB00275, Olmesartan
DB01092, Ouabain
DB01229, Paclitaxel
DB13154, Parachlorophenol
DB09297, Paritaprevir
DB12978, Pexidartinib
DB13878, Pibrentasvir
DB01132, Pioglitazone
DB08860, Pitavastatin
DB01708, Prasterone
DB05804, Prasterone sulfate
DB00175, Pravastatin
DB00396, Progesterone
DB00481, Raloxifene
DB11855, Revefenacin
DB01045, Rifampicin
DB11753, Rifamycin
DB08864, Rilpivirine
DB12457, Rimegepant
DB00503, Ritonavir
DB06176, Romidepsin
DB01098, Rosuvastatin
DB12332, Rucaparib
DB09292, Sacubitril
DB11362, Selexipag
DB11942, Selinexor
DB09298, Silibinin
DB06290, Simeprevir
DB00641, Simvastatin
DB09142, Sincalide
DB00795, Sulfasalazine
DB04348, Taurocholic acid
DB09137, Technetium Tc-99m mebrofenin
DB00976, Telithromycin
DB09299, Tenofovir alafenamide
DB00624, Testosterone
DB13946, Testosterone undecanoate
DB00932, Tipranavir
DB14962, Trastuzumab deruxtecan
DB15328, Ubrogepant
DB00177, Valsartan
DB11869, Valspodar
DB11613, Velpatasvir
DB00541, Vincristine
DB12026, Voxilaprevir

DrugCentral

More...DrugCentrali		Q9NPD5

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1221

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLCO1B3

Domain mapping of disease mutations (DMDM)

More...DMDMi		27734563

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910531 – 702Solute carrier organic anion transporter family member 1B3Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei293PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
Glycosylationi503N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei683PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NPD5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPD5

PeptideAtlas

More...PeptideAtlasi		Q9NPD5

PRoteomics IDEntifications database

More...PRIDEi		Q9NPD5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62988
81974 [Q9NPD5-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NPD5, 8 sites, 1 N-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NPD5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NPD5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111700, Expressed in liver and 87 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NPD5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPD5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111700, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118182, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261196

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NPD5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NPD5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini453 – 508Kazal-likePROSITE-ProRule annotationAdd BLAST56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3626, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00980000198486

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008954_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPD5

KEGG Orthology (KO)

More...KOi		K05043

Identification of Orthologs from Complete Genome Data

More...OMAi		SHCKCAS

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPD5

TreeFam database of animal gene trees

More...TreeFami		TF317540

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004156, OATP

The PANTHER Classification System

More...PANTHERi		PTHR11388, PTHR11388, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07648, Kazal_2, 1 hit
PF03137, OATP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895, SSF100895, 1 hit
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00805, oat, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51465, KAZAL_2, 1 hit
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI 
        60         70         80         90        100
SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG 
       110        120        130        140        150
CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF 
       160        170        180        190        200
NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA 
       210        220        230        240        250
KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK 
       260        270        280        290        300
DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK 
       310        320        330        340        350
TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS 
       360        370        380        390        400
SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF 
       410        420        430        440        450
KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS 
       460        470        480        490        500
HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV 
       510        520        530        540        550
FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT 
       560        570        580        590        600
GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM 
       610        620        630        640        650
KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK 
       660        670        680        690        700
FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA 

AN
Length:702
Mass (Da):77,403
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D2AE371D782C7FB
GO
Isoform 2 (identifier: Q9NPD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-664: GRVYLGLSIA...DTKASDNERK → GIVQPELKAL...DTKVLENERQ
     676-677: NG → DS
     685-702: GTDSKTCNLDMQDNAAAN → EEQ

Show »
Length:748
Mass (Da):82,544
Checksum:i09A644194BDE3B85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGG9H0YGG9_HUMAN
Solute carrier organic anion transp...
SLCO1B3
479Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H8K0F5H8K0_HUMAN
Solute carrier organic anion transp...
SLCO1B3
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024645112S → A. Corresponds to variant dbSNP:rs4149117EnsemblClinVar.1
Natural variantiVAR_053672233M → I. Corresponds to variant dbSNP:rs7311358EnsemblClinVar.1
Natural variantiVAR_062150256G → A. Corresponds to variant dbSNP:rs60140950EnsemblClinVar.1
Natural variantiVAR_036410292I → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053673560V → A. Corresponds to variant dbSNP:rs12299012EnsemblClinVar.1
Natural variantiVAR_036411647M → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs556554798Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056615622 – 664GRVYL…DNERK → GIVQPELKALAIGFHSMIMR SLGGILVPIYFGALIDTTCM KWSTNSCGARGACRIYNSTY LGRAFFGLKVALIFPVLVLL TVFIFVVRKKSHGKDTKVLE NERQ in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_056616676 – 677NG → DS in isoform 2. 1 Publication2
Alternative sequenceiVSP_056617685 – 702GTDSK…NAAAN → EEQ in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ400763 AJ400776 Genomic DNA Translation: CAB97008.1
AJ251506 mRNA Translation: CAB96997.1
AF187815 mRNA Translation: AAG43445.1
AY257471 mRNA Translation: AAP81212.1
AY442326 mRNA Translation: AAS01768.1
AC011604 Genomic DNA No translation available.
AC087309 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8684.1 [Q9NPD5-1]

NCBI Reference Sequences

More...RefSeqi		NP_062818.1, NM_019844.3 [Q9NPD5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261196; ENSP00000261196; ENSG00000111700 [Q9NPD5-1]
ENST00000381545; ENSP00000370956; ENSG00000111700 [Q9NPD5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		28234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:28234

UCSC genome browser

More...UCSCi		uc001rel.5, human [Q9NPD5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400763 AJ400776 Genomic DNA Translation: CAB97008.1
AJ251506 mRNA Translation: CAB96997.1
AF187815 mRNA Translation: AAG43445.1
AY257471 mRNA Translation: AAP81212.1
AY442326 mRNA Translation: AAS01768.1
AC011604 Genomic DNA No translation available.
AC087309 Genomic DNA No translation available.
CCDSiCCDS8684.1 [Q9NPD5-1]
RefSeqiNP_062818.1, NM_019844.3 [Q9NPD5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi118182, 1 interactor
STRINGi9606.ENSP00000261196

Chemistry databases

BindingDBiQ9NPD5
ChEMBLiCHEMBL1743121
DrugBankiDB06403, Ambrisentan
DB11586, Asunaprevir
DB05016, Ataluren
DB01072, Atazanavir
DB01076, Atorvastatin
DB11817, Baricitinib
DB00394, Beclomethasone dipropionate
DB11936, Bempedoic acid
DB06772, Cabazitaxel
DB00520, Caspofungin
DB08862, Cholecystokinin
DB02659, Cholic Acid
DB01211, Clarithromycin
DB00257, Clotrimazole
DB09065, Cobicistat
DB05239, Cobimetinib
DB00286, Conjugated estrogens
DB00091, Cyclosporine
DB08912, Dabrafenib
DB09102, Daclatasvir
DB12941, Darolutamide
DB00975, Dipyridamole
DB01248, Docetaxel
DB05928, Dovitinib
DB08861, DPDPE
DB04855, Dronedarone
DB15444, Elexacaftor
DB13874, Enasidenib
DB00199, Erythromycin
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB01590, Everolimus
DB12500, Fedratinib
DB00950, Fexofenadine
DB01095, Fluvastatin
DB08884, Gadoxetic acid
DB01241, Gemfibrozil
DB06749, Ginsenoside Rb1
DB06750, Ginsenoside Rg1
DB13879, Glecaprevir
DB02691, Glycocholic acid
DB11575, Grazoprevir
DB09054, Idelalisib
DB11757, Istradefylline
DB00602, Ivermectin
DB12070, Letermovir
DB08855, Leukotriene C4
DB13153, Levomenol
DB13139, Levosalbutamol
DB00451, Levothyroxine
DB00279, Liothyronine
DB01583, Liotrix
DB01601, Lopinavir
DB00227, Lovastatin
DB00563, Methotrexate
DB00834, Mifepristone
DB00688, Mycophenolate mofetil
DB01149, Nefazodone
DB00220, Nelfinavir
DB01051, Novobiocin
DB00646, Nystatin
DB00275, Olmesartan
DB01092, Ouabain
DB01229, Paclitaxel
DB13154, Parachlorophenol
DB09297, Paritaprevir
DB12978, Pexidartinib
DB13878, Pibrentasvir
DB01132, Pioglitazone
DB08860, Pitavastatin
DB01708, Prasterone
DB05804, Prasterone sulfate
DB00175, Pravastatin
DB00396, Progesterone
DB00481, Raloxifene
DB11855, Revefenacin
DB01045, Rifampicin
DB11753, Rifamycin
DB08864, Rilpivirine
DB12457, Rimegepant
DB00503, Ritonavir
DB06176, Romidepsin
DB01098, Rosuvastatin
DB12332, Rucaparib
DB09292, Sacubitril
DB11362, Selexipag
DB11942, Selinexor
DB09298, Silibinin
DB06290, Simeprevir
DB00641, Simvastatin
DB09142, Sincalide
DB00795, Sulfasalazine
DB04348, Taurocholic acid
DB09137, Technetium Tc-99m mebrofenin
DB00976, Telithromycin
DB09299, Tenofovir alafenamide
DB00624, Testosterone
DB13946, Testosterone undecanoate
DB00932, Tipranavir
DB14962, Trastuzumab deruxtecan
DB15328, Ubrogepant
DB00177, Valsartan
DB11869, Valspodar
DB11613, Velpatasvir
DB00541, Vincristine
DB12026, Voxilaprevir
DrugCentraliQ9NPD5
GuidetoPHARMACOLOGYi1221

Protein family/group databases

TCDBi2.A.60.1.12, the organo anion transporter (oat) family

PTM databases

GlyGeniQ9NPD5, 8 sites, 1 N-linked glycan (2 sites)
iPTMnetiQ9NPD5
PhosphoSitePlusiQ9NPD5

Polymorphism and mutation databases

BioMutaiSLCO1B3
DMDMi27734563

Proteomic databases

MassIVEiQ9NPD5
PaxDbiQ9NPD5
PeptideAtlasiQ9NPD5
PRIDEiQ9NPD5
ProteomicsDBi62988
81974 [Q9NPD5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12268, 222 antibodies

The DNASU plasmid repository

More...DNASUi		28234

Genome annotation databases

EnsembliENST00000261196; ENSP00000261196; ENSG00000111700 [Q9NPD5-1]
ENST00000381545; ENSP00000370956; ENSG00000111700 [Q9NPD5-1]
GeneIDi28234
KEGGihsa:28234
UCSCiuc001rel.5, human [Q9NPD5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		28234
DisGeNETi28234
EuPathDBiHostDB:ENSG00000111700.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLCO1B3
GeneReviewsiSLCO1B3
HGNCiHGNC:10961, SLCO1B3
HPAiENSG00000111700, Tissue enriched (liver)
MalaCardsiSLCO1B3
MIMi237450, phenotype
605495, gene
neXtProtiNX_Q9NPD5
OpenTargetsiENSG00000111700
ENSG00000257046
Orphaneti3111, Rotor syndrome
PharmGKBiPA35844

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3626, Eukaryota
GeneTreeiENSGT00980000198486
HOGENOMiCLU_008954_4_0_1
InParanoidiQ9NPD5
KOiK05043
OMAiSHCKCAS
PhylomeDBiQ9NPD5
TreeFamiTF317540

Enzyme and pathway databases

PathwayCommonsiQ9NPD5
ReactomeiR-HSA-159418, Recycling of bile acids and salts
R-HSA-189483, Heme degradation
R-HSA-5619058, Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518, Transport of organic anions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		28234, 4 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLCO1B3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLCO1B3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		28234
PharosiQ9NPD5, Tchem

Protein Ontology

More...PROi		PR:Q9NPD5
RNActiQ9NPD5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111700, Expressed in liver and 87 other tissues
ExpressionAtlasiQ9NPD5, baseline and differential
GenevisibleiQ9NPD5, HS

Family and domain databases

InterProiView protein in InterPro
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004156, OATP
PANTHERiPTHR11388, PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648, Kazal_2, 1 hit
PF03137, OATP, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00805, oat, 1 hit
PROSITEiView protein in PROSITE
PS51465, KAZAL_2, 1 hit
PS50850, MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO1B3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPD5
Secondary accession number(s): E7EMT8, Q5JAR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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