UniProtKB - Q9NPC7 (MYNN_HUMAN)
Protein
Myoneurin
Gene
MYNN
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 302 – 324 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 330 – 352 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 381 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 387 – 409 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 415 – 437 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 443 – 465 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 471 – 493 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 499 – 522 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NPC7 |
Names & Taxonomyi
Protein namesi | Recommended name: MyoneurinAlternative name(s): Zinc finger and BTB domain-containing protein 31 |
Gene namesi | Name:MYNN Synonyms:OSZF, ZBTB31 ORF Names:SBBIZ1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000085274.15 |
HGNCi | HGNC:14955, MYNN |
MIMi | 606042, gene |
neXtProti | NX_Q9NPC7 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55892 |
OpenTargetsi | ENSG00000085274 |
PharmGKBi | PA31393 |
Miscellaneous databases
Pharosi | Q9NPC7, Tbio |
Polymorphism and mutation databases
BioMutai | MYNN |
DMDMi | 74761639 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248217 | 1 – 610 | MyoneurinAdd BLAST | 610 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 289 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NPC7 |
jPOSTi | Q9NPC7 |
MassIVEi | Q9NPC7 |
MaxQBi | Q9NPC7 |
PaxDbi | Q9NPC7 |
PeptideAtlasi | Q9NPC7 |
PRIDEi | Q9NPC7 |
ProteomicsDBi | 81968 [Q9NPC7-1] 81969 [Q9NPC7-2] 81970 [Q9NPC7-3] 81971 [Q9NPC7-4] |
PTM databases
iPTMneti | Q9NPC7 |
PhosphoSitePlusi | Q9NPC7 |
Expressioni
Tissue specificityi
Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.2 Publications
Gene expression databases
Bgeei | ENSG00000085274, Expressed in buccal mucosa cell and 224 other tissues |
ExpressionAtlasi | Q9NPC7, baseline and differential |
Genevisiblei | Q9NPC7, HS |
Organism-specific databases
HPAi | ENSG00000085274, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9NPC7
With | #Exp. | IntAct |
---|---|---|
ANP32B [Q92688] | 3 | EBI-3446748,EBI-762428 |
FDXACB1 [Q9BRP7] | 3 | EBI-3446748,EBI-10297077 |
Protein-protein interaction databases
BioGRIDi | 120982, 8 interactors |
IntActi | Q9NPC7, 7 interactors |
STRINGi | 9606.ENSP00000326240 |
Miscellaneous databases
RNActi | Q9NPC7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NPC7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NPC7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 89 | BTBPROSITE-ProRule annotationAdd BLAST | 66 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 174 – 190 | Nuclear localization signalSequence analysisAdd BLAST | 17 | |
Motifi | 257 – 262 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 180 – 184 | Poly-Lys | 5 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 302 – 324 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 330 – 352 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 381 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 387 – 409 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 415 – 437 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 443 – 465 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 471 – 493 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 499 – 522 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161266 |
HOGENOMi | CLU_022540_1_0_1 |
InParanoidi | Q9NPC7 |
OMAi | LVQPQAK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NPC7 |
TreeFami | TF330787 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NPC7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQYSHHCEHL LERLNKQREA GFLCDCTIVI GEFQFKAHRN VLASFSEYFG
60 70 80 90 100
AIYRSTSENN VFLDQSQVKA DGFQKLLEFI YTGTLNLDSW NVKEIHQAAD
110 120 130 140 150
YLKVEEVVTK CKIKMEDFAF IANPSSTEIS SITGNIELNQ QTCLLTLRDY
160 170 180 190 200
NNREKSEVST DLIQANPKQG ALAKKSSQTK KKKKAFNSPK TGQNKTVQYP
210 220 230 240 250
SDILENASVE LFLDANKLPT PVVEQVAQIN DNSELELTSV VENTFPAQDI
260 270 280 290 300
VHTVTVKRKR GKSQPNCALK EHSMSNIASV KSPYEAENSG EELDQRYSKA
310 320 330 340 350
KPMCNTCGKV FSEASSLRRH MRIHKGVKPY VCHLCGKAFT QCNQLKTHVR
360 370 380 390 400
THTGEKPYKC ELCDKGFAQK CQLVFHSRMH HGEEKPYKCD VCNLQFATSS
410 420 430 440 450
NLKIHARKHS GEKPYVCDRC GQRFAQASTL TYHVRRHTGE KPYVCDTCGK
460 470 480 490 500
AFAVSSSLIT HSRKHTGEKP YICGICGKSF ISSGELNKHF RSHTGERPFI
510 520 530 540 550
CELCGNSYTD IKNLKKHKTK VHSGADKTLD SSAEDHTLSE QDSIQKSPLS
560 570 580 590 600
ETMDVKPSDM TLPLALPLGT EDHHMLLPVT DTQSPTSDTL LRSTVNGYSE
610
PQLIFLQQLY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GMT1 | R4GMT1_HUMAN | Myoneurin | MYNN | 238 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 198 | Q → R in BAC55898 (Ref. 2) Curated | 1 | |
Sequence conflicti | 198 | Q → R in BAC55899 (Ref. 2) Curated | 1 | |
Sequence conflicti | 292 | E → D in CAB61393 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020213 | 89 – 91 | SWN → RDI in isoform 4. 2 Publications | 3 | |
Alternative sequenceiVSP_020214 | 92 – 610 | Missing in isoform 4. 2 PublicationsAdd BLAST | 519 | |
Alternative sequenceiVSP_020215 | 495 – 500 | GERPFI → VVWSMN in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_020216 | 496 – 524 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_020217 | 501 – 610 | Missing in isoform 3. 1 PublicationAdd BLAST | 110 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000349841; ENSP00000326240; ENSG00000085274 [Q9NPC7-1] ENST00000356716; ENSP00000349150; ENSG00000085274 [Q9NPC7-1] ENST00000544106; ENSP00000440637; ENSG00000085274 [Q9NPC7-2] ENST00000602751; ENSP00000473654; ENSG00000085274 [Q9NPC7-4] |
GeneIDi | 55892 |
KEGGi | hsa:55892 |
UCSCi | uc003fft.4, human [Q9NPC7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VPK | X-ray | 2.00 | A | 4-117 | [»] | |
SMRi | Q9NPC7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120982, 8 interactors |
IntActi | Q9NPC7, 7 interactors |
STRINGi | 9606.ENSP00000326240 |
PTM databases
iPTMneti | Q9NPC7 |
PhosphoSitePlusi | Q9NPC7 |
Polymorphism and mutation databases
BioMutai | MYNN |
DMDMi | 74761639 |
Proteomic databases
EPDi | Q9NPC7 |
jPOSTi | Q9NPC7 |
MassIVEi | Q9NPC7 |
MaxQBi | Q9NPC7 |
PaxDbi | Q9NPC7 |
PeptideAtlasi | Q9NPC7 |
PRIDEi | Q9NPC7 |
ProteomicsDBi | 81968 [Q9NPC7-1] 81969 [Q9NPC7-2] 81970 [Q9NPC7-3] 81971 [Q9NPC7-4] |
Protocols and materials databases
Antibodypediai | 18640, 240 antibodies |
DNASUi | 55892 |
Genome annotation databases
Ensembli | ENST00000349841; ENSP00000326240; ENSG00000085274 [Q9NPC7-1] ENST00000356716; ENSP00000349150; ENSG00000085274 [Q9NPC7-1] ENST00000544106; ENSP00000440637; ENSG00000085274 [Q9NPC7-2] ENST00000602751; ENSP00000473654; ENSG00000085274 [Q9NPC7-4] |
GeneIDi | 55892 |
KEGGi | hsa:55892 |
UCSCi | uc003fft.4, human [Q9NPC7-1] |
Organism-specific databases
CTDi | 55892 |
DisGeNETi | 55892 |
EuPathDBi | HostDB:ENSG00000085274.15 |
GeneCardsi | MYNN |
HGNCi | HGNC:14955, MYNN |
HPAi | ENSG00000085274, Low tissue specificity |
MIMi | 606042, gene |
neXtProti | NX_Q9NPC7 |
OpenTargetsi | ENSG00000085274 |
PharmGKBi | PA31393 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161266 |
HOGENOMi | CLU_022540_1_0_1 |
InParanoidi | Q9NPC7 |
OMAi | LVQPQAK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NPC7 |
TreeFami | TF330787 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPC7 |
Miscellaneous databases
BioGRID-ORCSi | 55892, 3 hits in 871 CRISPR screens |
ChiTaRSi | MYNN, human |
EvolutionaryTracei | Q9NPC7 |
GenomeRNAii | 55892 |
Pharosi | Q9NPC7, Tbio |
PROi | PR:Q9NPC7 |
RNActi | Q9NPC7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000085274, Expressed in buccal mucosa cell and 224 other tissues |
ExpressionAtlasi | Q9NPC7, baseline and differential |
Genevisiblei | Q9NPC7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYNN_HUMAN | |
Accessioni | Q9NPC7Primary (citable) accession number: Q9NPC7 Secondary accession number(s): B2R6C9 Q9UIW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families