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UniProtKB - Q9NPC4 (A4GAT_HUMAN)

Entry version 178 (25 May 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Lactosylceramide 4-alpha-galactosyltransferase

Gene

A4GALT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143).

Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143).

Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952).

1 Publication2 Publications

(Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=54.5 µM for beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E))1 Publication
  2. KM=132 µM for beta-D-Gal-(1<->1')-Cer1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Glycolipid biosynthesis

This protein is involved in Glycolipid biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Glycolipid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.4.1.228, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NPC4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NPC4

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT32, Glycosyltransferase Family 32

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000760

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lactosylceramide 4-alpha-galactosyltransferase (EC:2.4.1.2281 Publication)
Alternative name(s):
Alpha-1,4-N-acetylglucosaminyltransferase
Alpha-1,4-galactosyltransferase
Alpha4Gal-T1
CD77 synthase
Globotriaosylceramide synthase
Short name:
Gb3 synthase
P1/Pk synthase
UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:A4GALT
Synonyms:A14GALT, A4GALT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18149, A4GALT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607922, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPC4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000128274

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini44 – 353LumenalSequence analysisAdd BLAST310

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		53947

MalaCards human disease database

More...MalaCardsi		A4GALT
MIMi111400, phenotype

Open Targets

More...OpenTargetsi		ENSG00000128274

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24359

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NPC4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		A4GALT

Domain mapping of disease mutations (DMDM)

More...DMDMi		25452796

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000805781 – 353Lactosylceramide 4-alpha-galactosyltransferaseAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NPC4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NPC4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NPC4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPC4

PeptideAtlas

More...PeptideAtlasi		Q9NPC4

PRoteomics IDEntifications database

More...PRIDEi		Q9NPC4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81966

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NPC4, 4 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NPC4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NPC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128274, Expressed in heart left ventricle and 164 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NPC4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPC4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128274, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119825, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q9NPC4, 6 interactors

Molecular INTeraction database

More...MINTi		Q9NPC4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384794

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NPC4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NPC4

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi192 – 194DXD motifBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The conserved DXD motif is involved in enzyme activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 32 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1928, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000047981

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049512_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPC4

Identification of Orthologs from Complete Genome Data

More...OMAi		AFYPIRW

Database of Orthologous Groups

More...OrthoDBi		1082380at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPC4

TreeFam database of animal gene trees

More...TreeFami		TF324053

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007652, A1-4-GlycosylTfrase_dom
IPR007577, GlycoTrfase_DXD_sugar-bd_CS
IPR029044, Nucleotide-diphossugar_trans

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04572, Gb3_synth, 1 hit
PF04488, Gly_transf_sug, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NPC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKPPDLLLR LLRGAPRQRV CTLFIIGFKF TFFVSIMIYW HVVGEPKEKG 
        60         70         80         90        100
QLYNLPAEIP CPTLTPPTPP SHGPTPGNIF FLETSDRTNP NFLFMCSVES 
       110        120        130        140        150
AARTHPESHV LVLMKGLPGG NASLPRHLGI SLLSCFPNVQ MLPLDLRELF 
       160        170        180        190        200
RDTPLADWYA AVQGRWEPYL LPVLSDASRI ALMWKFGGIY LDTDFIVLKN 
       210        220        230        240        250
LRNLTNVLGT QSRYVLNGAF LAFERRHEFM ALCMRDFVDH YNGWIWGHQG 
       260        270        280        290        300
PQLLTRVFKK WCSIRSLAES RACRGVTTLP PEAFYPIPWQ DWKKYFEDIN 
       310        320        330        340        350
PEELPRLLSA TYAVHVWNKK SQGTRFEATS RALLAQLHAR YCPTTHEAMK 

MYL
Length:353
Mass (Da):40,499
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8755865BDA5DA205
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in A4GALT is responsible for the P1PK system blood group phenotypes [MIMi:111400]. Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p phenotype, which is rare and does not express any antigens. It is also known as null phenotype; p individuals have antibodies against P, P1 and Pk antigens in their sera. These antibodies are clinically important because they can cause severe transfusion reactions and miscarriage (PubMed:10993874, PubMed:11896312). Genetic variation in A4GALT is also responsible for the NOR polyagglutination syndrome [MIMi:111400]. Polyagglutination is the occurrence of red cell agglutination by virtually all human sera, but not by autologous serum or sera from newborns, creating a risk of complications during transfusions of NOR erythrocytes. It is caused by the unusual Gal(alpha1-4)GalNAc glycolipid epitope (PubMed:22965229).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01429637M → V3 PublicationsCorresponds to variant dbSNP:rs11541159Ensembl.1
Natural variantiVAR_01750780Missing in p individuals. 1 Publication1
Natural variantiVAR_022320163Q → R1 PublicationCorresponds to variant dbSNP:rs28915383EnsemblClinVar.1
Natural variantiVAR_014297183M → K in p individuals; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs74315453EnsemblClinVar.1
Natural variantiVAR_017508187G → D in p individuals; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs28940572EnsemblClinVar.1
Natural variantiVAR_080910211Q → E in individuals with NOR polyagglutination syndrome; causes the synthesis of both Gal(alpha1-4)Gal and Gal(alpha1-4)GalNAc moieties. 1 PublicationCorresponds to variant dbSNP:rs397514502EnsemblClinVar.1
Natural variantiVAR_017509251P → L in p individuals; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs28940571EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB037883 mRNA Translation: BAA95915.1
AJ245581 mRNA Translation: CAB93532.1
AB041418 Genomic DNA Translation: BAA94503.1
AY941797 Genomic DNA Translation: AAX20109.1
AK312927 mRNA Translation: BAG35771.1
Z82176 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73274.1
BC017068 mRNA Translation: AAH17068.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14041.1

NCBI Reference Sequences

More...RefSeqi		NP_001304967.1, NM_001318038.1
NP_059132.1, NM_017436.5
XP_005261701.1, XM_005261644.2
XP_005261703.1, XM_005261646.4
XP_005261704.1, XM_005261647.2
XP_005261705.1, XM_005261648.3
XP_006724328.1, XM_006724265.3
XP_006724329.1, XM_006724266.3
XP_011528535.1, XM_011530233.2
XP_016884320.1, XM_017028831.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000249005.3; ENSP00000249005.2; ENSG00000128274.17
ENST00000381278.4; ENSP00000370678.3; ENSG00000128274.17
ENST00000401850.5; ENSP00000384794.1; ENSG00000128274.17
ENST00000642412.2; ENSP00000494127.1; ENSG00000128274.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53947

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:53947

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000642412.2; ENSP00000494127.1; NM_017436.7; NP_059132.1

UCSC genome browser

More...UCSCi		uc062ewk.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - GTase

Lactosylceramide 4-alpha-galactosyltransferase

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037883 mRNA Translation: BAA95915.1
AJ245581 mRNA Translation: CAB93532.1
AB041418 Genomic DNA Translation: BAA94503.1
AY941797 Genomic DNA Translation: AAX20109.1
AK312927 mRNA Translation: BAG35771.1
Z82176 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73274.1
BC017068 mRNA Translation: AAH17068.1
CCDSiCCDS14041.1
RefSeqiNP_001304967.1, NM_001318038.1
NP_059132.1, NM_017436.5
XP_005261701.1, XM_005261644.2
XP_005261703.1, XM_005261646.4
XP_005261704.1, XM_005261647.2
XP_005261705.1, XM_005261648.3
XP_006724328.1, XM_006724265.3
XP_006724329.1, XM_006724266.3
XP_011528535.1, XM_011530233.2
XP_016884320.1, XM_017028831.1

3D structure databases

AlphaFoldDBiQ9NPC4
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi119825, 13 interactors
IntActiQ9NPC4, 6 interactors
MINTiQ9NPC4
STRINGi9606.ENSP00000384794

Chemistry databases

SwissLipidsiSLP:000000760

Protein family/group databases

CAZyiGT32, Glycosyltransferase Family 32

PTM databases

GlyGeniQ9NPC4, 4 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ9NPC4
PhosphoSitePlusiQ9NPC4

Genetic variation databases

BioMutaiA4GALT
DMDMi25452796

Proteomic databases

EPDiQ9NPC4
jPOSTiQ9NPC4
MassIVEiQ9NPC4
PaxDbiQ9NPC4
PeptideAtlasiQ9NPC4
PRIDEiQ9NPC4
ProteomicsDBi81966

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		239, 233 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		53947

Genome annotation databases

EnsembliENST00000249005.3; ENSP00000249005.2; ENSG00000128274.17
ENST00000381278.4; ENSP00000370678.3; ENSG00000128274.17
ENST00000401850.5; ENSP00000384794.1; ENSG00000128274.17
ENST00000642412.2; ENSP00000494127.1; ENSG00000128274.17
GeneIDi53947
KEGGihsa:53947
MANE-SelectiENST00000642412.2; ENSP00000494127.1; NM_017436.7; NP_059132.1
UCSCiuc062ewk.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53947
DisGeNETi53947

GeneCards: human genes, protein and diseases

More...GeneCardsi		A4GALT
HGNCiHGNC:18149, A4GALT
HPAiENSG00000128274, Low tissue specificity
MalaCardsiA4GALT
MIMi111400, phenotype
607922, gene
neXtProtiNX_Q9NPC4
OpenTargetsiENSG00000128274
PharmGKBiPA24359
VEuPathDBiHostDB:ENSG00000128274

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1928, Eukaryota
GeneTreeiENSGT00510000047981
HOGENOMiCLU_049512_2_0_1
InParanoidiQ9NPC4
OMAiAFYPIRW
OrthoDBi1082380at2759
PhylomeDBiQ9NPC4
TreeFamiTF324053

Enzyme and pathway databases

BRENDAi2.4.1.228, 2681
PathwayCommonsiQ9NPC4
SignaLinkiQ9NPC4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53947, 14 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		A4GALT, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		A4GALT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53947
PharosiQ9NPC4, Tbio

Protein Ontology

More...PROi		PR:Q9NPC4
RNActiQ9NPC4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000128274, Expressed in heart left ventricle and 164 other tissues
ExpressionAtlasiQ9NPC4, baseline and differential
GenevisibleiQ9NPC4, HS

Family and domain databases

InterProiView protein in InterPro
IPR007652, A1-4-GlycosylTfrase_dom
IPR007577, GlycoTrfase_DXD_sugar-bd_CS
IPR029044, Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF04572, Gb3_synth, 1 hit
PF04488, Gly_transf_sug, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4GAT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPC4
Secondary accession number(s): B2R7C4, Q9P1X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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