UniProtKB - Q9NPC3 (CIP1_HUMAN)
Protein
E3 ubiquitin-protein ligase CCNB1IP1
Gene
CCNB1IP1
Organism
Homo sapiens (Human)
Status
Functioni
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.By similarity2 Publications
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 4 – 51 | RING-type; atypicalAdd BLAST | 48 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: InterPro
GO - Biological processi
- blastocyst formation Source: Ensembl
- chiasma assembly Source: UniProtKB
- reciprocal meiotic recombination Source: UniProtKB
- spermatid development Source: Ensembl
Keywordsi
Molecular function | Transferase |
Biological process | Meiosis, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NPC3 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase CCNB1IP1 (EC:2.3.2.271 Publication)Alternative name(s): Cyclin-B1-interacting protein 1 Human enhancer of invasion 10 RING-type E3 ubiquitin transferase CCNB1IP1Curated |
Gene namesi | Name:CCNB1IP1 Synonyms:C14orf18, HEI10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100814.17 |
HGNCi | HGNC:19437, CCNB1IP1 |
MIMi | 608249, gene |
neXtProti | NX_Q9NPC3 |
Subcellular locationi
Nucleus
Other locations
Note: Associates to the synaptonemal complex.
Nucleus
- synaptonemal complex Source: Ensembl
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | C → A: Abrogates induction of filamentous growth in yeast; when associated with A-30 and A-33. 1 Publication | 1 | |
Mutagenesisi | 30 | H → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-33. 1 Publication | 1 | |
Mutagenesisi | 33 | C → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-30. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 57820 |
OpenTargetsi | ENSG00000100814 |
PharmGKBi | PA134863884 |
Miscellaneous databases
Pharosi | Q9NPC3, Tbio |
Polymorphism and mutation databases
BioMutai | CCNB1IP1 |
DMDMi | 37078756 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055874 | 1 – 277 | E3 ubiquitin-protein ligase CCNB1IP1Add BLAST | 277 |
Post-translational modificationi
Ubiquitinated; autoubiquitinated.1 Publication
Phosphorylated by CDK1 on serine or threonine residues (in vitro).1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | Q9NPC3 |
PaxDbi | Q9NPC3 |
PeptideAtlasi | Q9NPC3 |
PRIDEi | Q9NPC3 |
ProteomicsDBi | 81965 |
PTM databases
iPTMneti | Q9NPC3 |
PhosphoSitePlusi | Q9NPC3 |
Expressioni
Tissue specificityi
Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.1 Publication
Gene expression databases
Bgeei | ENSG00000100814, Expressed in right ovary and 237 other tissues |
ExpressionAtlasi | Q9NPC3, baseline and differential |
Genevisiblei | Q9NPC3, HS |
Organism-specific databases
HPAi | ENSG00000100814, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CCNB1, UBE2L3 and NF2.
2 PublicationsBinary interactionsi
Hide detailsQ9NPC3
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 121779, 16 interactors |
IntActi | Q9NPC3, 12 interactors |
STRINGi | 9606.ENSP00000409896 |
Miscellaneous databases
RNActi | Q9NPC3, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 127 – 182 | Sequence analysisAdd BLAST | 56 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 4 – 51 | RING-type; atypicalAdd BLAST | 48 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502RMFV, Eukaryota |
GeneTreei | ENSGT00390000002849 |
HOGENOMi | CLU_049340_3_0_1 |
InParanoidi | Q9NPC3 |
OMAi | DGDFHFR |
OrthoDBi | 1383870at2759 |
PhylomeDBi | Q9NPC3 |
TreeFami | TF328863 |
Family and domain databases
InterProi | View protein in InterPro IPR042448, CCNB1IP1 IPR001841, Znf_RING |
PANTHERi | PTHR14305, PTHR14305, 1 hit |
Pfami | View protein in Pfam PF14634, zf-RING_5, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9NPC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLCEDMLLC NYRKCRIKLS GYAWVTACSH IFCDQHGSGE FSRSPAICPA
60 70 80 90 100
CNSTLSGKLD IVRTELSPSE EYKAMVLAGL RPEIVLDISS RALAFWTYQV
110 120 130 140 150
HQERLYQEYN FSKAEGHLKQ MEKIYTQQIQ SKDVELTSMK GEVTSMKKVL
160 170 180 190 200
EEYKKKFSDI SEKLMERNRQ YQKLQGLYDS LRLRNITIAN HEGTLEPSMI
210 220 230 240 250
AQSGVLGFPL GNNSKFPLDN TPVRNRGDGD GDFQFRPFFA GSPTAPEPSN
260 270
SFFSFVSPSR ELEQQQVSSR AFKVKRI
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V5E6 | G3V5E6_HUMAN | E3 ubiquitin-protein ligase CCNB1IP... | CCNB1IP1 | 67 | Annotation score: | ||
G3V5Q4 | G3V5Q4_HUMAN | E3 ubiquitin-protein ligase CCNB1IP... | CCNB1IP1 | 102 | Annotation score: | ||
G3V5S3 | G3V5S3_HUMAN | E3 ubiquitin-protein ligase CCNB1IP... | CCNB1IP1 | 154 | Annotation score: | ||
H0YJ70 | H0YJ70_HUMAN | E3 ubiquitin-protein ligase CCNB1IP... | CCNB1IP1 | 64 | Annotation score: | ||
H0YJB2 | H0YJB2_HUMAN | E3 ubiquitin-protein ligase CCNB1IP... | CCNB1IP1 | 31 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216381 mRNA Translation: AAF36386.1 AL161994 mRNA Translation: CAB82326.1 AK026233 mRNA Translation: BAB15403.1 BX161423 mRNA Translation: CAD61896.1 BX161424 mRNA Translation: CAD61897.1 BX247978 mRNA Translation: CAD62312.1 BC000369 mRNA Translation: AAH00369.1 BC001218 mRNA Translation: AAH01218.1 BC004435 mRNA Translation: AAH04435.1 |
CCDSi | CCDS9547.1 |
PIRi | T47153 |
RefSeqi | NP_067001.3, NM_021178.4 NP_878269.1, NM_182849.2 NP_878272.1, NM_182852.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216381 mRNA Translation: AAF36386.1 AL161994 mRNA Translation: CAB82326.1 AK026233 mRNA Translation: BAB15403.1 BX161423 mRNA Translation: CAD61896.1 BX161424 mRNA Translation: CAD61897.1 BX247978 mRNA Translation: CAD62312.1 BC000369 mRNA Translation: AAH00369.1 BC001218 mRNA Translation: AAH01218.1 BC004435 mRNA Translation: AAH04435.1 |
CCDSi | CCDS9547.1 |
PIRi | T47153 |
RefSeqi | NP_067001.3, NM_021178.4 NP_878269.1, NM_182849.2 NP_878272.1, NM_182852.3 |
3D structure databases
SMRi | Q9NPC3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121779, 16 interactors |
IntActi | Q9NPC3, 12 interactors |
STRINGi | 9606.ENSP00000409896 |
PTM databases
iPTMneti | Q9NPC3 |
PhosphoSitePlusi | Q9NPC3 |
Polymorphism and mutation databases
BioMutai | CCNB1IP1 |
DMDMi | 37078756 |
Proteomic databases
MassIVEi | Q9NPC3 |
PaxDbi | Q9NPC3 |
PeptideAtlasi | Q9NPC3 |
PRIDEi | Q9NPC3 |
ProteomicsDBi | 81965 |
Protocols and materials databases
Antibodypediai | 22006, 220 antibodies |
DNASUi | 57820 |
Genome annotation databases
Organism-specific databases
CTDi | 57820 |
DisGeNETi | 57820 |
EuPathDBi | HostDB:ENSG00000100814.17 |
GeneCardsi | CCNB1IP1 |
HGNCi | HGNC:19437, CCNB1IP1 |
HPAi | ENSG00000100814, Low tissue specificity |
MIMi | 608249, gene |
neXtProti | NX_Q9NPC3 |
OpenTargetsi | ENSG00000100814 |
PharmGKBi | PA134863884 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RMFV, Eukaryota |
GeneTreei | ENSGT00390000002849 |
HOGENOMi | CLU_049340_3_0_1 |
InParanoidi | Q9NPC3 |
OMAi | DGDFHFR |
OrthoDBi | 1383870at2759 |
PhylomeDBi | Q9NPC3 |
TreeFami | TF328863 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9NPC3 |
Miscellaneous databases
BioGRID-ORCSi | 57820, 9 hits in 847 CRISPR screens |
ChiTaRSi | CCNB1IP1, human |
GeneWikii | CCNB1IP1 |
GenomeRNAii | 57820 |
Pharosi | Q9NPC3, Tbio |
PROi | PR:Q9NPC3 |
RNActi | Q9NPC3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100814, Expressed in right ovary and 237 other tissues |
ExpressionAtlasi | Q9NPC3, baseline and differential |
Genevisiblei | Q9NPC3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042448, CCNB1IP1 IPR001841, Znf_RING |
PANTHERi | PTHR14305, PTHR14305, 1 hit |
Pfami | View protein in Pfam PF14634, zf-RING_5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CIP1_HUMAN | |
Accessioni | Q9NPC3Primary (citable) accession number: Q9NPC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM