CCNB1IP1

Functionⁱ

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.By similarity2 Publications

E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	4 – 51	RING-type; atypicalAdd BLAST		48

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
ubiquitin protein ligase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst formation Source: Ensembl
chiasma assembly Source: UniProtKB
protein ubiquitination Source: GO_Central
reciprocal meiotic recombination Source: UniProtKB
spermatid development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Meiosis, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase CCNB1IP1 (EC:2.3.2.271 Publication) Alternative name(s): Cyclin-B1-interacting protein 1 Human enhancer of invasion 10 RING-type E3 ubiquitin transferase CCNB1IP1Curated
Gene namesⁱ	Name:CCNB1IP1 Synonyms:C14orf18, HEI10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100814.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19437 CCNB1IP1
MIMⁱ	608249 gene
neXtProtⁱ	NX_Q9NPC3

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	28	C → A: Abrogates induction of filamentous growth in yeast; when associated with A-30 and A-33. 1 Publication	1
Mutagenesisⁱ	30	H → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-33. 1 Publication	1
Mutagenesisⁱ	33	C → A: Abrogates induction of filamentous growth in yeast; when associated with A-28 and A-30. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000100814
PharmGKBⁱ	PA134863884

Polymorphism and mutation databases

BioMutaⁱ	CCNB1IP1
DMDMⁱ	37078756

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055874	1 – 277	E3 ubiquitin-protein ligase CCNB1IP1Add BLAST		277

Post-translational modificationⁱ

Ubiquitinated; autoubiquitinated.1 Publication

Phosphorylated by CDK1 on serine or threonine residues (in vitro).1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9NPC3
PeptideAtlas More...PeptideAtlasⁱ	Q9NPC3
PRIDEⁱ	Q9NPC3
ProteomicsDBⁱ	81965

PTM databases

iPTMnetⁱ	Q9NPC3
PhosphoSitePlusⁱ	Q9NPC3

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000100814
CleanExⁱ	HS_CCNB1IP1
ExpressionAtlasⁱ	Q9NPC3 baseline and differential
Genevisibleⁱ	Q9NPC3 HS

Interactionⁱ

Subunit structureⁱ

Interacts with CCNB1, UBE2L3 and NF2.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P62972	2	EBI-745269,EBI-412964	From Xenopus laevis.
CCNB1	P14635	2	EBI-745269,EBI-495332
EPM2AIP1	Q7L775	3	EBI-745269,EBI-6255981
KEAP1	Q14145	3	EBI-745269,EBI-751001
KRT15	P19012	3	EBI-745269,EBI-739566
PRD1	P25375	3	EBI-745269,EBI-13932	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PRKAA2	P54646	3	EBI-745269,EBI-1383852

Show more details

Protein-protein interaction databases

BioGridⁱ	121779, 13 interactors
IntActⁱ	Q9NPC3, 12 interactors
STRINGⁱ	9606.ENSP00000337396

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NPC3
SMRⁱ	Q9NPC3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	127 – 182	Sequence analysisAdd BLAST		56

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	4 – 51	RING-type; atypicalAdd BLAST		48

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IE9K Eukaryota ENOG410XTEP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002849
HOGENOMⁱ	HOG000111677
HOVERGENⁱ	HBG050962
InParanoidⁱ	Q9NPC3
KEGG Orthology (KO) More...KOⁱ	K10639
OMAⁱ	IANHEGT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RN7
PhylomeDBⁱ	Q9NPC3
TreeFamⁱ	TF328863

Family and domain databases

InterProⁱ	View protein in InterPro IPR001841 Znf_RING
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14634 zf-RING_5, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9NPC3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLCEDMLLC NYRKCRIKLS GYAWVTACSH IFCDQHGSGE FSRSPAICPA 
        60         70         80         90        100
CNSTLSGKLD IVRTELSPSE EYKAMVLAGL RPEIVLDISS RALAFWTYQV 
       110        120        130        140        150
HQERLYQEYN FSKAEGHLKQ MEKIYTQQIQ SKDVELTSMK GEVTSMKKVL 
       160        170        180        190        200
EEYKKKFSDI SEKLMERNRQ YQKLQGLYDS LRLRNITIAN HEGTLEPSMI 
       210        220        230        240        250
AQSGVLGFPL GNNSKFPLDN TPVRNRGDGD GDFQFRPFFA GSPTAPEPSN 
       260        270 
SFFSFVSPSR ELEQQQVSSR AFKVKRI

Length:277

Mass (Da):31,544

Last modified:October 1, 2000 - v1

Checksum:ⁱ885723B01A35225A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF216381 mRNA Translation: AAF36386.1 AL161994 mRNA Translation: CAB82326.1 AK026233 mRNA Translation: BAB15403.1 BX161423 mRNA Translation: CAD61896.1 BX161424 mRNA Translation: CAD61897.1 BX247978 mRNA Translation: CAD62312.1 BC000369 mRNA Translation: AAH00369.1 BC001218 mRNA Translation: AAH01218.1 BC004435 mRNA Translation: AAH04435.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9547.1
PIRⁱ	T47153
NCBI Reference Sequences More...RefSeqⁱ	NP_067001.3, NM_021178.4 NP_878269.1, NM_182849.2 NP_878272.1, NM_182852.3
UniGeneⁱ	Hs.107003 Hs.741214

Genome annotation databases

Ensemblⁱ	ENST00000353689; ENSP00000337396; ENSG00000100814 ENST00000358932; ENSP00000351810; ENSG00000100814 ENST00000398160; ENSP00000381226; ENSG00000100814 ENST00000398163; ENSP00000381229; ENSG00000100814 ENST00000398169; ENSP00000381235; ENSG00000100814 ENST00000437553; ENSP00000409896; ENSG00000100814
GeneIDⁱ	57820
KEGGⁱ	hsa:57820
UCSC genome browser More...UCSCⁱ	uc001vwv.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9NPC3	Cyclin B1 interacting protein 1		CANLF		336
UPI0003F0FB71		CHRAS		278
E3 ubiquitin-protein ligase CCNB1IP1		ERIEU		278
Cyclin B1 interacting protein 1		CALJA		277
Cyclin B1 interacting protein 1		BOVIN		277
+59

Protein	Similar proteins		Species	Score	Length
Q9NPC3	Cyclin B1 interacting protein 1		CANLF		336
E3 ubiquitin-protein ligase CCNB1IP1		ERIEU		278
UPI0003F0FB71		CHRAS		278
UPI00042C8505		PHYCD		277
UPI000643E110		MICMU		277
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF216381 mRNA Translation: AAF36386.1 AL161994 mRNA Translation: CAB82326.1 AK026233 mRNA Translation: BAB15403.1 BX161423 mRNA Translation: CAD61896.1 BX161424 mRNA Translation: CAD61897.1 BX247978 mRNA Translation: CAD62312.1 BC000369 mRNA Translation: AAH00369.1 BC001218 mRNA Translation: AAH01218.1 BC004435 mRNA Translation: AAH04435.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9547.1
PIRⁱ	T47153
NCBI Reference Sequences More...RefSeqⁱ	NP_067001.3, NM_021178.4 NP_878269.1, NM_182849.2 NP_878272.1, NM_182852.3
UniGeneⁱ	Hs.107003 Hs.741214

3D structure databases

ProteinModelPortalⁱ	Q9NPC3
SMRⁱ	Q9NPC3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121779, 13 interactors
IntActⁱ	Q9NPC3, 12 interactors
STRINGⁱ	9606.ENSP00000337396

PTM databases

iPTMnetⁱ	Q9NPC3
PhosphoSitePlusⁱ	Q9NPC3

Polymorphism and mutation databases

BioMutaⁱ	CCNB1IP1
DMDMⁱ	37078756

Proteomic databases

PaxDbⁱ	Q9NPC3
PeptideAtlas More...PeptideAtlasⁱ	Q9NPC3
PRIDEⁱ	Q9NPC3
ProteomicsDBⁱ	81965

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57820
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000353689; ENSP00000337396; ENSG00000100814 ENST00000358932; ENSP00000351810; ENSG00000100814 ENST00000398160; ENSP00000381226; ENSG00000100814 ENST00000398163; ENSP00000381229; ENSG00000100814 ENST00000398169; ENSP00000381235; ENSG00000100814 ENST00000437553; ENSP00000409896; ENSG00000100814
GeneIDⁱ	57820
KEGGⁱ	hsa:57820
UCSC genome browser More...UCSCⁱ	uc001vwv.5 human

Organism-specific databases

CTDⁱ	57820
EuPathDBⁱ	HostDB:ENSG00000100814.17
GeneCardsⁱ	CCNB1IP1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19437 CCNB1IP1
MIMⁱ	608249 gene
neXtProtⁱ	NX_Q9NPC3
Open Targets More...OpenTargetsⁱ	ENSG00000100814
PharmGKBⁱ	PA134863884
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IE9K Eukaryota ENOG410XTEP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002849
HOGENOMⁱ	HOG000111677
HOVERGENⁱ	HBG050962
InParanoidⁱ	Q9NPC3
KEGG Orthology (KO) More...KOⁱ	K10639
OMAⁱ	IANHEGT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RN7
PhylomeDBⁱ	Q9NPC3
TreeFamⁱ	TF328863

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Miscellaneous databases

ChiTaRSⁱ	CCNB1IP1 human
GeneWikiⁱ	CCNB1IP1
GenomeRNAiⁱ	57820
Protein Ontology More...PROⁱ	PR:Q9NPC3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100814
CleanExⁱ	HS_CCNB1IP1
ExpressionAtlasⁱ	Q9NPC3 baseline and differential
Genevisibleⁱ	Q9NPC3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001841 Znf_RING
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14634 zf-RING_5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CIP1_HUMAN
Accessionⁱ	Q9NPC3Primary (citable) accession number: Q9NPC3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
	Last sequence update:	October 1, 2000
	Last modified:	July 18, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - Q9NPC3 (CIP1_HUMAN)

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E3 ubiquitin-protein ligase CCNB1IP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Zinc finger

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ