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UniProtKB - Q9NPC2 (KCNK9_HUMAN)

Entry version 169 (23 Feb 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Potassium channel subfamily K member 9

Gene

KCNK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

pH-dependent, voltage-insensitive, background potassium channel protein.

3 Publications

Miscellaneous

Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.
Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NPC2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1299316, TWIK-releated acid-sensitive K+ channel (TASK)
R-HSA-5576886, Phase 4 - resting membrane potential

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NPC2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NPC2

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.9.11, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Two pore potassium channel KT3.2
Short name:
Two pore K(+) channel KT3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNK9
Synonyms:TASK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6283, KCNK9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605874, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPC2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000169427

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 88ExtracellularSequence analysisAdd BLAST59
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei89 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST13
Topological domaini102 – 107ExtracellularSequence analysis6
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 194ExtracellularSequence analysisAdd BLAST15
Intramembranei195 – 207Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST13
Topological domaini208 – 218ExtracellularSequence analysisAdd BLAST11
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 374CytoplasmicSequence analysisAdd BLAST135

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Birk-Barel syndrome (BIBARS)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism. BIBARS transmission pattern is consistent with autosomal dominant inheritance with paternal imprinting.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054373236G → R in BIBARS; inactive. 2 PublicationsCorresponds to variant dbSNP:rs121908332EnsemblClinVar.1
Natural variantiVAR_084510237A → D in BIBARS. 1 Publication1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		51305

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		KCNK9

MalaCards human disease database

More...MalaCardsi		KCNK9
MIMi612292, phenotype

Open Targets

More...OpenTargetsi		ENSG00000169427

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		166108, Intellectual disability, Birk-Barel type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30065

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NPC2, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2321614

Drug and drug target database

More...DrugBanki		DB00561, Doxapram
DB01159, Halothane

DrugCentral

More...DrugCentrali		Q9NPC2

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNK9

Domain mapping of disease mutations (DMDM)

More...DMDMi		13431426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001017541 – 374Potassium channel subfamily K member 9Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPC2

PeptideAtlas

More...PeptideAtlasi		Q9NPC2

PRoteomics IDEntifications database

More...PRIDEi		Q9NPC2

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NPC2, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NPC2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NPC2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169427, Expressed in right hemisphere of cerebellum and 108 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NPC2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPC2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169427, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable). Heterodimer with KCNK1.

Curated1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119456, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000430676

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NPC2

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NPC2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NPC2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NPC2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4404, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159791

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022504_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPC2

Identification of Orthologs from Complete Genome Data

More...OMAi		NHQLMRR

Database of Orthologous Groups

More...OrthoDBi		1109218at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPC2

TreeFam database of animal gene trees

More...TreeFami		TF313947

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003280, 2pore_dom_K_chnl
IPR003092, 2pore_dom_K_chnl_TASK
IPR013099, K_chnl_dom
IPR005407, KCNK9

The PANTHER Classification System

More...PANTHERi		PTHR11003, PTHR11003, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07885, Ion_trans_2, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038061, K_channel_subfamily_K_type, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01333, 2POREKCHANEL
PR01585, TASK3CHANNEL
PR01095, TASKCHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NPC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRQNVRTLS LIVCTFTYLL VGAAVFDALE SDHEMREEEK LKAEEIRIKG 
        60         70         80         90        100
KYNISSEDYR QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA 
       110        120        130        140        150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR 
       160        170        180        190        200
NTDVSMENMV TVGFFSCMGT LCIGAAAFSQ CEEWSFFHAY YYCFITLTTI 
       210        220        230        240        250
GFGDYVALQT KGALQKKPLY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN 
       260        270        280        290        300
SEDERRDAEE RASLAGNRNS MVIHIPEEPR PSRPRYKADV PDLQSVCSCT 
       310        320        330        340        350
CYRSQDYGGR SVAPQNSFSA KLAPHYFHSI SYKIEEISPS TLKNSLFPSP 
       360        370 
ISSISPGLHS FTDHQRLMKR RKSV
Length:374
Mass (Da):42,264
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A19EAEE5A4D7F38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IU12A0A3B3IU12_HUMAN
Potassium channel subfamily K membe...
KCNK9
362Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITR0A0A3B3ITR0_HUMAN
Potassium channel subfamily K membe...
KCNK9
290Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054373236G → R in BIBARS; inactive. 2 PublicationsCorresponds to variant dbSNP:rs121908332EnsemblClinVar.1
Natural variantiVAR_084510237A → D in BIBARS. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF212829 mRNA Translation: AAF63708.1
AF248241 mRNA Translation: AAG31730.1
AF257080 mRNA Translation: AAG33126.1
AY190605 mRNA Translation: AAO38739.1
AF279809 mRNA Translation: AAF85982.1
BC075079 mRNA Translation: AAH75079.1
BC075080 mRNA Translation: AAH75080.1
BC112063 mRNA Translation: AAI12064.1
BC112065 mRNA Translation: AAI12066.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6377.1

NCBI Reference Sequences

More...RefSeqi		NP_001269463.1, NM_001282534.1
XP_011515404.1, XM_011517102.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303015; ENSP00000302166; ENSG00000169427
ENST00000520439; ENSP00000430676; ENSG00000169427
ENST00000522317; ENSP00000429847; ENSG00000169427
ENST00000648164; ENSP00000498198; ENSG00000169427
ENST00000650269; ENSP00000496915; ENSG00000169427

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51305

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51305

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000520439.3; ENSP00000430676.1; NM_001282534.2; NP_001269463.1

UCSC genome browser

More...UCSCi		uc003yvg.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212829 mRNA Translation: AAF63708.1
AF248241 mRNA Translation: AAG31730.1
AF257080 mRNA Translation: AAG33126.1
AY190605 mRNA Translation: AAO38739.1
AF279809 mRNA Translation: AAF85982.1
BC075079 mRNA Translation: AAH75079.1
BC075080 mRNA Translation: AAH75080.1
BC112063 mRNA Translation: AAI12064.1
BC112065 mRNA Translation: AAI12066.1
CCDSiCCDS6377.1
RefSeqiNP_001269463.1, NM_001282534.1
XP_011515404.1, XM_011517102.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P1NX-ray1.40P369-374[»]
3P1OX-ray1.90P369-374[»]
3P1PX-ray1.95P369-374[»]
3P1QX-ray1.70P369-374[»]
3P1RX-ray1.70P369-374[»]
3P1SX-ray1.65P369-374[»]
3SMKX-ray2.10P369-374[»]
3SMLX-ray1.90P370-374[»]
3SMMX-ray2.00P369-374[»]
3SMNX-ray2.00P369-374[»]
3SMOX-ray1.80P369-374[»]
3SP5X-ray1.80P369-374[»]
3SPRX-ray1.99P369-374[»]
3UX0X-ray1.75P369-374[»]
4FR3X-ray1.90P369-374[»]
6GHPX-ray1.95P368-374[»]
SMRiQ9NPC2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119456, 2 interactors
STRINGi9606.ENSP00000430676

Chemistry databases

BindingDBiQ9NPC2
ChEMBLiCHEMBL2321614
DrugBankiDB00561, Doxapram
DB01159, Halothane
DrugCentraliQ9NPC2

Protein family/group databases

TCDBi1.A.1.9.11, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniQ9NPC2, 1 site
iPTMnetiQ9NPC2
PhosphoSitePlusiQ9NPC2

Genetic variation databases

BioMutaiKCNK9
DMDMi13431426

Proteomic databases

PaxDbiQ9NPC2
PeptideAtlasiQ9NPC2
PRIDEiQ9NPC2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27582, 102 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		51305

Genome annotation databases

EnsembliENST00000303015; ENSP00000302166; ENSG00000169427
ENST00000520439; ENSP00000430676; ENSG00000169427
ENST00000522317; ENSP00000429847; ENSG00000169427
ENST00000648164; ENSP00000498198; ENSG00000169427
ENST00000650269; ENSP00000496915; ENSG00000169427
GeneIDi51305
KEGGihsa:51305
MANE-SelectiENST00000520439.3; ENSP00000430676.1; NM_001282534.2; NP_001269463.1
UCSCiuc003yvg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51305
DisGeNETi51305

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNK9
GeneReviewsiKCNK9
HGNCiHGNC:6283, KCNK9
HPAiENSG00000169427, Tissue enriched (brain)
MalaCardsiKCNK9
MIMi605874, gene
612292, phenotype
neXtProtiNX_Q9NPC2
OpenTargetsiENSG00000169427
Orphaneti166108, Intellectual disability, Birk-Barel type
PharmGKBiPA30065
VEuPathDBiHostDB:ENSG00000169427

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4404, Eukaryota
GeneTreeiENSGT00940000159791
HOGENOMiCLU_022504_4_0_1
InParanoidiQ9NPC2
OMAiNHQLMRR
OrthoDBi1109218at2759
PhylomeDBiQ9NPC2
TreeFamiTF313947

Enzyme and pathway databases

PathwayCommonsiQ9NPC2
ReactomeiR-HSA-1299316, TWIK-releated acid-sensitive K+ channel (TASK)
R-HSA-5576886, Phase 4 - resting membrane potential
SignaLinkiQ9NPC2
SIGNORiQ9NPC2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51305, 9 hits in 1036 CRISPR screens
EvolutionaryTraceiQ9NPC2

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNK9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51305
PharosiQ9NPC2, Tclin

Protein Ontology

More...PROi		PR:Q9NPC2
RNActiQ9NPC2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169427, Expressed in right hemisphere of cerebellum and 108 other tissues
ExpressionAtlasiQ9NPC2, baseline and differential
GenevisibleiQ9NPC2, HS

Family and domain databases

InterProiView protein in InterPro
IPR003280, 2pore_dom_K_chnl
IPR003092, 2pore_dom_K_chnl_TASK
IPR013099, K_chnl_dom
IPR005407, KCNK9
PANTHERiPTHR11003, PTHR11003, 1 hit
PfamiView protein in Pfam
PF07885, Ion_trans_2, 2 hits
PIRSFiPIRSF038061, K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333, 2POREKCHANEL
PR01585, TASK3CHANNEL
PR01095, TASKCHANNEL

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNK9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPC2
Secondary accession number(s): Q2M290, Q540F2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: February 23, 2022
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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