UniProtKB - Q9NPC2 (KCNK9_HUMAN)
Protein
Potassium channel subfamily K member 9
Gene
KCNK9
Organism
Homo sapiens (Human)
Status
Functioni
pH-dependent, voltage-insensitive, background potassium channel protein.3 Publications
Miscellaneous
Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.
Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.
GO - Molecular functioni
- potassium channel activity Source: MGI
- potassium ion leak channel activity Source: GO_Central
- voltage-gated potassium channel activity Source: Ensembl
GO - Biological processi
- potassium ion import across plasma membrane Source: MGI
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: UniProtKB
- stabilization of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q9NPC2 |
Reactomei | R-HSA-1299316, TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-5576886, Phase 4 - resting membrane potential |
SIGNORi | Q9NPC2 |
Protein family/group databases
TCDBi | 1.A.1.9.11, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel subfamily K member 9Alternative name(s): Acid-sensitive potassium channel protein TASK-3 TWIK-related acid-sensitive K(+) channel 3 Two pore potassium channel KT3.2 Short name: Two pore K(+) channel KT3.2 |
Gene namesi | Name:KCNK9 Synonyms:TASK3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6283, KCNK9 |
MIMi | 605874, gene |
neXtProti | NX_Q9NPC2 |
VEuPathDBi | HostDB:ENSG00000169427.6 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- synaptic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 88 | ExtracellularSequence analysisAdd BLAST | 59 | |
Intramembranei | 89 – 101 | Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST | 13 | |
Topological domaini | 102 – 107 | ExtracellularSequence analysis | 6 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 158 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 194 | ExtracellularSequence analysisAdd BLAST | 15 | |
Intramembranei | 195 – 207 | Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST | 13 | |
Topological domaini | 208 – 218 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 219 – 239 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 240 – 374 | CytoplasmicSequence analysisAdd BLAST | 135 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Birk-Barel mental retardation dysmorphism syndrome (BIBAS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054373 | 236 | G → R in BIBAS; inactive. 1 PublicationCorresponds to variant dbSNP:rs121908332EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 51305 |
GeneReviewsi | KCNK9 |
MalaCardsi | KCNK9 |
MIMi | 612292, phenotype |
OpenTargetsi | ENSG00000169427 |
Orphaneti | 166108, Intellectual disability, Birk-Barel type |
PharmGKBi | PA30065 |
Miscellaneous databases
Pharosi | Q9NPC2, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2321614 |
DrugBanki | DB00561, Doxapram DB01159, Halothane |
DrugCentrali | Q9NPC2 |
Genetic variation databases
BioMutai | KCNK9 |
DMDMi | 13431426 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101754 | 1 – 374 | Potassium channel subfamily K member 9Add BLAST | 374 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9NPC2 |
PeptideAtlasi | Q9NPC2 |
PRIDEi | Q9NPC2 |
ProteomicsDBi | 81964 |
PTM databases
GlyGeni | Q9NPC2, 1 site |
iPTMneti | Q9NPC2 |
PhosphoSitePlusi | Q9NPC2 |
Expressioni
Tissue specificityi
Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.2 Publications
Gene expression databases
Bgeei | ENSG00000169427, Expressed in right hemisphere of cerebellum and 106 other tissues |
ExpressionAtlasi | Q9NPC2, baseline and differential |
Genevisiblei | Q9NPC2, HS |
Organism-specific databases
HPAi | ENSG00000169427, Group enriched (adrenal gland, brain) |
Interactioni
Subunit structurei
Homodimer (Probable). Heterodimer with KCNK1.
Curated1 PublicationProtein-protein interaction databases
BioGRIDi | 119456, 2 interactors |
STRINGi | 9606.ENSP00000430676 |
Chemistry databases
BindingDBi | Q9NPC2 |
Miscellaneous databases
RNActi | Q9NPC2, protein |
Structurei
3D structure databases
SMRi | Q9NPC2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NPC2 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4404, Eukaryota |
GeneTreei | ENSGT00940000159791 |
HOGENOMi | CLU_022504_4_0_1 |
InParanoidi | Q9NPC2 |
OMAi | DFEMREK |
OrthoDBi | 1109218at2759 |
PhylomeDBi | Q9NPC2 |
TreeFami | TF313947 |
Family and domain databases
InterProi | View protein in InterPro IPR003280, 2pore_dom_K_chnl IPR003092, 2pore_dom_K_chnl_TASK IPR013099, K_chnl_dom IPR005407, KCNK9 |
Pfami | View protein in Pfam PF07885, Ion_trans_2, 2 hits |
PIRSFi | PIRSF038061, K_channel_subfamily_K_type, 1 hit |
PRINTSi | PR01333, 2POREKCHANEL PR01585, TASK3CHANNEL PR01095, TASKCHANNEL |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9NPC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRQNVRTLS LIVCTFTYLL VGAAVFDALE SDHEMREEEK LKAEEIRIKG
60 70 80 90 100
KYNISSEDYR QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR
160 170 180 190 200
NTDVSMENMV TVGFFSCMGT LCIGAAAFSQ CEEWSFFHAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQT KGALQKKPLY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN
260 270 280 290 300
SEDERRDAEE RASLAGNRNS MVIHIPEEPR PSRPRYKADV PDLQSVCSCT
310 320 330 340 350
CYRSQDYGGR SVAPQNSFSA KLAPHYFHSI SYKIEEISPS TLKNSLFPSP
360 370
ISSISPGLHS FTDHQRLMKR RKSV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITR0 | A0A3B3ITR0_HUMAN | Potassium channel subfamily K membe... | KCNK9 | 290 | Annotation score: | ||
A0A3B3IU12 | A0A3B3IU12_HUMAN | Potassium channel subfamily K membe... | KCNK9 | 362 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054373 | 236 | G → R in BIBAS; inactive. 1 PublicationCorresponds to variant dbSNP:rs121908332EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212829 mRNA Translation: AAF63708.1 AF248241 mRNA Translation: AAG31730.1 AF257080 mRNA Translation: AAG33126.1 AY190605 mRNA Translation: AAO38739.1 AF279809 mRNA Translation: AAF85982.1 BC075079 mRNA Translation: AAH75079.1 BC075080 mRNA Translation: AAH75080.1 BC112063 mRNA Translation: AAI12064.1 BC112065 mRNA Translation: AAI12066.1 |
CCDSi | CCDS6377.1 |
RefSeqi | NP_001269463.1, NM_001282534.1 XP_011515404.1, XM_011517102.2 |
Genome annotation databases
Ensembli | ENST00000303015; ENSP00000302166; ENSG00000169427 ENST00000520439; ENSP00000430676; ENSG00000169427 ENST00000522317; ENSP00000429847; ENSG00000169427 ENST00000648164; ENSP00000498198; ENSG00000169427 ENST00000650269; ENSP00000496915; ENSG00000169427 |
GeneIDi | 51305 |
KEGGi | hsa:51305 |
UCSCi | uc003yvg.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212829 mRNA Translation: AAF63708.1 AF248241 mRNA Translation: AAG31730.1 AF257080 mRNA Translation: AAG33126.1 AY190605 mRNA Translation: AAO38739.1 AF279809 mRNA Translation: AAF85982.1 BC075079 mRNA Translation: AAH75079.1 BC075080 mRNA Translation: AAH75080.1 BC112063 mRNA Translation: AAI12064.1 BC112065 mRNA Translation: AAI12066.1 |
CCDSi | CCDS6377.1 |
RefSeqi | NP_001269463.1, NM_001282534.1 XP_011515404.1, XM_011517102.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3P1N | X-ray | 1.40 | P | 369-374 | [»] | |
3P1O | X-ray | 1.90 | P | 369-374 | [»] | |
3P1P | X-ray | 1.95 | P | 369-374 | [»] | |
3P1Q | X-ray | 1.70 | P | 369-374 | [»] | |
3P1R | X-ray | 1.70 | P | 369-374 | [»] | |
3P1S | X-ray | 1.65 | P | 369-374 | [»] | |
3SMK | X-ray | 2.10 | P | 369-374 | [»] | |
3SML | X-ray | 1.90 | P | 370-374 | [»] | |
3SMM | X-ray | 2.00 | P | 369-374 | [»] | |
3SMN | X-ray | 2.00 | P | 369-374 | [»] | |
3SMO | X-ray | 1.80 | P | 369-374 | [»] | |
3SP5 | X-ray | 1.80 | P | 369-374 | [»] | |
3SPR | X-ray | 1.99 | P | 369-374 | [»] | |
3UX0 | X-ray | 1.75 | P | 369-374 | [»] | |
4FR3 | X-ray | 1.90 | P | 369-374 | [»] | |
6GHP | X-ray | 1.95 | P | 368-374 | [»] | |
SMRi | Q9NPC2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119456, 2 interactors |
STRINGi | 9606.ENSP00000430676 |
Chemistry databases
BindingDBi | Q9NPC2 |
ChEMBLi | CHEMBL2321614 |
DrugBanki | DB00561, Doxapram DB01159, Halothane |
DrugCentrali | Q9NPC2 |
Protein family/group databases
TCDBi | 1.A.1.9.11, the voltage-gated ion channel (vic) superfamily |
PTM databases
GlyGeni | Q9NPC2, 1 site |
iPTMneti | Q9NPC2 |
PhosphoSitePlusi | Q9NPC2 |
Genetic variation databases
BioMutai | KCNK9 |
DMDMi | 13431426 |
Proteomic databases
PaxDbi | Q9NPC2 |
PeptideAtlasi | Q9NPC2 |
PRIDEi | Q9NPC2 |
ProteomicsDBi | 81964 |
Protocols and materials databases
Antibodypediai | 27582, 97 antibodies |
Genome annotation databases
Ensembli | ENST00000303015; ENSP00000302166; ENSG00000169427 ENST00000520439; ENSP00000430676; ENSG00000169427 ENST00000522317; ENSP00000429847; ENSG00000169427 ENST00000648164; ENSP00000498198; ENSG00000169427 ENST00000650269; ENSP00000496915; ENSG00000169427 |
GeneIDi | 51305 |
KEGGi | hsa:51305 |
UCSCi | uc003yvg.3, human |
Organism-specific databases
CTDi | 51305 |
DisGeNETi | 51305 |
GeneCardsi | KCNK9 |
GeneReviewsi | KCNK9 |
HGNCi | HGNC:6283, KCNK9 |
HPAi | ENSG00000169427, Group enriched (adrenal gland, brain) |
MalaCardsi | KCNK9 |
MIMi | 605874, gene 612292, phenotype |
neXtProti | NX_Q9NPC2 |
OpenTargetsi | ENSG00000169427 |
Orphaneti | 166108, Intellectual disability, Birk-Barel type |
PharmGKBi | PA30065 |
VEuPathDBi | HostDB:ENSG00000169427.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4404, Eukaryota |
GeneTreei | ENSGT00940000159791 |
HOGENOMi | CLU_022504_4_0_1 |
InParanoidi | Q9NPC2 |
OMAi | DFEMREK |
OrthoDBi | 1109218at2759 |
PhylomeDBi | Q9NPC2 |
TreeFami | TF313947 |
Enzyme and pathway databases
PathwayCommonsi | Q9NPC2 |
Reactomei | R-HSA-1299316, TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-5576886, Phase 4 - resting membrane potential |
SIGNORi | Q9NPC2 |
Miscellaneous databases
BioGRID-ORCSi | 51305, 8 hits in 985 CRISPR screens |
EvolutionaryTracei | Q9NPC2 |
GeneWikii | KCNK9 |
GenomeRNAii | 51305 |
Pharosi | Q9NPC2, Tclin |
PROi | PR:Q9NPC2 |
RNActi | Q9NPC2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169427, Expressed in right hemisphere of cerebellum and 106 other tissues |
ExpressionAtlasi | Q9NPC2, baseline and differential |
Genevisiblei | Q9NPC2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003280, 2pore_dom_K_chnl IPR003092, 2pore_dom_K_chnl_TASK IPR013099, K_chnl_dom IPR005407, KCNK9 |
Pfami | View protein in Pfam PF07885, Ion_trans_2, 2 hits |
PIRSFi | PIRSF038061, K_channel_subfamily_K_type, 1 hit |
PRINTSi | PR01333, 2POREKCHANEL PR01585, TASK3CHANNEL PR01095, TASKCHANNEL |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNK9_HUMAN | |
Accessioni | Q9NPC2Primary (citable) accession number: Q9NPC2 Secondary accession number(s): Q2M290, Q540F2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families