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UniProtKB - Q9NPC1 (LT4R2_HUMAN)

Entry version 173 (02 Jun 2021)
Sequence version 2 (13 Feb 2019)
Previous versions | rss
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Protein

Leukotriene B4 receptor 2

Gene

LTB4R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NPC1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-391906, Leukotriene receptors
R-HSA-416476, G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NPC1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001556

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukotriene B4 receptor 2
Short name:
LTB4-R 2
Short name:
LTB4-R2
Alternative name(s):
LTB4 receptor JULF2
Leukotriene B4 receptor BLT2
Seven transmembrane receptor BLTR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTB4R2
Synonyms:BLT2R, BLTR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19260, LTB4R2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605773, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NPC1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000213906.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 60CytoplasmicSequence analysisAdd BLAST15
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 96ExtracellularSequence analysisAdd BLAST15
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 140CytoplasmicSequence analysisAdd BLAST23
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 185ExtracellularSequence analysisAdd BLAST24
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 224CytoplasmicSequence analysisAdd BLAST18
Transmembranei225 – 245Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini246 – 275ExtracellularSequence analysisAdd BLAST30
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 358CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56413

Open Targets

More...OpenTargetsi		ENSG00000213906

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134910672

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NPC1, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3191

Drug and drug target database

More...DrugBanki		DB06248, Amelubant
DB12961, Leukotriene B4

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		268

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LTB4R2

Domain mapping of disease mutations (DMDM)

More...DMDMi		23821812

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000697111 – 358Leukotriene B4 receptor 2Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NPC1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NPC1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NPC1

PeptideAtlas

More...PeptideAtlasi		Q9NPC1

PRoteomics IDEntifications database

More...PRIDEi		Q9NPC1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63551

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NPC1, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NPC1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NPC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213906, Expressed in ectocervix and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NPC1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NPC1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000213906, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121143, 49 interactors

Protein interaction database and analysis system

More...IntActi		Q9NPC1, 46 interactors

Molecular INTeraction database

More...MINTi		Q9NPC1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445772

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NPC1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NPC1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni311 – 358DisorderedSequence analysisAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182966

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NPC1

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NPC1

TreeFam database of animal gene trees

More...TreeFami		TF330976

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003981, Leukotriene_B4_rcpt
IPR003982, Leukotriene_B4_typ-2_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01478, LTB2RECEPTOR
PR01476, LTBRECEPTOR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NPC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVCYRPPGN ETLLSWKTSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP 
        60         70         80         90        100
ARGRPLAATL VLHLALADGA VLLLTPLFVA FLTRQAWPLG QAGCKAVYYV 
       110        120        130        140        150
CALSMYASVL LTGLLSLQRC LAVTRPFLAP RLRSPALARR LLLAVWLAAL 
       160        170        180        190        200
LLAVPAAVYR HLWRDRVCQL CHPSPVHAAA HLSLETLTAF VLPFGLMLGC 
       210        220        230        240        250
YSVTLARLRG ARWGSGRHGA RVGRLVSAIV LAFGLLWAPY HAVNLLQAVA 
       260        270        280        290        300
ALAPPEGALA KLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG 
       310        320        330        340        350
PRFLTRLFEG SGEARGGGRS REGTMELRTT PQLKVVGQGR GNGDPGGGME 

KDGPEWDL
Length:358
Mass (Da):37,942
Last modified:February 13, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F5D98179CE00F3D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q5ACI7A0A3Q5ACI7_HUMAN
Leukotriene B4 receptor 2
LTB4R2
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNJ6E9PNJ6_HUMAN
Leukotriene B4 receptor 2
LTB4R2
319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIC1E9PIC1_HUMAN
Leukotriene B4 receptor 2
LTB4R2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF81261 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAP23200 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB96134 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF277230 mRNA Translation: AAF81261.1 Different initiation.
AB044402 mRNA Translation: BAA99539.1
AF308571 mRNA Translation: AAG40857.1
AB008193 Genomic DNA Translation: BAB00610.1
AB029892 mRNA Translation: BAA99553.1
AB083604 Genomic DNA Translation: BAB89317.1
AB032558 mRNA Translation: BAD83590.1
AJ278605 Genomic DNA Translation: CAB96134.1 Sequence problems.
AY268433 Genomic DNA Translation: AAP23200.1 Sequence problems.
AL096870 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66030.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9625.2

Protein sequence database of the Protein Information Resource

More...PIRi		JC7356

NCBI Reference Sequences

More...RefSeqi		NP_001158164.1, NM_001164692.2
NP_062813.2, NM_019839.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000533293; ENSP00000433290; ENSG00000213906
ENST00000543919; ENSP00000445772; ENSG00000213906
ENST00000643080; ENSP00000494694; ENSG00000285203
ENST00000644309; ENSP00000494877; ENSG00000285203

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56413

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56413

UCSC genome browser

More...UCSCi		uc001wor.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277230 mRNA Translation: AAF81261.1 Different initiation.
AB044402 mRNA Translation: BAA99539.1
AF308571 mRNA Translation: AAG40857.1
AB008193 Genomic DNA Translation: BAB00610.1
AB029892 mRNA Translation: BAA99553.1
AB083604 Genomic DNA Translation: BAB89317.1
AB032558 mRNA Translation: BAD83590.1
AJ278605 Genomic DNA Translation: CAB96134.1 Sequence problems.
AY268433 Genomic DNA Translation: AAP23200.1 Sequence problems.
AL096870 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66030.1
CCDSiCCDS9625.2
PIRiJC7356
RefSeqiNP_001158164.1, NM_001164692.2
NP_062813.2, NM_019839.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121143, 49 interactors
IntActiQ9NPC1, 46 interactors
MINTiQ9NPC1
STRINGi9606.ENSP00000445772

Chemistry databases

BindingDBiQ9NPC1
ChEMBLiCHEMBL3191
DrugBankiDB06248, Amelubant
DB12961, Leukotriene B4
GuidetoPHARMACOLOGYi268
SwissLipidsiSLP:000001556

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ9NPC1, 1 site
iPTMnetiQ9NPC1
PhosphoSitePlusiQ9NPC1

Genetic variation databases

BioMutaiLTB4R2
DMDMi23821812

Proteomic databases

EPDiQ9NPC1
MassIVEiQ9NPC1
PaxDbiQ9NPC1
PeptideAtlasiQ9NPC1
PRIDEiQ9NPC1
ProteomicsDBi63551

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9159, 227 antibodies

The DNASU plasmid repository

More...DNASUi		56413

Genome annotation databases

EnsembliENST00000533293; ENSP00000433290; ENSG00000213906
ENST00000543919; ENSP00000445772; ENSG00000213906
ENST00000643080; ENSP00000494694; ENSG00000285203
ENST00000644309; ENSP00000494877; ENSG00000285203
GeneIDi56413
KEGGihsa:56413
UCSCiuc001wor.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56413
DisGeNETi56413

GeneCards: human genes, protein and diseases

More...GeneCardsi		LTB4R2
HGNCiHGNC:19260, LTB4R2
HPAiENSG00000213906, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue)
MIMi605773, gene
neXtProtiNX_Q9NPC1
OpenTargetsiENSG00000213906
PharmGKBiPA134910672
VEuPathDBiHostDB:ENSG00000213906.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00950000182966
InParanoidiQ9NPC1
PhylomeDBiQ9NPC1
TreeFamiTF330976

Enzyme and pathway databases

PathwayCommonsiQ9NPC1
ReactomeiR-HSA-391906, Leukotriene receptors
R-HSA-416476, G alpha (q) signalling events
SIGNORiQ9NPC1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56413, 116 hits in 993 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56413
PharosiQ9NPC1, Tchem

Protein Ontology

More...PROi		PR:Q9NPC1
RNActiQ9NPC1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000213906, Expressed in ectocervix and 111 other tissues
ExpressionAtlasiQ9NPC1, baseline and differential
GenevisibleiQ9NPC1, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003981, Leukotriene_B4_rcpt
IPR003982, Leukotriene_B4_typ-2_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01478, LTB2RECEPTOR
PR01476, LTBRECEPTOR
PROSITEiView protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLT4R2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPC1
Secondary accession number(s): Q5KU28, Q9NPE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: February 13, 2019
Last modified: June 2, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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