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Protein

Leukotriene B4 receptor 2

Gene

LTB4R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiQ9NPC1

Chemistry databases

SwissLipidsiSLP:000001556

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 2
Short name:
LTB4-R 2
Short name:
LTB4-R2
Alternative name(s):
LTB4 receptor JULF2
Leukotriene B4 receptor BLT2
Seven transmembrane receptor BLTR2
Gene namesi
Name:LTB4R2
Synonyms:BLT2R, BLTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000213906.9
HGNCiHGNC:19260 LTB4R2
MIMi605773 gene
neXtProtiNX_Q9NPC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 91CytoplasmicSequence analysisAdd BLAST15
Transmembranei92 – 112Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini113 – 127ExtracellularSequence analysisAdd BLAST15
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 172CytoplasmicSequence analysisAdd BLAST24
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini194 – 216ExtracellularSequence analysisAdd BLAST23
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 256CytoplasmicSequence analysisAdd BLAST19
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 306ExtracellularSequence analysisAdd BLAST29
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 389CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56413
OpenTargetsiENSG00000213906
PharmGKBiPA134910672

Chemistry databases

ChEMBLiCHEMBL3191
GuidetoPHARMACOLOGYi268

Polymorphism and mutation databases

BioMutaiLTB4R2
DMDMi23821812

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697111 – 389Leukotriene B4 receptor 2Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NPC1
PaxDbiQ9NPC1
PRIDEiQ9NPC1
ProteomicsDBi81963

PTM databases

iPTMnetiQ9NPC1
PhosphoSitePlusiQ9NPC1

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000213906
CleanExiHS_LTB4R2
ExpressionAtlasiQ9NPC1 baseline and differential
GenevisibleiQ9NPC1 HS

Organism-specific databases

HPAiCAB022689
HPA029680
HPA072921

Interactioni

Protein-protein interaction databases

BioGridi121143, 4 interactors
IntActiQ9NPC1, 1 interactor
MINTiQ9NPC1
STRINGi9606.ENSP00000433290

Chemistry databases

BindingDBiQ9NPC1

Structurei

3D structure databases

ProteinModelPortaliQ9NPC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000149097
HOGENOMiHOG000008594
HOVERGENiHBG104134
InParanoidiQ9NPC1
KOiK04297
OMAiSREGTME
OrthoDBiEOG091G0G5V
PhylomeDBiQ9NPC1
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003981 Leukotriene_B4_rcpt
IPR003982 Leukotriene_B4_typ-2_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01478 LTB2RECEPTOR
PR01476 LTBRECEPTOR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NPC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSHRASQV GFCPTPERPL WRLPPTCRPR RMSVCYRPPG NETLLSWKTS
60 70 80 90 100
RATGTAFLLL AALLGLPGNG FVVWSLAGWR PARGRPLAAT LVLHLALADG
110 120 130 140 150
AVLLLTPLFV AFLTRQAWPL GQAGCKAVYY VCALSMYASV LLTGLLSLQR
160 170 180 190 200
CLAVTRPFLA PRLRSPALAR RLLLAVWLAA LLLAVPAAVY RHLWRDRVCQ
210 220 230 240 250
LCHPSPVHAA AHLSLETLTA FVLPFGLMLG CYSVTLARLR GARWGSGRHG
260 270 280 290 300
ARVGRLVSAI VLAFGLLWAP YHAVNLLQAV AALAPPEGAL AKLGGAGQAA
310 320 330 340 350
RAGTTALAFF SSSVNPVLYV FTAGDLLPRA GPRFLTRLFE GSGEARGGGR
360 370 380
SREGTMELRT TPQLKVVGQG RGNGDPGGGM EKDGPEWDL
Length:389
Mass (Da):41,525
Last modified:October 1, 2000 - v1
Checksum:i8D6BC5A73A42F544
GO
Isoform 2 (identifier: Q9NPC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):37,942
Checksum:i5F5D98179CE00F3D
GO

Sequence cautioni

The sequence BAB00610 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448851 – 31Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277230 mRNA Translation: AAF81261.1
AB029892 mRNA Translation: BAA99553.1
AB008193 Genomic DNA Translation: BAB00610.1 Different initiation.
AB032558 mRNA Translation: BAD83590.1
AJ278605 Genomic DNA Translation: CAB96134.1
AY268433 Genomic DNA Translation: AAP23200.1
AL096870 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66030.1
AF308571 mRNA Translation: AAG40857.1
AB044402 mRNA Translation: BAA99539.1
AB083604 Genomic DNA Translation: BAB89317.1
CCDSiCCDS9625.2 [Q9NPC1-2]
PIRiJC7356
RefSeqiNP_001158164.1, NM_001164692.2 [Q9NPC1-2]
NP_062813.2, NM_019839.4 [Q9NPC1-2]
UniGeneiHs.642693
Hs.657595

Genome annotation databases

EnsembliENST00000528054; ENSP00000432146; ENSG00000213906 [Q9NPC1-1]
ENST00000533293; ENSP00000433290; ENSG00000213906 [Q9NPC1-2]
ENST00000543919; ENSP00000445772; ENSG00000213906 [Q9NPC1-2]
ENST00000643080; ENSP00000494694; ENSG00000285203 [Q9NPC1-2]
ENST00000644309; ENSP00000494877; ENSG00000285203 [Q9NPC1-2]
ENST00000645084; ENSP00000496382; ENSG00000285203 [Q9NPC1-1]
GeneIDi56413
KEGGihsa:56413
UCSCiuc001wor.4 human [Q9NPC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLT4R2_HUMAN
AccessioniPrimary (citable) accession number: Q9NPC1
Secondary accession number(s): Q5KU28, Q9NPE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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