UniProtKB - Q9NPC1 (LT4R2_HUMAN)
Protein
Leukotriene B4 receptor 2
Gene
LTB4R2
Organism
Homo sapiens (Human)
Status
Functioni
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
GO - Molecular functioni
- galanin receptor activity Source: GO_Central
- G protein-coupled peptide receptor activity Source: GO_Central
- leukotriene B4 receptor activity Source: GO_Central
- leukotriene receptor activity Source: ProtInc
GO - Biological processi
- chemotaxis Source: ProtInc
- G protein-coupled receptor signaling pathway Source: Reactome
- inflammatory response Source: GO_Central
- keratinocyte migration Source: Ensembl
- negative regulation of adenylate cyclase activity Source: ProtInc
- neuropeptide signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-391906 Leukotriene receptors R-HSA-416476 G alpha (q) signalling events |
SIGNORi | Q9NPC1 |
Chemistry databases
SwissLipidsi | SLP:000001556 |
Names & Taxonomyi
Protein namesi | Recommended name: Leukotriene B4 receptor 2Short name: LTB4-R 2 Short name: LTB4-R2 Alternative name(s): LTB4 receptor JULF2 Leukotriene B4 receptor BLT2 Seven transmembrane receptor BLTR2 |
Gene namesi | Name:LTB4R2 Synonyms:BLT2R, BLTR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000213906.9 |
HGNCi | HGNC:19260 LTB4R2 |
MIMi | 605773 gene |
neXtProti | NX_Q9NPC1 |
Subcellular locationi
Plasma membrane
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 25 – 45 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 46 – 60 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 61 – 81 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 82 – 96 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 97 – 117 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 140 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 141 – 161 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 185 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 186 – 206 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 207 – 224 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 225 – 245 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 246 – 275 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 358 | CytoplasmicSequence analysisAdd BLAST | 62 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 56413 |
OpenTargetsi | ENSG00000213906 |
PharmGKBi | PA134910672 |
Chemistry databases
ChEMBLi | CHEMBL3191 |
GuidetoPHARMACOLOGYi | 268 |
Polymorphism and mutation databases
BioMutai | LTB4R2 |
DMDMi | 23821812 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069711 | 1 – 358 | Leukotriene B4 receptor 2Add BLAST | 358 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9NPC1 |
PaxDbi | Q9NPC1 |
PRIDEi | Q9NPC1 |
ProteomicsDBi | 81963 |
PTM databases
iPTMneti | Q9NPC1 |
PhosphoSitePlusi | Q9NPC1 |
Expressioni
Tissue specificityi
Widely expressed.
Gene expression databases
Bgeei | ENSG00000213906 Expressed in 86 organ(s), highest expression level in ectocervix |
ExpressionAtlasi | Q9NPC1 baseline and differential |
Genevisiblei | Q9NPC1 HS |
Organism-specific databases
HPAi | CAB022689 HPA029680 HPA072921 |
Interactioni
Protein-protein interaction databases
BioGridi | 121143, 4 interactors |
IntActi | Q9NPC1, 46 interactors |
MINTi | Q9NPC1 |
STRINGi | 9606.ENSP00000433290 |
Chemistry databases
BindingDBi | Q9NPC1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000155452 |
HOGENOMi | HOG000008594 |
HOVERGENi | HBG104134 |
InParanoidi | Q9NPC1 |
KOi | K04297 |
OMAi | YAVIITC |
OrthoDBi | 516965at2759 |
PhylomeDBi | Q9NPC1 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003981 Leukotriene_B4_rcpt IPR003982 Leukotriene_B4_typ-2_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01478 LTB2RECEPTOR PR01476 LTBRECEPTOR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NPC1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVCYRPPGN ETLLSWKTSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP
60 70 80 90 100
ARGRPLAATL VLHLALADGA VLLLTPLFVA FLTRQAWPLG QAGCKAVYYV
110 120 130 140 150
CALSMYASVL LTGLLSLQRC LAVTRPFLAP RLRSPALARR LLLAVWLAAL
160 170 180 190 200
LLAVPAAVYR HLWRDRVCQL CHPSPVHAAA HLSLETLTAF VLPFGLMLGC
210 220 230 240 250
YSVTLARLRG ARWGSGRHGA RVGRLVSAIV LAFGLLWAPY HAVNLLQAVA
260 270 280 290 300
ALAPPEGALA KLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG
310 320 330 340 350
PRFLTRLFEG SGEARGGGRS REGTMELRTT PQLKVVGQGR GNGDPGGGME
KDGPEWDL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PNJ6 | E9PNJ6_HUMAN | Leukotriene B4 receptor 2 | LTB4R2 | 319 | Annotation score: |
Sequence cautioni
The sequence AAF81261 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP23200 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB96134 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF277230 mRNA Translation: AAF81261.1 Different initiation. AB044402 mRNA Translation: BAA99539.1 AF308571 mRNA Translation: AAG40857.1 AB008193 Genomic DNA Translation: BAB00610.1 AB029892 mRNA Translation: BAA99553.1 AB083604 Genomic DNA Translation: BAB89317.1 AB032558 mRNA Translation: BAD83590.1 AJ278605 Genomic DNA Translation: CAB96134.1 Sequence problems. AY268433 Genomic DNA Translation: AAP23200.1 Sequence problems. AL096870 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66030.1 |
PIRi | JC7356 |
UniGenei | Hs.642693 Hs.657595 |
Genome annotation databases
GeneIDi | 56413 |
KEGGi | hsa:56413 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF277230 mRNA Translation: AAF81261.1 Different initiation. AB044402 mRNA Translation: BAA99539.1 AF308571 mRNA Translation: AAG40857.1 AB008193 Genomic DNA Translation: BAB00610.1 AB029892 mRNA Translation: BAA99553.1 AB083604 Genomic DNA Translation: BAB89317.1 AB032558 mRNA Translation: BAD83590.1 AJ278605 Genomic DNA Translation: CAB96134.1 Sequence problems. AY268433 Genomic DNA Translation: AAP23200.1 Sequence problems. AL096870 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66030.1 |
PIRi | JC7356 |
UniGenei | Hs.642693 Hs.657595 |
3D structure databases
ProteinModelPortali | Q9NPC1 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 121143, 4 interactors |
IntActi | Q9NPC1, 46 interactors |
MINTi | Q9NPC1 |
STRINGi | 9606.ENSP00000433290 |
Chemistry databases
BindingDBi | Q9NPC1 |
ChEMBLi | CHEMBL3191 |
GuidetoPHARMACOLOGYi | 268 |
SwissLipidsi | SLP:000001556 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q9NPC1 |
PhosphoSitePlusi | Q9NPC1 |
Polymorphism and mutation databases
BioMutai | LTB4R2 |
DMDMi | 23821812 |
Proteomic databases
EPDi | Q9NPC1 |
PaxDbi | Q9NPC1 |
PRIDEi | Q9NPC1 |
ProteomicsDBi | 81963 |
Protocols and materials databases
DNASUi | 56413 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
GeneIDi | 56413 |
KEGGi | hsa:56413 |
Organism-specific databases
CTDi | 56413 |
DisGeNETi | 56413 |
EuPathDBi | HostDB:ENSG00000213906.9 |
GeneCardsi | LTB4R2 |
H-InvDBi | HIX0131234 |
HGNCi | HGNC:19260 LTB4R2 |
HPAi | CAB022689 HPA029680 HPA072921 |
MIMi | 605773 gene |
neXtProti | NX_Q9NPC1 |
OpenTargetsi | ENSG00000213906 |
PharmGKBi | PA134910672 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000155452 |
HOGENOMi | HOG000008594 |
HOVERGENi | HBG104134 |
InParanoidi | Q9NPC1 |
KOi | K04297 |
OMAi | YAVIITC |
OrthoDBi | 516965at2759 |
PhylomeDBi | Q9NPC1 |
TreeFami | TF330976 |
Enzyme and pathway databases
Reactomei | R-HSA-391906 Leukotriene receptors R-HSA-416476 G alpha (q) signalling events |
SIGNORi | Q9NPC1 |
Miscellaneous databases
GenomeRNAii | 56413 |
PROi | PR:Q9NPC1 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213906 Expressed in 86 organ(s), highest expression level in ectocervix |
ExpressionAtlasi | Q9NPC1 baseline and differential |
Genevisiblei | Q9NPC1 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003981 Leukotriene_B4_rcpt IPR003982 Leukotriene_B4_typ-2_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01478 LTB2RECEPTOR PR01476 LTBRECEPTOR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | LT4R2_HUMAN | |
Accessioni | Q9NPC1Primary (citable) accession number: Q9NPC1 Secondary accession number(s): Q5KU28, Q9NPE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | February 13, 2019 | |
Last modified: | February 13, 2019 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries