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Protein

Partitioning defective 6 homolog alpha

Gene

PARD6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTP-dependent protein binding Source: UniProtKB
  • protein kinase C binding Source: GO_Central
  • Rho GTPase binding Source: UniProtKB
  • transcription factor binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions
R-HSA-4608870 Asymmetric localization of PCP proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NPB6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NPB6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Partitioning defective 6 homolog alpha
Short name:
PAR-6
Short name:
PAR-6 alpha
Short name:
PAR-6A
Alternative name(s):
PAR6C
Tax interaction protein 40
Short name:
TIP-40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARD6A
Synonyms:PAR6A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102981.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15943 PARD6A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607484 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPB6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19K → A: Loss of interaction with ECT2 and PRKCI. 2 Publications1
Mutagenesisi28R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-89. 1 Publication1
Mutagenesisi89R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-28. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
50855

Open Targets

More...
OpenTargetsi
ENSG00000102981

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32937

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARD6A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30913215

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001125131 – 346Partitioning defective 6 homolog alphaAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei278PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by the TGF-beta receptor.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NPB6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NPB6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NPB6

PeptideAtlas

More...
PeptideAtlasi
Q9NPB6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NPB6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81959
81960 [Q9NPB6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NPB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NPB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102981 Expressed in 186 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_PARD6A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NPB6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NPB6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009733
HPA041551

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI. Interacts with DCTN1 and PCM1 (PubMed:20719959).By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119157, 56 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NPB6

Database of interacting proteins

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DIPi
DIP-31312N

Protein interaction database and analysis system

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IntActi
Q9NPB6, 48 interactors

Molecular INTeraction database

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MINTi
Q9NPB6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000219255

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NPB6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NPB6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NPB6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 95PB1PROSITE-ProRule annotationAdd BLAST81
Domaini133 – 150Pseudo-CRIBAdd BLAST18
Domaini157 – 250PDZPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 116Interaction with PRKCI and PRKCZAdd BLAST116
Regioni126 – 253Interaction with PARD3 and CDC42By similarityAdd BLAST128

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity
The PB1 domain mediates interactions with MAP2K5.By similarity
The PDZ domain mediates the interaction with CRB3.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAR6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3606 Eukaryota
ENOG410XRJ3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156264

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231716

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053509

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NPB6

KEGG Orthology (KO)

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KOi
K06093

Identification of Orthologs from Complete Genome Data

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OMAi
ENRQPPC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0FFH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NPB6

TreeFam database of animal gene trees

More...
TreeFami
TF312899

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06403 PB1_Par6, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034872 PAR-6_a
IPR000270 PB1_dom
IPR034868 PB1_Par6
IPR001478 PDZ
IPR036034 PDZ_sf

The PANTHER Classification System

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PANTHERi
PTHR14102:SF9 PTHR14102:SF9, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00564 PB1, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00666 PB1, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH
60 70 80 90 100
QIPGLDVLLG YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEADS
110 120 130 140 150
SGLAFASNSL QRRKKGLLLR PVAPLRTRPP LLISLPQDFR QVSSVIDVDL
160 170 180 190 200
LPETHRRVRL HKHGSDRPLG FYIRDGMSVR VAPQGLERVP GIFISRLVRG
210 220 230 240 250
GLAESTGLLA VSDEILEVNG IEVAGKTLDQ VTDMMVANSH NLIVTVKPAN
260 270 280 290 300
QRNNVVRGAS GRLTGPPSAG PGPAEPDSDD DSSDLVIENR QPPSSNGLSQ
310 320 330 340
GPPCWDLHPG CRHPGTRSSL PSLDDQEQAS SGWGSRIRGD GSGFSL
Length:346
Mass (Da):37,388
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9241E0EDC3694AD4
GO
Isoform 2 (identifier: Q9NPB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-96: Missing.

Show »
Length:345
Mass (Da):37,317
Checksum:i035F9FA6BB62F085
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMM2R4GMM2_HUMAN
Partitioning defective 6 homolog al...
PARD6A
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050454286V → I. Corresponds to variant dbSNP:rs35356834Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00745996Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ277095 mRNA Translation: CAB85490.1
AF265565 mRNA Translation: AAF75548.1
AF252292 mRNA Translation: AAF71529.1
AB043634 mRNA Translation: BAA96235.1
AB041642 mRNA Translation: BAB16105.1
BC015626 mRNA Translation: AAH15626.1
AF028827 mRNA Translation: AAB84252.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10843.1 [Q9NPB6-1]
CCDS45514.1 [Q9NPB6-2]

NCBI Reference Sequences

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RefSeqi
NP_001032358.1, NM_001037281.1 [Q9NPB6-2]
NP_058644.1, NM_016948.2 [Q9NPB6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.112933

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000219255; ENSP00000219255; ENSG00000102981 [Q9NPB6-1]
ENST00000458121; ENSP00000392388; ENSG00000102981 [Q9NPB6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
50855

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:50855

UCSC genome browser

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UCSCi
uc002ets.3 human [Q9NPB6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277095 mRNA Translation: CAB85490.1
AF265565 mRNA Translation: AAF75548.1
AF252292 mRNA Translation: AAF71529.1
AB043634 mRNA Translation: BAA96235.1
AB041642 mRNA Translation: BAB16105.1
BC015626 mRNA Translation: AAH15626.1
AF028827 mRNA Translation: AAB84252.1
CCDSiCCDS10843.1 [Q9NPB6-1]
CCDS45514.1 [Q9NPB6-2]
RefSeqiNP_001032358.1, NM_001037281.1 [Q9NPB6-2]
NP_058644.1, NM_016948.2 [Q9NPB6-1]
UniGeneiHs.112933

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMHX-ray1.50B14-95[»]
ProteinModelPortaliQ9NPB6
SMRiQ9NPB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119157, 56 interactors
CORUMiQ9NPB6
DIPiDIP-31312N
IntActiQ9NPB6, 48 interactors
MINTiQ9NPB6
STRINGi9606.ENSP00000219255

PTM databases

iPTMnetiQ9NPB6
PhosphoSitePlusiQ9NPB6

Polymorphism and mutation databases

BioMutaiPARD6A
DMDMi30913215

Proteomic databases

EPDiQ9NPB6
MaxQBiQ9NPB6
PaxDbiQ9NPB6
PeptideAtlasiQ9NPB6
PRIDEiQ9NPB6
ProteomicsDBi81959
81960 [Q9NPB6-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
50855
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219255; ENSP00000219255; ENSG00000102981 [Q9NPB6-1]
ENST00000458121; ENSP00000392388; ENSG00000102981 [Q9NPB6-2]
GeneIDi50855
KEGGihsa:50855
UCSCiuc002ets.3 human [Q9NPB6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
50855
DisGeNETi50855
EuPathDBiHostDB:ENSG00000102981.9

GeneCards: human genes, protein and diseases

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GeneCardsi
PARD6A
HGNCiHGNC:15943 PARD6A
HPAiCAB009733
HPA041551
MIMi607484 gene
neXtProtiNX_Q9NPB6
OpenTargetsiENSG00000102981
PharmGKBiPA32937

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3606 Eukaryota
ENOG410XRJ3 LUCA
GeneTreeiENSGT00940000156264
HOGENOMiHOG000231716
HOVERGENiHBG053509
InParanoidiQ9NPB6
KOiK06093
OMAiENRQPPC
OrthoDBiEOG091G0FFH
PhylomeDBiQ9NPB6
TreeFamiTF312899

Enzyme and pathway databases

ReactomeiR-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions
R-HSA-4608870 Asymmetric localization of PCP proteins
SignaLinkiQ9NPB6
SIGNORiQ9NPB6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PARD6A human
EvolutionaryTraceiQ9NPB6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PARD6A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
50855

Protein Ontology

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PROi
PR:Q9NPB6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000102981 Expressed in 186 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_PARD6A
ExpressionAtlasiQ9NPB6 baseline and differential
GenevisibleiQ9NPB6 HS

Family and domain databases

CDDicd06403 PB1_Par6, 1 hit
InterProiView protein in InterPro
IPR034872 PAR-6_a
IPR000270 PB1_dom
IPR034868 PB1_Par6
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR14102:SF9 PTHR14102:SF9, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAR6A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPB6
Secondary accession number(s): O14911, Q9NPJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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