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Protein

Partitioning defective 6 homolog alpha

Gene

PARD6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).2 Publications

GO - Molecular functioni

  • GTP-dependent protein binding Source: UniProtKB
  • Rho GTPase binding Source: UniProtKB
  • transcription factor binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions
R-HSA-4608870 Asymmetric localization of PCP proteins
SignaLinkiQ9NPB6
SIGNORiQ9NPB6

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 6 homolog alpha
Short name:
PAR-6
Short name:
PAR-6 alpha
Short name:
PAR-6A
Alternative name(s):
PAR6C
Tax interaction protein 40
Short name:
TIP-40
Gene namesi
Name:PARD6A
Synonyms:PAR6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102981.9
HGNCiHGNC:15943 PARD6A
MIMi607484 gene
neXtProtiNX_Q9NPB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19K → A: Loss of interaction with ECT2 and PRKCI. 2 Publications1
Mutagenesisi28R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-89. 1 Publication1
Mutagenesisi89R → A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-28. 1 Publication1

Organism-specific databases

DisGeNETi50855
OpenTargetsiENSG00000102981
PharmGKBiPA32937

Polymorphism and mutation databases

BioMutaiPARD6A
DMDMi30913215

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125131 – 346Partitioning defective 6 homolog alphaAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by the TGF-beta receptor.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NPB6
MaxQBiQ9NPB6
PaxDbiQ9NPB6
PeptideAtlasiQ9NPB6
PRIDEiQ9NPB6
ProteomicsDBi81959
81960 [Q9NPB6-2]

PTM databases

iPTMnetiQ9NPB6
PhosphoSitePlusiQ9NPB6

Expressioni

Tissue specificityi

Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

Gene expression databases

BgeeiENSG00000102981 Expressed in 186 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_PARD6A
ExpressionAtlasiQ9NPB6 baseline and differential
GenevisibleiQ9NPB6 HS

Organism-specific databases

HPAiCAB009733
HPA041551

Interactioni

Subunit structurei

Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI. Interacts with DCTN1 and PCM1 (PubMed:20719959).By similarity13 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119157, 56 interactors
CORUMiQ9NPB6
DIPiDIP-31312N
IntActiQ9NPB6, 48 interactors
MINTiQ9NPB6
STRINGi9606.ENSP00000219255

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NPB6
SMRiQ9NPB6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPB6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 95PB1PROSITE-ProRule annotationAdd BLAST81
Domaini133 – 150Pseudo-CRIBAdd BLAST18
Domaini157 – 250PDZPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 116Interaction with PRKCI and PRKCZAdd BLAST116
Regioni126 – 253Interaction with PARD3 and CDC42By similarityAdd BLAST128

Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity
The PB1 domain mediates interactions with MAP2K5.By similarity
The PDZ domain mediates the interaction with CRB3.1 Publication

Sequence similaritiesi

Belongs to the PAR6 family.Curated

Phylogenomic databases

eggNOGiKOG3606 Eukaryota
ENOG410XRJ3 LUCA
GeneTreeiENSGT00390000005255
HOGENOMiHOG000231716
HOVERGENiHBG053509
InParanoidiQ9NPB6
KOiK06093
OMAiEQASSGW
OrthoDBiEOG091G0FFH
PhylomeDBiQ9NPB6
TreeFamiTF312899

Family and domain databases

CDDicd06403 PB1_Par6, 1 hit
InterProiView protein in InterPro
IPR034872 PAR-6_a
IPR000270 PB1_dom
IPR034868 PB1_Par6
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR14102:SF9 PTHR14102:SF9, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50106 PDZ, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH
60 70 80 90 100
QIPGLDVLLG YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEADS
110 120 130 140 150
SGLAFASNSL QRRKKGLLLR PVAPLRTRPP LLISLPQDFR QVSSVIDVDL
160 170 180 190 200
LPETHRRVRL HKHGSDRPLG FYIRDGMSVR VAPQGLERVP GIFISRLVRG
210 220 230 240 250
GLAESTGLLA VSDEILEVNG IEVAGKTLDQ VTDMMVANSH NLIVTVKPAN
260 270 280 290 300
QRNNVVRGAS GRLTGPPSAG PGPAEPDSDD DSSDLVIENR QPPSSNGLSQ
310 320 330 340
GPPCWDLHPG CRHPGTRSSL PSLDDQEQAS SGWGSRIRGD GSGFSL
Length:346
Mass (Da):37,388
Last modified:October 1, 2000 - v1
Checksum:i9241E0EDC3694AD4
GO
Isoform 2 (identifier: Q9NPB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-96: Missing.

Show »
Length:345
Mass (Da):37,317
Checksum:i035F9FA6BB62F085
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMM2R4GMM2_HUMAN
Partitioning defective 6 homolog al...
PARD6A
316Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050454286V → I. Corresponds to variant dbSNP:rs35356834Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00745996Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277095 mRNA Translation: CAB85490.1
AF265565 mRNA Translation: AAF75548.1
AF252292 mRNA Translation: AAF71529.1
AB043634 mRNA Translation: BAA96235.1
AB041642 mRNA Translation: BAB16105.1
BC015626 mRNA Translation: AAH15626.1
AF028827 mRNA Translation: AAB84252.1
CCDSiCCDS10843.1 [Q9NPB6-1]
CCDS45514.1 [Q9NPB6-2]
RefSeqiNP_001032358.1, NM_001037281.1 [Q9NPB6-2]
NP_058644.1, NM_016948.2 [Q9NPB6-1]
UniGeneiHs.112933

Genome annotation databases

EnsembliENST00000219255; ENSP00000219255; ENSG00000102981 [Q9NPB6-1]
ENST00000458121; ENSP00000392388; ENSG00000102981 [Q9NPB6-2]
GeneIDi50855
KEGGihsa:50855
UCSCiuc002ets.3 human [Q9NPB6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277095 mRNA Translation: CAB85490.1
AF265565 mRNA Translation: AAF75548.1
AF252292 mRNA Translation: AAF71529.1
AB043634 mRNA Translation: BAA96235.1
AB041642 mRNA Translation: BAB16105.1
BC015626 mRNA Translation: AAH15626.1
AF028827 mRNA Translation: AAB84252.1
CCDSiCCDS10843.1 [Q9NPB6-1]
CCDS45514.1 [Q9NPB6-2]
RefSeqiNP_001032358.1, NM_001037281.1 [Q9NPB6-2]
NP_058644.1, NM_016948.2 [Q9NPB6-1]
UniGeneiHs.112933

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMHX-ray1.50B14-95[»]
ProteinModelPortaliQ9NPB6
SMRiQ9NPB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119157, 56 interactors
CORUMiQ9NPB6
DIPiDIP-31312N
IntActiQ9NPB6, 48 interactors
MINTiQ9NPB6
STRINGi9606.ENSP00000219255

PTM databases

iPTMnetiQ9NPB6
PhosphoSitePlusiQ9NPB6

Polymorphism and mutation databases

BioMutaiPARD6A
DMDMi30913215

Proteomic databases

EPDiQ9NPB6
MaxQBiQ9NPB6
PaxDbiQ9NPB6
PeptideAtlasiQ9NPB6
PRIDEiQ9NPB6
ProteomicsDBi81959
81960 [Q9NPB6-2]

Protocols and materials databases

DNASUi50855
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219255; ENSP00000219255; ENSG00000102981 [Q9NPB6-1]
ENST00000458121; ENSP00000392388; ENSG00000102981 [Q9NPB6-2]
GeneIDi50855
KEGGihsa:50855
UCSCiuc002ets.3 human [Q9NPB6-1]

Organism-specific databases

CTDi50855
DisGeNETi50855
EuPathDBiHostDB:ENSG00000102981.9
GeneCardsiPARD6A
HGNCiHGNC:15943 PARD6A
HPAiCAB009733
HPA041551
MIMi607484 gene
neXtProtiNX_Q9NPB6
OpenTargetsiENSG00000102981
PharmGKBiPA32937
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3606 Eukaryota
ENOG410XRJ3 LUCA
GeneTreeiENSGT00390000005255
HOGENOMiHOG000231716
HOVERGENiHBG053509
InParanoidiQ9NPB6
KOiK06093
OMAiEQASSGW
OrthoDBiEOG091G0FFH
PhylomeDBiQ9NPB6
TreeFamiTF312899

Enzyme and pathway databases

ReactomeiR-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions
R-HSA-4608870 Asymmetric localization of PCP proteins
SignaLinkiQ9NPB6
SIGNORiQ9NPB6

Miscellaneous databases

ChiTaRSiPARD6A human
EvolutionaryTraceiQ9NPB6
GeneWikiiPARD6A
GenomeRNAii50855
PROiPR:Q9NPB6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102981 Expressed in 186 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_PARD6A
ExpressionAtlasiQ9NPB6 baseline and differential
GenevisibleiQ9NPB6 HS

Family and domain databases

CDDicd06403 PB1_Par6, 1 hit
InterProiView protein in InterPro
IPR034872 PAR-6_a
IPR000270 PB1_dom
IPR034868 PB1_Par6
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR14102:SF9 PTHR14102:SF9, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAR6A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPB6
Secondary accession number(s): O14911, Q9NPJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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