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Protein

Zinc finger protein 64 homolog, isoforms 1 and 2

Gene

ZFP64

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi345Zinc 11
Metal bindingi348Zinc 11
Metal bindingi361Zinc 11
Metal bindingi365Zinc 11
Metal bindingi373Zinc 21
Metal bindingi376Zinc 21
Metal bindingi389Zinc 21
Metal bindingi394Zinc 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri315 – 337C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri425 – 447C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • regulation of gene expression Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 64 homolog, isoforms 1 and 2
Short name:
Zfp-64
Alternative name(s):
Zinc finger protein 338
Gene namesi
Name:ZFP64
Synonyms:ZNF338
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000020256.19
HGNCiHGNC:15940 ZFP64
neXtProtiNX_Q9NPA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55734
OpenTargetsiENSG00000020256
PharmGKBiPA38060

Polymorphism and mutation databases

BioMutaiSALL4
DMDMi116242854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473071 – 681Zinc finger protein 64 homolog, isoforms 1 and 2Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei547PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NPA5
PaxDbiQ9NPA5
PeptideAtlasiQ9NPA5
PRIDEiQ9NPA5
ProteomicsDBi81951
81952 [Q9NPA5-2]

PTM databases

iPTMnetiQ9NPA5
PhosphoSitePlusiQ9NPA5

Expressioni

Gene expression databases

BgeeiENSG00000020256 Expressed in 231 organ(s), highest expression level in vagina
CleanExiHS_ZFP64
ExpressionAtlasiQ9NPA5 baseline and differential
GenevisibleiQ9NPA5 HS

Organism-specific databases

HPAiHPA035112
HPA058387

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120853, 29 interactors
IntActiQ9NPA5, 13 interactors
STRINGi9606.ENSP00000216923

Structurei

Secondary structure

1681
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NPA5
SMRiQ9NPA5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPA5

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri315 – 337C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri425 – 447C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139371
HOGENOMiHOG000230887
HOVERGENiHBG056373
InParanoidiQ9NPA5
OrthoDBiEOG091G0SH1
PhylomeDBiQ9NPA5
TreeFamiTF333046

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK
60 70 80 90 100
QSGCQLTGTS AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE
110 120 130 140 150
FVFEHGYQTY LPTESNENQT ATVISLPAKS RTKKPTTPPA QKRLNCCYPG
160 170 180 190 200
CQFKTAYGMK DMERHLKIHT GDKPHKCEVC GKCFSRKDKL KTHMRCHTGV
210 220 230 240 250
KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS RNSSQLTVHL
260 270 280 290 300
RSHTGDAPFQ CWLCSAKFKI SSDLKRHMRV HSGEKPFKCE FCNVRCTMKG
310 320 330 340 350
NLKSHIRIKH SGNNFKCPHC DFLGDSKATL RKHSRVHQSE HPEKCSECSY
360 370 380 390 400
SCSSKAALRI HERIHCTDRP FKCNYCSFDT KQPSNLSKHM KKFHGDMVKT
410 420 430 440 450
EALERKDTGR QSSRQVAKLD AKKSFHCDIC DASFMREDSL RSHKRQHSEY
460 470 480 490 500
SESKNSDVTV LQFQIDPSKQ PATPLTVGHL QVPLQPSQVP QFSEGRVKII
510 520 530 540 550
VGHQVPQANT IVQAAAAAVN IVPPALVAQN PEELPGNSRL QILRQVSLIA
560 570 580 590 600
PPQSSRCPSE AGAMTQPAVL LTTHEQTDGA TLHQTLIPTA SGGPQEGSGN
610 620 630 640 650
QTFITSSGIT CTDFEGLNAL IQEGTAEVTV VSDGGQNIAV ATTAPPVFSS
660 670 680
SSQQELPKQT YSIIQGAAHP ALLCPADSIP D
Length:681
Mass (Da):74,644
Last modified:October 17, 2006 - v3
Checksum:i949C2DB54BB97E2E
GO
Isoform 2 (identifier: Q9NPA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-149: Missing.

Show »
Length:627
Mass (Da):68,621
Checksum:iA4EE9B17845C00EF
GO
Isoform 3 (identifier: Q9NTW7-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:645
Mass (Da):72,217
GO
Isoform 4 (identifier: Q9NTW7-2) [UniParc]FASTAAdd to basket
Also known as: ZNF338
The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:426
Mass (Da):48,165
GO
Isoform 5 (identifier: Q9NTW7-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:415
Mass (Da):46,253
GO
Isoform 6 (identifier: Q9NTW7-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9NTW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Gene prediction based on EST data.
Length:679
Mass (Da):74,463
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2N5A2A2N5_HUMAN
Zinc finger protein 64 homolog, iso...
ZFP64
221Annotation score:
H0Y669H0Y669_HUMAN
Zinc finger protein 64 homolog, iso...
ZFP64
120Annotation score:
A2A2N6A2A2N6_HUMAN
Zinc finger protein 64 homolog, iso...
ZFP64
131Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02801968Q → P. Corresponds to variant dbSNP:rs7353222Ensembl.1
Natural variantiVAR_028020139P → L. Corresponds to variant dbSNP:rs6021773Ensembl.1
Natural variantiVAR_028021425F → Y. Corresponds to variant dbSNP:rs16996517Ensembl.1
Natural variantiVAR_028022451S → N2 PublicationsCorresponds to variant dbSNP:rs3746414Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00728496 – 149Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001596 mRNA Translation: BAA91777.1
AK001744 mRNA Translation: BAA91876.1
AL121771 Genomic DNA No translation available.
BC012759 mRNA Translation: AAH12759.1
BC041622 mRNA Translation: AAH41622.1
CCDSiCCDS13440.1 [Q9NPA5-1]
CCDS13441.1 [Q9NPA5-2]
RefSeqiNP_060667.2, NM_018197.2 [Q9NPA5-1]
NP_071371.3, NM_022088.4 [Q9NPA5-2]
NP_955458.1, NM_199426.1
NP_955459.2, NM_199427.2
UniGeneiHs.473082

Genome annotation databases

EnsembliENST00000216923; ENSP00000216923; ENSG00000020256 [Q9NPA5-1]
ENST00000346617; ENSP00000344615; ENSG00000020256 [Q9NPA5-2]
GeneIDi55734
KEGGihsa:55734
UCSCiuc002xwl.4 human [Q9NPA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001596 mRNA Translation: BAA91777.1
AK001744 mRNA Translation: BAA91876.1
AL121771 Genomic DNA No translation available.
BC012759 mRNA Translation: AAH12759.1
BC041622 mRNA Translation: AAH41622.1
CCDSiCCDS13440.1 [Q9NPA5-1]
CCDS13441.1 [Q9NPA5-2]
RefSeqiNP_060667.2, NM_018197.2 [Q9NPA5-1]
NP_071371.3, NM_022088.4 [Q9NPA5-2]
NP_955458.1, NM_199426.1
NP_955459.2, NM_199427.2
UniGeneiHs.473082

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5WNMR-A341-397[»]
2DMDNMR-A174-256[»]
ProteinModelPortaliQ9NPA5
SMRiQ9NPA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120853, 29 interactors
IntActiQ9NPA5, 13 interactors
STRINGi9606.ENSP00000216923

PTM databases

iPTMnetiQ9NPA5
PhosphoSitePlusiQ9NPA5

Polymorphism and mutation databases

BioMutaiSALL4
DMDMi116242854

Proteomic databases

EPDiQ9NPA5
PaxDbiQ9NPA5
PeptideAtlasiQ9NPA5
PRIDEiQ9NPA5
ProteomicsDBi81951
81952 [Q9NPA5-2]

Protocols and materials databases

DNASUi55734
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216923; ENSP00000216923; ENSG00000020256 [Q9NPA5-1]
ENST00000346617; ENSP00000344615; ENSG00000020256 [Q9NPA5-2]
GeneIDi55734
KEGGihsa:55734
UCSCiuc002xwl.4 human [Q9NPA5-1]

Organism-specific databases

CTDi55734
DisGeNETi55734
EuPathDBiHostDB:ENSG00000020256.19
GeneCardsiZFP64
HGNCiHGNC:15940 ZFP64
HPAiHPA035112
HPA058387
neXtProtiNX_Q9NPA5
OpenTargetsiENSG00000020256
PharmGKBiPA38060
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139371
HOGENOMiHOG000230887
HOVERGENiHBG056373
InParanoidiQ9NPA5
OrthoDBiEOG091G0SH1
PhylomeDBiQ9NPA5
TreeFamiTF333046

Miscellaneous databases

ChiTaRSiZFP64 human
EvolutionaryTraceiQ9NPA5
GeneWikiiZFP64
GenomeRNAii55734

Gene expression databases

BgeeiENSG00000020256 Expressed in 231 organ(s), highest expression level in vagina
CleanExiHS_ZFP64
ExpressionAtlasiQ9NPA5 baseline and differential
GenevisibleiQ9NPA5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZF64A_HUMAN
AccessioniPrimary (citable) accession number: Q9NPA5
Secondary accession number(s): Q9NTS7, Q9NVH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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