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Entry version 143 (13 Feb 2019)
Sequence version 2 (07 Mar 2006)
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Protein

Calcium-activated potassium channel subunit beta-3

Gene

KCNMB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-activated potassium channel activity Source: UniProtKB
  • potassium channel regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.14.1.4 the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-3
Alternative name(s):
BK channel subunit beta-3
Short name:
BKbeta3
Short name:
Hbeta3
Calcium-activated potassium channel, subfamily M subunit beta-3
Charybdotoxin receptor subunit beta-3
K(VCA)beta-3
Maxi K channel subunit beta-3
Slo-beta-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNMB3
Synonyms:KCNMB2, KCNMBL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000171121.16

Human Gene Nomenclature Database

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HGNCi
HGNC:6287 KCNMB3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605222 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 60CytoplasmicSequence analysisAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei61 – 81Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini82 – 207ExtracellularSequence analysisAdd BLAST126
Transmembranei208 – 228Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini229 – 279CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27094

Open Targets

More...
OpenTargetsi
ENSG00000171121

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30067

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01110 Miconazole
DB00721 Procaine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNMB3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90111824

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870541 – 279Calcium-activated potassium channel subunit beta-3Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
The extracellular domain contains disulfide bond essential for the gating mechanism.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NPA1

PRoteomics IDEntifications database

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PRIDEi
Q9NPA1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81945
81946 [Q9NPA1-2]
81947 [Q9NPA1-3]
81948 [Q9NPA1-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171121 Expressed in 87 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NPA1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NPA1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015665
HPA019185

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9NPA1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319370

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NPA1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NPA1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site.
The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF7H Eukaryota
ENOG410YQCT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290180

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108059

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NPA1

KEGG Orthology (KO)

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KOi
K04939

Identification of Orthologs from Complete Genome Data

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OMAi
ESNCTTI

Database of Orthologous Groups

More...
OrthoDBi
1178937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NPA1

TreeFam database of animal gene trees

More...
TreeFami
TF328589

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu

The PANTHER Classification System

More...
PANTHERi
PTHR10258 PTHR10258, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03185 CaKB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPA1-1) [UniParc]FASTAAdd to basket
Also known as: 3d

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFSPSSELG FHFVAFILLT RHRTAFPASG KKRETDYSDG DPLDVHKRLP
60 70 80 90 100
SSAGEDRAVM LGFAMMGFSV LMFFLLGTTI LKPFMLSIQR EESTCTAIHT
110 120 130 140 150
DIMDDWLDCA FTCGVHCHGQ GKYPCLQVFV NLSHPGQKAL LHYNEEAVQI
160 170 180 190 200
NPKCFYTPKC HQDRNDLLNS ALDIKEFFDH KNGTPFSCFY SPASQSEDVI
210 220 230 240 250
LIKKYDQMAI FHCLFWPSLT LLGGALIVGM VRLTQHLSLL CEKYSTVVRD
260 270
EVGGKVPYIE QHQFKLCIMR RSKGRAEKS
Length:279
Mass (Da):31,604
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC5F0D5D3E040C4C
GO
Isoform 2 (identifier: Q9NPA1-2) [UniParc]FASTAAdd to basket
Also known as: 3a

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG

Show »
Length:277
Mass (Da):31,351
Checksum:iEBF06FF8686F0655
GO
Isoform 3 (identifier: Q9NPA1-3) [UniParc]FASTAAdd to basket
Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MFPLLYELTAVSPSPFPQ

Show »
Length:275
Mass (Da):31,089
Checksum:i9C7C5A523D37D5C2
GO
Isoform 4 (identifier: Q9NPA1-4) [UniParc]FASTAAdd to basket
Also known as: 3b

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     23-23: R → M

Show »
Length:257
Mass (Da):29,045
Checksum:i0B5D59CB0551295D
GO
Isoform 5 (identifier: Q9NPA1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDFSPSSELGFHFVAFILLTRH → MQPFSIPVQITLQGSRRRQG
     154-175: CFYTPKCHQDRNDLLNSALDIK → RDVTDCRVKEKQTLTVSDEHKQ
     176-279: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):19,474
Checksum:i7EACEF7D7202F1B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV41A0A087WV41_HUMAN
Calcium-activated potassium channel...
KCNMB3
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24T → P in BAH14265 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01817344D → G. Corresponds to variant dbSNP:rs1170672Ensembl.1
Natural variantiVAR_01817453A → T5 PublicationsCorresponds to variant dbSNP:rs7645550Ensembl.1
Natural variantiVAR_01817575L → V1 PublicationCorresponds to variant dbSNP:rs2276802Ensembl.1
Natural variantiVAR_018176165N → S2 PublicationsCorresponds to variant dbSNP:rs55710741Ensembl.1
Natural variantiVAR_018177230M → T1 PublicationCorresponds to variant dbSNP:rs145985409Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0098271 – 22MDFSP…LLTRH → MQPFSIPVQITLQGSRRRQG in isoform 2 and isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0098281 – 22MDFSP…LLTRH → MFPLLYELTAVSPSPFPQ in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0098291 – 22Missing in isoform 4. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_00983023R → M in isoform 4. 2 Publications1
Alternative sequenceiVSP_046090154 – 175CFYTP…ALDIK → RDVTDCRVKEKQTLTVSDEH KQ in isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_046091176 – 279Missing in isoform 5. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF139471 mRNA Translation: AAD54771.1
AF214561 mRNA Translation: AAF36598.1
AF204159 Genomic DNA Translation: AAF97031.1
AF204160 Genomic DNA Translation: AAF97032.1
AF204161 Genomic DNA Translation: AAF97033.1
AF204162 Genomic DNA Translation: AAF97034.1
AF160968 mRNA Translation: AAF67811.1
AF170916 mRNA Translation: AAF89698.1
AK304837 mRNA Translation: BAH14265.1
AC007823 Genomic DNA No translation available.
AC076966 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78418.1
CH471052 Genomic DNA Translation: EAW78421.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3225.1 [Q9NPA1-2]
CCDS3226.1 [Q9NPA1-1]
CCDS43172.1 [Q9NPA1-4]
CCDS43173.1 [Q9NPA1-3]
CCDS54683.1 [Q9NPA1-5]

NCBI Reference Sequences

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RefSeqi
NP_001157149.1, NM_001163677.1 [Q9NPA1-5]
NP_055222.3, NM_014407.3 [Q9NPA1-1]
NP_741979.1, NM_171828.2 [Q9NPA1-2]
NP_741980.1, NM_171829.2 [Q9NPA1-4]
NP_741981.1, NM_171830.1 [Q9NPA1-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591285

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314235; ENSP00000319370; ENSG00000171121 [Q9NPA1-1]
ENST00000349697; ENSP00000327866; ENSG00000171121 [Q9NPA1-2]
ENST00000392685; ENSP00000376451; ENSG00000171121 [Q9NPA1-3]
ENST00000392686; ENSP00000376452; ENSG00000171121 [Q9NPA1-4]
ENST00000485523; ENSP00000418536; ENSG00000171121 [Q9NPA1-4]
ENST00000497599; ENSP00000417091; ENSG00000171121 [Q9NPA1-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27094

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27094

UCSC genome browser

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UCSCi
uc003fjm.4 human [Q9NPA1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139471 mRNA Translation: AAD54771.1
AF214561 mRNA Translation: AAF36598.1
AF204159 Genomic DNA Translation: AAF97031.1
AF204160 Genomic DNA Translation: AAF97032.1
AF204161 Genomic DNA Translation: AAF97033.1
AF204162 Genomic DNA Translation: AAF97034.1
AF160968 mRNA Translation: AAF67811.1
AF170916 mRNA Translation: AAF89698.1
AK304837 mRNA Translation: BAH14265.1
AC007823 Genomic DNA No translation available.
AC076966 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78418.1
CH471052 Genomic DNA Translation: EAW78421.1
CCDSiCCDS3225.1 [Q9NPA1-2]
CCDS3226.1 [Q9NPA1-1]
CCDS43172.1 [Q9NPA1-4]
CCDS43173.1 [Q9NPA1-3]
CCDS54683.1 [Q9NPA1-5]
RefSeqiNP_001157149.1, NM_001163677.1 [Q9NPA1-5]
NP_055222.3, NM_014407.3 [Q9NPA1-1]
NP_741979.1, NM_171828.2 [Q9NPA1-2]
NP_741980.1, NM_171829.2 [Q9NPA1-4]
NP_741981.1, NM_171830.1 [Q9NPA1-3]
UniGeneiHs.591285

3D structure databases

ProteinModelPortaliQ9NPA1
SMRiQ9NPA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NPA1, 1 interactor
STRINGi9606.ENSP00000319370

Chemistry databases

DrugBankiDB01110 Miconazole
DB00721 Procaine

Protein family/group databases

TCDBi8.A.14.1.4 the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family

Polymorphism and mutation databases

BioMutaiKCNMB3
DMDMi90111824

Proteomic databases

PaxDbiQ9NPA1
PRIDEiQ9NPA1
ProteomicsDBi81945
81946 [Q9NPA1-2]
81947 [Q9NPA1-3]
81948 [Q9NPA1-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27094
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314235; ENSP00000319370; ENSG00000171121 [Q9NPA1-1]
ENST00000349697; ENSP00000327866; ENSG00000171121 [Q9NPA1-2]
ENST00000392685; ENSP00000376451; ENSG00000171121 [Q9NPA1-3]
ENST00000392686; ENSP00000376452; ENSG00000171121 [Q9NPA1-4]
ENST00000485523; ENSP00000418536; ENSG00000171121 [Q9NPA1-4]
ENST00000497599; ENSP00000417091; ENSG00000171121 [Q9NPA1-5]
GeneIDi27094
KEGGihsa:27094
UCSCiuc003fjm.4 human [Q9NPA1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27094
DisGeNETi27094
EuPathDBiHostDB:ENSG00000171121.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNMB3
HGNCiHGNC:6287 KCNMB3
HPAiHPA015665
HPA019185
MIMi605222 gene
neXtProtiNX_Q9NPA1
OpenTargetsiENSG00000171121
PharmGKBiPA30067

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF7H Eukaryota
ENOG410YQCT LUCA
GeneTreeiENSGT00940000154220
HOGENOMiHOG000290180
HOVERGENiHBG108059
InParanoidiQ9NPA1
KOiK04939
OMAiESNCTTI
OrthoDBi1178937at2759
PhylomeDBiQ9NPA1
TreeFamiTF328589

Enzyme and pathway databases

ReactomeiR-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KCNMB3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNMB3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27094

Protein Ontology

More...
PROi
PR:Q9NPA1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171121 Expressed in 87 organ(s), highest expression level in spleen
ExpressionAtlasiQ9NPA1 baseline and differential
GenevisibleiQ9NPA1 HS

Family and domain databases

InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCMB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPA1
Secondary accession number(s): B7Z9C9
, D3DNR2, E9PER5, Q9NPG7, Q9NRM9, Q9UHN3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 7, 2006
Last modified: February 13, 2019
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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