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Protein

ER membrane protein complex subunit 7

Gene

EMC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Has been termed C11orf3, but is not the official C11orf3 as defined by HGNC and furthermore maps to chromosome 15.1 Publication

GO - Molecular functioni

Protein family/group databases

TCDBi3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 7
Gene namesi
Name:EMC7
Synonyms:C11orf3, C15orf24
ORF Names:HT022, UNQ905/PRO1926
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000134153.9
HGNCiHGNC:24301 EMC7
neXtProtiNX_Q9NPA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 159ExtracellularSequence analysisAdd BLAST136
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 242CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56851
OpenTargetsiENSG00000134153
PharmGKBiPA134900493

Polymorphism and mutation databases

BioMutaiEMC7
DMDMi74752878

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisCombined sourcesAdd BLAST23
ChainiPRO_000024086024 – 242ER membrane protein complex subunit 7Add BLAST219

Proteomic databases

EPDiQ9NPA0
MaxQBiQ9NPA0
PaxDbiQ9NPA0
PeptideAtlasiQ9NPA0
PRIDEiQ9NPA0
ProteomicsDBi81944

PTM databases

iPTMnetiQ9NPA0
PhosphoSitePlusiQ9NPA0

Expressioni

Gene expression databases

BgeeiENSG00000134153 Expressed in 225 organ(s), highest expression level in substantia nigra
CleanExiHS_C15orf24
ExpressionAtlasiQ9NPA0 baseline and differential
GenevisibleiQ9NPA0 HS

Organism-specific databases

HPAiHPA010029
HPA047572

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

BioGridi121211, 41 interactors
IntActiQ9NPA0, 21 interactors
STRINGi9606.ENSP00000256545

Structurei

3D structure databases

ProteinModelPortaliQ9NPA0
SMRiQ9NPA0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NPA0

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC7 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3306 Eukaryota
ENOG4111IA7 LUCA
GeneTreeiENSGT00390000017490
HOGENOMiHOG000230739
HOVERGENiHBG058796
InParanoidiQ9NPA0
OMAiMPEMSEV
OrthoDBiEOG091G0MDG
PhylomeDBiQ9NPA0
TreeFamiTF106158

Family and domain databases

InterProiView protein in InterPro
IPR013784 Carb-bd-like_fold
IPR019008 DUF2012
IPR039163 EMC7
PANTHERiPTHR13605 PTHR13605, 1 hit
PfamiView protein in Pfam
PF09430 DUF2012, 1 hit
SUPFAMiSSF49452 SSF49452, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NPA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR
60 70 80 90 100
AVVPGVKPQD WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS
110 120 130 140 150
PAYRFDPVRV DITSKGKMRA RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI
160 170 180 190 200
KRESWGWTDF LMNPMVMMMV LPLLIFVLLP KVVNTSDPDM RREMEQSMNM
210 220 230 240
LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK RR
Length:242
Mass (Da):26,471
Last modified:October 1, 2000 - v1
Checksum:iA71930B89A4C2458
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDX2H0YDX2_HUMAN
ER membrane protein complex subunit...
EMC7
160Annotation score:
H0YDT8H0YDT8_HUMAN
ER membrane protein complex subunit...
EMC7
192Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250344 mRNA Translation: CAB96539.1
AJ245874 mRNA Translation: CAC01611.1
AF242729 mRNA Translation: AAG44477.1
AY358445 mRNA Translation: AAQ88810.1
AK314883 mRNA Translation: BAG37397.1
BC012456 mRNA Translation: AAH12456.1
BC104934 mRNA Translation: AAI04935.1
BC104936 mRNA Translation: AAI04937.1
CCDSiCCDS10032.1
RefSeqiNP_064539.1, NM_020154.2
UniGeneiHs.160565

Genome annotation databases

EnsembliENST00000256545; ENSP00000256545; ENSG00000134153
GeneIDi56851
KEGGihsa:56851
UCSCiuc001zhm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250344 mRNA Translation: CAB96539.1
AJ245874 mRNA Translation: CAC01611.1
AF242729 mRNA Translation: AAG44477.1
AY358445 mRNA Translation: AAQ88810.1
AK314883 mRNA Translation: BAG37397.1
BC012456 mRNA Translation: AAH12456.1
BC104934 mRNA Translation: AAI04935.1
BC104936 mRNA Translation: AAI04937.1
CCDSiCCDS10032.1
RefSeqiNP_064539.1, NM_020154.2
UniGeneiHs.160565

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B0GX-ray2.50C/F4-12[»]
1LP9X-ray2.00C/J4-12[»]
2J8UX-ray2.88C/J4-12[»]
2JCCX-ray2.50C/J4-12[»]
2UWEX-ray2.40C/J4-12[»]
ProteinModelPortaliQ9NPA0
SMRiQ9NPA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121211, 41 interactors
IntActiQ9NPA0, 21 interactors
STRINGi9606.ENSP00000256545

Protein family/group databases

TCDBi3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

PTM databases

iPTMnetiQ9NPA0
PhosphoSitePlusiQ9NPA0

Polymorphism and mutation databases

BioMutaiEMC7
DMDMi74752878

Proteomic databases

EPDiQ9NPA0
MaxQBiQ9NPA0
PaxDbiQ9NPA0
PeptideAtlasiQ9NPA0
PRIDEiQ9NPA0
ProteomicsDBi81944

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256545; ENSP00000256545; ENSG00000134153
GeneIDi56851
KEGGihsa:56851
UCSCiuc001zhm.4 human

Organism-specific databases

CTDi56851
DisGeNETi56851
EuPathDBiHostDB:ENSG00000134153.9
GeneCardsiEMC7
H-InvDBiHIX0012085
HGNCiHGNC:24301 EMC7
HPAiHPA010029
HPA047572
neXtProtiNX_Q9NPA0
OpenTargetsiENSG00000134153
PharmGKBiPA134900493
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3306 Eukaryota
ENOG4111IA7 LUCA
GeneTreeiENSGT00390000017490
HOGENOMiHOG000230739
HOVERGENiHBG058796
InParanoidiQ9NPA0
OMAiMPEMSEV
OrthoDBiEOG091G0MDG
PhylomeDBiQ9NPA0
TreeFamiTF106158

Miscellaneous databases

ChiTaRSiEMC7 human
EvolutionaryTraceiQ9NPA0
GenomeRNAii56851
PROiPR:Q9NPA0

Gene expression databases

BgeeiENSG00000134153 Expressed in 225 organ(s), highest expression level in substantia nigra
CleanExiHS_C15orf24
ExpressionAtlasiQ9NPA0 baseline and differential
GenevisibleiQ9NPA0 HS

Family and domain databases

InterProiView protein in InterPro
IPR013784 Carb-bd-like_fold
IPR019008 DUF2012
IPR039163 EMC7
PANTHERiPTHR13605 PTHR13605, 1 hit
PfamiView protein in Pfam
PF09430 DUF2012, 1 hit
SUPFAMiSSF49452 SSF49452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMC7_HUMAN
AccessioniPrimary (citable) accession number: Q9NPA0
Secondary accession number(s): B2RC00, Q96ED5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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