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Protein

Myozenin-1

Gene

MYOZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

GO - Molecular functioni

  • actin binding Source: GO_Central
  • FATZ binding Source: UniProtKB
  • telethonin binding Source: GO_Central

GO - Biological processi

  • myofibril assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-1
Alternative name(s):
Calsarcin-2
Filamin-, actinin- and telethonin-binding protein
Protein FATZ
Gene namesi
Name:MYOZ1Imported
Synonyms:MYOZImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000177791.11
HGNCiHGNC:13752 MYOZ1
MIMi605603 gene
neXtProtiNX_Q9NP98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58529
OpenTargetsiENSG00000177791
PharmGKBiPA31420

Polymorphism and mutation databases

BioMutaiMYOZ1
DMDMi74734300

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001110951 – 299Myozenin-1Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NP98
PeptideAtlasiQ9NP98
PRIDEiQ9NP98
ProteomicsDBi81941

PTM databases

iPTMnetiQ9NP98
PhosphoSitePlusiQ9NP98

Expressioni

Tissue specificityi

Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.3 Publications

Gene expression databases

BgeeiENSG00000177791 Expressed in 130 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MYOZ1
GenevisibleiQ9NP98 HS

Organism-specific databases

HPAiHPA037848
HPA038437

Interactioni

Subunit structurei

Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121849, 15 interactors
IntActiQ9NP98, 35 interactors
MINTiQ9NP98
STRINGi9606.ENSP00000352272

Structurei

3D structure databases

ProteinModelPortaliQ9NP98
SMRiQ9NP98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 175Gly-richSequence analysisAdd BLAST81

Sequence similaritiesi

Belongs to the myozenin family.Curated

Phylogenomic databases

eggNOGiENOG410IICS Eukaryota
ENOG4111KTQ LUCA
GeneTreeiENSGT00530000063184
HOGENOMiHOG000030910
HOVERGENiHBG071289
InParanoidiQ9NP98
OMAiMFKLRQL
OrthoDBiEOG091G0GA9
PhylomeDBiQ9NP98
TreeFamiTF331748

Family and domain databases

InterProiView protein in InterPro
IPR008438 MYOZ
PANTHERiPTHR15941 PTHR15941, 1 hit
PfamiView protein in Pfam
PF05556 Calsarcin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NP98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS
60 70 80 90 100
LLTNRGSKMF KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT
110 120 130 140 150
AGQGFSYSKS NGRGGSQAGG SGSAGQYGSD QQHHLGSGSG AGGTGGPAGQ
160 170 180 190 200
AGRGGAAGTA GVGETGSGDQ AGGEGKHITV FKTYISPWER AMGVDPQQKM
210 220 230 240 250
ELGIDLLAYG AKAELPKYKS FNRTAMPYGG YEKASKRMTF QMPKFDLGPL
260 270 280 290
LSEPLVLYNQ NLSNRPSFNR TPIPWLSSGE PVDYNVDIGI PLDGETEEL
Length:299
Mass (Da):31,745
Last modified:October 1, 2000 - v1
Checksum:iAADEB488C66B5E27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153R → K in AAG38940 (PubMed:11114196).Curated1
Sequence conflicti160A → T in AAG38940 (PubMed:11114196).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278124 mRNA Translation: CAB92967.1
AY013297 mRNA Translation: AAG38940.1
AF240633 mRNA Translation: AAG24509.1
AF243390
, AF243387, AF243388, AF243389 Genomic DNA Translation: AAG27296.1
AL359210 mRNA Translation: CAB94568.1
BC025753 mRNA Translation: AAH25753.1
CCDSiCCDS7330.1
RefSeqiNP_067068.1, NM_021245.3
UniGeneiHs.238756

Genome annotation databases

EnsembliENST00000359322; ENSP00000352272; ENSG00000177791
GeneIDi58529
KEGGihsa:58529
UCSCiuc001jur.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278124 mRNA Translation: CAB92967.1
AY013297 mRNA Translation: AAG38940.1
AF240633 mRNA Translation: AAG24509.1
AF243390
, AF243387, AF243388, AF243389 Genomic DNA Translation: AAG27296.1
AL359210 mRNA Translation: CAB94568.1
BC025753 mRNA Translation: AAH25753.1
CCDSiCCDS7330.1
RefSeqiNP_067068.1, NM_021245.3
UniGeneiHs.238756

3D structure databases

ProteinModelPortaliQ9NP98
SMRiQ9NP98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121849, 15 interactors
IntActiQ9NP98, 35 interactors
MINTiQ9NP98
STRINGi9606.ENSP00000352272

PTM databases

iPTMnetiQ9NP98
PhosphoSitePlusiQ9NP98

Polymorphism and mutation databases

BioMutaiMYOZ1
DMDMi74734300

Proteomic databases

PaxDbiQ9NP98
PeptideAtlasiQ9NP98
PRIDEiQ9NP98
ProteomicsDBi81941

Protocols and materials databases

DNASUi58529
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359322; ENSP00000352272; ENSG00000177791
GeneIDi58529
KEGGihsa:58529
UCSCiuc001jur.5 human

Organism-specific databases

CTDi58529
DisGeNETi58529
EuPathDBiHostDB:ENSG00000177791.11
GeneCardsiMYOZ1
HGNCiHGNC:13752 MYOZ1
HPAiHPA037848
HPA038437
MIMi605603 gene
neXtProtiNX_Q9NP98
OpenTargetsiENSG00000177791
PharmGKBiPA31420
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICS Eukaryota
ENOG4111KTQ LUCA
GeneTreeiENSGT00530000063184
HOGENOMiHOG000030910
HOVERGENiHBG071289
InParanoidiQ9NP98
OMAiMFKLRQL
OrthoDBiEOG091G0GA9
PhylomeDBiQ9NP98
TreeFamiTF331748

Miscellaneous databases

ChiTaRSiMYOZ1 human
GeneWikiiMYOZ1
GenomeRNAii58529
PROiPR:Q9NP98
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177791 Expressed in 130 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MYOZ1
GenevisibleiQ9NP98 HS

Family and domain databases

InterProiView protein in InterPro
IPR008438 MYOZ
PANTHERiPTHR15941 PTHR15941, 1 hit
PfamiView protein in Pfam
PF05556 Calsarcin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYOZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9NP98
Secondary accession number(s): Q9H1I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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