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Protein

Dynein light chain roadblock-type 1

Gene

DYNLRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

GO - Molecular functioni

  • dynein intermediate chain binding Source: GO_Central
  • microtubule motor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport
SIGNORiQ9NP97

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain roadblock-type 1
Alternative name(s):
Bithoraxoid-like protein
Short name:
BLP
Dynein light chain 2A, cytoplasmic
Dynein-associated protein Km23
Roadblock domain-containing protein 1
Gene namesi
Name:DYNLRB1
Synonyms:BITH, DNCL2A, DNLC2A, ROBLD1
ORF Names:HSPC162
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125971.16
HGNCiHGNC:15468 DYNLRB1
MIMi607167 gene
neXtProtiNX_Q9NP97

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi83658
OpenTargetsiENSG00000125971
PharmGKBiPA27436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00002209552 – 96Dynein light chain roadblock-type 1Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NP97
MaxQBiQ9NP97
PaxDbiQ9NP97
PeptideAtlasiQ9NP97
PRIDEiQ9NP97
ProteomicsDBi81939
81940 [Q9NP97-2]
TopDownProteomicsiQ9NP97-1 [Q9NP97-1]
Q9NP97-2 [Q9NP97-2]

PTM databases

iPTMnetiQ9NP97
PhosphoSitePlusiQ9NP97

Expressioni

Tissue specificityi

High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.1 Publication

Gene expression databases

BgeeiENSG00000125971 Expressed in 228 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_DYNLRB1
ExpressionAtlasiQ9NP97 baseline and differential
GenevisibleiQ9NP97 HS

Organism-specific databases

HPAiCAB009845

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNLRB2. Interacts with DYNC1I1 and DYNC1I2. Interacts with RAB6A isoform 1 (GTP-bound); the interaction is direct. Interacts with RAB6A isoform 2 (GDP-bound); the interaction is direct. Interacts with RAB6B (GDP-bound).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DYNC1I2Q134093EBI-372128,EBI-742998

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123715, 35 interactors
CORUMiQ9NP97
IntActiQ9NP97, 30 interactors
MINTiQ9NP97
STRINGi9606.ENSP00000349679

Structurei

Secondary structure

196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NP97
SMRiQ9NP97
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NP97

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4115 Eukaryota
ENOG4111NDV LUCA
GeneTreeiENSGT00390000011067
HOGENOMiHOG000232033
HOVERGENiHBG058598
InParanoidiQ9NP97
KOiK10419
PhylomeDBiQ9NP97
TreeFamiTF315165

Family and domain databases

InterProiView protein in InterPro
IPR016561 DYNLRB1/2
IPR004942 Roadblock/LAMTOR2_dom
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
PIRSFiPIRSF009998 DLC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NP97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYASLMHSFI
60 70 80 90
LKARSTVRDI DPQNDLTFLR IRSKKNEIMV APDKDYFLIV IQNPTE
Length:96
Mass (Da):10,922
Last modified:January 23, 2007 - v3
Checksum:iAAE1EFCD372897B3
GO
Isoform 2 (identifier: Q9NP97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-47: IPIKSTMDNPTTTQYASLMH → GWEPLGHCGDRSRPPAQGCP
     48-96: Missing.

Note: May result from the retention of an intron in the cDNA.
Show »
Length:47
Mass (Da):5,060
Checksum:i17421DC72701A8A2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKR6B1AKR6_HUMAN
Dynein light chain roadblock-type 1
DYNLRB1
148Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04912413S → R. Corresponds to variant dbSNP:rs1063616Ensembl.1
Natural variantiVAR_04912571I → F. Corresponds to variant dbSNP:rs10036Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00723628 – 47IPIKS…ASLMH → GWEPLGHCGDRSRPPAQGCP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_00723748 – 96Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132750 mRNA Translation: AAL75951.1
AF165516 mRNA Translation: AAF86646.1
AF178431 mRNA Translation: AAK95342.1
AY026513 mRNA Translation: AAK18712.1
AF161511 mRNA Translation: AAF29126.1
AL109923 Genomic DNA No translation available.
AL136173 Genomic DNA No translation available.
BC002481 mRNA Translation: AAH02481.1
BC007223 mRNA No translation available.
CCDSiCCDS13235.1 [Q9NP97-1]
RefSeqiNP_001268656.1, NM_001281727.1
NP_001268657.1, NM_001281728.1
NP_001268658.1, NM_001281729.1
NP_054902.1, NM_014183.3 [Q9NP97-1]
NP_808852.1, NM_177953.2
UniGeneiHs.593920

Genome annotation databases

EnsembliENST00000300469; ENSP00000300469; ENSG00000125971 [Q9NP97-2]
ENST00000357156; ENSP00000349679; ENSG00000125971 [Q9NP97-1]
GeneIDi83658
KEGGihsa:83658
UCSCiuc002xal.5 human [Q9NP97-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132750 mRNA Translation: AAL75951.1
AF165516 mRNA Translation: AAF86646.1
AF178431 mRNA Translation: AAK95342.1
AY026513 mRNA Translation: AAK18712.1
AF161511 mRNA Translation: AAF29126.1
AL109923 Genomic DNA No translation available.
AL136173 Genomic DNA No translation available.
BC002481 mRNA Translation: AAH02481.1
BC007223 mRNA No translation available.
CCDSiCCDS13235.1 [Q9NP97-1]
RefSeqiNP_001268656.1, NM_001281727.1
NP_001268657.1, NM_001281728.1
NP_001268658.1, NM_001281729.1
NP_054902.1, NM_014183.3 [Q9NP97-1]
NP_808852.1, NM_177953.2
UniGeneiHs.593920

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z09NMR-A/B1-96[»]
2B95NMR-A/B1-96[»]
2E8JNMR-A/B1-96[»]
2HZ5X-ray2.10A/B1-96[»]
6F1Telectron microscopy3.50k/l/s/t1-96[»]
6F1Zelectron microscopy3.40s/t1-96[»]
6F38electron microscopy6.70k/l/s/t1-96[»]
6F3Aelectron microscopy8.20k/l1-96[»]
ProteinModelPortaliQ9NP97
SMRiQ9NP97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123715, 35 interactors
CORUMiQ9NP97
IntActiQ9NP97, 30 interactors
MINTiQ9NP97
STRINGi9606.ENSP00000349679

PTM databases

iPTMnetiQ9NP97
PhosphoSitePlusiQ9NP97

Proteomic databases

EPDiQ9NP97
MaxQBiQ9NP97
PaxDbiQ9NP97
PeptideAtlasiQ9NP97
PRIDEiQ9NP97
ProteomicsDBi81939
81940 [Q9NP97-2]
TopDownProteomicsiQ9NP97-1 [Q9NP97-1]
Q9NP97-2 [Q9NP97-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300469; ENSP00000300469; ENSG00000125971 [Q9NP97-2]
ENST00000357156; ENSP00000349679; ENSG00000125971 [Q9NP97-1]
GeneIDi83658
KEGGihsa:83658
UCSCiuc002xal.5 human [Q9NP97-1]

Organism-specific databases

CTDi83658
DisGeNETi83658
EuPathDBiHostDB:ENSG00000125971.16
GeneCardsiDYNLRB1
HGNCiHGNC:15468 DYNLRB1
HPAiCAB009845
MIMi607167 gene
neXtProtiNX_Q9NP97
OpenTargetsiENSG00000125971
PharmGKBiPA27436
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4115 Eukaryota
ENOG4111NDV LUCA
GeneTreeiENSGT00390000011067
HOGENOMiHOG000232033
HOVERGENiHBG058598
InParanoidiQ9NP97
KOiK10419
PhylomeDBiQ9NP97
TreeFamiTF315165

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport
SIGNORiQ9NP97

Miscellaneous databases

ChiTaRSiDYNLRB1 human
EvolutionaryTraceiQ9NP97
GeneWikiiDYNLRB1
GenomeRNAii83658
PROiPR:Q9NP97
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125971 Expressed in 228 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_DYNLRB1
ExpressionAtlasiQ9NP97 baseline and differential
GenevisibleiQ9NP97 HS

Family and domain databases

InterProiView protein in InterPro
IPR016561 DYNLRB1/2
IPR004942 Roadblock/LAMTOR2_dom
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
PIRSFiPIRSF009998 DLC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLRB1_HUMAN
AccessioniPrimary (citable) accession number: Q9NP97
Secondary accession number(s): B1AKR5
, Q5TC72, Q96IV3, Q9NQM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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