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Entry version 143 (02 Dec 2020)
Sequence version 2 (18 May 2010)
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Protein

Zinc transporter ZIP2

Gene

SLC39A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates zinc uptake. Zinc uptake may be mediated by a Zn2+-HCO3- symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.

Miscellaneous

Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu2+, Co2+ and Mn2+ ions. Not inhibited by Fe2+.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • zinc ion transmembrane transport Source: GO_Central
  • zinc ion transport Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9NP94

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-442380, Zinc influx into cells by the SLC39 gene family

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.5.3.1, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter ZIP2
Alternative name(s):
6A1
Eti-1
Solute carrier family 39 member 2
Zrt- and Irt-like protein 2
Short name:
ZIP-2
Short name:
hZIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC39A2
Synonyms:ZIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000165794.9

Human Gene Nomenclature Database

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HGNCi
HGNC:17127, SLC39A2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612166, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NP94

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8ExtracellularSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 46CytoplasmicSequence analysisAdd BLAST17
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 103ExtracellularSequence analysisAdd BLAST36
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 164CytoplasmicSequence analysisAdd BLAST40
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 189ExtracellularSequence analysis4
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 224CytoplasmicSequence analysisAdd BLAST14
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 258ExtracellularSequence analysisAdd BLAST13
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 288CytoplasmicSequence analysis9
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29986

Open Targets

More...
OpenTargetsi
ENSG00000165794

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38202

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NP94, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC39A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452889

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000687671 – 309Zinc transporter ZIP2Add BLAST309

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NP94

PeptideAtlas

More...
PeptideAtlasi
Q9NP94

PRoteomics IDEntifications database

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PRIDEi
Q9NP94

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
33651
81937 [Q9NP94-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in prostate and uterine epithelial cells.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Shows a dramatic induction in normal epithelial cells contact inhibition.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165794, Expressed in ectocervix and 102 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NP94, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000165794, Tissue enhanced (ductus deferens, seminal vesicle, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NP94
With#Exp.IntAct
AQP1 [P29972]3EBI-12898013,EBI-745213
AQP6 [Q13520]3EBI-12898013,EBI-13059134
ARL13B [Q3SXY8]3EBI-12898013,EBI-11343438
BCL2L2 [Q92843]3EBI-12898013,EBI-707714
BTN2A2 [Q8WVV5]3EBI-12898013,EBI-8648738
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-12898013,EBI-12003442
CD79A [P11912]3EBI-12898013,EBI-7797864
CNR2 [P34972]3EBI-12898013,EBI-2835940
COL4A5 - isoform 2 [P29400-2]3EBI-12898013,EBI-12211159
COMT [P21964]3EBI-12898013,EBI-372265
CREB3L1 [Q96BA8]3EBI-12898013,EBI-6942903
CXCR2 [P25025]3EBI-12898013,EBI-2835281
CYB561 [P49447]3EBI-12898013,EBI-8646596
EHHADH [Q08426]3EBI-12898013,EBI-2339219
EMC6 [Q9BV81]3EBI-12898013,EBI-2820492
FAM3C [Q92520]3EBI-12898013,EBI-2876774
FXYD3 - isoform 3 [Q14802-3]3EBI-12898013,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-12898013,EBI-713304
FZD7 [O75084]3EBI-12898013,EBI-746917
GJA8 [P48165]3EBI-12898013,EBI-17458373
GPR152 [Q8TDT2]3EBI-12898013,EBI-13345167
GPR42 [O15529]3EBI-12898013,EBI-18076404
LY6G6C [O95867]3EBI-12898013,EBI-9088345
MFSD6 [Q6ZSS7]3EBI-12898013,EBI-2858252
MS4A13 [Q5J8X5]3EBI-12898013,EBI-12070086
NRM [Q8IXM6]3EBI-12898013,EBI-10262547
PLN [P26678]3EBI-12898013,EBI-692836
PNLIPRP1 [P54315]3EBI-12898013,EBI-8652812
SEC22A [Q96IW7]3EBI-12898013,EBI-8652744
SLC18A1 - isoform 3 [P54219-3]3EBI-12898013,EBI-17595455
SLC30A2 [Q9BRI3]3EBI-12898013,EBI-8644112
SLC30A8 [Q8IWU4]3EBI-12898013,EBI-10262251
SLC39A9 [Q9NUM3]3EBI-12898013,EBI-2823239
SLC66A1 - isoform 3 [Q6ZP29-3]3EBI-12898013,EBI-12889586
SLC7A1 [P30825]3EBI-12898013,EBI-4289564
SSMEM1 [Q8WWF3]3EBI-12898013,EBI-17280858
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-12898013,EBI-12908338
STATH [P02808]3EBI-12898013,EBI-738687
TMEM107 [Q6UX40]3EBI-12898013,EBI-12845616
TMEM14B [Q9NUH8]3EBI-12898013,EBI-8638294
TMEM229B [Q8NBD8]3EBI-12898013,EBI-12195227
TMEM237 - isoform 2 [Q96Q45-2]3EBI-12898013,EBI-10982110
TMEM54 [Q969K7]3EBI-12898013,EBI-3922833
TMEM60 [Q9H2L4]3EBI-12898013,EBI-2852148
TMEM86A [Q8N2M4]3EBI-12898013,EBI-12015604
TRHR [P34981]3EBI-12898013,EBI-18055230
TTMP [Q5BVD1]3EBI-12898013,EBI-10243654
UBE2J1 [Q9Y385]3EBI-12898013,EBI-988826
UPK1B [O75841]3EBI-12898013,EBI-12237619
VAMP5 [O95183]3EBI-12898013,EBI-10191195
YIPF6 [Q96EC8]3EBI-12898013,EBI-751210

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119012, 48 interactors

Protein interaction database and analysis system

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IntActi
Q9NP94, 51 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298681

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NP94, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni175 – 176Heavy metals bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1558, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000160962

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_2512017_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NP94

Identification of Orthologs from Complete Genome Data

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OMAi
EEWGGTH

Database of Orthologous Groups

More...
OrthoDBi
981397at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NP94

TreeFam database of animal gene trees

More...
TreeFami
TF317098

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003689, ZIP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02535, Zip, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NP94-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC
60 70 80 90 100
ISAGVFLGAG FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM
110 120 130 140 150
EYPYGELIIS LGFFFVFFLE SLALQCCPGA AGGSTVQDEE WGGAHIFELH
160 170 180 190 200
SHGHLPSPSK GPLRALVLLL SLSFHSVFEG LAVGLQPTVA ATVQLCLAVL
210 220 230 240 250
AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA VGLAVTGGDS
260 270 280 290 300
EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA

FMAFIALWA
Length:309
Mass (Da):32,742
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC71A0BF8533B5D51
GO
Isoform 2 (identifier: Q9NP94-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-85: NRS → ISK
     86-309: Missing.

Show »
Length:85
Mass (Da):9,349
Checksum:i64748ED4523960D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12L → P in AAH98254 (PubMed:15489334).Curated1
Sequence conflicti43L → R in BAA94313 (PubMed:7751801).Curated1
Sequence conflicti43L → R in AAF35832 (PubMed:10681536).Curated1
Sequence conflicti43L → R in AAH96723 (PubMed:15489334).Curated1
Sequence conflicti43L → R in AAH98254 (PubMed:15489334).Curated1
Sequence conflicti43L → R in AAI10058 (PubMed:15489334).Curated1
Sequence conflicti120E → V in BAG37473 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05748048L → P. Corresponds to variant dbSNP:rs2234633Ensembl.1
Natural variantiVAR_02026580M → V. Corresponds to variant dbSNP:rs2234634Ensembl.1
Natural variantiVAR_055452115F → L3 PublicationsCorresponds to variant dbSNP:rs2234636Ensembl.1
Natural variantiVAR_020266129G → E. Corresponds to variant dbSNP:rs6413532Ensembl.1
Natural variantiVAR_020267154H → Y. Corresponds to variant dbSNP:rs2234637Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04688983 – 85NRS → ISK in isoform 2. Curated3
Alternative sequenceiVSP_04689086 – 309Missing in isoform 2. CuratedAdd BLAST224

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D83039 mRNA Translation: BAA94313.1
AF186081 mRNA Translation: AAF35832.1
AK314974 mRNA Translation: BAG37473.1
AL161668 Genomic DNA No translation available.
AL355922 Genomic DNA No translation available.
BC096723 mRNA Translation: AAH96723.1
BC098254 mRNA Translation: AAH98254.1
BC110057 mRNA Translation: AAI10058.1
AY029483 mRNA Translation: AAK40258.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58303.1 [Q9NP94-2]
CCDS9563.1 [Q9NP94-1]

NCBI Reference Sequences

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RefSeqi
NP_001243517.1, NM_001256588.1 [Q9NP94-2]
NP_055394.2, NM_014579.3 [Q9NP94-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298681; ENSP00000298681; ENSG00000165794 [Q9NP94-1]
ENST00000554422; ENSP00000452568; ENSG00000165794 [Q9NP94-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29986

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29986

UCSC genome browser

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UCSCi
uc001vyr.4, human [Q9NP94-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83039 mRNA Translation: BAA94313.1
AF186081 mRNA Translation: AAF35832.1
AK314974 mRNA Translation: BAG37473.1
AL161668 Genomic DNA No translation available.
AL355922 Genomic DNA No translation available.
BC096723 mRNA Translation: AAH96723.1
BC098254 mRNA Translation: AAH98254.1
BC110057 mRNA Translation: AAI10058.1
AY029483 mRNA Translation: AAK40258.1
CCDSiCCDS58303.1 [Q9NP94-2]
CCDS9563.1 [Q9NP94-1]
RefSeqiNP_001243517.1, NM_001256588.1 [Q9NP94-2]
NP_055394.2, NM_014579.3 [Q9NP94-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119012, 48 interactors
IntActiQ9NP94, 51 interactors
STRINGi9606.ENSP00000298681

Chemistry databases

DrugBankiDB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Protein family/group databases

TCDBi2.A.5.3.1, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Polymorphism and mutation databases

BioMutaiSLC39A2
DMDMi296452889

Proteomic databases

PaxDbiQ9NP94
PeptideAtlasiQ9NP94
PRIDEiQ9NP94
ProteomicsDBi33651
81937 [Q9NP94-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22081, 88 antibodies

Genome annotation databases

EnsembliENST00000298681; ENSP00000298681; ENSG00000165794 [Q9NP94-1]
ENST00000554422; ENSP00000452568; ENSG00000165794 [Q9NP94-2]
GeneIDi29986
KEGGihsa:29986
UCSCiuc001vyr.4, human [Q9NP94-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29986
DisGeNETi29986
EuPathDBiHostDB:ENSG00000165794.9

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC39A2
HGNCiHGNC:17127, SLC39A2
HPAiENSG00000165794, Tissue enhanced (ductus deferens, seminal vesicle, skin)
MIMi612166, gene
neXtProtiNX_Q9NP94
OpenTargetsiENSG00000165794
PharmGKBiPA38202

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1558, Eukaryota
GeneTreeiENSGT00940000160962
HOGENOMiCLU_2512017_0_0_1
InParanoidiQ9NP94
OMAiEEWGGTH
OrthoDBi981397at2759
PhylomeDBiQ9NP94
TreeFamiTF317098

Enzyme and pathway databases

PathwayCommonsiQ9NP94
ReactomeiR-HSA-442380, Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
29986, 4 hits in 839 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC39A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29986
PharosiQ9NP94, Tbio

Protein Ontology

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PROi
PR:Q9NP94
RNActiQ9NP94, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165794, Expressed in ectocervix and 102 other tissues
GenevisibleiQ9NP94, HS

Family and domain databases

InterProiView protein in InterPro
IPR003689, ZIP
PfamiView protein in Pfam
PF02535, Zip, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS39A2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NP94
Secondary accession number(s): B2RC76
, G3V5X2, Q4QQJ1, Q4V9S4, Q96JT6, Q9UD20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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