SLC6A20

Functionⁱ

Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine.2 Publications

GO - Molecular functionⁱ

amino acid transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15632147
neurotransmitter:sodium symporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amino acid transport
Source: UniProtKB
Inferred from direct assayⁱ
- 15632147
glycine transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19033659
proline transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19033659

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Symport, Transport

Biological process

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619101 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)

Reactomeⁱ

R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619101 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
R-HSA-5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)

Protein family/group databases

TCDBⁱ	2.A.22.6.8 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.6.8 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium- and chloride-dependent transporter XTRP3 Alternative name(s): Sodium/imino-acid transporter 1 Solute carrier family 6 member 20 Transporter rB21A homolog
Gene namesⁱ	Name:SLC6A20 Synonyms:SIT1, XT3, XTRP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163817.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30927 SLC6A20
MIMⁱ	605616 gene
neXtProtⁱ	NX_Q9NP91

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 5	CytoplasmicSequence analysis	5
Transmembraneⁱ	6 – 26	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	27 – 42	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	43 – 63	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	64 – 79	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	80 – 100	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	101 – 165	ExtracellularSequence analysisAdd BLAST	65
Transmembraneⁱ	166 – 186	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	187 – 194	CytoplasmicSequence analysis	8
Transmembraneⁱ	195 – 215	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	216 – 241	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	242 – 262	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	263 – 276	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	277 – 297	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	298 – 389	ExtracellularSequence analysisAdd BLAST	92
Transmembraneⁱ	390 – 410	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	411 – 431	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	432 – 452	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	453 – 465	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	466 – 486	Helical; Name=10Sequence analysisAdd BLAST	21
Topological domainⁱ	487 – 504	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	505 – 525	Helical; Name=11Sequence analysisAdd BLAST	21
Topological domainⁱ	526 – 554	ExtracellularSequence analysisAdd BLAST	29
Transmembraneⁱ	555 – 575	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	576 – 592	CytoplasmicSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyperglycinuria (HG)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones.

Iminoglycinuria (IG)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. Haploinsufficiency of SLC6A20 combined with deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families.

Disease descriptionA disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54716
MalaCards human disease database More...MalaCardsⁱ	SLC6A20
MIMⁱ	138500 phenotype 242600 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163817
Orphanetⁱ	42062 Iminoglycinuria
PharmGKBⁱ	PA134865308

Polymorphism and mutation databases

BioMutaⁱ	SLC6A20
DMDMⁱ	46397768

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214812	1 – 592	Sodium- and chloride-dependent transporter XTRP3Add BLAST		592

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	131	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	357	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9NP91
PeptideAtlas More...PeptideAtlasⁱ	Q9NP91
PRIDEⁱ	Q9NP91
ProteomicsDBⁱ	81934 81935 [Q9NP91-2]

PTM databases

iPTMnetⁱ	Q9NP91
PhosphoSitePlusⁱ	Q9NP91

Expressionⁱ

Tissue specificityⁱ

Kidney and small intestine. Expressed in the S3 segment of the proximal tubule.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000163817
CleanExⁱ	HS_SIT1 HS_SLC6A20
ExpressionAtlasⁱ	Q9NP91 baseline and differential
Genevisibleⁱ	Q9NP91 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029873

HPAⁱ

HPA029873

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ADAMTSL4	Q6UY14-3	3	EBI-10311198,EBI-10173507
KRTAP10-5	P60370	3	EBI-10311198,EBI-10172150
KRTAP10-7	P60409	3	EBI-10311198,EBI-10172290
KRTAP10-8	P60410	5	EBI-10311198,EBI-10171774
KRTAP10-9	P60411	3	EBI-10311198,EBI-10172052
NOTCH2NL	Q7Z3S9	5	EBI-10311198,EBI-945833

Show more details

Protein-protein interaction databases

BioGridⁱ	120108, 28 interactors
IntActⁱ	Q9NP91, 8 interactors
STRINGⁱ	9606.ENSP00000346298

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NP91
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119044
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q9NP91
KEGG Orthology (KO) More...KOⁱ	K05048
OMAⁱ	SVCPLNG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q9NP91
TreeFamⁱ	TF343812

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002438 Na/ntran_symport_orphan IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT PR01206 ORPHTRNSPORT
SUPFAMⁱ	SSF161070 SSF161070, 2 hits
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9NP91-1) [UniParc]FASTA Add to basket

Also known as: XT3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKARPLWAN SLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM 
        60         70         80         90        100
LIVEGMPLLY LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM 
       110        120        130        140        150
YYNVINAWAF WYLFHSFQDP LPWSVCPLNG NHTGYDEECE KASSTQYFWY 
       160        170        180        190        200
RKTLNISPSL QENGGVQWEP ALCLLLAWLV VYLCILRGTE STGKVVYFTA 
       210        220        230        240        250
SLPYCVLIIY LIRGLTLHGA TNGLMYMFTP KIEQLANPKA WINAATQIFF 
       260        270        280        290        300
SLGLGFGSLI AFASYNEPSN NCQKHAIIVS LINSFTSIFA SIVTFSIYGF 
       310        320        330        340        350
KATFNYENCL KKVSLLLTNT FDLEDGFLTA SNLEQVKGYL ASAYPSKYSE 
       360        370        380        390        400
MFPQIKNCSL ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL 
       410        420        430        440        450
MLGIGSMLGN TAAILTPLTD SKIISSHLPK EAISGLVCLV NCAIGMVFTM 
       460        470        480        490        500
EAGNYWFDIF NDYAATLSLL LIVLVETIAV CYVYGLRRFE SDLKAMTGRA 
       510        520        530        540        550
VSWYWKVMWA GVSPLLIVSL FVFYLSDYIL TGTLKYQAWD ASQGQLVTKD 
       560        570        580        590 
YPAYALAVIG LLVASSTMCI PLAALGTFVQ RRLKRGDADP VA

Length:592

Mass (Da):65,914

Last modified:October 1, 2000 - v1

Checksum:ⁱAF6E94E19895377F

GO

Isoform 2 (identifier: Q9NP91-2) [UniParc]FASTA Add to basket

Also known as: XT3a

The sequence of this isoform differs from the canonical sequence as follows:
195-231: Missing.

« Hide

        10         20         30         40         50
MEKARPLWAN SLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM 
        60         70         80         90        100
LIVEGMPLLY LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM 
       110        120        130        140        150
YYNVINAWAF WYLFHSFQDP LPWSVCPLNG NHTGYDEECE KASSTQYFWY 
       160        170        180        190        200
RKTLNISPSL QENGGVQWEP ALCLLLAWLV VYLCILRGTE STGKIEQLAN 
       210        220        230        240        250
PKAWINAATQ IFFSLGLGFG SLIAFASYNE PSNNCQKHAI IVSLINSFTS 
       260        270        280        290        300
IFASIVTFSI YGFKATFNYE NCLKKVSLLL TNTFDLEDGF LTASNLEQVK 
       310        320        330        340        350
GYLASAYPSK YSEMFPQIKN CSLESELDTA VQGTGLAFIV YTEAIKNMEV 
       360        370        380        390        400
SQLWSVLYFF MLLMLGIGSM LGNTAAILTP LTDSKIISSH LPKEAISGLV 
       410        420        430        440        450
CLVNCAIGMV FTMEAGNYWF DIFNDYAATL SLLLIVLVET IAVCYVYGLR 
       460        470        480        490        500
RFESDLKAMT GRAVSWYWKV MWAGVSPLLI VSLFVFYLSD YILTGTLKYQ 
       510        520        530        540        550
AWDASQGQLV TKDYPAYALA VIGLLVASST MCIPLAALGT FVQRRLKRGD 

ADPVA

Show »

Length:555

Mass (Da):61,751

Checksum:ⁱA7CE6C1CE318CF69

GO

Sequence cautionⁱ

The sequence AAL75944 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	31	F → N in AAC27755 (Ref. 2) Curated		1
Sequence conflictⁱ	217	L → V in AAC27755 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021862	9	A → G. Corresponds to variant dbSNP:rs2271615EnsemblClinVar.		1
Natural variantⁱVAR_052068	199	T → M Common variant that contributes to hyperglycinuria and iminoglycinuria in patients carrying variants in SLC36A2, SLC6A19 or SLC6A18; results in SLC6A20 inactivation due to a 8-fold decrease of Vmax. 1 PublicationCorresponds to variant dbSNP:rs17279437EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_050002	195 – 231	Missing in isoform 2. 2 PublicationsAdd BLAST		37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ276207 mRNA Translation: CAB99310.1 AJ276208 mRNA Translation: CAB99311.1 AJ289880 Genomic DNA Translation: CAB96872.1 AF125107 mRNA Translation: AAL75944.1 Different initiation. CH471055 Genomic DNA Translation: EAW64748.1 BC126197 mRNA Translation: AAI26198.1 BC136431 mRNA Translation: AAI36432.1 AF075260 mRNA Translation: AAC27755.1 AL389979 mRNA Translation: CAB97535.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2730.1 [Q9NP91-2] CCDS43077.1 [Q9NP91-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_064593.1, NM_020208.3 [Q9NP91-1] NP_071800.1, NM_022405.3 [Q9NP91-2]
UniGeneⁱ	Hs.413095

Genome annotation databases

Ensemblⁱ	ENST00000353278; ENSP00000296133; ENSG00000163817 [Q9NP91-2] ENST00000358525; ENSP00000346298; ENSG00000163817 [Q9NP91-1]
GeneIDⁱ	54716
KEGGⁱ	hsa:54716
UCSC genome browser More...UCSCⁱ	uc011bai.3 human [Q9NP91-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9NP91	UPI0005CFF69F		HUMAN		493
UPI000C9E8851		HORSE		705
UPI0005FADA53		OVIMU		594
UPI0004BE14FE		EQUPR		593
Transporter		MACMU		592
+59
Q9NP91-2	Transporter		PANTR		555
Transporter		SAIBB		555
Transporter		PROCO		555
Transporter		CALJA		555
Transporter		MACMU		555
+27

Protein	Similar proteins		Species	Score	Length
Q9NP91	UPI0005CFF69F		HUMAN		493
UPI000C9E8851		HORSE		705
UPI0005FADA53		OVIMU		594
UPI0004BE14FE		EQUPR		593
UPI0004ED1B13		NANGA		592
+62
Q9NP91-2	UPI000A3104D9		MUSPA		555
UPI00045E3E40		Orycteropus afer afer		555
UPI0002741378		OTOGA		555
UPI00045457C9		CRIGR		555
Transporter		COLAP		555
+55

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ276207 mRNA Translation: CAB99310.1 AJ276208 mRNA Translation: CAB99311.1 AJ289880 Genomic DNA Translation: CAB96872.1 AF125107 mRNA Translation: AAL75944.1 Different initiation. CH471055 Genomic DNA Translation: EAW64748.1 BC126197 mRNA Translation: AAI26198.1 BC136431 mRNA Translation: AAI36432.1 AF075260 mRNA Translation: AAC27755.1 AL389979 mRNA Translation: CAB97535.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2730.1 [Q9NP91-2] CCDS43077.1 [Q9NP91-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_064593.1, NM_020208.3 [Q9NP91-1] NP_071800.1, NM_022405.3 [Q9NP91-2]
UniGeneⁱ	Hs.413095

3D structure databases

ProteinModelPortalⁱ	Q9NP91
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120108, 28 interactors
IntActⁱ	Q9NP91, 8 interactors
STRINGⁱ	9606.ENSP00000346298

Protein family/group databases

TCDBⁱ	2.A.22.6.8 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.6.8 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetⁱ	Q9NP91
PhosphoSitePlusⁱ	Q9NP91

Polymorphism and mutation databases

BioMutaⁱ	SLC6A20
DMDMⁱ	46397768

Proteomic databases

PaxDbⁱ	Q9NP91
PeptideAtlas More...PeptideAtlasⁱ	Q9NP91
PRIDEⁱ	Q9NP91
ProteomicsDBⁱ	81934 81935 [Q9NP91-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000353278; ENSP00000296133; ENSG00000163817 [Q9NP91-2] ENST00000358525; ENSP00000346298; ENSG00000163817 [Q9NP91-1]
GeneIDⁱ	54716
KEGGⁱ	hsa:54716
UCSC genome browser More...UCSCⁱ	uc011bai.3 human [Q9NP91-1]

Organism-specific databases

CTDⁱ	54716
DisGeNET More...DisGeNETⁱ	54716
EuPathDBⁱ	HostDB:ENSG00000163817.15
GeneCardsⁱ	SLC6A20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30927 SLC6A20
Human Protein Atlas More...HPAⁱ	HPA029873
MalaCards human disease database More...MalaCardsⁱ	SLC6A20
MIMⁱ	138500 phenotype 242600 phenotype 605616 gene
neXtProtⁱ	NX_Q9NP91
Open Targets More...OpenTargetsⁱ	ENSG00000163817
Orphanetⁱ	42062 Iminoglycinuria
PharmGKBⁱ	PA134865308
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119044
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q9NP91
KEGG Orthology (KO) More...KOⁱ	K05048
OMAⁱ	SVCPLNG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q9NP91
TreeFamⁱ	TF343812

Enzyme and pathway databases

Reactomeⁱ	R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619101 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)

Reactomeⁱ

R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619101 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
R-HSA-5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)

Miscellaneous databases

ChiTaRSⁱ	SLC6A20 human
GeneWikiⁱ	SLC6A20
GenomeRNAiⁱ	54716
Protein Ontology More...PROⁱ	PR:Q9NP91
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163817
CleanExⁱ	HS_SIT1 HS_SLC6A20
ExpressionAtlasⁱ	Q9NP91 baseline and differential
Genevisibleⁱ	Q9NP91 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002438 Na/ntran_symport_orphan IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT PR01206 ORPHTRNSPORT
SUPFAMⁱ	SSF161070 SSF161070, 2 hits
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S6A20_HUMAN
Accessionⁱ	Q9NP91Primary (citable) accession number: Q9NP91 Secondary accession number(s): A1A4F2 , O75590, Q8TF10, Q9NPQ2, Q9NQ77
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	October 1, 2000
	Last modified:	June 20, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NP91 (S6A20_HUMAN)

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Sodium- and chloride-dependent transporter XTRP3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ