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Entry version 159 (31 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

DNA-directed DNA/RNA polymerase mu

Gene

POLM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.4 Publications

Miscellaneous

DPOLM has a reduced ability to distinguish dNTP and rNTP as substrates, and elongates them on DNA primer strand with a similar efficiency. It is able to polymerize nucleotides on RNA primer strands.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi330MagnesiumBy similarity1
Metal bindingi332MagnesiumBy similarity1
Metal bindingi418MagnesiumBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei433Responsible for the low discrimination between dNTP and rNTP1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed DNA/RNA polymerase mu (EC:2.7.7.7)
Short name:
Pol Mu
Alternative name(s):
Terminal transferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLM
Synonyms:polmu
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9185 POLM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606344 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NP87

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27434

Open Targets

More...
OpenTargetsi
ENSG00000122678

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33505

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1914260

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POLM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17366980

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187871 – 494DNA-directed DNA/RNA polymerase muAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NP87

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NP87

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NP87

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NP87

PeptideAtlas

More...
PeptideAtlasi
Q9NP87

PRoteomics IDEntifications database

More...
PRIDEi
Q9NP87

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67013
70190
81932 [Q9NP87-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NP87

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NP87

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a number of tissues. Abundant in thymus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122678 Expressed in 89 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NP87 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NP87 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA058900
HPA066007

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
taxP140793EBI-9675790,EBI-9675698From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118168, 14 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9NP87

Protein interaction database and analysis system

More...
IntActi
Q9NP87, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9NP87

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379174

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NP87

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1494
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NP87

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NP87

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 122BRCTPROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni323 – 332Involved in ssDNA bindingBy similarity10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2534 Eukaryota
COG1796 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158490

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000263600

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NP87

KEGG Orthology (KO)

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KOi
K03513

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRWAGHE

Database of Orthologous Groups

More...
OrthoDBi
1212057at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NP87

TreeFam database of animal gene trees

More...
TreeFami
TF103012

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00141 NT_POLXc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR002054 DNA-dir_DNA_pol_X
IPR027249 DNA/RNApol_mu
IPR019843 DNA_pol-X_BS
IPR010996 DNA_pol_b-like_N
IPR028207 DNA_pol_B_palm_palm
IPR018944 DNA_pol_lambd_fingers_domain
IPR027421 DNA_pol_lamdba_lyase_dom_sf
IPR037160 DNA_Pol_thumb_sf
IPR022312 DNA_pol_X
IPR029398 PolB_thumb
IPR001726 TdT/Mu

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14792 DNA_pol_B_palm, 1 hit
PF14791 DNA_pol_B_thumb, 1 hit
PF10391 DNA_pol_lambd_f, 1 hit
PF14716 HHH_8, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000817 DNA_NT, 1 hit
PIRSF501176 DNApol_mu, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00869 DNAPOLX
PR00871 DNAPOLXTDT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00483 POLXc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47802 SSF47802, 1 hit
SSF52113 SSF52113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS00522 DNA_POLYMERASE_X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NP87-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPKRRRARV GSPSGDAASS TPPSTRFPGV AIYLVEPRMG RSRRAFLTGL
60 70 80 90 100
ARSKGFRVLD ACSSEATHVV MEETSAEEAV SWQERRMAAA PPGCTPPALL
110 120 130 140 150
DISWLTESLG AGQPVPVECR HRLEVAGPRK GPLSPAWMPA YACQRPTPLT
160 170 180 190 200
HHNTGLSEAL EILAEAAGFE GSEGRLLTFC RAASVLKALP SPVTTLSQLQ
210 220 230 240 250
GLPHFGEHSS RVVQELLEHG VCEEVERVRR SERYQTMKLF TQIFGVGVKT
260 270 280 290 300
ADRWYREGLR TLDDLREQPQ KLTQQQKAGL QHHQDLSTPV LRSDVDALQQ
310 320 330 340 350
VVEEAVGQAL PGATVTLTGG FRRGKLQGHD VDFLITHPKE GQEAGLLPRV
360 370 380 390 400
MCRLQDQGLI LYHQHQHSCC ESPTRLAQQS HMDAFERSFC IFRLPQPPGA
410 420 430 440 450
AVGGSTRPCP SWKAVRVDLV VAPVSQFPFA LLGWTGSKLF QRELRRFSRK
460 470 480 490
EKGLWLNSHG LFDPEQKTFF QAASEEDIFR HLGLEYLPPE QRNA
Length:494
Mass (Da):54,816
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB944059725F8B61F
GO
Isoform 2 (identifier: Q9NP87-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     279-356: GLQHHQDLST...LPRVMCRLQD → APPGPEHPSP...GHRHADRRLP

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):50,430
Checksum:iDE56D41438283CF3
GO
Isoform 3 (identifier: Q9NP87-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-276: YQTMKLFTQI...EQPQKLTQQQ → APAPPGPEHP...GHRHADRRLP
     277-356: Missing.
     467-494: KTFFQAASEEDIFRHLGLEYLPPEQRNA → GSSSGKTPRS...GALSASLITV

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):55,070
Checksum:i25EF59F10FC7D7FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PIY2Q6PIY2_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM
270Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDE4F8WDE4_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J222C9J222_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB78F8WB78_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEJ1F8WEJ1_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9H980Q9H980_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM hCG_1745198
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF34C9JF34_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2M2H7C2M2_HUMAN
DNA-directed DNA/RNA polymerase mu
POLM
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022287107E → D1 PublicationCorresponds to variant dbSNP:rs28382635Ensembl.1
Natural variantiVAR_022288220G → A1 PublicationCorresponds to variant dbSNP:rs28382644Ensembl.1
Natural variantiVAR_022289246V → F1 PublicationCorresponds to variant dbSNP:rs28382653Ensembl.1
Natural variantiVAR_022290484L → F1 PublicationCorresponds to variant dbSNP:rs28382661Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055288234 – 276YQTMK…LTQQQ → APAPPGPEHPSPAVRCRCPA AGGGGSCGAGPAWGHRHADR RLP in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_055289277 – 356Missing in isoform 3. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_055290279 – 356GLQHH…CRLQD → APPGPEHPSPAVRCRCPAAG GGGSCGAGPAWGHRHADRRL P in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_055291467 – 494KTFFQ…EQRNA → GSSSGKTPRSRKSCFCCRRH FSKRLQRKTSSDTWALSTFL QSRETPEPACVPHFHSGNWA APNLATECLQADMLPPDPHL HPSPPRPGSSGGQLCLQDQL SPCWCAAGCDEVGALSASLI TV in isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ131891 mRNA Translation: CAB65075.2
AF176097 mRNA Translation: AAF26284.1
AY899911 Genomic DNA Translation: AAW65376.1
AC017116 Genomic DNA No translation available.
CH471128 Genomic DNA Translation: EAW61122.1
CH471128 Genomic DNA Translation: EAW61123.1
CH471128 Genomic DNA Translation: EAW61124.1
CH471128 Genomic DNA Translation: EAW61126.1
BC049202 mRNA Translation: AAH49202.2
BC062590 mRNA Translation: AAH62590.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34625.1 [Q9NP87-1]
CCDS64635.1 [Q9NP87-2]
CCDS64636.1 [Q9NP87-3]

NCBI Reference Sequences

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RefSeqi
NP_001271259.1, NM_001284330.1 [Q9NP87-3]
NP_001271260.1, NM_001284331.1 [Q9NP87-2]
NP_037416.1, NM_013284.3 [Q9NP87-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000242248; ENSP00000242248; ENSG00000122678 [Q9NP87-1]
ENST00000335195; ENSP00000335141; ENSG00000122678 [Q9NP87-2]
ENST00000395831; ENSP00000379174; ENSG00000122678 [Q9NP87-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27434

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27434

UCSC genome browser

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UCSCi
uc003tjt.5 human [Q9NP87-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131891 mRNA Translation: CAB65075.2
AF176097 mRNA Translation: AAF26284.1
AY899911 Genomic DNA Translation: AAW65376.1
AC017116 Genomic DNA No translation available.
CH471128 Genomic DNA Translation: EAW61122.1
CH471128 Genomic DNA Translation: EAW61123.1
CH471128 Genomic DNA Translation: EAW61124.1
CH471128 Genomic DNA Translation: EAW61126.1
BC049202 mRNA Translation: AAH49202.2
BC062590 mRNA Translation: AAH62590.1
CCDSiCCDS34625.1 [Q9NP87-1]
CCDS64635.1 [Q9NP87-2]
CCDS64636.1 [Q9NP87-3]
RefSeqiNP_001271259.1, NM_001284330.1 [Q9NP87-3]
NP_001271260.1, NM_001284331.1 [Q9NP87-2]
NP_037416.1, NM_013284.3 [Q9NP87-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DUNNMR-A24-143[»]
2HTFNMR-A21-124[»]
4LZDX-ray1.85A132-397[»]
A411-494[»]
4LZGX-ray1.60A132-397[»]
A411-494[»]
4M04X-ray1.90A132-397[»]
A411-494[»]
4M0AX-ray1.85A132-397[»]
A411-494[»]
4YCXX-ray2.10A134-494[»]
4YD1X-ray1.75A134-494[»]
4YD2X-ray2.47A134-397[»]
A411-494[»]
5TWPX-ray2.00A134-397[»]
A411-494[»]
5TWQX-ray1.80A134-397[»]
A411-494[»]
5TWRX-ray1.90A134-397[»]
A411-494[»]
5TWSX-ray1.85A134-397[»]
A411-494[»]
5TXXX-ray1.95A132-494[»]
5TXZX-ray1.65A132-494[»]
5TYBX-ray1.85A132-494[»]
5TYCX-ray2.10A132-494[»]
5TYDX-ray1.90A132-494[»]
5TYEX-ray2.05A132-494[»]
5TYFX-ray1.97A132-494[»]
5TYGX-ray1.73A132-494[»]
5TYUX-ray2.05A132-494[»]
5TYVX-ray1.93A132-494[»]
5TYWX-ray1.88A132-494[»]
5TYXX-ray1.95A132-494[»]
5TYYX-ray1.93A132-494[»]
5TYZX-ray1.98A132-494[»]
5VZ7X-ray1.55A134-397[»]
A411-494[»]
5VZ8X-ray1.60A134-397[»]
A411-494[»]
5VZ9X-ray1.65A134-397[»]
A411-494[»]
5VZAX-ray1.50A134-397[»]
A411-494[»]
5VZBX-ray1.50A134-397[»]
A411-494[»]
5VZCX-ray1.55A134-397[»]
A411-494[»]
5VZDX-ray1.60A134-397[»]
A411-494[»]
5VZEX-ray1.51A134-397[»]
A411-494[»]
5VZFX-ray1.65A134-397[»]
A411-494[»]
5VZGX-ray1.85A134-397[»]
A411-494[»]
5VZHX-ray1.95A134-397[»]
A411-494[»]
5VZIX-ray1.50A134-397[»]
A411-494[»]
5W4FX-ray1.98A/D2-30[»]
5ZLCX-ray2.00A132-397[»]
A411-494[»]
6AECX-ray1.72A132-397[»]
A411-494[»]
6AEHX-ray1.64A132-397[»]
A411-494[»]
6AK5X-ray1.70A132-397[»]
A411-494[»]
6AK6X-ray1.75A132-397[»]
A411-494[»]
6AK8X-ray1.74A132-397[»]
A411-494[»]
6AK9X-ray1.91A132-397[»]
A411-494[»]
6AKHX-ray1.75A132-397[»]
A411-494[»]
6IPDX-ray1.70A132-397[»]
A411-494[»]
6IPEX-ray1.70A132-397[»]
A411-494[»]
6IPFX-ray1.77A132-397[»]
A411-494[»]
6IPGX-ray1.62A132-397[»]
A411-494[»]
6IPHX-ray1.65A132-397[»]
A411-494[»]
6IPIX-ray1.80A132-397[»]
A411-494[»]
6IPJX-ray1.98A132-397[»]
A411-494[»]
6IPKX-ray2.15A132-397[»]
A411-494[»]
6IPLX-ray1.64A132-397[»]
A411-494[»]
6IPMX-ray1.72A132-397[»]
A411-494[»]
6IPNX-ray1.60A132-397[»]
A411-494[»]
SMRiQ9NP87
ModBaseiSearch...

Protein-protein interaction databases

BioGridi118168, 14 interactors
ELMiQ9NP87
IntActiQ9NP87, 3 interactors
MINTiQ9NP87
STRINGi9606.ENSP00000379174

Chemistry databases

BindingDBiQ9NP87
ChEMBLiCHEMBL1914260

PTM databases

iPTMnetiQ9NP87
PhosphoSitePlusiQ9NP87

Polymorphism and mutation databases

BioMutaiPOLM
DMDMi17366980

Proteomic databases

EPDiQ9NP87
jPOSTiQ9NP87
MaxQBiQ9NP87
PaxDbiQ9NP87
PeptideAtlasiQ9NP87
PRIDEiQ9NP87
ProteomicsDBi67013
70190
81932 [Q9NP87-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242248; ENSP00000242248; ENSG00000122678 [Q9NP87-1]
ENST00000335195; ENSP00000335141; ENSG00000122678 [Q9NP87-2]
ENST00000395831; ENSP00000379174; ENSG00000122678 [Q9NP87-3]
GeneIDi27434
KEGGihsa:27434
UCSCiuc003tjt.5 human [Q9NP87-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27434
DisGeNETi27434

GeneCards: human genes, protein and diseases

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GeneCardsi
POLM
HGNCiHGNC:9185 POLM
HPAiHPA058900
HPA066007
MIMi606344 gene
neXtProtiNX_Q9NP87
OpenTargetsiENSG00000122678
PharmGKBiPA33505

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2534 Eukaryota
COG1796 LUCA
GeneTreeiENSGT00940000158490
HOGENOMiHOG000263600
InParanoidiQ9NP87
KOiK03513
OMAiRRWAGHE
OrthoDBi1212057at2759
PhylomeDBiQ9NP87
TreeFamiTF103012

Enzyme and pathway databases

ReactomeiR-HSA-5693571 Nonhomologous End-Joining (NHEJ)

Miscellaneous databases

EvolutionaryTraceiQ9NP87

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DNA_polymerase_mu

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27434

Protein Ontology

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PROi
PR:Q9NP87

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122678 Expressed in 89 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ9NP87 baseline and differential
GenevisibleiQ9NP87 HS

Family and domain databases

CDDicd00141 NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR002054 DNA-dir_DNA_pol_X
IPR027249 DNA/RNApol_mu
IPR019843 DNA_pol-X_BS
IPR010996 DNA_pol_b-like_N
IPR028207 DNA_pol_B_palm_palm
IPR018944 DNA_pol_lambd_fingers_domain
IPR027421 DNA_pol_lamdba_lyase_dom_sf
IPR037160 DNA_Pol_thumb_sf
IPR022312 DNA_pol_X
IPR029398 PolB_thumb
IPR001726 TdT/Mu
PfamiView protein in Pfam
PF14792 DNA_pol_B_palm, 1 hit
PF14791 DNA_pol_B_thumb, 1 hit
PF10391 DNA_pol_lambd_f, 1 hit
PF14716 HHH_8, 1 hit
PIRSFiPIRSF000817 DNA_NT, 1 hit
PIRSF501176 DNApol_mu, 1 hit
PRINTSiPR00869 DNAPOLX
PR00871 DNAPOLXTDT
SMARTiView protein in SMART
SM00483 POLXc, 1 hit
SUPFAMiSSF47802 SSF47802, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00522 DNA_POLYMERASE_X, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOLM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NP87
Secondary accession number(s): D3DVK4, Q6P5X8, Q86WQ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: July 31, 2019
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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