UniProtKB - Q9NP86 (CABP5_HUMAN)
Protein
Calcium-binding protein 5
Gene
CABP5
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 41 – 52 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 118 – 129 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 155 – 166 | 3PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
GO - Biological processi
- signal transduction Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-binding protein 5Short name: CaBP5 |
Gene namesi | Name:CABP5 Synonyms:CABP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13714 CABP5 |
MIMi | 607315 gene |
neXtProti | NX_Q9NP86 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 56344 |
OpenTargetsi | ENSG00000105507 |
PharmGKBi | PA26004 |
Miscellaneous databases
Pharosi | Q9NP86 |
Polymorphism and mutation databases
BioMutai | CABP5 |
DMDMi | 13431356 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073524 | 1 – 173 | Calcium-binding protein 5Add BLAST | 173 |
Proteomic databases
MassIVEi | Q9NP86 |
PaxDbi | Q9NP86 |
PeptideAtlasi | Q9NP86 |
PRIDEi | Q9NP86 |
ProteomicsDBi | 81931 |
PTM databases
PhosphoSitePlusi | Q9NP86 |
Expressioni
Tissue specificityi
Retina.1 Publication
Gene expression databases
Bgeei | ENSG00000105507 Expressed in 21 organ(s), highest expression level in leukocyte |
Genevisiblei | Q9NP86 HS |
Organism-specific databases
HPAi | HPA043698 |
Interactioni
Subunit structurei
Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner (By similarity).
Interacts with STXBP1 (By similarity).
Interacts with MYO6 (By similarity).
By similarityBinary interactionsi
Protein-protein interaction databases
BioGridi | 121142, 8 interactors |
IntActi | Q9NP86, 29 interactors |
STRINGi | 9606.ENSP00000293255 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 63 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 64 – 99 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 105 – 140 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 142 – 173 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 32 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027 Eukaryota COG5126 LUCA |
GeneTreei | ENSGT00940000160506 |
HOGENOMi | HOG000233018 |
InParanoidi | Q9NP86 |
KOi | K23531 |
OMAi | QQVRMNL |
OrthoDBi | 1470794at2759 |
PhylomeDBi | Q9NP86 |
TreeFami | TF334804 |
Family and domain databases
CDDi | cd00051 EFh, 1 hit |
InterProi | View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom |
Pfami | View protein in Pfam PF13499 EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054 EFh, 3 hits |
SUPFAMi | SSF47473 SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018 EF_HAND_1, 3 hits PS50222 EF_HAND_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q9NP86-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQFPMGPACI FLRKGIAEKQ RERPLGQDEI EELREAFLEF DKDRDGFISC
60 70 80 90 100
KDLGNLMRTM GYMPTEMELI ELGQQIRMNL GGRVDFDDFV ELMTPKLLAE
110 120 130 140 150
TAGMIGVQEM RDAFKEFDTN GDGEITLVEL QQAMQRLLGE RLTPREISEV
160 170
VREADVNGDG TVDFEEFVKM MSR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033695 | 65 | T → R. Corresponds to variant dbSNP:rs34862923Ensembl. | 1 | |
Natural variantiVAR_048633 | 80 | L → P. Corresponds to variant dbSNP:rs8105198Ensembl. | 1 | |
Natural variantiVAR_020020 | 128 | V → A. Corresponds to variant dbSNP:rs3745746Ensembl. | 1 | |
Natural variantiVAR_048634 | 140 | E → K. Corresponds to variant dbSNP:rs34681062Ensembl. | 1 | |
Natural variantiVAR_048635 | 147 | I → S. Corresponds to variant dbSNP:rs10425606Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF170815 AF170814 Genomic DNA Translation: AAF25798.1 AF169159 mRNA Translation: AAF25793.1 BC126133 mRNA Translation: AAI26134.1 BC126135 mRNA Translation: AAI26136.1 |
CCDSi | CCDS12709.1 |
RefSeqi | NP_062829.1, NM_019855.4 |
Genome annotation databases
Ensembli | ENST00000293255; ENSP00000293255; ENSG00000105507 |
GeneIDi | 56344 |
KEGGi | hsa:56344 |
UCSCi | uc002phu.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF170815 AF170814 Genomic DNA Translation: AAF25798.1 AF169159 mRNA Translation: AAF25793.1 BC126133 mRNA Translation: AAI26134.1 BC126135 mRNA Translation: AAI26136.1 |
CCDSi | CCDS12709.1 |
RefSeqi | NP_062829.1, NM_019855.4 |
3D structure databases
SMRi | Q9NP86 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 121142, 8 interactors |
IntActi | Q9NP86, 29 interactors |
STRINGi | 9606.ENSP00000293255 |
PTM databases
PhosphoSitePlusi | Q9NP86 |
Polymorphism and mutation databases
BioMutai | CABP5 |
DMDMi | 13431356 |
Proteomic databases
MassIVEi | Q9NP86 |
PaxDbi | Q9NP86 |
PeptideAtlasi | Q9NP86 |
PRIDEi | Q9NP86 |
ProteomicsDBi | 81931 |
Protocols and materials databases
DNASUi | 56344 |
Genome annotation databases
Ensembli | ENST00000293255; ENSP00000293255; ENSG00000105507 |
GeneIDi | 56344 |
KEGGi | hsa:56344 |
UCSCi | uc002phu.3 human |
Organism-specific databases
CTDi | 56344 |
DisGeNETi | 56344 |
GeneCardsi | CABP5 |
HGNCi | HGNC:13714 CABP5 |
HPAi | HPA043698 |
MIMi | 607315 gene |
neXtProti | NX_Q9NP86 |
OpenTargetsi | ENSG00000105507 |
PharmGKBi | PA26004 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0027 Eukaryota COG5126 LUCA |
GeneTreei | ENSGT00940000160506 |
HOGENOMi | HOG000233018 |
InParanoidi | Q9NP86 |
KOi | K23531 |
OMAi | QQVRMNL |
OrthoDBi | 1470794at2759 |
PhylomeDBi | Q9NP86 |
TreeFami | TF334804 |
Miscellaneous databases
GenomeRNAii | 56344 |
Pharosi | Q9NP86 |
PROi | PR:Q9NP86 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105507 Expressed in 21 organ(s), highest expression level in leukocyte |
Genevisiblei | Q9NP86 HS |
Family and domain databases
CDDi | cd00051 EFh, 1 hit |
InterProi | View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom |
Pfami | View protein in Pfam PF13499 EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054 EFh, 3 hits |
SUPFAMi | SSF47473 SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018 EF_HAND_1, 3 hits PS50222 EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CABP5_HUMAN | |
Accessioni | Q9NP86Primary (citable) accession number: Q9NP86 Secondary accession number(s): A0AUY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot